2014-1991年
| Retinoid X receptor a attenuates host antiviral response by suppressing type I interferon. Ma, F.; Liu, S.-Y.; Razani, B.; Arora, N.; Li, B.; Kagechika, H.; Tontonoz, P.; Nunez, V.; Ricote, M.; Cheng, G. Nat. Commun. 2014, 5, 5494. |
| Retinoic acid receptor-α up-regulates proopiomelanocortin gene expres sion in AtT20 corticotroph cells. Uruno, A.; Saito-Hakoda, A.; Yokoyama, A.; Kogure, N.; Matsuda, K.; Parvin, R.; Shimizu, K.; Sato, I.; Kudo, M.; Yoshikawa, T.; Kagechika, H.; Iwasaki, Y.; Ito, S.; Sugawara, A. Endocr. J. 2014, 61, 1105-1114. |
| Lipase-catalyzed asymmetric acylation of boron cluster-containing secondary alcohols. Mori, S.; Takagaki, R.; Fujii, S.; Matsumura, M.; Tanatani, A.; Kagechika, H. Tetrahedron Asy. 2014, 25, 1505-1512. |
| Activation of liver X receptor suppresses the production of the IL-12 family of cytokines by blocking nuclear translocation of NF-kappa Bp50. Canavan, M.; McCarthy, C.; Ben Larbi, N.; Dowling, J. K.; Collins, L.; O'Sullivan, F.; Hurley, G.; Murphy, C.; Quinlan, A.; Moloney, G.; Darby, T.; MacSharry, J.; Kagechika, H.; Moynagh, P.; Melgar, S.; Loscher, C. E. Innate Immun. 2014, 20, 675-687. |
| Development of a novel fluorescent sensor to detect a specific range of pH. Shiraishi, T.; Saito, T.; Kagechika, H.; Hirano, T. Tetrahedron Lett. 2014, 55, 6784-6786. |
| Structural development of p-carborane-based potent non-secosteroidal vitamin D analogs. Fujii, S.; Sekine, R.; Kano, A.; Masuno, H.; Songkram, C.; Kawachi, E.; Hirano, T.; Tanatani, A.; Kagechika, H. Bioorg. Med. Chem. 2014, 22, 589-5901. |
| The Retinoic Acid Receptor Agonist Am80 Increases Mu cosal Inflammation in an IL-6 Dependent Manner During Trichuris muris Infection. Hurst, R. J. M.; De Caul, A.; Little, M. C.; Kagechika, H.; Else, K. J. J. Clin. Immunol., 2013, 33, 1386-1394. |
| Design and synthesis of 4-(4-benzoylaminophenoxy)phenol derivatives as androgen receptor antagonists. Yamada, A.; Fujii, S.; Mori, S.; Kagechika, H. ACS Med. Chem. Lett., 2013, 4, 937-941. |
| Crystal structures of complexes of vitamin D receptor ligand-binding domain with lithocholic acid derivatives. Masuno, H.; Ikura, T.; Morizono, D.; Orita, I.; Yamada, S.; Shimizu, M.; Ito, N. J. Lipid Res., 2013, 54, 2206-2213. |
| Synthesis of porphyrinylamide and observation of N-methylation-induced trans-cis amide conformational alteration. Matsumura, M.; Tanatani, A.; Kaneko, T.; Azumaya, I.; Masu, H.; Hashizume, D.; Kagechika, H.; Muranaka, A.; Uchiyama, M. Tetrahedron, 2013, 69, 10927-10932. |
| Chemical library screening for WNK signalling inhibitors using fluorescence correlation spectroscopy. Mori, T.; Kikuchi, E.; Watanabe, Y.; Fujii, S.; Ishigami?Yuasa, M.; Kagechika, H.; Sohara, E.; Rai, T.; Sasaki, S.; Uchida, S. Biochem. J., 2013, 455, 339-345. |
| Retinoid X Receptor Agonists Modulate Foxp3 + Regulatory T Cell and Th17 Cell Differentiation with Differential Dependence on Retinoic Acid Receptor Activation. Takeuchi, H.; Yokota-Nakatsuma, A.; Ohoka, Y.; Kagechika, H.; Kato, C.; Si-Young Song, S.-Y.; Iwata, M. J. Immunol., 2013, 191, 3725-3733. |
| Copper-mediated C-C cross-coupling reaction of monocarba-closo-dodecaborate anion for construction of functional molecules. Kanazawa, J.; Takita, R.; Jankowiak, A.; Fujii, S.; Kagechika, H.; Hashizume, D.; Shudo, K.; Kaszy?ski, P.; Uchiyama, M. Angew. Chem. Int. Ed., 2013, 52, 8017-8021. |
| Molecular mechanism of 9-cis-retinoic acid inhibition of adipogenesis in 3T3-L1 cells. Sagara, C.; Takahashi, K.; Kagechika, H.; Takahashi, N. Biochem. Biophys. Res. Commun., 2013, 433, 102-107. |
| Cellular retinoic acid binding protein I mediates rapid non-canonical activation of ERK1/2 by all-trans retinoic acid. Persaud, S. D.; Lin, Y.-W.; Wu, C.-Y.; Kagechika, H.; Wei, L.-N. Cell. Signal., 2013, 25, 19-25. |
| Unusual conformational preference of an aromatic secondary urea: solvent-dependent open- closed conformational switching of N,N’-bis(porphyrinyl)urea. Matsumura, M.; Tanatani, A.; Azumaya, I.; Masu, H.; Hashizume, D.; Kagechika, H.; Muranaka, A.; Uchiyama, M. Chem. Commun., 2013, 49, 2290-2292. The manuscript was selected as image picture of the backcover page. |
| Structures of histone methyltransferase SET7/9 in complexes with adenosylmethionine derivatives. Niwa, H.; Handa, N.; Tomabechi, Y.; Honda, K.; Toyama, M.; Ohsawa, N.; Shirouzu, M.; Kagechika, H.; Hirano, T.; Umehara, T.; Yokoyama, S. Acta Cryst., 2013, D69, 595-602. |
| Increased Hydrophobicity and Estrogenic Activity of Simple Phenols with Silicon and Germanium-Containing Substituents. Fujii, S.; Miyajima, Y.; Masuno, H.; Kagechika, H. J. Med. Chem., 2013, 56, 160-166. |
| Structure--activity relationship study on benzoic acid part of diphenylamine-based retinoids. Ohta, K.; Kawachi, E.; Shudo, K.; Kagechika, H. Bioorg. Med. Chem. Lett., 2013, 23, 81-84. |
| The retinoic acid receptor agonist Am80 increases mucosal inflammation during an intestinal helminth infection of mice. Hurst, R. J. M.; Bell, L. V.; de Caul, A.; Kagechika, H.; Else, K. J. Immunology, 2012, 137, 125-126. |
| Fluorescent properties of coumarins with dual functions constructed by two sequential reactions. Hirano, T.; Kubo, H.; Shiraishi, T.; Hiromoto, K.; Fujiwara, T.; Kagechika, H. Tetrahedron Lett., 2012, 53, 5916-5919. |
| A Fluorescent Alkaloid from Quassia amara and Its Properties in Living Cells. Taniguchi, K.; Takizawa, S.; Hirano, T.; Murata, S.; Kagechika, H.; Kishida, A.; Ohsaki. A. ChemPlusChem, 2012, 77, 427-431. |
| Redox-responsive conformational alteration of aromatic amides bearing N-quinonyl system. Okamoto, I.; Takahashi, Y.; Sawamura, M.; Matsumura, M.; Masu, H.; Katagiri, K.; Azumaya, I.; Nishino, M.; Kohama, Y.; Morita, N.; Tamura, O.; Kagechika, H.; Tanatani, A. Tetrahedron, 2012, 68, 5346-5355. |
| Development of androgen receptor ligands by application of ten-vertex para-carborane as a novel hydrophobic core structure. Fujii,S.; Ohta, K.; Goto, T.; Oda, A.; Masuno, H.; Endo, Y.; Kagechika, H. Med. Chem. Commun., 2012, 3, 680-684. |
| Retinoic acid receptor agonists regulate expression of ATP-binding cassette transporter G1 in macrophages. Ayaori, M.; Yakushiji, E.; Ogura, M.; Nakaya, K.; Hisada, T.; Uto- Kondo, H.; Takiguchi, S.; Terao, Y.; Sasaki, M.; Komatsu, T.; Iizuka, M.; Yogo, M.; Uehara, Y.; Kagechika, H.; Nakanishi, T.; Ikewaki, K. Biochim. Biophys. Acta- Mol Cell Biol. Lipids, 2012, 1821, 561-572. |
| Synthesis and helical properties of aromatic multilayered oligoureas. Kudo, M.; Katagiri, K.; Azumaya, I.; Kagechika, H.; Tanatani, A. Tetrahedron, 2012, 68, 4455-4463. |
| Molecular Chirality and Chiral Capsule-type Dimer Formation of Cyclic Triamides via Hydrogen-Bonding Interactions. Fujimoto, N.;Matsumura, M.;Azumaya, I.; Nishiyama, S.; Masu, H.;Kagechika, H.; Tanatani, A. Chem. Commun., 2012, 48, 4809-4811. The manuscript was selected as Chem Commun Hot Article, and as image picture of the cover page. |
| Solvent-dependent conformational and fluorescence change of an N-phenylbenzohydroxamic acid derivative bearing two pyrene moieties. Kanai, M.; Hirano, T.; Azumaya I.; Okamoto I.; Kagechika H.; Tanatani, A. Tetrahedron, 2012, 68, 2778-2783. |
| RXR antagonism induces G0/G1 cell cycle arrest and ameliorates obesity by up-regulating the p53.p21Cip1 pathway in adipocytes. Nakatsuka, A.; Wada, J.; Hida, K.; Hida, A.; Eguchi, J.; Teshigawara, S.; Murakami, K.; Kanzaki, M.; Inoue, K.; Terami, T.; Katayama, A.; Ogawa, D.; Kagechika, H.; Makino, H. J. pathology, 2012, 226, 784-795. |
| NR4A nuclear receptors mediate carnitine palmitoyltransferase 1A gene expression by the rexinoid HX600. Ishizawa, M. Kagechika, H.; Makishima, M. Biochem. Biophys. Res. Commun., 2012, 418, 780-785. |
| Novel vitamin D receptor ligands bearing a spherical hydrophobic core structure―Comparison of bicyclic hydrocarbon derivatives with boron cluster derivatives. Wongmayura, A.; Fujii, S.; Ito, S.; Kano, A.; Taoda, Y.; Kawachi, E.; Kagechika, H.; Tanatani, A. Bioorg. Med Chem. Lett., 2012, 22, 1756-1760. |
| Boron Cluster-based Development of Potent Non-Secosteroidal Vitamin D Receptor Ligands: Direct Observation of Hydrophobic Interaction between Protein Surface and Carborane. Fujii, S.; Masuno, H.; Taoda, H.; Kano, A.; Wongmayura, A.; Nakabayashi, M.; Ito, N.; Shimizu, M.; Kawachi, E.; Hirano, T.; Endo, Y.; Tanatani, A.; Kagechika, H. J. Am. Chem. Soc., 2011, 133, 20933-20941. |
| Synthesis of soluble aromatic multilayered tetra(m-phenylurea) and analysis of its helical conformation in various solvents. Kudo, M.; Azumaya, I.; Kagechika, H.; Tanatani, A. Chirality, 2011, 1E, E84-E90. |
| 6-Arylcoumarins as novel nonsteroidal type progesterone antagonists: An example with receptor-binding- dependent fluorescence. Sakai,H.; Hirano, T.; Mori,S.; Fujii, S.; Masuno, H.; Kinoshita, M.; Kagechika, H.; Tanatani, A. J. Med. Chem., 2011, 54, 7055-7065. |
| Crystal structure, docking study and structure-activity relationship of carborane-containing androgen receptor antagonist 3-(12-hydroxymethyl-1,12-dicarba-closo- dodecarboran-1-yl)benzonitrile. Ohta, K., Goto, T., Fujii, S., Kawahata, M., Oda, A., Ohta, S., Yamaguchi, K., Hirono, S., Endo, Y. Bioorg. Med. Chem., 2011, 19, 3540-3548. |
| p-Carborane-based androgen antagonists active in LNCaP cells with a mutated androgen receptor. Fujii, S.; Yamada, A.; Tomita, K.; Nagano, M.; Goto, T.; Ohta, K.; Harayama, T.; Endo, Y.; Kagechika, H. Med. Chem. Commun., 2011, 2, 877. |
| Efficient and diversity-oriented total synthesis of Riccardin C and application to develop novel macrolactam derivatives. Iwashita, M.; Fujii, S.; Ito, S.; Hirano, T.; Kagechika, H. Tetrahedron, 2011, 67, 6073-6082. |
| All-trans retinoic acid and a novel synthetic retinoid tamibarotene (Am80) differentially regulate CD38 expression in human leukemia HL-60 cells: possible involvement of protein kinase C-delta. Uruno, A.; Noguchi, N.; Matsuda, K.; Nata, K.; Yoshikawa, T.; Chikamatsu, Y.; Kagechika, H.; Harigae, H.; Ito, S.; Okamoto, H.; Sugawara, A. J. Leukocyte Biol., 2011, 90, 235-247. |
| MyD88 and Retinoic Acid Signaling Pathways Interact to Modulate Gastrointestinal Activities of Dendritic Cells. Villablanca, E. J.; Wang, S.; de Calisto, J.; Gomes, D. C. O.; Kane, M. A.; Napoli, J. L.; Blaner, W. S.; Kagechika, H.; Blomhoff, R.; Rosemblatt, M.; Bono, M. R.; von Andrian, U. H.; Mora, J. R. Gastroenterology, 2011, 141, 176-185. |
| c-Jun N-terminal kinase activation by oxidative stress suppresses retinoid signaling through proteasomal degradation of retinoic acid receptor alpha protein in hepatic cells. Hoshikawa, Y.; Kanki, K.; Ashla, A.A.; Arakaki, Y.; Azumi, J.; Yasui, T.; Tezuka, Y.; Matsumi, Y.; Tsuchiya, H.; Kurimasa, A.; Hisatome, I.; Hirano, T.; Fujimoto, J.; Kagechika, H.; Shomori, K.; Ito, H.; Shiota, G. Cancer Sci., 2011, 102 (5), 934-941. |
| Crystal structure of spherical aromatic amide: pseudopolymorphs and formation of infinite water cluster in the channel structure. Masu, H.; Sagara, Y.; Imabeppu, F.; Takayanagi, H.; Katagiri, K.; Kawahata, M.; Tominaga, M.; Kagechika, H.; Yamaguchi, K.; Azumaya, I. CrystEngComm., 2011, 13, 406-409. |
| Hmx4 regulates Sonic hedgehog signaling through control of retinoic acid synthesis during forebrain patterning. Gongal, P. A.; March L. D.; Holly V. L.; Pillay L. M.; Berry-Wynne K. M.; Kagechika, H.; Waskiewicz, A. J. Div. Biol., 2011, 355, 55-64. |
| Diphenylamine-based Retinoid Antagonists: Regulation of RAR and RXR Function Depending on the N-Substituent. Ohta, K.; Kawachi, E,; Fukasawa H,; Shudo, K.; Kagechika, H. Bioorg. Med. Chem., 2011, 19, 2501-2507. |
| Retinoid X receptor gamma signaling accelerates CNS remyelination. Huang, J. K.; Jarjour, A. A.; Nait-Oumesmar, B.; Kerninon, C.; Williams, A. Krezel, W.; Kagechika, H.; Bauer, J.; Zhao, C.; Baron-Van Evercooren, A.; Chambon, P.; ffrench-Constant, C.; Franklin, R. J. M. Nature Neurosci., 2011, 14, 45-53. |
| Tributyltin chloride induces ABCA1 expression and apolipoprotein A-I -mediated cellular cholesterol efflux by activating LXRalpha/RXR. Cui, H.; Okuhira, K.; Ohoka, N.; Naito, M.; Kagechika, H.; Hirose, A,; Nishimaki-Mogami, T. Biochem. Pharmacol., 2011, 81, 819-824. |
| Calix[3]amide-based anion receptors: High affinity for fluoride ion and a twisted binding model. Katagiri, K.; Furuyama, T.; Masu, H.; Kato, T.; Matsumura, M.; Uchiyama, M.; Tanatani, A.; Tominaga, M.; Kagechika, H.; Yamaguchi, K.; Azumaya, I. Supramol. Chem., 2011, 23, 125-130. |
| Modulation of intramolecular heterodimer-induced fluorescence quenching of tricarbocyanine dye for the development of fluorescent sensors. Hirano, T.; Akiyama, J.; Mori, S.; Kagechika, H. Org. Biomol. Chem., 2010, 8, 5568-5575. |
| Design and Synthesis of Novel Retinoid Synergists having a Dibenzodiazepine Skeleton. Ohta, K.; Kawachi, E.; Shudo, K.; Kagechika, H. Heterocycles., 2010, 81, 2465-2470. |
| Design and synthesis of androgen receptor full antagonists bearing a p-carborane cage: Promising ligands for anti-androgen withdrawal syndrome. Goto, T.; Ohta, K.; Fujii, S.; Ohta, S.; Endo, Y. J. Med. Chem., 2010, 53, 4917-4926. |
| Synthesis and Biological Activity of Fluorinated Vitamin D. Fujishima, T.; Fujii, S.; Harayama, T. Curr. Org. Chem., 2010, 14, 962-976. |
| Development of novel bisubstrate-type inhibitors of histone methyltransferase SET7/9. Mori, S.; Iwase, K.; Iwanami, N.; Tanaka, Y.; Kagechika, H.; Hirano, T. Bioorg. Med. Chem., 2010, 18, 8158-8168. |
| Efficient Induction of CCR9 on T Cells Requires Coactivation of Retinoic Acid Receptors and Retinoid X Receptors (RXRs): Exaggerated T Cell Homing to the Intestine by RXR Activation with Organotins. Takeuchi, H.; Yokota, A.; Ohoka, Y.; Kagechika, H.; kato, C.; Song, S.-Y.; Iwata, M. J. Immunol., 2010, 185, 5289-5299. |
| Cyclic-tri(N-methyl-meta-benzamide)s: substituent effects on the bowl- shaped conformation in the crystal and solution states. Kakuta, H.; Azumaya, I.; Masu, H.; Matsumura, M.; Yamaguchi, K.; Kagechika, H.; Tanatani, A. Tetrahedron., 2010, 66, 8254-8260. |
| Retinoic Acid Induces Expression of the Thyroid Hormone Transporter, Monocarboxylate Transporter 8 (Mct8). Kogai, T.; Liu, Y.-Y.; Richter, L. L.; Mody, K.; Kagechika, H.; Bent, G. A. J. Biol. Chem., 2010, 285, 27279-27288. |
| Effect of oxygen substituent in the aniline part of benzanilide on the regioselectivity in direct arylation using palladium-phosphine reagents. Harayama, T.; Asai, M.; Miyagoe, T.; Abe, H.; Takeuchi, Y.; Yamaguchi, A.; Fujii, S. Heterocycles, 2010, 81, 1881-1889. |
| In Vitro Murine Spermatogenesis in an Organ Culture System. Gohbara, A.; Katagiri, K.; Sato, T.; Kubota, Y.; Kagechika, H.; Araki, Y.; Araki, Y.; Ogawa, T. Biol. Reprod., 2010, 83, 262-267. |
| Latent Enamine Functionality of 5-Methyl-2,3-dihydropyradines. Ito, S.; Hirano, T.; Sugimoto, A.; Kagechika, H.; Takeuchi, S.; Yamaguchi, T. Chem. Pharm. Bull., 2010, 58, 885-1002. |
| Inhibition of Mammary Carcinoma Cell Growth by RXR is Mediated by the Receptor's Oligomeric Switch. Yasmin, R.; Kannan-Thulasiraman, P.; Kagechika, H.; Dawson, M. I.; Noy, N. J. Mol. Biol., 2010, 397, 1121-1131. |
| Enhancement of imatinib-induced apoptosis of BCR/ABL-expressing cells by nutlin-3 through synergistic activation of the mitochondrial apoptoic pathway. Kurosu, T.; Wu, N.; Oshikawa, G.; Kagechika, H.; Miura, O. Apoptosis., 2010, 15, 608-620. |
| Activation of Testicular Orphan Receptor 4 by Fatty Acids. Tsai, N.-P.; Huq, M.; Gupta, P.; Yamamoto, K.; Kagechika, H.; Wei, L.-N. Biochim. Biophys. Acta- Gene Regul. Mech., 2009, 1789, 734-740 |
| Identification of Absolute Helical Structures of Aromatic Multi-layered Oligo(m-phenylurea)s in solution Kudo, M.; Hanashima, T.; Muranaka, A.; Sato, H.; Uchiyama, M.; Azumaya, I.; Hirano, T.; Kagechika, H.; Tanatani, A. J. Org. Chem., 2009, 74, 8154-8163. |
| Hypoxia-Inducible Factor-3α Functions as an Accelerator of 3T3-L1 Adipose Differentiation. Hatanaka, M.; Shimba, S.; Sakaue, M.; Kondo, Y.; Kagechika, H.; Kokame, K.; Miyata, T.; Hara, S. Biol. Pharm. Bull., 2009, 32, 1166-1172. |
| Docosahexaenoic acid induces adipose differentiation-related protein through activation of retinoid X receptor in human choriocarcinoma BeWo cells. Suzuki, K.; Takahashi, K.; Nishinaki-Mogami, T.; Kagechika, H.; Yamamoto, M.; Itabe, H. Biol. Pharm. Bull., 2009, 32, 1177-1182. |
| Encapsulation of the synthetic retinoids Am80 and LE540 into polymeric micelles and the retinoids' rerease control. Satoh, T.; Higuchi, Y.; Kawakami, S.; Hashida, M.; Kagechika, H.; Shudo, K.; Yokoyama, M. J. Controlled Release., 2009, 136, 187-195. |
| Sorafenib induces apoptosis specifically in cells expressing BCR/ABL by inhibiting its kinase activity to activate the intrinsic mitochondrial pathway. Kurosu, T.; Ohki, M.; Wu, N.; Kagechika, H.; Miura, O. Cancer Res., 2009, 69, 3927-3936. |
| Activation of the PI3 Kinase Pathway By Retinoic Acid Mediates Sodium/Iodide Symporter Induction and Iodide Transport in MCF-7 Breast Cancer Cells. Ohashi, E.; Kogai, T.; Kagechika, H.; Brent, G. A. Cancer Res., 2009, 69, 3443-3450. |
| The transcriotion factors Nur77 and retinoid X receptors participate in amphetamine-induced locomotor activities. Bourhis E1, Maheux J, Paquet B, Kagechika H, Shudo K, Rompré PP,Rouillard C, Lévesque D. Psychopharmacol., 2009, 202, 6335-648. |
| ApoC-III gene expression is sharply increased during adipogenesis and is augmented by retinoid X receptor (RXR) agonists. Takahashi, Y.; Inoue, J.; Kagechika, H.; Sato, R. FEBS Lett., 2009, 583, 493-497. |
| Contribution of AP-1 interference induced by TAC-101 to tumor growth suppression in a hepatocellular carcinoma model. Eshima, K.; Fukaya S.; Sugimoto, A.; Mori, T.; Yokoi, H.; Yamamoto, Y.; Sugiura, S.; Honda, S.; Masuko, N.; Murakami, K.; Yamasaki, Y.; Kagechika, H. Tumor Biol., 2009, 30, 1-7. |
| Fluorescent visualization of the conformational change of aromatic amide or urea induced by N-methylation. Hirano, T.; Osaki, T.; Fujii, S.; Komatsu, D.; Azumaya, I.; Tanatani, A.; Kagachika, H. Tetrahedron Lett., 2009, 50, 488-491. |
| Acidic heterocycles as novel hydrophilic pharmacophore of androgen receptor ligands with a carborane core structure. Fujii, S.; Ohta, K.; Goto, T.; Kagechika, H.; Endo, Y. Bioorg. Med. Chem., 2009, 17, 344-350. |
| The RXR agonists PA024 and HX630 have different abilities to activate LXR/RXR and to induce ABCA1 expression in macrophage cell line. Nishimaki-Mogami, T.; Tamehiro, N.; Sato, Y.; Okuhira, K.; Sai, K.; Kagechika, H.; Shudo, K.; Abe-Dohmae, S.; Yokoyama, S.; Ohno, Y.; Inoue, K.; Sawada, J. Biochem. Pharmacol., 2008, 76, 1006-1013. |
| Polymorphism and Pseudopolymorphism of an Aromatic Amide: Spontaneous Resolution and Crystal-to-Crystal Phase Transition. Kato, T.; Okamoto, I.; Masu, H.; Katagiri, K.; Tominaga, M.; Yamaguchi, K.; Kagechika, H.; Azumaya, I. Cryst. Growth Des., 2008, 8, 3871-3877. |
| Effects of retinoic acids on the dendritic morphology of cultured hippocampal meurons. Liu, Y.; Kagechika, H.; Ishikawa, J.; Hirano, H.; Matsukuma, S.; Tanaka, K.; Nakamura, S. J. Neurochem., 2008, 106, 1104-1116. |
| Chiral Spherical Molecules Constructed from Aromatic Amides: Facile Synthesis and Highly Ordered Network Structure in the Crystal. Masu, H.; Katagiri, K.; Kato, T.; Kagechika, H.; Tominaga, M.; Azumaya, I. J Org. Chem., 2008, 73, 5143-5146. |
| Identification of An Intermediate in the Deboronation of ortho-Carborane: An Adduct of ortho-Carborane with Two Nucleophiles on One Boron Atom. Taoda, Y.; Sawabe, T.; Endo, Y. Yamaguchi, K.; Fujii, S.; Kagechika, H. Chem. Commun., 2008, 2049-2051. |
| 13-cis-Retinoic acid alters the cellular morphology of slice-cultured serotonergic neurons in the rat. Ishikawa, J.; Sutoh, C.; Ishikawa, A.; Kagechika, H.; Hirano, H.; Nakamura, S. Eur. J. Neurosci., 2008, 27, 23363-2372. |
| Redox-Induced Conformational Alteration of N,N-Diarylamides. Okamoto, I.; Yamasaki, R.; Sawamura, M.; Kato, T.; Nagayama, N.; Takeya, T.; Tamura, O.; Masu, H.; Azumaya, I.; Yamaguchi, K.; Kagechika, H.; Tanatani, A. Org. Lett., 2007, 9, 5545-5547. |
| β-Cryptoxanthin, a novel natural RAR ligand, induces ATP-binding cassette transporters in macrophages. Matsumoto, A.; Mizukami, H.; Mizuno, S.; Umegaki, K.; Nishikawa, J.; Shudo, K.; Kagechika, H.; Inoue, M. Biochem. Pharmacol., 2007, 74, 256-264. |
| Effects of retinoic acids on the dendritic morphology of cultured hippocampal meurons. Liu, Y.; Kagechika, H.; Ishikawa, J.; Hirano, H.; Matsukuma, S.; Tanaka, K.; Nakamura, S. J. Neurochem., 2007, 106, 1104-1116. |
| STAT5α/PPARγ Pathway Regulates Involucrin Expression in Keratinocyte Differentiation. Dai, X.; Sayama, K.; Shirakata, Y.; Hanakawa, Y.; Yamasaki, K.; Tokumaru, S.; Yang, L.; Wang, X.; Hirakawa, S.; Tohyama, M.; Yamauchi, T.; Kadowaki, T.; Kagechika, H.; Hashimoto, K. J. Invest. Dermatol., 2007, 127, 1728-1735. |
| Novel Thyroid Hormone Receptor Antagonists With An N-Alkylated Diphenylamine Skeleton. Komatsu, T.; Hirano, T.; Songkram, C.; Kawachi, E.; Kagechika, H. Bioorg. Med. Chem., 2007, 15, 3115-3126. |
| All-trans Development of a Library of 6-Arylcoumarins as Candidate Fluorescent Sensors. Hirano, T.; Hiromoto, K.; Kagechika, H. Organic Lett., 2007, 9, 1315-1318. |
| All-trans Retinoic Acid Induces In Vitro Angiogenesis via Retinoic Acid Receptor: Possible Involvement of Paracrine Effects of Endogenous Vascular Endothelial Growth Factor Signaling. Saito, A.; Sugawara, A.; Uruno, A.; Kudo, M.; Kagechika, H.; Sato, Y.; Owada, Y.; Kondo, H.; Sato, M.; Kurabayashi, M.; Imaizumi, M.; Tsuchiya, S.; Ito, S. Endocrinology., 2007, 148, 1412-1423. |
| Construction of anomalously bent biphenyl structure using conformational properties of calix[4]amide. Tominaga, M.; Hatano, T.; Uchiyama, M.; Masu, H.; Kagechika, H.; Azumaya, I. Teterahedron Lett., 2006, 47, 9369-9371. |
| A New RXR Agonist, HX630, suppresses intimal hyperplasia in a mouse blood flow cessation model. Haraguchi, G.; Suzuki, J.; Kosuge, H.; Ogawa, M.; Koga, N.; Muto, S.; Itai, A.; Kagechika, H.; Shudo, K.; Isobe, M. J. Mol. Cell. Cardiol., 2006, 41, 885-892. |
| Spontaneous Resolution of Aromatic Sulfonamides: Effective Screening Method and Discrimination of Absolute Structure. Kato, T.; Okamoto, I.; Tanatani, A.; Hatano, T.; Uchiyama, M.; Kagechika, H.; Masu, H.; Katagiri, K.; Tominaga, M.; Yamaguchi, K.; Azumaya, I. Org. Lett., 2006, 8, 5017-5020. |
| Retinoids Induce Growth Inhibition and Apoptosis in Mast Cell Tumor Cell Lines. Ohashi , E.; Miyajima, N.; Nakagawa, T.; Takahashi, T.; Kagechika, H.; Mochizuki, M.; Nishimura, R.; Sasaki, N. J. Vet. Med. Sci., 2006, 68, 797-802. |
| Solvent-Dependent Conformational Switching of N-Phenylhydroxamic Acid and Its Application in Crystal Engineering. Yamasaki, R.; Tanatani, A.; Azumaya, I.; Masu, H.; Yamaguchi, K.; Kagechika, H. Crystal Growth Des., 2006, 6, 2007-2010. |
| Genetic and pharmacological evidence that a retinoic acid cannot be the RXR-activating ligand in mouse epidermis keratinocytes. Calleja, C.; Messaddeq, N.; Chapellier, B.; Yang, H.; Krezel, W.; Li, M.; Metzger, D.; Mascrez, B.; Ohta, K.; Kagechika, H.; Endo, Y.; Mark, M.; Ghyselinck, N. B.; Chambon, P. Genes Develop., 2006, 20, 1525-1538. |
| The synthetic retinoid Am80 reduces scavenger receptor expression and atherosclrosis in mice by inhibiting IL-6. Takeda, N.; Manabe, I.; Shindo, T.; Iwata, H.; Iimuro, S.; Kagechika, H.; Shudo, K.; Nagai, R. Arterioscl. Thromb. Vas., 2006, 26, 1177-1183. |
| Calix[3]amides－bowl-shaped cyclic trimers toward building block for molecular recognition: self-complementary dimeric structure in the crystal. Calleja, C.; Messaddeq, N.; Chapellier, B.; Yang, H.; Krezel, W.; Li, M.; Metzger, D.; Mascrez, B.; Ohta, K.; Kagechika, H.; Endo, Y.; Mark, M.; Ghyselinck, N. B.; Chambon, P. Tetrahedron Lett., 2006, 47, 413-416. |
| PPARγ ligands stimulate myeloid differentiation and lipogenensis in the human leukemia NB4 cells. Imabeppu, F.; Katagiri, K.; Masu, H.; Kato, T.; Tominaga, M.; Therrien, B.; Takayanagi, H.; Kaji, E.; Yamaguchi, K.; Kagechika, H.; Azumaya, I. Dev. Growth Differ., 2006, 48, 177-188. |
| Synthetic Retinoid Am80 Suppresses Smooth Muscle Phenotypic Modulation and In-Stent Neointima Formaiton by Inhibiting KLF5 Fujiu, K.; Manabe, I.; Ishihara, A.; Oishi, Y.; Iwata, H.; Nishimura, G.; Shindo, T.; Maemura, K.; Kagechika, H.; Shudo, K.; Nagai, R. Circulation Res. 2005, 97, 1132-1141. |
| Retinoic acid via RAR alpha inhibits the expression of 24-hydroxylase in human prostate stromal cells. Lou, Y.-R.; Miettinen, S.; Kagechika, H.; Gronemeyer, H.; Tuohima, P. Biochem. Biophys. Res. Commun. 2005, 338, 1973-1981. |
| Biochem. Biophys. Res. Commun. Morita, K.; Kawana, K.; Sodeyama, M.; Shimomura, I.; Kagechika, H.; Makishima, M. Biochem. Pharmacol. 2005, 71, 98-107. |
| Upregulation of Nitric Oxide Production in Vascular Endothelical Cells by All-trans Retinoic Acid Through the Phosphoinositide 3-Kinase/Akt Pathway. Uruno, A.; Sugawara, A.; Kanatsuka, H.; Kagechika, H.; Sato, K.; Kudo, M.; Takeuchi, K.; Ito, S. Circulation. 2005, 112, 727-736. |
| RXR Agonist Enhances the Differentiation of Cardiomyocytes Derived from Embryonic Stem Cells in Serum-Free Conditions. Honda, T.; Hamazaki, T. S.; Komazaki, S.; Kagachika, H.; Shudo, K.; Asashima, M. Biochmem. Biophys. Res. Commun. 2005, 33, 1334-1340. |
| Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis. Ishida, S.; Shigemoto-Mogami, Y.; Shinozaki, Y.; Kagechika, H.; Shudo, K.; Ozawa, S.; Sawada, J.; Ohno, Y.; Inoue, K. Biochem. Pharmacol. 2004, 68, 2177-2186. |
| ASynthetic Retinoid Am80 (Tamibarotene) Rescue the Memory Deficit Caused by Scopolamine in a Passive Avoidance Paradigm. Shudo, K.; Kagechika, H.; Yamazaki, N.; Igarashi, M.; Takeda, C. Biol. Pharm. Bull. 2004, 27, 1887-1889. |
| Retinoic Acid Imprintis Gut-Homing Specificity on T cells. Iwata, M.; Hirakiyama, A.; Eshima, Y.; Kagechika, H.; Kato, C.; Song S.-Y. Immunity. 2004, 21, 527-538. |
| Docosahexaenoic Acid Reduces Haloperidol-Induced Dyskinesias in Mice: Involvement of Nur77 and Retinoid Receptors. Ethier, I.; Kagechika, H.; Shudo, K.; Rouillard, C.; Levesque, D. Biol. Psychiatry. 2004, 56, 522-526. |
| The Endocrine Disrutors Nonylphenol and Octylphenol Exert Direct Effects on T cells to Suppress Th1 Development and Enhance Th2 Development. Iwata, M.; Eshima, Y.; Kagechika, H.; Miyaura, H. Immunol. Lett. 2004, 94, 135-139. |
| Novel Retinoid X Receptor (RXR) Antagonists Having a Dicarba-closo-dodecaborane as a Hydrophobic Moiety Ohta, K.; Iijima, I.; Kawachi, E.; Kagechika, H.; Endo, Y. Bioorg. Med. Chem. Lett. 2004, 14, 5913-5918. |
| Design and synthesis cyclic urea compounds: a pharmacological study for retinoidal activity. Kurihara, M.; Rouf, A. S. S.; Kansui, H.; Kagechika, H.; Okuda, H.; Miyata, N. Bioorg. Med. Chem. Lett. 2004, 14, 4131-4134. |
| A Novel Melatonin Derivative Modulates Sleep-wake Cycle in Rats. Akanmu, M. A.; Songkram, C.; Kagechika, H.; Honda, K. Neurosci. Lett. 2004, 364, 199-202. |
| Utility of Boron Clusters for Drug Design. Relation Between Estrogen Receptor Binding Affinity and Hydrophobicity of Phenols Bearing Various Types of Carboranyl Groups. Endo, Y.; Yamamoto, K.; Kagechika, H. Bioorg. Med. Chem. Lett. 2003, 13, 4089-4092. |
| Absolute Helical Arrangement of Sulfonamide in the Crystal. Azumaya, I.; Kato, T.; Okamoto, I.: Yamasaki, R.; Tanatani, A.; Yamaguchi, K.; Kagechika, H.; Takayanagi, H. Org. Lett. 2003, 5, 3939-3942. |
| Cyclooxygenase Inhibitors Derived from Thalidomide. Suidu, M.; Muroya, Y.; Kakuta, H.; Kagechika, H.; Tanatani, A.; Nagasawa, K.; Hashimoto, Y. Chem. Pharm. Bull. 2003, 51, 1098-1102. |
| Retinoic Acids Exert Direct Effects on T Cells to Suppress Th1 Development and Enhance Th2 Development via Retinoic Acid Receptors. Iwata, M.; Eshima, Y.; Kagechika, H. Int. Immunol. 2003, 15, 1017-1025. |
| Amide Conformational Switching induced by Protonation of Aromatic Substituent. Yamasaki, R.; Tanatani, A.; Azumaya, I.; Saito, S.; Yamaguchi, K.; Kagechika, H. Org. Lett. 2003, 5, 1265-1267. |
| A retinoic acid receptor-selective agonist causes jaw deformity in the Japanese flounder, Paralichthys olivaceus Haga, Y.; Suzuki, T.; Kagechika, H.; Takeuchi, T. Aquaculture. 2003, 221, 381-392. |
| Effects of Retinoid Ligands on RIP140: Molecular Interaction with Retinoid Receptors and Biological Activity. Farooqui, M.; Franco, P. J.; Thompson, J.; Kagechika, H.; Chandraratna, R. A. S.; Banaszak, L.; Wei, L.-N. Biochemsitry. 2003, 42, 971-979. |
| Clinically Potential Subclasses of Retinoid Synergists Revealed by Gene Expression Profiling. Ishida, S.; Shigemoto-Mogami, Y.; Kagechika, H.; Shudo, K.; Ozawa, S.; Sawada, J.; Ohno, Y.; Inoue, K. Molecular Cancer Therapeutics. 2003, 2, 49-58. |
| Effect of Synthetic Retinoid, TAC-101, on Experimental Autoimmune Disease. Miyagawa, N.; Homma, T.; Kagechika, H.; Shudo, K.; Nagaia, H. Pharmacology. 2003, 67, 21-31. |
| Determination of Endogenous Levels of Retinoic Acid Isomers in Type II Diabetes Mellitus Patients. Possible Correlation with HbA1c Values. Yamakoshi, Y.; Fukasawa, H.; Yamauchi, T.; Waki, H.; Kadowaki, T.; Shudo, K.; Kagechika, H. Biol. Pharm. Bull. 2002, 25, 1268-1271. |
| Molecular construction based on icosahedral carboranes and aromatic N,N'-dimethylurea groups. Aromatic layered molecules and a transition metal complex. Endo, Y.; Songkram, C.; Yamasaki, R.; Tanatani, A.; Kagechika, H.; Takaishi, K.; Yamaguchi, K. J. Organomet. Chem. 2002, 657, 48-58. |
| Krueppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling. Shindo, T.; Manabe, I.; Fukushima, Y.; Tobe, K.; Aizawa, K.; Miyamoto, S.; Kawai-Kowase, K.; Moriyama, N.; Imai, Y.; Kawakami, H.; Nishimatsu, H.; Ishikawa, T.; Suzuki, T.; Morita, H.; Maemura, K.; Sata, M.; Hirata, Y.; Komukai, M.; Kagechika, H.; Kadowaki, T.; Kurabayashi, M.; Nagai, R. Nature Medicine. 2002, 8, 856-863. |
| Novel Retinoid X Receptor Antagonists: Specific Inhibition of Retinoid Synersism in RXR-RAR Heterodimer Actions. Takahashi, B.; Ohta, K.; Kawachi, E.; Fukasawa, H.; Hashimoto, Y.; Kagechika, H. J. Med. Chem. 2002, 45, 3327-3330. |
| Effect of natural and synthetic retinoids on the proliferation and differentiation of three canine melanoma cell lines. Ohashi, E.; Inoue, K.; Kagechika, H.; Hong, S.-H.; Nakagawa, T.; Takahashi, T.; Mochizuki, M.; Nishimura, R.; Sasaki, N. J. Vet. Med. Sci. 2002, 64, 169-172. |
| Inhibition of RXR and PPAR ameliorates diet-induced obesity and type 2 diabetes. Yamauchi, T.; Waki, H.; Kamon, J.; Murakami, K.; Motojima, K.; Komeda, K.; Miki, H.; Kubota, N.; Terauchi, Y.; Tsuchida, A.; Tsuboyama-Kasaoka, N.; Yamauchi, N.; Ide, T.; Hori, W.; Kato, S.; Fukayama, M.; Akanuma, Y.; Ezaki, O.; Itai, A.; Nagai, R.; Kimura, S.; Tobe, K.; Kagechika, H.; Shudo, K.; Kadowaki, T. J. Clin. Invest. 2001, 108, 1001-1013. |
| Structures of bis- and tris(2-phenyl-o-carboran-1-yl)benzenes. construction of three-dimensional structures converted from planar arylacetylenic arrays. Songkram, C.; Takaishi, K.; Yamaguchi, K.; Kagechika, H.; Endo, Y. Tetrahedron Lett. 2001, 42, 6365-6368. |
| Replenishment of the fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Yamauchi, T.; Kamon, J.; Waki, H.; Terauchi, Y.; Kubota, N.; Hara, K.; Mori, Y.; Abe, M.; Tanaka, J.; Ohsumi, J.; Ide, T.; Murakami, K.; Tsuboyama-Kasaoka, N.; Ezaki, O.; Akanuma, Y.; Gavrilova, O.; Vinson, C.; Reitman, M.; Kagechika, H.; Shudo, K.; Yoda, M.; Nakano, Y.; Tobe, K.; Nagai, R.; Kimura, S.; Tomita, M.; Froguel P.; Kadowaki, T. Nature Medicine. 2001, 7, 941-946. |
| Molecular Construction Based on Icosahedral Carboranes and Aromatic Urea Groups. A New Type of Carboracycles. Songkram, C.; Yamasaki, R.; Tanatani, A.; Takaishi, K.; Yamaguchi, K.; Kagechika, H.; Endo, Y. Tetrahedron Lett. 2001, 42, 5913-5916. |
| α-Glucosidase Inhibitors with a 4,5,6,7-Tetrachlorophthalimide Skeleton Pendanted with a Cycloalkyl or Dicarba-closo-dodecaborane Group Sou, S.; Takahashi, H.; Yamasaki, R.; Kagechika, H.; Endo, Y.; Hashimoto, Y. Chem. Pharm. Bull. 2001, 49, 791-793. |
| Structure-Activity Study of Retinoid Agonists Bearing Substituted Dicarba-closo-dodecaborane. Relation between Retinoidal Activity and Conformation of Two Aromatic Nuclei. Endo, Y.; Iijima, T.; Yaguchi, K.; Kawachi, E.; Inoue, N.; Kagechika, H.; Kubo, A.; Itai, A. Bioorg. Med. Chem. Lett. 2001, 11, 1307-1311. |
| Inhibition by retinoids of antigen-induced IL-4 production in rat mast cell line RBL-2H3. Hirasawa, N.; Kagechika, H.; Shudo, K.; Ohuchi, K. Life Sci. 2001, 68, 1287-1294. |
| Novel Retinoidal Tropolone Derivatives. Bioisosteric Relationship of Tropolone Ring with Benzoic Acid Moiety in Retinoid Structure. Ebisawa, M.; Ohta, K.; Kawachi, E.; Fukasawa, H.; Hashimoto, Y.; Kagechika, H. Chem. Pharm. Bull. 2001, 49, 501-503. |
| Synergistic Potentiation of Thiazolidinedione-Induced ST 13 Preadipocyte Differentiation by RAR Synergists. Sato, M.; Yajima, Y.; Kawashima, S.; Tanaka, K.; Kagechika, H. Biochem. Biophys. Res. Commun. 2001, 280, 646-651. |
| RXR Antagonist Provides a Novel Treatment for Obesity and Type 2 Diabetes. Yamauchi, T.; Waki, H.; Komeda, K.; Miki, H.; Tobe, K.; Akanuma, Y.; Nagai, R.; Kimura, S.; Kagechika, H.; Shudo, K.; Kadowaki, T. Diabetes. 2000, 49S, A38. |
| Retinoidal Piperidinecarboxylic Acids. Unexpected Diaza-Substituent Effects in Retinobenzoic Acids. Ohta, K.; Kawachi, E.; Inoue, N.; Fukasawa, H.; Hashimoto, Y.; Itai, A.; Kagechika, H. Chem. Pharm. Bull. 2000, 48, 1504-1513. |
| Structures of N,N'-Bis(1,2-dicarba-closo-dodecaborane-1-yl)phenylureas: Building Blocks for Carborane-containing Macromolecules. Songkram, C.; Tanatani, A.; Yamasaki, R.; Yamaguchi, K.; Kagechika, H.; Endo, Y. Tetrahedron Lett. 2000, 41, 7065-7070. |
| Polymethylcarborane as a novel bioactive moiety: derivatives with potent retinoid antagonistic activity. Endo, Y.; Yaguchi, K.; Kawachi, E.; Kagechika, H. Bioorg. Med. Chem. Lett. 2000, 10, 1733-1736. |
| Retinoid X Receptor-Antagonistic Diazepinylbenzoic Acids. Ebisawa, M.; Umemiya, H.; Ohta, K.; Fukasawa, H.; Kawachi, E.; Christoffel, G.; Gronemeyer, H.; Tsuji, M.; Hashimoto, Y.; Shudo, K.; Kagechika, H. Chem. Pharm. Bull. 1999, 47, 1778-1786. |
| Thiazolidinediones with Thyroid Hormone Receptor Agonistic Activity. Ebisawa, M.; Inoue, N.; Fukasawa, H.; Sotome, T.; Kagechika, H. Chem. Pharm. Bull. 1999, 47, 1348-1350. |
| A Chiral N-Methylbenzamide: Spontaneous Generation of Optical Activity. Azumaya, I.; Okamoto, I.; Nakayama, S.; Tanatani, A.; Yamaguchi, K.; Shudo, K.; Kagechika, H. Tetrahedron. 1999, 55, 11237-11246. |
| Identification of a Novel Class of RARb-selective Retinoid Antagonists and their Inhibitory Effects on AP-1 activity and Retinoic Acid-induced Apoptosis in Human Breast Cancer Cells. Li, Y.; Hashimoto, Y.; Agadir, A.; Kagechika, H.; Zhang, X.-K. J. Biol. Chem. 1999, 274, 15360-15367. |
| A Layered Artificial Dinucleotide Complex. Kagechika, H.; Azumaya, I.; Tanatani, A.; Yamaguchi K.; Shudo, K. Tetrahedron Lett. 1999, 40, 3413-3426. |
| Dicarba-closo-dodecaboranes as a Pharmacophore. Novel Potent Retinoidal Agonists. Endo, Y.; Iijima, T.; Kagechika, H.; Ohta, K.; Kawachi E.; Shudo, K. Chem. Pharm. Bull. 1999, 47, 585-587. |
| Dicarba-closo-dodecaboranes as a Pharmacophore. Retinoidal Antagonists and Potential Agonists Iijima, T.; Endo, Y.; Tsuji, M.; Kawachi, E.; Kagechika H.; Shudo, K. Chem. Pharm. Bull. 1999, 47, 398-404. |
| Novel DNA minor groove binders with an aromatic layered structure. Tanatani, A.; Fukutomi, R.; Kakuta, H.; Tomioka, N.; Itai, A.; Hashimoto, Y.; Shudo, K.; Kagechika, H. Nucleic Acids Symp. Ser. 1998, 39, 31-32. |
| Aromatic Layered Guanidines Bind Sequence-Specifically to DNA Minor Groove with Precise Fit. Fukutomi, R.; Tanatani, A.; Kakuta, H.; Tomioka, N.; Itai, A.; Hashimoto, Y.; Shudo, K.; Kagechika, H. Tetrahedron Lett. 1998, 39, 6475-6478. |
| N-Methylated Diphenylguanidines: Conformations, Propeller-type Molecular Chirality, and Construction of Water-soluble Oligomers with Multi-layered Aromatic Structures. Tanatani, A.; Yamaguchi, K.; Azumaya, I.; Fukutomi, R.; Shudo, K.; Kagechika, H. J. Am. Chem. Soc. 1998, 120, 6433-6442. |
| Novel Thiazolidinedione Derivatives with Retinoid Synergistic Activity. Ebisawa, M.; Kawachi, E.; Fukasawa, H.; Hashimoto, Y.; Itai, A.; Shudo, K.; Kagechika, H. Biol. Pharm. Bull. 1998, 21, 547-549. |
| Potent Retinoid Synergists with A Diphenylamine Skeleton. Ohta, K.; Tsuji, M.; Kawachi, E.; Fukasawa, H.; Hashimoto, Y.; Shudo, K.; Kagechika, H. Biol. Pharm. Bull. 1998, 21, 544-546. |
| Regulation of Retinoidal Actions by Diazepinylbenzoic Acids. Retinoid Synergists which Activate the RXR-RAR Heterodimers. Umemiya, H. Fukasawa, H.; Ebisawa, M.; Eyrolles, L.; Kawachi, E.; Eisenmann, G.; Gronemeyer, H.; Hashimoto, Y.; Shudo, K.; Kagechika, H. J. Med. Chem. 1997, 40, 4222-4234. |
| Dinucleotide-Analogous Tetrapeptides. Specific Triplex Formation with Complementary Polynucleotides. Yamazaki, T.; Komatsu, K.; Umemiya, H.; Hashimoto, Y.; Shudo, K.; Kagechika, H. Tetrahedron Lett. 1997, 38, 8363-8366. |
| Polyenylidene Thiazolidine Derivatives with Retiniodal Activities. Tashima, T.; Kagechika, H.; Tsuji, M.; Fukasawa, H.; Kawachi, E.; Hashimoto, Y.; Shudo, K. Chem. Pharm. Bull. 1997, 45, 1805-1813. |
| A mutation mimicking the ligand-induced conformational change yields a constitutive RXR that senses allosteric effects in heterodimers. Vivat, V.; Zechel, C.; Wurtz, J.-M.; Bourguet, W.; Kagechika, H.; Umemiya, H.; Shudo, K.; Moras, D.; Gronemeyer, H.; Chambon, P. EMBO J. 1997, 16, 5697-5709. |
| Photoaffinity-labeling of the Ligand-Interacting Helix of Retinoic Acid Receptor Alpha. Sasaki, T.; Morisaki, N.; Iwasaki, S.; Kagechika, H.; Fukasawa, H.; Shudo, K.; Shida, Y.; Hashimoto, Y. Biol. Pharm. Bull. 1997, 20, 913-916. |
| Aromatic Helical Urea and Guanidine. Tanatani, A.; Kagechika, H.; Azumaya, I.; Fukutomi, R.; Ito, Y.; Yamaguchi, K.; Shudo, K. Tetrahedron Lett. 1997, 38, 4435-4428. |
| Action Mechanism of Retinoid-Synergistic Dibenzodiazepines. Umemiya, H.; Kagechika, H.; Fukasawa, H.; Kawachi, E.; Ebisawa, M.; Hashimoto, Y.; Eisenmann, G.; Erb, C.; Pornon, A.; Chambon, P.; Gronemeyer, H.; Shudo, K. Biochem. Biophys. Res. Commun. 1997, 233, 121-125. |
| Inhibition of IL-1-induced IL-6 Production by Synthetic Retinoids. Kagechika, H.; Kawachi, E.; Fukasawa, H.; Saito, G.; Iwanami, N.; Umemiya, H.; Hashimoto, Y.; Shudo, K. Biochem. Biophys. Res. Commun. 1997, 231, 243-248. |
| Evaluation of Differentiation-Inducing Activity of Retinoids on Human Leukemia Cell Lines HL-60 and NB4. Hashimoto, Y.; Kagechika, H.; Kawachi, E.; Fukasawa, H.; Saito, G.; Shudo, K. Biol. Pharm. Bull. 1996, 19, 1322-1328. |
| Novel Aromatic Urea Derivatives with DNA-Binding Ability. Fukutomi, R.; Kagechika, H.; Hashimoto, Y.; Shudo, K. Chem. Pharm. Bull. 1996, 44, 1983-1985. |
| Facile Formation of Aromatic Cyclic N-Methylamides Based on cis Conformational Preference. Azumaya, I.; Kagechika, H.; Yamaguchi, K.; Shudo, K. Tetrahedron Lett. 1996, 37, 5003-5006. |
| Deiodo-trifluoromethylation of Ethyl 3,3',5-Triiodothyroacetate. Divergent Derivatization Based on the Combinatorial Concept. Sagi, K.; Kagechika, H.; Fukasawa, H.; Hashimoto, Y.; Shudo, K. Chem. Pharm. Bull. 1996, 44, 1273-1275. |
| (Cis)-Preference of N,N'-Dimethyl-n,N'-Diphenylguanidine and the Guanidinium Salt. Construction of Water-Soluble Aromatic Layered Structure. Tanatani, A.; Kagechika, H.; Azumaya, I.; Yamaguchi, K.; Shudo, K. Chem. Pharm. Bull. 1996, 44, 1135-1137. |
| Synthesis of Oligopeptides as Polynucleotide Analogs. Umemiya, H.; Kagechika, H.; Hashimoto, Y.; Shudo, K. Nucleosides and Nucleotides. 1996, 15, 465-475. |
| Sterical Properties of N,N'-Dimethylurea Moiety Enhance Formation of Triply Hydrogen-bonded Complexes. Kagechika, H.; Azumaya, I.; Yamaguchi. K.; Shudo, K. Chem. Pharm. Bull. 1996, 44, 460-462. |
| Synthesis of Vitamin E Analogues: Possible Active Forms of Vitamin E. Fujishima, T.; Kagechika, H.; Shudo, K. Arch. Pharm. Pharm. Med. Chem. 1996, 329, 27-34. |
| Synthesisof Oligopeptides as Polynucleotide Analogs. Umemiya, H.; Komatsu, K.; Yamazaki, T.; Kagechika, H.; Shudo, K.; Hashimoto, Y. Nucleic Acids Symp. Ser. 1995, 34, 37-38. |
| Correlation of Differentiation-Inducing Activity of Retinoids on Human Leukemia Cell Lines HL-60 and NB4. Hashimoto, Y.; Kagechika, H.; Kawachi, E.; Fukasawa, H.; Saito, G.; Shudo, K. J. Cancer Res. Clin. Oncol. 1995, 121, 696-698. |
| Synergists for Retinoid in Cellular Differentiation of Human Promyelocytic Leukemia Cells HL-60. Umemiya, H.; Kawachi, E.; Kagechika, H.; Fukasawa, H.; Hashimoto, Y.; Shudo, K. Chem. Pharm. Bull. 1995, 43, 1827-1829. |
| Total Asymmetric Transformation of an N-Methylbenzamide. Azumaya, I.; Yamaguchi, K.; Okamoto, I.; Kagechika, H.; Shudo, K. J. Am. Chem. Soc. 1995, 117, 9083-9084. |
| Stereochemistries of Aromatic N-Methylamides in Crystal and Solution. Temperature-dependent Conformational Conversion and Attracting Aromatic-Aromatic Interactions. Azumaya, I.; Kagechika, H.; Yamaguchi, K.; Shudo, K. Tetrahedron. 1995, 51, 5277-5290. |
| Specific Oxidation of Retinoic Acid to 4-oxo-Retinoic Acid in Diluted Acid Solutions Tanaka, H.; Kagechika, H.; Shudo, K. Chem. Pharm. Bull. 1995, 43, 356-358. |
| Possible Involvement of Retinoid-like Cofactor in Serum in Hemin/Protoporphyrin-IX-Induced Differentiation of Human Leukemia K562 Cells. Nakajima, O.; Kagechika, H.; Shudo, K.; Hashimoto, Y.; Iwasaki, S. Biochem. Biophys. Res. Commun. 1995, 206, 1003-1010. |
| Retinoidal Dienamides and Related Aromatic Amides. Replacement of the 9-Ene Structure of Retinoic acid with a trans- or cis-Amide Group. Shimasaki, H.; Kagechika, H.; Fukasawa, H.; Kawachi , E.; Shudo, K. Chem. Pharm. Bull. 1995, 43, 100-107. |
| Synthesis and Biological Activity of Carboxyphenylquinolines and Related Compounds as New Potent Retinoids. Retinobenzoic Acids. VII. Eyrolles, L.; Kawachi, E.; Kagechika, H.; Hashimoto, Y.; Shudo, K. Chem. Pharm. Bull. 1994, 42, 2575-2581. |
| Retinoids Shudo, K.; Kagechika, H. In "Cancer Chemotherapy: Challenges for the Future Vol. 8" (Excerpta Medica, Ltd. Tokyo) pp 172-177,1993. |
| Expression of the Ligand-Binding Domain-Containing Region of Retinoic Acid Receptors a, b and g in Escherichia coli and Evaluation of Ligand-Binding Selectivity. Fukasawa, H.; Iijima, T.; Kagechika, H.; Hashimoto, Y.; Shudo, K. Biol. Pharm. Bull. 1993, 16, 343-348. |
| Preference of cis-Amide Structure in N-Acyl-N-methylanilines. Itai, A.; Toriumi, Y.; Saito, S.; Kagechika, H.; Shudo, K. J. Am. Chem. Soc. 1992, 114, 10649-10650. |
| Differentiation-Inducing Activity of Retinoic Acid Isomers and Their Oxidized Analogs on Human Promyelocytic Leukemia HL-60 Cells. Matsushima, Y.; Kawachi, E.; Tanaka, H.; Kagechika, H.; Hashimoto, Y.; Shudo, K. Biochem. Biophys. Res. Commun. 1992, 189, 1136-1142. |
| Retinoid Antagonists: Molecular Design Based On The Ligand Superfamily Concept. Eyrolles, L.; Kawachi, E.; Matsushima, Y.; Nakajima, O.; Kagechika, H.; Hashimoto, Y.; Shudo, K. Med. Chem. Res. 1992, 2, 362-367. |
| Base-catalyzed Isomerization of Retinoic Acid. Synthesis and Differentiation-Inducing Activities of 14-Alkylated all-trans-, 13-cis-, and 20,14-retro-Retinoic Acids. Tanaka, H.; Kagechika, H.; Kawachi, E.; Fukasawa, H.; Hashimoto, Y.; Shudo, K. J. Med. Chem. 1992, 35, 567-572. |
| Fluorescent Probes for Retinoic Acid Receptors: Molecular Measures for the Ligand Binding Pocket. Shimazawa, R.; Hibino, S.; Mizoguchi, H.; Hashimoto, Y.; Iwasaki, S.; Kagechika, H.; Shudo, K. Biochem. Biophys. Res. Commun. 1991, 180, 249-254. |
| Fluorescent and Photoaffinity Labeling Probes for Retinoic Acid Receptors. Shimazawa, R.; Sanda, R.; Mizoguchi, H.; Hashimoto, Y.; Iwasaki, S.; Tanaka, H.; Kagechika, H.; Shudo, K. Biochem. Biophys. Res. Commun. 1991, 179, 259-265. |
| Retinoid Antagonists. Kaneko, S.; Kagechika, H.; Kawachi, E.; Hashimoto, Y.; Shudo, K. Med. Chem. Res. 1991, 1, 220-225. |
| An Unsymmetrical 1,1,3,3-Tetramethylallyl Cation. Gassman, P. G.; Singleton, D. A.; Kagechika, H. J. Am. Chem. Soc. 1991, 113, 6271-6272. |
| Aromatic Architecture. Use of the N-Methylamide Structure as a Molecular Splint. Yamaguchi, K.; Matsumura, G.; Kagechika, H.; Azumaya, I.; Ito, Y.; Itai , A.; Shudo, K. J. Am. Chem. Soc. 1991, 113, 5474-5475. |
| Twisted Intramolecular Charge-Transfer Fluorescence of Aromatic Amides: Conformation of the Amide Bonds in the Excited States. Azumaya, I.; Kagechika, H.; Fujiwara, Y.; Itoh, M.; Yamaguchi, K.; Shudo, K. J. Am. Chem. Soc. 1991, 113, 2833-2838. |