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ホーム  > 難治疾患研究所免疫疾患分野・医歯学総合研究科免疫学分野  > Immunology Department, Medical Research Institute

Immunology Department, Medical Research Institute

(1) Research
The nature of immune responses depends on whether they respond to protein or non-protein antigens because T lymphocytes recognize only protein antigens. Normal immune system removes pathogens and cancer cells but does not respond to non-microbial foreign substances or self-antigens. Immune responses to non-microbial foreign substances and self-antigens cause allergy and autoimmune diseases, respectively. How the immune system distinguishes pathogens from non-microbial antigens and self-antigens is already clarified for protein antigens. However, little is known about such distinction for non-protein antigens. Immune responses to non-protein antigens play crucial roles in host defense against pathogens such as tuberculosis bacilli and meningococci, and autoimmune diseases such as lupus and immuno-neurological disorders. Thus, immune responses to non-protein antigens constitute a remaining frontier in immunology research. Followings are our research subjects.

(2) Lecture course on immunology at the master course aims at giving the students the basic ideas how immune system recognize and respond to the antigens, and how immune system efficiently remove pathogens without responding to self-antigens and environmental antigens. In the lecture course in bioscience at the doctor course, lectures on immune responses are given so that the students are introduced with the current topics in the field of humoral immune responses. Research projects in both master and doctor courses aims at training the students to acquire basic research techniques on immunology, molecular biology and biochemistry, and abilities to conduct cutting-edge research in the field of immunology by themselves under supervision.