A collaborative research group from Germany (MPIIB, DRFZ, Humboldt foundation) and Japan (TMDU) newly developed a simple, rapid and safe method for the robust expansion of hematopoietic progenitors from normal mice without any genetic manipulations. These hematopoietic progenitors termed as “cCLP” can develop to a variety of immune cells (except for granulocytes). This method will make contributions not only to clarify the mechanisms of protective roles by immune cells from cancers as endogenous enemies as well as from a variety of pathogens as exogenous enemies, but also to provide a fundamental of the development for a new immune cell therapy in humans.

JOUNAL:
Blood

TITLE:
Stable lines and clones of long-term proliferating normal, genetically unmodified murine common lymphoid progenitors

DOI:
https://doi.org/10.1182/blood-2017-09-805259

Yohei Kawano, Assistant Professor
Department of Immune Regulation
Graduate School of Medical and Dental Sciences
Tokyo Medical and Dental University (TMDU)
E-mail: youhei.mbch(at)tmd.ac.jp