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最近の業績

2012年

1. Ramakrishman R, Donahue H, Garcia D, Tan J, Shimizu N, Rice AP, Ling PD. Epstein-Barr virus BART9 miRNA modulates LMP1 levels and affects growth rate of nasal NK T cell lymphomas. PLoS One. 2011:e27271.

2. Ogawa M, Sugita S, Shimizu N, Watanabe K, Nakagawa I, Mochizuki M. Broad-range real-time PCR assay for detection of bacterial DNA in ocular samples from infectious endophthalmitis. Japanese Journal of Ophthalmology. 2012 Aug 31. [Epub ahead of print]

3. Sugita S, Shimizu N, Watanabe K, Ogawa M, Maruyama K, Usui N, Mochizuki M. Virological analysis in patients with human herpes virus 6-associated ocular inflammatory disorders. Investigative Ophthalmoogyl &Visual Science. 2012 Jul 12; 53(8):4692-8. Print 2012 Jul.

4. Ogawa M, Sugita S, Watanabe K, Shimizu N, Mochizuki M. Novel diagnosis of fungal endophthalmitis by broad-range real-time PCR detection of fungal 28S ribosomal DNA. Graefe’s Archive for Clinical and Experimental Ophthalmology. 2012 Apr 15. [Epub ahead of print]

2011年

1. Sugita S, Shimizu N, Watanabe K, Katayama M, Horie S, Ogawa M, Sugimoto Y and Mochizuki M. Diagnosis of bacterial endophthalmitis by broad-range quantitative PCR. British Journal of Ophthalmology. 2011 Mar; 95:345- 349. Epub 2010 Jul 31.

2. Karbe K, Nakagawa M, Tsuzuki S, Takeuchi I, Honma K, Nakashima Y, Shimizu N, Ko YH, Morishima Y, Ohshima K, Nakamura S, Seto M. Identification of FOXO3 and PRDM1 as tumor-suppressor gene candidates in NK-cell neoplasms by genomic and functional analyses. Blood. 2011 Sep 22; 118(12):3195-3204. Epub 2011 Jun 20.

3. Ng SB, Selvarajan V, Huang G, Zhou J, Feldman AL, Law M, Kwong YS, Shimizu N, Nagami Y, Aozasa K, Salto-Tellez M and Chng WJ. Activated oncogenic pathways and therapeutic targets in extranodal nasal-type NK/T cell lymphoma revealed by gene expression profiling. The Journal of Phatology. 2011 Mar; 223(4):496-510. Epub 2011 Jan 5.

4. Abe T, Segawa Y, Watanabe H, Yotoriyama T, Kai Y, Yasuda A, Shimizu N and Tojo N. Point-of-Care Testing System Enabling 30-min Detection of Influenza Genes. Lab on a Chip. 2011 Mar 21; 11:1166-1167. Epub 2011 Feb 11.

5. Yagasaki H, Kato M, Shimizu N, Shichino H, Chin M and Mugishima H. Autoimmune hemolytic anemia and autoimmune neutropenia in a child with erythroblastopenia of childhood (TEC) caused by human herpesvirus-6 (HHV6). Annals of Hematology. 2011 Jul; 90(7):851-852. Epub 2010 Oct 5.

6. Watanabe A, Tagawa H, Yamashita J, Teshima K, Nara M, Iwamoto K, Kume M, Kameoka Y, Takahashi N, Nakagawa T, Shimizu N and Sawada K. The role of microRNA-150 as a tumor suppressor in malignant lymphoma. Leukemia. 2011 Aug; 25(8):1324-1334. Epub 2011 Apr 19.

7. Sugita S, Ogawa M, Inoue S, Shimizu N and Mochizuki M. Diagnosis of ocular toxoplasmosis by two polymerase chain reaction (PCR) examinations: qualitative multiples and quantitative real-time. Japanese Journal of Ophthalmology. 2011 Sep; 55(5):495-501. Epub 2011 Jul 13.

8. Sugita S, Shimizu N, Watanabe K, Katayama M, Horie S, Ogawa M, Sugimoto Y and Mochizuki M. Detection of Candida & Aspergillus species DNA using broad-range real-time PCR for fungal endophthalmitis. Graefe’s Archive for Clinical and Experimental Ophthalmology. 2012 Mar; 250(3):391-398. Epub 2011 Sep 27.

9. Ng SB, Yan J, Huang G, Selvarajan V, Tay J, Lin B, Bi C, Tan J, Kwong YL, Shimizu N, Aozasa K, Chng W. Dysregulated MicroRNAs Affect Pathways and Targets of Biological Relevance in Nasal-type Natural Killer / T-cell Lymphoma. Blood. 2011 Nov 3; 118(18):4919-4129. Epub 2011 Sep 14.

10. Imadome K, Yajima M, Arai A, Nakazawa A, Kawano F, Ichikawa S, Shimizu N, Yamamoto N, Morio T, Ohga S, Nakamura H, Ito M, Miura O, Komano J, and Fujiwara S. Novel Mouse Xenograft Models Reveal a Critical Role of CD4+ T Cells in the Proliferation of EBV-Infected T and NK Cells. PLoS Pathogens. 2011 Oct; 7(10):e1002326. Epub 2011 Oct 20.

11. Kuwana Y, Takei M, Yajima M, Imadome K, Inomata H, Shiozaki M, Inomata H, Ikumi N, Nozaki T, Shiraiwa H, Kitamura N, Takeuchi J, Sawada S, Yamamoto N, Shimizu N, Ito M and Fujiwara S. Epstein-Barr Virus Induces Erosive Arthritis in Humanized Mice. PloS ONE. 2011; 6(10):e26630. Epub 2011 Oct 19.

2010年

1. Miyanaga M, Sugita S, Shimizu N, Morio T, Miyata K, Maruyama K, Kinoshita S and Mochizuki M. A significant association of viral loads with corneal endothelial cell damage in cytomegalovirus anterior uveitis. British Journal of Ophthalmology. 2010 Mar; 94(3):336-340. Epub 2009 Sep 3.

2. Nagasawa M., Ogawa K., Nagata K and Shimizu N. Serum granulysin as a possible biomarker of NK cell neoplasm. British Journal of Haematology. 2010 Mar; 148(5):812-814. Epub 2009 Nov 13.【Last Author】

3. Zhang Y, Ohyashiki JH, Shimizu N and Ohyashiki K. Aberrant expression of NK cell receptors in Epstein-Barr virus-positive gammadelta T-cell lymphoproliferative disorders. Hematology. 2010 Feb; 15(1):43-47.

4. Kariya Y, Hamatake M, Urano E, Yoshiyama H, Shimizu N and Komano J. Dominant-negative derivative of EBNA1 represses EBNA1-mediated transforming gene expression of Epstein-Barr virus infection independent of rapid loss of viral genome. Cancer Science. 2010 Apr; 101(4):876-881. Epub 2009 Dec 16.

5. Iwata S, Wada K, Tobita S, Gotoh K, Ito Y, Demachi-Okamura A, Shimizu N, Nishiyama Y and Kimura H. Quantitative Analysis of Epstein-Barr Virus (EBV)-Related Gene Expression in Patients with Chronic Active EBV Infection. Journal of General Virology. 2010 Jan; 91(Pt1):42-50. Epub 2009 Sep 30.

6. Miyagawa Y, Kiyokawa N, Ochiai N, Imadome K, Horiuchi Y, Onda K, Yajima M, Nakamura H, Katagiri Y, Okita H, Morio T, Shimizu N, Fujimoto J and Fujiwara S. Ex vivo expanded cord blood CD4 T lymphocytes exhibit a distinct expression profile of cytokine-related genes from those of peripheral blood origin. Immunology. 2010; 128(3):405- 419.

7. Chan KK, Shen L, Au WY, Yuen HF, Wong KY, Guo T, Wong ML, Shimizu N, Tsuchiyama J, Kwong YL, Liang RH and Srivastava G. Interleukin-2 induces NF-kappaB activation through BCL10 and affects its subcellular localization in natural killer lymphoma cells. The Journal of Phatology. 2010 Jun; 221(2):164-74.

8. Miyanaga M, Sugita S, Shimizu N, Morio T, Miyata K, Maruyama K, Kinoshita S, Mochizuki M. A significant association of viral loads with corneal endothelial cell damage in cytomegalovirus anterior uveitis. British Journal of Ophthalmology. 2010 Mar;94(3):336-40.Epub 2009 Sep 3.

9. Nagasawa M, Ogawa K, Nagata K, Shimizu N. Serum granulysin as a possible biomarker of NK cell neoplasm. British Journal of Haematology. 2010 Mar;148(5):812-4. Epub 2009 Nov 13.

10. 山本紗也香、杉田 直、堀江真太郎、清水則夫、森尾友宏、望月 學:角膜炎を伴わない単純ヘルペスウイルス1型虹彩毛様体炎の3例 あたらしい眼科2010; 27: 252-255.

11. 小川学, 杉田直, 井上静, 望月學, 片山未来, 渡邊健, 清水則夫, 森尾友弘:ヘルペスウイルスの関与が疑われるぶどう膜炎に対する眼内液PCR検査の有用性の検討、日本眼科学会雑誌114巻臨増 Page306(2010.03)

12. 小野敏明, 遠藤明史, 満生紀子, 高木正稔, 長澤正之, 片山未来, 渡部健, 落合央, 大山敦, 峯岸志津子, 清水則夫, 森尾友宏, 水谷修紀:急性白血病治療中にカリシウイルス腸炎を発症した3例の遷延性ウイルス排泄の検討、小児がん46巻プログラム・総会号 Page336(2009.11)

2009年

1. Yajima M, Imadome KI, Nakagawa A, Watanabe S, Terashima K, Nakamura H, Ito M, Shimizu N, Yamamoto N, Fujiwara S. T Cell-Mediated Control of Epstein-Barr Virus Infection in Humanized Mice. The Journal of Infectious Diseases. 2009 Nov 15; 200(10):1611-1615.

2. Yamanaka Y, Tagawa H, Takahashi N, Watanabe A, Guo Y-M, Iwamoto K, Yamashita J, Saitoh H, Kameoka Y, Shimizu N, Ichinohasama R, and Sawada K. Aberrant overexpression of microRNAs activate AKT signaling via down-regulation of tumor suppressors in natural killer–cell lymphoma/leukemia. Blood. 2009 Oct 8; 114(15): 3265 – 3275. Epub 2009 Jul 29.

3. Moriai S, Takahara M, Ogino T, Nagato T, Kishibe K, Ishii H, Katayama A, Shimizu N and Harabuchi Y. Production of Interferon-γ–Inducible Protein-10 and Its Role as an Autocrine Invasion Factor in Nasal Natural Killer/T-Cell Lymphoma Cells. Clinical Cancer Ressearch.2009 Nov 15; 15(22):6771-6779.Epub 2009 Nov 3.

4. Miyagawa Y, Kiyokawa N, Ochiai N, Imadome K, Horiuchi Y, Onda K, Yajima M, Nakamura H, Katagiri Y, Okita H, Morio T, Shimizu N, Fujimoto J. and Fujiwara S. Ex vivo expanded cord blood CD4 T lymphocytes exhibit a distinct expression profile of cytokine-related genes from those of peripheral blood origin. Immunology. 2009 Nov; 128(3):405-419.

5. Imadome K, Shimizu N, Yajima M, Watanabe K, Nakamura H, Takeuchi H, Fujiwara S. CD40 signaling activated by Epstein-Barr virus promotes cell survival and proliferation in gastric carcinoma-derived human epithelial cells. Microbes and Infection. 2009 Mar; 11(3):429-433.Epub Feb 10.

6. Ono Y, Terashima K, Liu A, Yokoyama M, Yokoshima K, Mizukami M, Watanabe K, Mochimaru Y, Furusaka T, Shimizu N, Yamamoto N, Ishiwata T, Sugisaki Y, Yagi T and Naito Z. Follicular dendritic cell sarcoma with microtubuloreticular structure and virus-like particle production in vitro. Pathology International. 2009 May; 59(5): 332–344.

2008年

1. Takahashi H, Sugita S, Shimizu N, Mochizuki M. A high viral load of Epstein-Barr virus (EBV) DNA in ocular fluids in a HLA-B27 negative acute anterior uveitis patient with psoriasis. Japanese Journal of Ophthalmology. 2008 Mar-Apr; 52(2):136-138.Epub 2008 Apr 30.

2. Sugita S, Shimizu N, Watanabe K, Mizukami, Morio T, Sugamoto Y and Mochizuki M. Use of multiplex PCR and real-time PCR to detect human herpes virus genome in ocular fluids of patients with uveitis. British Journal of Ophthalmology. 2008 Jul; 92(7):928-932.Epub 2008 Apr 11.

3. Kido S, Sugita S, Horie S, Miyanaga M, Miyata K, Shimizu N, Morio T and Mochizuki M. Association of varicella zoster virus load in the aqueous humor with clinical manifestations of anterior uveitis in herpes zoster ophthalmicus and zoster sine herpete. British Journal of Ophthalmology. 2008 Apr; 92(4):505-508.Epub 2008 Feb 1.

4. Nakamura H, Ishii C, Suehiro M, Iguchi A, Kuroda K, Shimizu K, Shimizu N, Imadome K, Yajima M and Fujiwara S. The latent membrane protein 1 (LMP1) encoded by Epstein-Barr virus induces expression of the putative oncogene Bcl-3 through activation of the nuclear factor-kappaB. Virus research. 2008 Feb; 131(2):170-179.Epub 2007 Oct 25.

5. Yajima M, Imadome K, Nakagawa A, Watanabe S, Terashima K, Nakamura H, Ito M, Shimizu N, Honda M, Yamamoto N, Fujiwara S. A new humanized mouse model of Epstein-Barr virus infection that reproduces persistent infection, lymphoproliferative disorder, and cell-mediated and humoral immune responses. Journal of Infectious Diseases. 2008 Sep; 198(5):673-682.

6. Kanno H, Watabe D, Shimizu N, Sawai T. Adhesion of Epstein-Barr virus-positive natural killer cell lines to cultured endothelial cells stimulated with inflammatory cytokines. Clinical Experimental Immunology. 2008 Mar; 151(3):519-527.Epub 2008 Jan 8.

2007年

1. Watanabe S, Terashima K, Ohta S, Horibata S, Yajima M, Shiozawa Y, Dewan Z, Yu Z, Ito M, Morio T, Shimizu N, Honda M, and Yamamoto N. Hematopoietic stem cell-engrafted NOD/SCID/IL2Rgamma null mice develop human lymphoid system and induce long-lasting HIV-1 infection with specific humoral Immune Responses. Blood. 2007 Jan 1; 109(1):212-218. Epub 2006 Sep 5.

2. Kawaguchi T, Sugita S, Shimizu N and Mochizuki M. Kinetics of aqueous flare, intraocular pressure and virus-DNA copies in a patient with cytomegalovirus iridocyclitis without retinitis. International Ophthalmology. 2007 Dec; 27(6):383-386.Epub 2007 May 24.

3. Watanabe S, Ohta S, Yajima M, Terashima K, Ito M, Mugishima H, Fujiwara S, Shimizu K, Honda M, Shimizu N and Yamamoto N. Humanized NOD/SCID/IL2Rgammanull mice transplanted with hematopoietic stem cell under non-myeloablative condition show prolonged life spans and allow detailed analysis of HIV-1 pathogenesis. Journal of Virology. 2007 Dec; 81(23):13259-13264.Epub 2007 Sep 19.

4. Sugita S, Shimizu N, Kawaguchi T, Akao N, Morio T, Mochizuki M. Identification of human herpesvirus 6 in a patient with severe unilateral panuveitis. Archives of Ophthalmology. 2007 Oct; 125(10):1426-1427.

2006年

1. Rouget-Quermalet V, Giustiniani J, Marie-Cardine A, Beaud G, Besnard F, Loyaux D, Ferrara P, Shimizu N, Gaulard P, Bensussan A and Schmitt C. Protocadherin 15 (PCDH15): a new secreted isoform and a potential marker for NK/T cell lymphomas. Oncogene. 2006 May 4; 25 (19): 2807-2811.

2. Zhang Y, Ohyashiki JH, Takaku T, Shimizu N, Ohyashiki K. Transcriptional profiling of Epstein-Barr virus (EBV) genes and host cellular genes in nasal NK/T-cell lymphoma and chronic active EBV infection. British Journal of Cancer. 2006 Feb 27; 94(4):599-608.

3. Minegishi Y, Saito M, Mori o T, Watanabe K, Agematsu K, Tsuchiya S, Takada H, Hara T, Kawamura N, Ariga T, Kaneko Ho, Kondo N, Tsuge I, Yachie A, Sakiyama Y, Iwata T, Bessho F, Ohishi T, Jo K, Imai K, Kogawa K, Shinohara M, Fujieda Ma, Wakiguchi H, Pasic S, Abinun M, Ochs HD, Renner ED, Jansson A, Belohradsky BH , Metin A, Shimizu N, Mizutani S, Miyawaki T, Nonoyama S and Karasuyama H. Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired immunity. Immunity. 2006 Nov; 25(5):745-755.

2005年

1. Tomizawa D, Aoki Y, Nagasawa M, Morio T, Kajiwara.M, Sekine T, Shimizu N, Kato M., Yachie A, and Mizutani S. Adopted immunotherapy for mixed chimerism after unrelated cord blood transplantation using reduced-intensity conditioning in Omenn disease. European Journal of Haematology. 2005 Nov; 75 (5):441-444.

2. Imadome K, Shimizu N, Arai A, Miura O, Watanabe K, Nakamura H, Nonoyama S, Yamamoto K, Fujiwara S. Coexpression of CD40 and CD40 ligand in Epstein-Barr virus-infected T and NK cells and their role in cell survival. Journal of Infectious Diseases. 2005 Oct 15; 192(8):1340-1348.Epub 2005 Sep 19.

3. Nagato T, Kobayashi H, Kishibe K, Takahara M, Ogino T, Ishii H, Oikawa K, Aoki N, Sato K, Kimura S, Shimizu N, Tateno M, and Harabuchi Y. Expression of interleukin-9 in nasal natural killer/T-cell lymphoma cell lines and patients. Clinical Cancer Research. 2005 Dec 1; 11(23):8250-8257.

4. Nagasawa M, Zhu Y, Isoda T, Tomizawa D, Itoh S, Kajiwara M, Morio T, Nonoyama S, Shimizu N and Mizutani S. Analysis of serum soluble CD40 ligand (sCD40L) in the patients undergoing allogeneic stem cell transplantation: platelet is a major source of serum sCD40L. European Journal of Haematology. 2005 Jan; 74(1):54-60.

2004年

1. Yamaguchi T, Bamba K, Kitayama A, Kuroiwa Y, Ogawa K, Sekine T, Shimizu N, Yamamoto N. Long-term intravenous administration of activated autologous lymphocytes for cancer patients does not induce anti-nuclear antibody and rheumatoid factor. Anticancer Research. 2004 Jul-Aug; 24(4):2423-2429.

2. Matsuo Y, Drexler HG, Harashima A, Okochi A, Shimizu N, Orita K. Transcription factor expression in cell lines derived from natural killer-cell and natural killer-like T-cell leukemia-lymphoma. Human Cell. 2004 Jun; 17(2):85-92.