Synthesis of Multisubstituted Aromatics via 3-Triazenylarynes
September 21, 2023
Abstract
An efficient method for generating 3-triazenylarynes from ortho-iodoaryl triflate-type precursors was developed. The generated arynes reacted with various arynophiles with high regioselectivity because of the triazenyl group. The 3-triazenylaryne precursors functioned as useful intermediates of diverse multisubstituted aromatic compounds through the transformation of the remaining triazenyl group of aryne adducts and triazenyl group-directed ortho-C–H functionalization.
Journal Article
JOURNAL：Organic Letters
TITLE：Synthesis of Multisubstituted Aromatics via 3-Triazenylarynes
DOI：https://doi.org/10.1021/acs.orglett.3c02615
TITLE：Synthesis of Multisubstituted Aromatics via 3-Triazenylarynes
DOI：https://doi.org/10.1021/acs.orglett.3c02615
Correspondence to
Takamitsu Hosoya, Professor
Laboratory of Chemical Bioscience,
Institute of Biomaterials and Bioengineering,
Tokyo Medical and Dental University
E-mail:thosoya.cb(at)tmd.ac.jp
*Please change (at) in the e-mail addresses to @ when sending correspondence.
Laboratory of Chemical Bioscience,
Institute of Biomaterials and Bioengineering,
Tokyo Medical and Dental University
E-mail:thosoya.cb(at)tmd.ac.jp
*Please change (at) in the e-mail addresses to @ when sending correspondence.