Homemade blenderized tube feeding improves gut microbiome communities in children with enteral nutrition
August 28, 2023
Abstract
Enteral nutrition for children is supplied through nasogastric or gastrostomy tubes. Diet not only influences nutritional intake but also interacts with the composition and function of the gut microbiota. Homemade blenderized tube feeding has been administered to children receiving enteral nutrition, in addition to ready-made tube feeding. The purpose of this study was to evaluate the oral/gut microbial communities in children receiving enteral nutrition with or without homemade blenderized tube feeding. Among a total of 30 children, 6 receiving mainly ready-made tube feeding (RTF) and 5 receiving mainly homemade blenderized tube feeding (HBTF) were analyzed in this study. Oral and gut microbiota community profiles were evaluated through 16S rRNA sequencing of saliva and fecal samples. The α-diversity representing the number of observed features, Shannon index, and Chao1 in the gut were significantly increased in HBTF only in the gut microbiome but not in the oral microbiome. In addition, the relative abundances of the phylum Proteobacteria, class Gammaproteobacteria, and genus Escherichia-Shigella were significantly low, whereas that of the genus Ruminococcus was significantly high in the gut of children with HBTF, indicating HBTF altered the gut microbial composition and reducing health risks. Metagenome prediction showed enrichment of carbon fixation pathways in prokaryotes at oral and gut microbiomes in children receiving HBTF. In addition, more complex network structures were observed in the oral cavity and gut in the HBTF group than in the RTF group. In conclusion, HBTF not only provides satisfaction and enjoyment during meals with the family but also alters the gut microbial composition to a healthy state.
Journal Article
JOURNAL：Frontiers in microbiology
TITLE：Homemade blenderized tube feeding improves gut microbiome communities in children with enteral nutrition
DOI：https://doi.org/10.3389/fmicb.2023.1215236
TITLE：Homemade blenderized tube feeding improves gut microbiome communities in children with enteral nutrition
DOI：https://doi.org/10.3389/fmicb.2023.1215236
Correspondence to
Sayaka Katagiri, Associate Professor
Department of Periodontology,
Graduated School of Medical and Dental Sciences,
Tokyo Medical and Dental University(TMDU)
E-mail：katagiri.peri(at)tmd.ac.jp
Shiba Takahiko,Assistant Professor
Department of Periodontology,
Graduate School of Medical and Dental Sciences,
Tokyo Medical and Dental University (TMDU)
E-mail：shiba.peri(at)tmd.ac.jp
Kanako Yoshimi,Assistant Professor
Department of Dysphagia Rehabilitation,
Graduate School of Medical and Dental Sciences,
Tokyo Medical and Dental University (TMDU)
E-mail：k.yoshimi.gerd(at)tmd.ac.jp
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