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Home  > Press Release  > Distinct types of stem cell divisions determine organ regeneration and aging in hair follicles

Distinct types of stem cell divisions determine organ regeneration and aging in hair follicles

Abstract

Hair follicles, mammalian mini-organs that grow hair, miniaturize during aging, leading to hair thinning and loss. Here we report that hair follicle stem cells (HFSCs) lose their regenerative capabilities during aging owing to the adoption of an atypical cell division program. Cell fate tracing and cell division axis analyses revealed that while HFSCs in young mice undergo typical symmetric and asymmetric cell divisions to regenerate hair follicles, upon aging or stress, they adopt an atypical ‘stress-responsive’ type of asymmetric cell division. This type of division is accompanied by the destabilization of hemidesmosomal protein COL17A1 and cell polarity protein aPKCλ and generates terminally differentiating epidermal cells instead of regenerating the hair follicle niche. With the repetition of these atypical divisions, HFSCs detach from the basal membrane causing their exhaustion, elimination and organ aging. The experimentally induced stabilization of COL17A1 rescued organ homeostasis through aPKCλ stabilization. These results demonstrate that distinct stem cell division programs may govern tissue and organ aging.

Journal Article

JOURNAL
Nature aging

TITLE
Distinct types of stem cell divisions determine organ regeneration and aging in hair follicles

DOI
https://doi.org/10.1038/s43587-021-00033-7

Correspondence to

Hiroyuki Matsumura,Assistant professor
Emi K. Nishimura,Professor

Department of Stem Cell Biology,
Medical Research Institute,
Tokyo Medical and Dental University(TMDU)
E-mail:matsscm(at)tmd.ac.jp
E-mail:nishscm(at)tmd.ac.jp


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