Press Release

High-Fat Diet Enhances Neutrophil Adhesion in LDLR-Null Mice Via Hypercitrullination of Histone H3

Highlights

•Neutrophil adhesion to the vascular endothelium in the femoral artery of low-density lipoprotein receptor–null mice fed with HFD was significantly enhanced compared with wild-type mice fed with HFD or low-density lipoprotein receptor–null mice fed with NC.

•HFD induced citrullinated histone H3 of neutrophils in LDL receptor–null mice through the up-regulation of CXCL1 in blood.

•Hypercitrullination of histone H3 in neutrophils by CXCL1 enhanced neutrophil adhesion in vitro and in vivo.

•Pemafibrate decreased neutrophil adhesion and citrullination of histone H3 through the reduction of CXCL1.

Journal Article

JOURNAL:JACC: Basic to Translational Science

TITLE:High-Fat Diet Enhances Neutrophil Adhesion in LDLR-Null Mice Via Hypercitrullination of Histone H3

DOIhttps://doi.org/10.1016/j.jacbts.2021.04.002

Correspondence to

Masayuki YOSHIDA, Professor

Department of Life Sciences and Bioethics,
Graduate School of Medical and Dental Sciences,
Tokyo Medical and Dental University(TMDU)
E-mail:masa.vasc(at)tmd.ac.jp

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