Press Release

Synthesis of Multisubstituted Aromatics via 3-Triazenylarynes

September 21, 2023


An efficient method for generating 3-triazenylarynes from ortho-iodoaryl triflate-type precursors was developed. The generated arynes reacted with various arynophiles with high regioselectivity because of the triazenyl group. The 3-triazenylaryne precursors functioned as useful intermediates of diverse multisubstituted aromatic compounds through the transformation of the remaining triazenyl group of aryne adducts and triazenyl group-directed ortho-C–H functionalization.

Journal Article

JOURNALOrganic Letters

TITLE:Synthesis of Multisubstituted Aromatics via 3-Triazenylarynes


Correspondence to

Takamitsu Hosoya, Professor

Laboratory of Chemical Bioscience,
Institute of Biomaterials and Bioengineering, 
Tokyo Medical and Dental University

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