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Press Release

2019/12/02: TMDU is ranked #74 for Clinical, Pre-clinical & Health in THE World University Rankings by Subject 2020!

2019/11/27: Temporospatial sonic hedgehog signalling is essential for neural crest-dependent patterning of the intrinsic tongue musculature

2019/11/06: Bile duct biomarker? Protein found to pinpoint patients with a lethal cancer

2019/11/01: A Nice Reactive Ring to It: New Synthetic Pathways for Diverse Aromatic Compounds

2019/10/21: “Instant Liver, Just Add Water”? Not Quite, but a Better Way to Grow Multiple Organs

2019/09/24: Comparative analysis demonstrates cell type-specific conservation of SOX9 targets between mouse and chicken

2019/09/11: Stem cell competition offers a mechanism for skin youthfulness and ageing

2019/08/06: Heterogeneity in fetal growth velocity

2019/08/02: 3D miniature livers lead the way to patient-specific drug discovery

2019/07/30: Involvement of N-type Ca2+ channel in microglial activation and its implications to aging-induced exaggerated cytokine response

2019/07/24: "HDO-antimiR represents a new weapon in the fight against microRNA-related disease"

2019/07/04: Enhancement of Motor Function Recovery After Spinal Cord Injury in Mice by Delivery of Brain Derived Neurotrophic Factor mRNA

2019/07/03: Fibroblast growth factor signals regulate transforming growth factor‐β‐induced endothelial‐to‐myofibroblast transition of tumor endothelial cells via Elk1

2019/07/01: Tolvaptan activates the Nrf2/HO-1 antioxidant pathway through PERK phosphorylation

2019/06/28: 3-Thioaryne Intermediates for the Synthesis of Diverse Thioarenes

2019/06/25: Blockade of microglial Cav1.2 Ca2+ channel exacerbates the symptoms in a Parkinson’s disease model

2019/06/13: Reciprocal cortical activation patterns during incisal and molar biting correlated with bite force levels: an fMRI study.

2019/06/05: MRTF A regulates proliferation and survival properties of pro atherogenic macrophages

2019/06/04: Wwp2 maintains cartilage homeostasis through regulation of Adamts5.

2019/05/31: Modeling Steatohepatitis in Human with Pluripotent Stem Cell-Derived Organoids

2019/05/29: Antibacterial activity of lysozyme-chitosan oligosaccharide conjugates (LYZOX) against Pseudomonas aeruginosa, Acinetobacter baumannii and Methicillin-resistant Staphylococcus aureus

2019/05/10: “Hard food, strong jaw: jawbone structure responds to forceful chewing”

2019/04/23: Synthesis of Alkynyl Sulfides by Copper-Catalyzed Thiolation of Terminal Alkynes Using Thiosulfonates

2019/04/16: ”Genome editing helps decipher a congenital liver disease”

2019/04/16: Silencing of PD-L2/B7-DC by Topical Application of Small Interfering RNA Inhibits Elicitation of Contact Hypersensitivity

2019/04/12: Development of a NanoBRET-based Sensitive Screening Method for CXCR4 Ligands

2019/04/10: Impact of novel NS5A resistance-associated substitutions of hepatitis C virus detected in treatment-experienced patients

2019/03/19: Loss of Fibrocystin Promotes Interleukin-8-Dependent Proliferation and CTGF Production of Biliary Epithelium

2019/03/15: "How does estrogen protect bones? Unraveling a pathway to menopausal bone loss"

2019/03/11: TMDU is ranked 1^st (Dentistry in Japan) and 3^rd (Medicine in Japan) in QS World University Rankings 2019 by Subject!

2019/03/07: A facile preparation of functional cycloalkynes via an azide-to-cycloalkyne switching approach

2019/02/26: Treatment of intervertebral disk disease by administration of messenger RNA encoding a cartilage-anabolic transcription factor

2019/02/15: LIM homeobox 2 promotes interaction between human iPS-derived hepatic progenitors and iPS-derived hepatic stellate-like cells

2019/02/08: "Adenoid and Tonsil Trouble for Teens"

2019/02/06: "Shedding Light on Zebrafish Daily Rhythms: Clock Gene Functions Revealed"

2019/02/05: Interleukin-13 receptor α2 is a novel marker and potential therapeutic target for human melanoma

2019/01/31: "Crunching the Data: New Liver Cancer Subtypes Revealed Immunologically"

2019/01/24: "Researchers Breathe New Life into COPD Research Using Mouse Models"

2019/01/24: Induced Proton Perturbation for Sensitive and Selective Detection of Tight Junction Breakdown

2019/01/17: ”Killer Blows? Knockout Study of Pair of Mouse MicroRNA Provides Cancer Insight”

2018/12/20: Short-term prognosis of emergently hospitalized dialysis-independent chronic kidney disease patients: a nationwide retrospective cohort study in Japan

2018/12/18: Loss of KDM6A characterizes a poor prognostic subtype of human pancreatic cancer and potentiates HDAC inhibitor lethality

2018/12/14: "Stop that clot! Quantitative assessment of the blood coagulation cascade"

2018/12/13: Ubiquitin D is up-regulated by synergy of Notch signaling and TNF-α in the inflamed intestinal epithelia of IBD patients.

2018/12/07: "Undiplomatic Immunity: Mutation Causing Arterial Autoimmune Disease Revealed"

2018/12/07: "Faulty sensing: cellular energy sensor linked to the progression of chronic kidney disease"

2018/12/04: Asymmetric dimethylation at histone H3 arginine 2 by PRMT6 in gastric cancer progression

2018/11/08: "Small populations of normal cells affect immunity in patients with XLP1"

2018/10/29: "Virus Production Boosted in Cells to Generate More Vectors for Gene Transfer"

2018/10/22: Gain-of-function IKBKB mutation causes human combined immune deficiency

2018/10/11: "Early Changes to Synapse Gene Regulation May Cause Alzheimer’s Disease"

2018/08/24: Combinatorial CRISPR/Cas9 approach to elucidate a far-upstream enhancer complex for tissue-specific Sox9 expression

2018/08/17: Downregulated Pancreatic Beta Cell Genes Indicate Poor Prognosis in Patients With Pancreatic Neuroendocrine Neoplasms.

2018/08/16: "Controlling STAT3 may provide new therapy for chronic active Epstein-Barr virus infection, a chemotherapy-resistant T- or NK-cell neoplasm"

2018/08/06: Integrated analysis of human genetic association study and mouse transcriptome suggests LBH and SHF genes as novel susceptible genes for amyloid-beta accumulation in Alzheimer's disease.

2018/07/19: Histamine Released From Skin-Infiltrating Basophils but Not Mast Cells Is Crucial for Acquired Tick Resistance in Mice.

2018/07/05: "New microsensor for pH mapping joins the fight against tooth decay"

2018/06/20: "Opening Up a Drug Delivery Route – Discovery of a New Vehicle Peptide"

2018/06/20: "Of Hearts and Giants: Moving a Cardiac Regulatory Protein to the Right Place"

2018/06/19: Angubindin-1 opens the blood-brain barrier in vivo for delivery of antisense oligonucleotide to the central nervous system.

2018/06/19: Transient Protection of Organic Azides from Click Reactions with Alkynes by Phosphazide Formation.

2018/06/12: Multi-ethnic genome-wide association study for atrial fibrillation

2018/06/06: Cytosolic Genomic DNA functions as a Natural Antisense

2018/06/05: Hematopoietic stem cell transplantation for progressive combined immunodeficiency and lymphoproliferation in patients with activated phosphatidylinositol-3-OH kinase δ syndrome type 1.

2018/05/22: Staudinger reaction using 2,6-dichlorophenyl azide derivatives for robust aza-ylide formation applicable to bioconjugation in living cells

2018/05/07: Stable lines and clones of long-term proliferating normal, genetically unmodified murine common lymphoid progenitors

2018/05/07: Region-specific deletions of the glutamate transporter GLT1 differentially affect nerve injury-induced neuropathic pain in mice.

2018/04/27: Dissecting the roles of miR-140 and its host gene

2018/04/26: Overexpression of heart-specific small subunit of myosin light chain phosphatase results in heart failure and conduction disturbance.

2018/04/17: CD22-Binding Synthetic Sialosides Regulate B Lymphocyte Proliferation Through CD22 Ligand-Dependent and Independent Pathways, and Enhance Antibody Production in Mice.

2018/04/13: AKAPs-PKA disruptors increase AQP2 activity independently of vasopressin in a model of nephrogenic diabetes insipidus

2018/04/04: IMSindel: An accurate intermediate-size indel detection tool incorporating de novo assembly and gapped global-local alignment with split read analysis

2018/04/03: Ovarian cancer therapeutic potential of glutamine depletion based on GS expression.

2018/03/26: "Colon Signaling Pathway Key to Inflammatory Bowel Disease"

2018/03/19: "Forming and resorbing bones: metastasizing cancer cells modify bone remodeling with small RNA secretion"

2018/03/13: "Potential RNA Markers of Abnormal Heart Rhythms Identified in Circulating Blood"

2018/03/06: "Technique Allows Live Imaging of “Ubiquitous” Player in Cellular Housekeeping"

2018/03/06: "Epigenetic Modulation of Fgf21 Gene in Early-Life Ameliorates Adulthood Diet-Induced Obesity "

2018/02/23: "Insights into familial middle-age dementia suggest new avenues for treatment"

2018/01/16: Microneedle‐Array Patch Fabricated with Enzyme‐Free Polymeric Components Capable of On‐Demand Insulin Delivery

2018/01/12: "Protein YAP in Early Life Influences Adult Spinocerebellar Ataxia Pathology"

2017/12/27: "Uncovering Molecular Targets for Childhood Cancer Therapeutics"

2017/12/12: "Role of Transcriptional Co-factor in Inflammation Hints at Possible Inflammatory Bowel Disease Treatment"

2017/12/08: "Monitoring Thyroid Response: Biomarker May Predict Graves’ Disease Relapse"

2017/10/20: "RANKL expressed by osteocytes has an important role in orthodontic tooth movement"

2017/10/18: ”Superior vena cava (or SVC) - derived atrial fibrillation attributes to both clinical and genetic factors”

2017/08/17: ”Signaling Pathway Controls Body Clock and Movement in Adult Mice”

2017/08/08: "Protein critical to early stages of cellular HIV infection identified"

2017/08/01: "Gene-Regulatory Factors Shown to Improve Pancreatic Cancer Response to Chemotherapy"

2017/08/01: ”Molecule’s Role in Maintaining Liver Size and Function Revealed”

2017/07/10: "Reduced mastication results in the impairment of memory and learning function"

2017/06/13: "Discovery of Human Blood Cell Destinies Revises Knowledge of Immune Cell Development"

2017/05/25: "A Lightning-Fast Flu Virus Detector"

2017/03/30: "Differences in Microbial Interactions Underlie Related Oral Diseases"

2017/03/30: "Method Identified to Boost Detection of Highly Cancerous Stem Cells"

2017/03/24: "New Synthetic Route to Complex Organofluorine Compounds Developed"

2017/01/17: "Metabolic Pathway Regulating Key Stage of Embryo Development Revealed"

2016/12/28: "Role of Sox17 Protein in Embryo Implantation Key to Mouse Fertility"

2016/12/27: "Alzheimer’s Disease Pathway Identification Enables Development of Novel Preclinical Therapy"

2016/12/16: "Degrader of Proteins Required for the Origin of Early Cancerous Lesions"

2016/12/14: "Breakthrough in Hepatitis Research as New Infected Cell Models are Developed"

2016/11/24: "Novel Method of Cellular Waste Disposal Revealed in Yeast and Mammals"

2016/11/24: ”Role for Autophagic Cellular Degradation Process in Maintaining Genomic Stability”

2016/11/22: ”Novel Type of Cell Death in Huntington’s Disease May Lead to Effective New Therapies”

2016/11/22: "How Cell Populations Weed Out “Loser” Cells to Maintain Vitality is Revealed"

2016/10/31: “Advancing Our Understanding of How the Disease Lupus is prevented in healthy individuals”

2016/10/05: “Breakthrough for Bone Regeneration via Double-cell-layered Tissue Engineering Technique”

2016/08/23: “Injected Mix of Bone-augmenting Agents Causes New Bone Growth in Mouse Jaws”

2016/07/01: “Blood Coagulation Detector May Help in Monitoring Stroke Risk”

2016/06/07: “World's First Measurement and Visualization of Cardiac Activity Using MR Sensors”

2016/02/16: “Periodic injections of synovial stem cells inhibit osteoarthritis progression in the knee”

2016/02/01: “Synthetic polymer-based elucidation of survival strategies of cancer stem cells”

2015/12/28: “Tooth regenerative technology by a mechanical ligation method”

2015/11/26: Tokyo Medical and Dental University (TMDU) becomes the first university in Japan to establish an international joint degree (JD) program, and has concluded an agreement with University of Chile and its associated hospital.

2015/11/26: Tokyo Medical and Dental University (TMDU) becomes the first university in Japan allowed to establish an international joint degree (JD) program having an agreement with Chulalongkorn University.

2015/09/29: Tokyo Medical and Dental University to establish an INCJ-backed venture company, Rena Therapeutics Inc.

2015/08/11: “DNA/RNA Heteroduplex oligonucleotide: the third class oligonucleotides”

2015/04/28: “Highly efficient CRISPR knock-in in mouse”

2014/12/16: “Gene therapy of model mice for spinocerebellar ataxia was successful.”

2014/08/18: “Transplanting Cultured Small Intestinal Epithelial Stem Cells onto Colon”

2014/04/23: “Discovery of the molecule Sox17 to maintain the hematopoietic stem cell at embryonic stages”

2014/02/04: “Identification of new molecular function that suppresses osteoporosis”

2013/09/13: “Discovery of a novel function of dendritic cells to fine-tune excessive immune responses”

2013/04/26: “Discovery of a novel source of dendritic cells, the control tower of the immune system”

2013/02/22: “Identification of a novel mechanism by which allergic inflammation is dampened”

2012/10/11: “3D MRI Analyses Clarify that Pathologic Myopia is Caused by Eye Globe Deformity”

2012/05/21: “Etiologic Link between Sarcoidosis and Propionibacterium acnes”

2012/04/24: “Anabolic action of PTH regulated by the β2-adrenergic receptor”

2012/03/12: “Functional Engraftment of Colon Epithelium Expanded In Vitro from a Single Adult Lgr5+ Stem Cell”

2012/02/27: “Identification of a key regulator molecule that prevents neutrophil over-activation”

2012/02/07: “Dissecting molecular mechanisms of tumor progression”

2012/01/18: “Development of non-human primate model of amyotrophic lateral sclerosis (ALS)”

2011/10/11: “Sympathetic control of bone mass regulated by osteopontin”

2011/09/28: “A Single-Use, Centrifugal Type Assist Heart with Excellent Durability and Biocompatibility”

2011/09/20: “Identification of the commander cell in the bone remodeling”

2011/08/26: “The first genetically engineered mouse model of diffuse-type gastric cancer”

2011/04/15: “Autophagy prevents spontaneous tumor development in the liver”

2011/02/04: “Hair Follicle Stem Cells Provide a Functional Niche for Melanocyte Stem Cells”

2010/07/27: “Basophils Play an Essential Role in Protective Immunity Against Ticks”

2010/06/08: “Clarification of a molecular mechanism underlying cerebellar degeneration”

2010/05/04: “Impairment of DNA-repair by mutant Huntingtin is a major cause of neurodegenerative pathology in Huntington’s disease.”

2010/04/12: “Identification of the gene regulating the development of T cells that cause autoimmune diseases”