Press Release

A Titanic Medical Discovery

May 9, 2022
Researchers at Tokyo Medical and Dental University (TMDU) discover what gives titanium implants their remarkable biocompatibility, which may lead to more affordable medical and dental procedures
Tokyo, Japan – Scientists from the Tokyo Medical and Dental University (TMDU) used photoelectrochemical measurement and X-ray photoelectron spectroscopy to clarify the source of titanium’s biocompatibility when implanted into the body, as with hip replacements and dental implants. They find that its reactivity with the correct ions in the extracellular fluid allows the body to recognize it. This work may lead to new generation medical implants that last longer.

Owing to its excellent strength and resistance to corrosion, titanium is commonly used in medical and dental implants. Over time, doctors have also noticed that patients with titanium implants generate less of an immune response than normally occurs when a foreign material is placed inside the body. This has been explained based on the biocompatibility of titanium. This biocompatibility may generate a problem, such as when screws made from titanium alloys assimilate too much into bone tissue after long-term implantation, which makes them difficult to remove later. Despite numerous studies on biological reactions with implanted materials, the reason for the biocompatibility of titanium remains poorly understood. A more complete explanation of the surface properties that give titanium these features is needed. 

Now, a team of researchers led by TMDU has tested thin disks of titanium in a solution containing ions meant to mimic the extracellular fluid of the body, as well as in saline. They measured how much photoelectrical current was generated when light of various wavelengths was illuminated on the disks. They also performed X-ray photoelectron spectroscopy to characterize the passive films that were naturally present on the surface of the titanium. “Passive films consisted of a very thin TiO2 layer containing small amounts of Ti2O3 and TiO, hydroxyl groups, and water. During polarization in Hanks, calcium and phosphate ions were incorporated or formed calcium phosphate but not in saline” says first author  Seong-Cheol Kim Calcium phosphate also formed much more easily, which could help reduce the foreign body response. “The reactivity of titanium with high corrosion resistance, as revealed in this experiment by its electronic band  structure, is one of the primary reasons for its excellent biocompatibility among metals,” says corresponding author Takao Hanawa. This research may lead to safer and less expensive implants for hip replacements or dental implants, because titanium is relatively rare and expensive. 

Electronic band structures of passive films formed on Ti in Hanks and saline

Band gap energies of the passive film on Ti are relatively small that is one factor generating the excellent biocompatibility.


The work is published in Science and Technology of Advanced Materials as “Band structures of passive films on titanium in simulated bioliquids determined by photoelectrochemical response: principle governing the biocompatibility” (Vol. 23, No. 1, pp. 66-75 (2022) DOI:10.1080/14686996.2022.2066960).


 TMDU researchers studied the electronic band structure of the passive film on titanium when submerged in a fluid meant to mimic the human body. They found that the relative reactivity of titanium, when compared with other passive metals like zirconium, remaining high corrosion resistance helps explain its strong biocompatibility. This work may allow more people to benefit from durable medical implants.

Journal Article

JOURNALScience and Technology of Advanced Materials

TITLE:Band structures of passive films on titanium in simulated bioliqids determined by photoelectrochemical response: Principle governing the biocompatibility


Correspondence to

Takao Hanawa, Professor

Department of Metallic Biomaterials,
Institute of Biomaterials and Bioengineering,
Tokyo Medical and Dental University(TMDU)

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