Nano Drug Delivery System (DDS) for mRNA Therapeutics by Satoshi Uchida

1. Transient stealth coating of liver sinusoidal wall by anchoring two-armed PEG for retargeting nanomedicines

Anjaneyulu Dirisala, Satoshi Uchida, Kazuko Toh, Junjie Li, Shigehito Osawa, Theofilus A. Tockary, Xueying Liu, Saed Abbasi, Kotaro Hayashi, Yuki Mochida, Shigeto Fukushima, Hiroaki Kinoh, Kensuke Osada and Kazunori Kataoka

Publication: Science Advances
Publication Date: 26 June 2020
DOI: https://doi.org/10.1126/sciadv.abb8133

2. Polyplex designs for improving the stability and safety of RNA therapeutics

Satoshi Uchida, Chun Yin Jerry Lau, Makoto Oba and Kanjiro Miyata

Publication: Advanced Drug Delivery Reviews
Publication Date: Epub 24 June 2023
DOI: https://doi.org/10.1016/j.addr.2023.114972

3. Comb-structured mRNA vaccine tethered with short double-stranded RNA adjuvants maximizes cellular immunity for cancer treatment

Theofilus A Tockary, Saed Abbasi, Miki Matsui-Masai, Akimasa Hayashi, Naoto Yoshinaga, Eger Boonstra, Zheng Wang, Shigeto Fukushima, Kazunori Kataoka, Satoshi Uchida 

Publication: Proceedings of the National Academy of Sciences of the United States of America (PNAS)
Publication Date: Epub 10 July 2023 
DOI: https://doi.org/10.1073/pnas.2214320120

Satoshi Uchida, Professor

E-mail: uchida.anme(at)tmd.ac.jp

Department of Advanced Nanomedical Engineering, 
Medical Research Institute, 
Tokyo Medical and Dental University(TMDU)

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Department of Advanced Nanomedical Engineering, Medical Research Institute
https://www.tmd.ac.jp/mri/anme/en/index.html