土田直樹研究助成基金について
土田直樹研究助成基金は、東京医科歯科大学におけるクローン病を中心とした炎症性腸疾患に関する研究の発展のため、故土田直樹氏のご遺志により設立されました。
土田直樹研究助成基金の助成申請手続きについて（学内専用）
土田直樹研究助成基金の助成申請手続きに関する案内ページです。
毎年10月ごろに各年度の公募要項を発表し、助成申請の受付を開始いたします。
土田直樹助成基金（学内専用ページ）
https://www1.tmd.ac.jp/kenkyuu/tmdu-research/grant/naoki-tsuchida/index.html
毎年10月ごろに各年度の公募要項を発表し、助成申請の受付を開始いたします。
土田直樹助成基金（学内専用ページ）
https://www1.tmd.ac.jp/kenkyuu/tmdu-research/grant/naoki-tsuchida/index.html
土田直樹研究助成基金による研究成果
論文発表
金兼 弘和 教授（大学院医歯学総合研究科 発生発達病態学分野）【平成29、令和3年度採択】
Haploinsufficiency of A20 causes autoinflammatory and autoimmune disorders
Tomonori Kadowaki, Hidenori Ohnishi, Norio Kawamoto, Tomohiro Hori, Kenichi Nishimura, Chie Kobayashi, Tomonari Shigemura, Shohei Ogata, Yuzaburo Inoue, Tomoki Kawai, Eitaro Hiejima, Masatoshi Takagi, Kohsuke Imai, Ryuta Nishikomori, Shuichi Ito, Toshio Heike, Osamu Ohara, Tomohiro Morio, Toshiyuki Fukao, Toshiyuki Fukao, Hirokazu Kanegane
J ALLERGY CLIN IMMUNOL, April 2018 Volume 141, Issue 4, Pages 1485–1488.e11
Hematopoietic cell transplantation rescues inflammatory bowel disease and dysbiosis of gut microbiota in XIAP deficiency
Ono S, Takeshita K, Kiridoshi Y, Kato M, Kamiya T, Hoshino A, Yanagimachi M, Arai K, Takeuchi I, Toita N, Imamura T, Sasahara Y, Sugita J, Hamamoto K, Takeuchi M, Saito S, Onuma M, Tsujimoto H, Yasui M, Taga T, Arakawa Y, Mitani Y, Yamamoto N, Imai K, Suda W, Hattori M, Ohara O, Morio T, Honda K, Kanegane H
J Allergy Clin Immunol Pract. 2021 Jul 8:S2213-2198(21)00765-0. doi: 10.1016/j.jaip.2021.05.045. Epub ahead of print. PMID: 34246792.
北詰 良雄 准教授（医学部附属病院 放射線診断科）【平成25-26年度採択】
Crohn Disease: A 5-Point MR Enterocolonography Classification Using Enteroscopic Findings
Kitazume Y, Fujioka T, Takenaka K, Oyama J, Ohtsuka K, Fujii T, Tateisi U. Crohn’s Disease: A 5-point Magnetic Resonance Enterocolonography Classification using Enteroscopic Findings. AJR Am J Roentgenol. 2019;212(1):67-76.
High b-value computed diffusion-weighted imaging for differentiating bowel inflammation in Crohn's disease
Kitazume Y, Tsuchiya J, Takenaka K, Ohtsuka K, Kimura K, Watanabe R, Fujioka T, Fujii T, Watanabe M, Tateisi U. High b-value computed diffusion-weighted imaging for differentiating bowel inflammation in Crohn's disease. Eur J Radiol 2020;133:109362. doi: 10.1016/j.ejrad.2020.109362
Crohn disease: magnetic resonance enterocolonography features of endoscopic ulcer stages reclassified with the healing process and the relationships to prognoses
Kitazume Y, Takenaka K, Ohtsuka K, Kimura K, Ogihara Y, Fujioka T, et al. Crohn disease: magnetic resonance enterocolonography features of endoscopic ulcer stages reclassified with the healing process and the relationships to prognoses. Jpn J Radiol 2021. doi: 10.1007/s11604-020-01082-5
安達 貴弘 准教授（難治疾患研究所 免疫疾患分野）【平成27,28,29年度採択】
B cell activation in the cecal patches during the development of an experimental colitis model.
Watabe T, Nagaishi T, Tsugawa N, Kojima Y, Jose N, Hosoya A, Onizawa M, Nemoto Y, Oshima S, Nakamura T, Karasuyama H, Adachi T, Watanabe M.
Biochem Biophys Res Commun. 2018 Feb 5;496(2):367-373. doi: 10.1016/j.bbrc.2018.01.053. Epub 2018 Jan 10.
中村 哲也 教授（大学院医歯学総合研究科 消化管先端治療学講座）【平成25-26年度採択】
Reconstruction of the human colon epithelium in vivo.
Sugimoto S, Ohta Y, Fujii M, Matano M, Shimokawa M, Nanki K, Date S, Nishikori S, Nakazato Y, Nakamura T, Kanai T, Sato T. Cell Stem Cell. 22(2): 171-176: 2018
YAP/TAZ-dependent reprogramming of colonic epithelisum links ECM remodeling to tissue regeneration.
Yui S, Azzolin L, Maimets M, Pedersen MT, Fordham RP, Hansen SL, Larsen HL, Guiu J, Alves MRP, Rundsten CF, Johansen JV, Li Y, Madsen CD, Nakamura T, Watanabe M, Nielsen OH, Schweiger PJ, Piccolo S, Jensen KB. Cell Stem Cell. 22(1): 35-49: 2018
Advancing intestinal organoid technology toward regenerative medicine.
Nakamura T, Sato T Cell Mol Gastroenterol Hepatol. 5(1): 51-60: 2018
Distinct intestinal adaptation for vitamin B12 and bile acid absorption revealed in a new mouse model of massive ileocecal resection.
Matsumoto Y, Mochizuki W, Akiyama S, Matsumoto T, Nozaki K, Watanabe M, Nakamura T, Biol Open. 6(9): 1364-1374: 2017
Intestinal stem cell transplantation.
Nakamura T, Watanabe M: J Gastroenterol. 52(2): 151-157: 2017
Retinol promotes in vitro growth of proximal colon organoids through a retinoic acid-independent mechanism.
Matsumoto T, Mochizuki W, Nibe Y, Akiyama S, Matsumoto Y, Nozaki K, Fukuda M, Hayashi A, Mizutani T, Oshima S, Watanabe M, Nakamura T: PLoS One. 11(8): e0162049. 2016.
Reduced human α-defensin 6 in noninflamed jejunal tissue of patients with Crohn's disease.
Hayashi R, Tsuchiya K, Fukushima K, Horita N, Hibiya S, Kitagaki K, Negi M, Itoh E, Akashi T, Eishi Y, Okada E, Araki A, Ohtsuka K, Fukuda S, Ohno H, Okamoto R, Nakamura T, Tanaka S, Chayama K, Watanabe M. Inflamm Bowel Dis. 22(5): 1119-1128: 2016
Co-culture with intestinal epithelial organoids allows efficient expansion and motility analysis of intraepithelial lymphocytes.
Nozaki K, Mochizuki W, Matsumoto Y, Matsumoto T, Fukuda M, Mizutani T, Watanabe M, Nakamura T: J Gastroenterol 51(3): 206-213: 2016
Small intestinal stem cell identity is maintained with functional Paneth cells in heterotopically grafted epithelium onto the colon.
Fukuda M, Mizutani T, Mochizuki W, Matsumoto T, Nozaki K, Sakamaki Y, Ichinose S, Okada Y, Tanaka T, Watanabe M, Nakamura T: Genes Dev. 28(16): 1752-1757: 2014
Transplantation of expanded fetal intestinal progenitors contributes to colon regeneration after injury.
Fordham RP, Yui S, Hannan NRF, S.ANxndergaard C, Madgwick A, Schweiger PJ, Nielsen OH, Vallier L, Pedersen RA, Nakamura T, Watanabe M, Jensen KB: Cell Stem Cell. 13(6): 734-744: 2013
清水重臣教授（難治疾患研究所 病態細胞生物学分野）【平成28年度採択】
Identification of PPM1D as an essential Ulk1 phosphatase for genotoxic stress-induced autophagy.
Satoru Torii, Tatsushi Yoshida, Satoko Arakawa, Shinya Honda, Akira Nakanishi, and Shigeomi Shimizu. EMBO R 11:1552-1564, 2016
Fluorescent small molecules for monitoring autophagic flux.
Hidefumi Iwashita, Hajime Tajima Sakurai, Noriyoshi Nagahora, Munetaka Ishiyama, Kosei Shioji, Kazumi Sasamoto, Kentaro Okuma, Shigeomi Shimizu and Yuichiro Ueno, FEBS let. 592:559-567, 2018
Dram1 regulates DNA damage-induced alternative autophagy.
Meruna Nagata, Satoko Arakawa, Hirofumi Yamaguchi, Satoru Torii, Hazuki Endo, Masatsune Tsujioka, Shinya Honda, Yuya Nishida, Akimitsu Konishi, Shigeomi Shimizu. Cell Stress, Vol. 2, No. 3, pp. 55 - 65; doi: 10.15698/cst2018.03.127
Haploinsufficiency of A20 causes autoinflammatory and autoimmune disorders
Tomonori Kadowaki, Hidenori Ohnishi, Norio Kawamoto, Tomohiro Hori, Kenichi Nishimura, Chie Kobayashi, Tomonari Shigemura, Shohei Ogata, Yuzaburo Inoue, Tomoki Kawai, Eitaro Hiejima, Masatoshi Takagi, Kohsuke Imai, Ryuta Nishikomori, Shuichi Ito, Toshio Heike, Osamu Ohara, Tomohiro Morio, Toshiyuki Fukao, Toshiyuki Fukao, Hirokazu Kanegane
J ALLERGY CLIN IMMUNOL, April 2018 Volume 141, Issue 4, Pages 1485–1488.e11
Hematopoietic cell transplantation rescues inflammatory bowel disease and dysbiosis of gut microbiota in XIAP deficiency
Ono S, Takeshita K, Kiridoshi Y, Kato M, Kamiya T, Hoshino A, Yanagimachi M, Arai K, Takeuchi I, Toita N, Imamura T, Sasahara Y, Sugita J, Hamamoto K, Takeuchi M, Saito S, Onuma M, Tsujimoto H, Yasui M, Taga T, Arakawa Y, Mitani Y, Yamamoto N, Imai K, Suda W, Hattori M, Ohara O, Morio T, Honda K, Kanegane H
J Allergy Clin Immunol Pract. 2021 Jul 8:S2213-2198(21)00765-0. doi: 10.1016/j.jaip.2021.05.045. Epub ahead of print. PMID: 34246792.
北詰 良雄 准教授（医学部附属病院 放射線診断科）【平成25-26年度採択】
Crohn Disease: A 5-Point MR Enterocolonography Classification Using Enteroscopic Findings
Kitazume Y, Fujioka T, Takenaka K, Oyama J, Ohtsuka K, Fujii T, Tateisi U. Crohn’s Disease: A 5-point Magnetic Resonance Enterocolonography Classification using Enteroscopic Findings. AJR Am J Roentgenol. 2019;212(1):67-76.
High b-value computed diffusion-weighted imaging for differentiating bowel inflammation in Crohn's disease
Kitazume Y, Tsuchiya J, Takenaka K, Ohtsuka K, Kimura K, Watanabe R, Fujioka T, Fujii T, Watanabe M, Tateisi U. High b-value computed diffusion-weighted imaging for differentiating bowel inflammation in Crohn's disease. Eur J Radiol 2020;133:109362. doi: 10.1016/j.ejrad.2020.109362
Crohn disease: magnetic resonance enterocolonography features of endoscopic ulcer stages reclassified with the healing process and the relationships to prognoses
Kitazume Y, Takenaka K, Ohtsuka K, Kimura K, Ogihara Y, Fujioka T, et al. Crohn disease: magnetic resonance enterocolonography features of endoscopic ulcer stages reclassified with the healing process and the relationships to prognoses. Jpn J Radiol 2021. doi: 10.1007/s11604-020-01082-5
安達 貴弘 准教授（難治疾患研究所 免疫疾患分野）【平成27,28,29年度採択】
B cell activation in the cecal patches during the development of an experimental colitis model.
Watabe T, Nagaishi T, Tsugawa N, Kojima Y, Jose N, Hosoya A, Onizawa M, Nemoto Y, Oshima S, Nakamura T, Karasuyama H, Adachi T, Watanabe M.
Biochem Biophys Res Commun. 2018 Feb 5;496(2):367-373. doi: 10.1016/j.bbrc.2018.01.053. Epub 2018 Jan 10.
中村 哲也 教授（大学院医歯学総合研究科 消化管先端治療学講座）【平成25-26年度採択】
Reconstruction of the human colon epithelium in vivo.
Sugimoto S, Ohta Y, Fujii M, Matano M, Shimokawa M, Nanki K, Date S, Nishikori S, Nakazato Y, Nakamura T, Kanai T, Sato T. Cell Stem Cell. 22(2): 171-176: 2018
YAP/TAZ-dependent reprogramming of colonic epithelisum links ECM remodeling to tissue regeneration.
Yui S, Azzolin L, Maimets M, Pedersen MT, Fordham RP, Hansen SL, Larsen HL, Guiu J, Alves MRP, Rundsten CF, Johansen JV, Li Y, Madsen CD, Nakamura T, Watanabe M, Nielsen OH, Schweiger PJ, Piccolo S, Jensen KB. Cell Stem Cell. 22(1): 35-49: 2018
Advancing intestinal organoid technology toward regenerative medicine.
Nakamura T, Sato T Cell Mol Gastroenterol Hepatol. 5(1): 51-60: 2018
Distinct intestinal adaptation for vitamin B12 and bile acid absorption revealed in a new mouse model of massive ileocecal resection.
Matsumoto Y, Mochizuki W, Akiyama S, Matsumoto T, Nozaki K, Watanabe M, Nakamura T, Biol Open. 6(9): 1364-1374: 2017
Intestinal stem cell transplantation.
Nakamura T, Watanabe M: J Gastroenterol. 52(2): 151-157: 2017
Retinol promotes in vitro growth of proximal colon organoids through a retinoic acid-independent mechanism.
Matsumoto T, Mochizuki W, Nibe Y, Akiyama S, Matsumoto Y, Nozaki K, Fukuda M, Hayashi A, Mizutani T, Oshima S, Watanabe M, Nakamura T: PLoS One. 11(8): e0162049. 2016.
Reduced human α-defensin 6 in noninflamed jejunal tissue of patients with Crohn's disease.
Hayashi R, Tsuchiya K, Fukushima K, Horita N, Hibiya S, Kitagaki K, Negi M, Itoh E, Akashi T, Eishi Y, Okada E, Araki A, Ohtsuka K, Fukuda S, Ohno H, Okamoto R, Nakamura T, Tanaka S, Chayama K, Watanabe M. Inflamm Bowel Dis. 22(5): 1119-1128: 2016
Co-culture with intestinal epithelial organoids allows efficient expansion and motility analysis of intraepithelial lymphocytes.
Nozaki K, Mochizuki W, Matsumoto Y, Matsumoto T, Fukuda M, Mizutani T, Watanabe M, Nakamura T: J Gastroenterol 51(3): 206-213: 2016
Small intestinal stem cell identity is maintained with functional Paneth cells in heterotopically grafted epithelium onto the colon.
Fukuda M, Mizutani T, Mochizuki W, Matsumoto T, Nozaki K, Sakamaki Y, Ichinose S, Okada Y, Tanaka T, Watanabe M, Nakamura T: Genes Dev. 28(16): 1752-1757: 2014
Transplantation of expanded fetal intestinal progenitors contributes to colon regeneration after injury.
Fordham RP, Yui S, Hannan NRF, S.ANxndergaard C, Madgwick A, Schweiger PJ, Nielsen OH, Vallier L, Pedersen RA, Nakamura T, Watanabe M, Jensen KB: Cell Stem Cell. 13(6): 734-744: 2013
清水重臣教授（難治疾患研究所 病態細胞生物学分野）【平成28年度採択】
Identification of PPM1D as an essential Ulk1 phosphatase for genotoxic stress-induced autophagy.
Satoru Torii, Tatsushi Yoshida, Satoko Arakawa, Shinya Honda, Akira Nakanishi, and Shigeomi Shimizu. EMBO R 11:1552-1564, 2016
Fluorescent small molecules for monitoring autophagic flux.
Hidefumi Iwashita, Hajime Tajima Sakurai, Noriyoshi Nagahora, Munetaka Ishiyama, Kosei Shioji, Kazumi Sasamoto, Kentaro Okuma, Shigeomi Shimizu and Yuichiro Ueno, FEBS let. 592:559-567, 2018
Dram1 regulates DNA damage-induced alternative autophagy.
Meruna Nagata, Satoko Arakawa, Hirofumi Yamaguchi, Satoru Torii, Hazuki Endo, Masatsune Tsujioka, Shinya Honda, Yuya Nishida, Akimitsu Konishi, Shigeomi Shimizu. Cell Stress, Vol. 2, No. 3, pp. 55 - 65; doi: 10.15698/cst2018.03.127
採択課題一覧
2024年度（助成期間：2024年4月1日～2025年3月31日）
『クローン病における新規融合タンパク質CiDREの機能解析』
申請者：佐藤 荘（大学院医歯学総合研究科 免疫学分野）
『携帯型超音波機器を使用したクローン病小腸病変評価方法の開発』
申請者：竹中 健人（大学院医歯学総合研究科 消化器連携医療学）
『小腸上皮細胞死におけるⅢ型インターフェロンの役割』
申請者：松沢 優（大学院医歯学総合研究科 疾患生理機能解析学分野）
『Crohn病特異的抗原提示細胞の誘導因子の同定』
申請者：山本 浩平（大学院医歯学総合研究科 人体病理学分野）
申請者：佐藤 荘（大学院医歯学総合研究科 免疫学分野）
『携帯型超音波機器を使用したクローン病小腸病変評価方法の開発』
申請者：竹中 健人（大学院医歯学総合研究科 消化器連携医療学）
『小腸上皮細胞死におけるⅢ型インターフェロンの役割』
申請者：松沢 優（大学院医歯学総合研究科 疾患生理機能解析学分野）
『Crohn病特異的抗原提示細胞の誘導因子の同定』
申請者：山本 浩平（大学院医歯学総合研究科 人体病理学分野）
上記より過去の採択課題についてはこちらをご覧ください