業績
2024年
総説:
Lihong Cheng, Caiyue Shi, Xixi Li, Toshiro Matsui. Impact of Peptide Transport and Memory Function in the Brain. Nutrients 2024,16(17),2947. doi: 10.3390/nu16172947.
英文原著論文:
Aiko Takada, Toshifumi Asano, Ken-Ichi Nakahama, Takashi Ono, Takao Nakata, Tomohiro Ishii. Development of an optogenetics tool, Opto-RANK, for control of osteoclast differentiation using blue light. Scientific Reports. 2024 Jan 19;14(1):1749. doi: 10.1038/s41598-024-52056-w.
Lihong Cheng, Caiyue Shi, Xixi Li, Toshiro Matsui. Impact of Peptide Transport and Memory Function in the Brain. Nutrients 2024,16(17),2947. doi: 10.3390/nu16172947.
英文原著論文:
Aiko Takada, Toshifumi Asano, Ken-Ichi Nakahama, Takashi Ono, Takao Nakata, Tomohiro Ishii. Development of an optogenetics tool, Opto-RANK, for control of osteoclast differentiation using blue light. Scientific Reports. 2024 Jan 19;14(1):1749. doi: 10.1038/s41598-024-52056-w.
2023年
英文原著論文:
Toshifumi Asano, Philipp Sasse, Takao Nakata. Development of a Cre-recombination-based color-switching reporter system for cell fusion detection. Biochemical and Biophysical Research Communications. 2024 Jan 1:690:149231. doi: 10.1016/j.bbrc.2023.149231. Epub 2023 Nov 17.
Toshifumi Asano, Philipp Sasse, Takao Nakata. Development of a Cre-recombination-based color-switching reporter system for cell fusion detection. Biochemical and Biophysical Research Communications. 2024 Jan 1:690:149231. doi: 10.1016/j.bbrc.2023.149231. Epub 2023 Nov 17.
2021年
英文原著論文:
Hironori Inaba, Qianqian Miao, Takao Nakata. Optogenetic control of small GTPases reveals RhoA mediates intracellular calcium signaling. Journal of Biological Chemistry. Jan-Jun 2021;296:100290. doi: 10.1016/j.jbc.2021.100290. Epub 2021 Jan 13.
Hironori Inaba, Qianqian Miao, Takao Nakata. Optogenetic control of small GTPases reveals RhoA mediates intracellular calcium signaling. Journal of Biological Chemistry. Jan-Jun 2021;296:100290. doi: 10.1016/j.jbc.2021.100290. Epub 2021 Jan 13.
2018年
英文原著論文:
Moe Sato, Toshifumi Asano, Jun Hosomichi, Takashi Ono, Takao Nakata. Optogenetic manipulation of intracellular calcium by BACCS promotes differentiation of MC3T3-E1 cells. Biochemical and Biophysical Research Communications. 2018 Oct 27. pii: S0006-291X(18)32269-1. doi: 10.1016/j.bbrc.2018.10.107.
Toshifumi Asano, Hiroyuki Igarashi, Toru Ishizuka, Hiromu Yawo. Organelle optogenetics: Direct manipulation of intracellular Ca2+ dynamics by light. Frontiers in Neuroscience. 2018 Aug 17. doi: 10.3389/fnins.2018.00561.
Moe Sato, Toshifumi Asano, Jun Hosomichi, Takashi Ono, Takao Nakata. Optogenetic manipulation of intracellular calcium by BACCS promotes differentiation of MC3T3-E1 cells. Biochemical and Biophysical Research Communications. 2018 Oct 27. pii: S0006-291X(18)32269-1. doi: 10.1016/j.bbrc.2018.10.107.
Toshifumi Asano, Hiroyuki Igarashi, Toru Ishizuka, Hiromu Yawo. Organelle optogenetics: Direct manipulation of intracellular Ca2+ dynamics by light. Frontiers in Neuroscience. 2018 Aug 17. doi: 10.3389/fnins.2018.00561.
2016年
総説:
石井 智浩, 中田 隆夫. 光スイッチによる細胞内Ca2+シグナル制御
実験医学. 2016.03; 34(4); 601-606
石井 智浩, 中田 隆夫. 光スイッチによる細胞内Ca2+シグナル制御
実験医学. 2016.03; 34(4); 601-606
2015年
英文原著論文:
Tomohiro Ishii, Koji Sato, Toshiyuki Kakumoto, Shigenori Miura, Kazushige Touhara, Shoji Takeuchi, Takao Nakata.
Light generation of intracellular Ca2+ signals by a genetically encoded protein BACCS. Nature Communications. 2015 Aug 18; 6:8021. doi: 10.1038/ncomms9021
Tomohiro Ishii, Koji Sato, Toshiyuki Kakumoto, Shigenori Miura, Kazushige Touhara, Shoji Takeuchi, Takao Nakata.
Light generation of intracellular Ca2+ signals by a genetically encoded protein BACCS. Nature Communications. 2015 Aug 18; 6:8021. doi: 10.1038/ncomms9021
2013年
英文原著論文:
T. Kakumoto, T. Nakata. Optogenetic control of PIP3: PIP3 is sufficient to induce the actin-based active part of growth cones and is regulated via endocytosis. PLoS One. 2013 Aug 7; 8(8):e70861. doi: 10.1371/journal.pone.0070861. eCollection 2013.
T. Kakumoto, T. Nakata. Optogenetic control of PIP3: PIP3 is sufficient to induce the actin-based active part of growth cones and is regulated via endocytosis. PLoS One. 2013 Aug 7; 8(8):e70861. doi: 10.1371/journal.pone.0070861. eCollection 2013.
2011年
英文原著論文:
T. Nakata, S. Niwa, Y. Okada, F. Perez, and N. Hirokawa. Preferential binding of a kinesin-1 motor to GTP-tubulin-rich microtubules underlies polarized vesicle transport. The Journal of Cell Biology 194:245-255. 2011.
T. Nakata, S. Niwa, Y. Okada, F. Perez, and N. Hirokawa. Preferential binding of a kinesin-1 motor to GTP-tubulin-rich microtubules underlies polarized vesicle transport. The Journal of Cell Biology 194:245-255. 2011.
2010年
和文総説:
中田隆夫 シグナル分子の光制御技術と神経の形態形成
ブレインサイエンス・レビュー2011(伊藤正男・川合述史編)p23-36 2011.3.10
中田隆夫 シグナル分子の光制御技術と神経の形態形成
ブレインサイエンス・レビュー2011(伊藤正男・川合述史編)p23-36 2011.3.10
2009年
和文総説:
中田隆夫 東京医科歯科大学の教授就任にあたって 解剖学雑誌 vol.84;26-27,2009
中田隆夫 東京医科歯科大学の教授就任にあたって 解剖学雑誌 vol.84;26-27,2009
2008年以前の業績
英文原著論文:
1. J. Teng, T. Ray, Y. Tanaka, Y. Takei, T. Nakata, M. Hirasawa, A.B. Kulkarni, N. Hirokawa. The KIF3 motor transports N-cadherin and organizes the developing neuroepithelium. Nature Cell Biology 2005 May;7(5):474-82.
2. T. Nakata and N. Hirokawa. Microtubules provide directional cues for polarized axonal transport through interaction with kinesin motor head. Journal of Cell Biology 162(6): 1045-55. 2003.
3. N. Homma, Y. Takei, Y. Tanaka, T. Nakata, S. Terada, M. Kikkawa, Y. Noda, and N. Hirokawa. Kinesin superfamily protein 2A (KIF2A) functions in suppression of collateral branch extension. Cell 114(2): 229-39. 2003.
4. Y. Xu, S. Takeda, T. Nakata, Y. Noda, Y. Tanaka, and N. Hirokawa. Role of KIFC3 motor protein in Golgi positioning and integration. Journal of Cell Biology 158(2): 293-303. 2002.
5. K. Nakajima, Y. Takei, Y. Tanaka, T. Nakagawa, T. Nakata, Y. Noda, M. Setou, and N. Hirokawa. Molecular motor KIF1C is not essential for mouse survival and motor-dependent retrograde Golgi apparatus-to-endoplasmic reticulum transport. Molecular and Cellular Biology 22(3): 866-73. 2002.
6. J. Teng, Y. Takei, A. Harada, T. Nakata, J. Chen, and N. Hirokawa. Synergistic effects of MAP2 and MAP1B knockout in neuronal migration, dendritic outgrowth, and microtubule organization. Journal of Cell Biology 155(1): 65-76. 2001.
7. C. Zhao, J. Takita, Y. Tanaka, M. Setou, T. Nakagawa, S. Takeda, H. W. Yang, S. Terada, T. Nakata, Y. Takei, M. Saito, S. Tsuji, Y. Hayashi, and N. Hirokawa. Charcot-Marie-Tooth disease type 2A caused by mutation in a microtubule motor KIF1Bbeta. Cell 105(5): 587-97. 2001.
8. J. Chen, T. Nakata, Z. Zhang, and N. Hirokawa. The C-terminal tail domain of neurofilament protein-H (NF-H) forms the crossbridges and regulates neurofilament bundle formation. Journal of Cell Science 113 Pt 21: 3861-9. 2000.
9. T. Nakata, S. Terada, and N. Hirokawa. Visualization of the dynamics of synaptic vesicle and plasma membrane proteins in living axons. Journal of Cell Biology 140(3): 659-74. 1998.
10. K. I. Nagata, A. Puls, C. Futter, P. Aspenstrom, E. Schaefer, T. Nakata, N. Hirokawa, and A. Hall. The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3. EMBO Journal 17(1): 149-58. 1998.
11. H. Yamazaki, T. Nakata, Y. Okada, and N. Hirokawa. Cloning and characterization of KAP3: a novel kinesin superfamily-associated protein of KIF3A/3B. Proceedings of the National Academy of Sciences of the United States of America 93(16): 8443-8. 1996.
12. S. Terada, T. Nakata, A. C. Peterson, and N. Hirokawa. Visualization of slow axonal transport in vivo. Science 273(5276): 784-8. 1996.
13. R. Takemura, T. Nakata, Y. Okada, H. Yamazaki, Z. Zhang, and N. Hirokawa. mRNA expression of KIF1A, KIF1B, KIF2, KIF3A, KIF3B, KIF4, KIF5, and cytoplasmic dynein during axonal regeneration. Journal of Neuroscience 16(1): 31-5. 1996.
14. T. Nakata, and N. Hirokawa. Point mutation of adenosine triphosphate-binding motif generated rigor kinesin that selectively blocks anterograde lysosome membrane transport. Journal of Cell Biology 131(4): 1039-53. 1995.
15. H. Yamazaki, T. Nakata, Y. Okada, and N. Hirokawa. KIF3A/B: a heterodimeric kinesin superfamily protein that works as a microtubule plus end-directed motor for membrane organelle transport. Journal of Cell Biology 130(6): 1387-99. 1995.
16. T. Hayashi, F. Soulie, T. Nakata, and N. Hirokawa. Redistribution of synapsin I and synaptophysin in response to electrical stimulation in the rat neurohypophysial nerve endings. Cell Structure and Function 19(4): 253-62. 1994.
17. M. Kikkawa, T. Ishikawa, T. Nakata, T. Wakabayashi, and N. Hirokawa. Direct visualization of the microtubule lattice seam both in vitro and in vivo. Journal of Cell Biology 127(6 Pt 2): 1965-71. 1994.
18. A. Ando, K. Yonezawa, I. Gout, T. Nakata, H. Ueda, K. Hara, Y. Kitamura, Y. Noda, T. Takenawa, and N. Hirokawa. A complex of GRB2-dynamin binds to tyrosine-phosphorylated insulin receptor substrate-1 after insulin treatment. EMBO Journal 13(13): 3033-8. 1994.
19. S. Kondo, R. Sato-Yoshitake, Y. Noda, H. Aizawa, T. Nakata, Y. Matsuura, and N. Hirokawa. KIF3A is a new microtubule-based anterograde motor in the nerve axon. Journal of Cell Biology 125(5): 1095-107. 1994.
20. H. Miki, K. Miura, K. Matuoka, T. Nakata, N. Hirokawa, S. Orita, K. Kaibuchi, Y. Takai, and T. Takenawa. Association of Ash/Grb-2 with dynamin through the Src homology 3 domain. Journal of Biological Chemistry 269(8): 5489-92. 1994.
21. T. Nakata, R. Sato-Yoshitake, Y. Okada, Y. Noda, and N. Hirokawa. Thermal drift is enough to drive a single microtubule along its axis even in the absence of motor proteins. Biophysical Journal 65(6): 2504-10. 1993.
22. Z. Zhang, Y. Tanaka, S. Nonaka, H. Aizawa, H. Kawasaki, T. Nakata, and N. Hirokawa. The primary structure of rat brain (cytoplasmic) dynein heavy chain, a cytoplasmic motor enzyme. Proceedings of the National Academy of Sciences of the United States of America 90(17): 7928-32. 1993.
23. Y. Noda, T. Nakata, and N. Hirokawa. Localization of dynamin: widespread distribution in mature neurons and association with membranous organelles. Neuroscience 55(1): 113-27. 1993.
24. T. Nakata, R. Takemura, and N. Hirokawa. A novel member of the dynamin family of GTP-binding proteins is expressed specifically in the testis. Journal of Cell Science 105 ( Pt 1): 1-5. 1993.
25. Y. Tanaka, K. Kawahata, T. Nakata, and N. Hirokawa. Chronological expression of microtubule-associated proteins (MAPs) in EC cell P19 after neuronal induction by retinoic acid. Brain Research 596(1-2): 269-78. 1992.
26. K. Maeda, T. Nakata, Y. Noda, R. Sato-Yoshitake, and N. Hirokawa. Interaction of dynamin with microtubules: its structure and GTPase activity investigated by using highly purified dynamin. Molecular Biology of the Cell 3(10): 1181-94. 1992.
27. T. Nakata, and N. Hirokawa. Organization of cortical cytoskeleton of cultured chromaffin cells and involvement in secretion as revealed by quick-freeze, deep-etching, and double-label immunoelectron microscopy. Journal of Neuroscience 12(6): 2186-97. 1992.
28. T. Nakata, A. Iwamoto, Y. Noda, R. Takemura, H. Yoshikura, and N. Hirokawa. Predominant and developmentally regulated expression of dynamin in neurons. Neuron 7(3): 461-9. 1991.
29. T. Nakata, K. Sobue, and N. Hirokawa. Conformational change and localization of calpactin I complex involved in exocytosis as revealed by quick-freeze, deep-etch electron microscopy and immunocytochemistry. Journal of Cell Biology 110(1): 13-25. 1990.
30. T. Nakata, and N. Hirokawa. Cytoskeletal reorganization of human platelets after stimulation revealed by the quick-freeze deep-etch technique. Journal of Cell Biology 105(4): 1771-80. 1987.
英文総説:
T.Nakata and N. Hirokawa. Neuronal polarity and the kinesin superfamily proteins. Sci STKE. 2007 Feb 6; (372):pe6.、2007
和文総説:
中田隆夫 細胞内膜動態に関わる細胞骨格蛋白質について(総説) 解剖学雑誌(0022-7722)73巻2号 頁107-110, (1998.04)
著書:
T. Nakata and N. Hirokawa. Is dynamin GTPase a microtubule based motor? In: Neuronal Cytoskeleton(N. Hirokawa, editor, CRC Press. London) p285-303 1993.
1. J. Teng, T. Ray, Y. Tanaka, Y. Takei, T. Nakata, M. Hirasawa, A.B. Kulkarni, N. Hirokawa. The KIF3 motor transports N-cadherin and organizes the developing neuroepithelium. Nature Cell Biology 2005 May;7(5):474-82.
2. T. Nakata and N. Hirokawa. Microtubules provide directional cues for polarized axonal transport through interaction with kinesin motor head. Journal of Cell Biology 162(6): 1045-55. 2003.
3. N. Homma, Y. Takei, Y. Tanaka, T. Nakata, S. Terada, M. Kikkawa, Y. Noda, and N. Hirokawa. Kinesin superfamily protein 2A (KIF2A) functions in suppression of collateral branch extension. Cell 114(2): 229-39. 2003.
4. Y. Xu, S. Takeda, T. Nakata, Y. Noda, Y. Tanaka, and N. Hirokawa. Role of KIFC3 motor protein in Golgi positioning and integration. Journal of Cell Biology 158(2): 293-303. 2002.
5. K. Nakajima, Y. Takei, Y. Tanaka, T. Nakagawa, T. Nakata, Y. Noda, M. Setou, and N. Hirokawa. Molecular motor KIF1C is not essential for mouse survival and motor-dependent retrograde Golgi apparatus-to-endoplasmic reticulum transport. Molecular and Cellular Biology 22(3): 866-73. 2002.
6. J. Teng, Y. Takei, A. Harada, T. Nakata, J. Chen, and N. Hirokawa. Synergistic effects of MAP2 and MAP1B knockout in neuronal migration, dendritic outgrowth, and microtubule organization. Journal of Cell Biology 155(1): 65-76. 2001.
7. C. Zhao, J. Takita, Y. Tanaka, M. Setou, T. Nakagawa, S. Takeda, H. W. Yang, S. Terada, T. Nakata, Y. Takei, M. Saito, S. Tsuji, Y. Hayashi, and N. Hirokawa. Charcot-Marie-Tooth disease type 2A caused by mutation in a microtubule motor KIF1Bbeta. Cell 105(5): 587-97. 2001.
8. J. Chen, T. Nakata, Z. Zhang, and N. Hirokawa. The C-terminal tail domain of neurofilament protein-H (NF-H) forms the crossbridges and regulates neurofilament bundle formation. Journal of Cell Science 113 Pt 21: 3861-9. 2000.
9. T. Nakata, S. Terada, and N. Hirokawa. Visualization of the dynamics of synaptic vesicle and plasma membrane proteins in living axons. Journal of Cell Biology 140(3): 659-74. 1998.
10. K. I. Nagata, A. Puls, C. Futter, P. Aspenstrom, E. Schaefer, T. Nakata, N. Hirokawa, and A. Hall. The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3. EMBO Journal 17(1): 149-58. 1998.
11. H. Yamazaki, T. Nakata, Y. Okada, and N. Hirokawa. Cloning and characterization of KAP3: a novel kinesin superfamily-associated protein of KIF3A/3B. Proceedings of the National Academy of Sciences of the United States of America 93(16): 8443-8. 1996.
12. S. Terada, T. Nakata, A. C. Peterson, and N. Hirokawa. Visualization of slow axonal transport in vivo. Science 273(5276): 784-8. 1996.
13. R. Takemura, T. Nakata, Y. Okada, H. Yamazaki, Z. Zhang, and N. Hirokawa. mRNA expression of KIF1A, KIF1B, KIF2, KIF3A, KIF3B, KIF4, KIF5, and cytoplasmic dynein during axonal regeneration. Journal of Neuroscience 16(1): 31-5. 1996.
14. T. Nakata, and N. Hirokawa. Point mutation of adenosine triphosphate-binding motif generated rigor kinesin that selectively blocks anterograde lysosome membrane transport. Journal of Cell Biology 131(4): 1039-53. 1995.
15. H. Yamazaki, T. Nakata, Y. Okada, and N. Hirokawa. KIF3A/B: a heterodimeric kinesin superfamily protein that works as a microtubule plus end-directed motor for membrane organelle transport. Journal of Cell Biology 130(6): 1387-99. 1995.
16. T. Hayashi, F. Soulie, T. Nakata, and N. Hirokawa. Redistribution of synapsin I and synaptophysin in response to electrical stimulation in the rat neurohypophysial nerve endings. Cell Structure and Function 19(4): 253-62. 1994.
17. M. Kikkawa, T. Ishikawa, T. Nakata, T. Wakabayashi, and N. Hirokawa. Direct visualization of the microtubule lattice seam both in vitro and in vivo. Journal of Cell Biology 127(6 Pt 2): 1965-71. 1994.
18. A. Ando, K. Yonezawa, I. Gout, T. Nakata, H. Ueda, K. Hara, Y. Kitamura, Y. Noda, T. Takenawa, and N. Hirokawa. A complex of GRB2-dynamin binds to tyrosine-phosphorylated insulin receptor substrate-1 after insulin treatment. EMBO Journal 13(13): 3033-8. 1994.
19. S. Kondo, R. Sato-Yoshitake, Y. Noda, H. Aizawa, T. Nakata, Y. Matsuura, and N. Hirokawa. KIF3A is a new microtubule-based anterograde motor in the nerve axon. Journal of Cell Biology 125(5): 1095-107. 1994.
20. H. Miki, K. Miura, K. Matuoka, T. Nakata, N. Hirokawa, S. Orita, K. Kaibuchi, Y. Takai, and T. Takenawa. Association of Ash/Grb-2 with dynamin through the Src homology 3 domain. Journal of Biological Chemistry 269(8): 5489-92. 1994.
21. T. Nakata, R. Sato-Yoshitake, Y. Okada, Y. Noda, and N. Hirokawa. Thermal drift is enough to drive a single microtubule along its axis even in the absence of motor proteins. Biophysical Journal 65(6): 2504-10. 1993.
22. Z. Zhang, Y. Tanaka, S. Nonaka, H. Aizawa, H. Kawasaki, T. Nakata, and N. Hirokawa. The primary structure of rat brain (cytoplasmic) dynein heavy chain, a cytoplasmic motor enzyme. Proceedings of the National Academy of Sciences of the United States of America 90(17): 7928-32. 1993.
23. Y. Noda, T. Nakata, and N. Hirokawa. Localization of dynamin: widespread distribution in mature neurons and association with membranous organelles. Neuroscience 55(1): 113-27. 1993.
24. T. Nakata, R. Takemura, and N. Hirokawa. A novel member of the dynamin family of GTP-binding proteins is expressed specifically in the testis. Journal of Cell Science 105 ( Pt 1): 1-5. 1993.
25. Y. Tanaka, K. Kawahata, T. Nakata, and N. Hirokawa. Chronological expression of microtubule-associated proteins (MAPs) in EC cell P19 after neuronal induction by retinoic acid. Brain Research 596(1-2): 269-78. 1992.
26. K. Maeda, T. Nakata, Y. Noda, R. Sato-Yoshitake, and N. Hirokawa. Interaction of dynamin with microtubules: its structure and GTPase activity investigated by using highly purified dynamin. Molecular Biology of the Cell 3(10): 1181-94. 1992.
27. T. Nakata, and N. Hirokawa. Organization of cortical cytoskeleton of cultured chromaffin cells and involvement in secretion as revealed by quick-freeze, deep-etching, and double-label immunoelectron microscopy. Journal of Neuroscience 12(6): 2186-97. 1992.
28. T. Nakata, A. Iwamoto, Y. Noda, R. Takemura, H. Yoshikura, and N. Hirokawa. Predominant and developmentally regulated expression of dynamin in neurons. Neuron 7(3): 461-9. 1991.
29. T. Nakata, K. Sobue, and N. Hirokawa. Conformational change and localization of calpactin I complex involved in exocytosis as revealed by quick-freeze, deep-etch electron microscopy and immunocytochemistry. Journal of Cell Biology 110(1): 13-25. 1990.
30. T. Nakata, and N. Hirokawa. Cytoskeletal reorganization of human platelets after stimulation revealed by the quick-freeze deep-etch technique. Journal of Cell Biology 105(4): 1771-80. 1987.
英文総説:
T.Nakata and N. Hirokawa. Neuronal polarity and the kinesin superfamily proteins. Sci STKE. 2007 Feb 6; (372):pe6.、2007
和文総説:
中田隆夫 細胞内膜動態に関わる細胞骨格蛋白質について(総説) 解剖学雑誌(0022-7722)73巻2号 頁107-110, (1998.04)
著書:
T. Nakata and N. Hirokawa. Is dynamin GTPase a microtubule based motor? In: Neuronal Cytoskeleton(N. Hirokawa, editor, CRC Press. London) p285-303 1993.