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ホーム  > 神経病理学分野  > Publications  > Publications (before 2011)

Publications (before 2011)

In-frame dystrophin following exon 51-skipping improves muscle pathology and function in the exon 52-deficient mdx mouse.
Aoki Y, Nakamura A, Yokota T, Saito T, Okazawa H, Nagata T, Takeda S
Molecular therapy 18(11) 1995-2005 Nov 2010

Efficiently differentiating vascular endothelial cells from adipose tissue-derived mesenchymal stem cells in serum-free culture.
Konno M, Hamazaki TS, Fukuda S, Tokuhara M, Uchiyama H, Okazawa H, Okochi H, Asashima M
Biochemical and biophysical research communications 400(4) 461-465 Oct 2010

Drosophila PQBP1 regulates learning acquisition at projection neurons in aversive olfactory conditioning.
Tamura T, Horiuchi D, Chen YC, Sone M, Miyashita T, Saitoe M, Yoshimura N, Chiang AS, Okazawa H
The Journal of neuroscience 30(42) 14091-14101 Oct 2010

Copy-number variations on the X chromosome in Japanese patients with mental retardation detected by array-based comparative genomic hybridization analysis.
Honda S, Hayashi S, Imoto I, Toyama J, Okazawa H, Nakagawa E, Goto Y, Inazawa J
Journal of human genetics 55 590-599 Sep 2010

Suppression of the novel ER protein Maxer by mutant ataxin-1 in Bergman glia contributes to non-cell-autonomous toxicity.
Shiwaku H, Yoshimura N, Tamura T, Sone M, Ogishima S, Watase K, Tagawa K, Okazawa H
The EMBO journal 29(14) 2446-2460 Jul 2010

Mutant huntingtin impairs Ku70-mediated DNA repair.
Enokido Y, Tamura T, Ito H, Arumughan A, Komuro A, Shiwaku H, Sone M, Foulle R, Sawada H, Ishiguro H, Ono T, Murata M, Kanazawa I, Tomilin N, Tagawa K, Wanker EE, Okazawa H
The Journal of cell biology 189(3) 425-443 May 2010

Polyglutamine tract-binding protein-1 binds to U5-15kD via a continuous 23-residue segment of the C-terminal domain.
Takahashi M, Mizuguchi M, Shinoda H, Aizawa T, Demura M, Okazawa H, Kawano K
Biochimica et biophysica acta 1804 1500-1507 Mar 2010

Knock-down of PQBP1 impairs anxiety-related cognition in mouse.
Ito H, Yoshimura N, Kurosawa M, Ishii S, Nukina N, Okazawa H
Human molecular genetics 18 4239-4254 Nov 2009

Neural stem cells express Oct-3/4.
Chin JH, Shiwaku H, Goda O, Komuro A, Okazawa H
Biochemical and biophysical research communications 388(2) 247-251 Oct 2009

Polyglutamine tract binding protein-1 is an intrinsically unstructured protein.
Takahashi M, Mizuguchi M, Shinoda H, Aizawa T, Demura M, Okazawa H, Kawano K
Biochimica et biophysica acta 1794 936-943 Jun 2009

[TRIAD--a form of type 3 cell death]
Okazawa H
Brain and nerve = Shinkei kenkyu no shinpo 61 285-292 Mar 2009

Progressive decrease in the level of YAPdeltaCs, prosurvival isoforms of YAP, in the spinal cord of transgenic mouse carrying a mutant SOD1 gene.
Morimoto N, Nagai M, Miyazaki K, Kurata T, Takehisa Y, Ikeda Y, Kamiya T, Okazawa H, Abe K
Journal of neuroscience research 87 928-936 Mar 2009

Loss of yata, a novel gene regulating the subcellular localization of APPL, induces deterioration of neural tissues and lifespan shortening.
Sone M, Uchida A, Komatsu A, Suzuki E, Ibuki I, Asada M, Shiwaku H, Tamura T, Hoshino M, Okazawa H, Nabeshima Y
PloS one 4 e4466

Glial cell lineage expression of mutant ataxin-1 and huntingtin induces developmental and late-onset neuronal pathologies in Drosophila models.
Tamura T, Sone M, Yamashita M, Wanker EE, Okazawa H
PloS one 4 e4262 2009

Nematode homologue of PQBP1, a mental retardation causative gene, is involved in lipid metabolism.
Takahashi K, Yoshina S, Masashi M, Ito W, Inoue T, Shiwaku H, Arai H, Mitani S, Okazawa H
PloS one 4 e4104 2009

Age-dependent change of HMGB1 and DNA double-strand break accumulation in mouse brain.
Enokido Y, Yoshitake A, Ito H, Okazawa H
Biochemical and biophysical research communications 376(1) 128-133 Nov 2008

Omi / HtrA2 is relevant to the selective vulnerability of striatal neurons in Huntington's disease.
Inagaki R, Tagawa K, Qi ML, Enokido Y, Ito H, Tamura T, Shimizu S, Oyanagi K, Arai N, Kanazawa I, Wanker EE, Okazawa H
The European journal of neuroscience 28 30-40 Jul 2008

Proteome analysis of soluble nuclear proteins reveals that HMGB1/2 suppress genotoxic stress in polyglutamine diseases.
Qi ML, Tagawa K, Enokido Y, Yoshimura N, Wada Y, Watase K, Ishiura S, Kanazawa I, Botas J, Saitoe M, Wanker EE, Okazawa H
Nature cell biology 9(4) 402-414 Apr 2007

[Is neurodegeneration apoptosis?--Regulation of neuronal death by YAPdeltaC]
Okazawa H
Seikagaku. The Journal of Japanese Biochemical Society 79 157-162 Feb 2007

The induction levels of heat shock protein 70 differentiate the vulnerabilities to mutant huntingtin among neuronal subtypes.
Tagawa K, Marubuchi S, Qi ML, Enokido Y, Tamura T, Inagaki R, Murata M, Kanazawa I, Wanker EE, Okazawa H
The Journal of neuroscience 27 868-880 Jan 2007

Hepatoma-derived growth factor, a new trophic factor for motor neurons, is up-regulated in the spinal cord of PQBP-1 transgenic mice before onset of degeneration.
Marubuchi S, Okuda T, Tagawa K, Enokido Y, Horiuchi D, Shimokawa R, Tamura T, Qi ML, Eishi Y, Watabe K, Shibata M, Nakagawa M, Okazawa H
Journal of neurochemistry 99(1) 70-83 Oct 2006

Expression of human PQBP-1 in Drosophila impairs long-term memory and induces abnormal courtship.
Yoshimura N, Horiuchi D, Shibata M, Saitoe M, Qi ML, Okazawa H
FEBS letters 580(9) 2335-2340 Apr 2006

Transcriptional repression induces a slowly progressive atypical neuronal death associated with changes of YAP isoforms and p73.
Hoshino M, Qi ML, Yoshimura N, Miyashita T, Tagawa K, Wada Y, Enokido Y, Marubuchi S, Harjes P, Arai N, Oyanagi K, Blandino G, Sudol M, Rich T, Kanazawa I, Wanker EE, Saitoe M, Okazawa H
The Journal of cell biology 172(4) 589-604 Feb 2006

Cystathionine beta-synthase, a key enzyme for homocysteine metabolism, is preferentially expressed in the radial glia/astrocyte lineage of developing mouse CNS.
Enokido Y, Suzuki E, Iwasawa K, Namekata K, Okazawa H, Kimura H
The FASEB journal 19 1854-1856 Nov 2005

Polyglutamine tract-binding protein-1 dysfunction induces cell death of neurons through mitochondrial stress.
Marubuchi S, Wada Y, Okuda T, Hara Y, Qi ML, Hoshino M, Nakagawa M, Kanazawa I, Okazawa H
Journal of neurochemistry 95(3) 858-870 Nov 2005

PQBP-1 is expressed predominantly in the central nervous system during development.
Qi Y, Hoshino M, Wada Y, Marubuchi S, Yoshimura N, Kanazawa I, Shinomiya K, Okazawa H
The European journal of neuroscience 22 1277-1286 Sep 2005

Oct-3/4 repression accelerates differentiation of neural progenitor cells in vitro and in vivo.
Okuda T, Tagawa K, Qi ML, Hoshio M, Ueda H, Kawano H, Kanazawa I, Muramatsu M, Okazawa H
Brain research. Molecular brain research 132 18-30 Dec 2004

Distinct aggregation and cell death patterns among different types of primary neurons induced by mutant huntingtin protein.
Tagawa K, Hoshino M, Okuda T, Ueda H, Hayashi H, Engemann S, Okado H, Ichikawa M, Wanker EE, Okazawa H
Journal of neurochemistry 89(4) 974-987 May 2004

General transcriptional repression by polyglutamine disease proteins is not directly linked to the presence of inclusion bodies.
Hoshino M, Tagawa K, Okuda T, Okazawa H
Biochemical and biophysical research communications 313(1) 110-116 Jan 2004

Histone deacetylase activity is retained in primary neurons expressing mutant huntingtin protein.
Hoshino M, Tagawa K, Okuda T, Murata M, Oyanagi K, Arai N, Mizutani T, Kanazawa I, Wanker EE, Okazawa H
Journal of neurochemistry 87(1) 257-267 Oct 2003

Mutant huntingtin promotes the fibrillogenesis of wild-type huntingtin: a potential mechanism for loss of huntingtin function in Huntington's disease.
Busch A, Engemann S, Lurz R, Okazawa H, Lehrach H, Wanker EE
The Journal of biological chemistry 278(42) 41452-41461 Oct 2003

PQBP-1 transgenic mice show a late-onset motor neuron disease-like phenotype.
Okuda T, Hattori H, Takeuchi S, Shimizu J, Ueda H, Palvimo JJ, Kanazawa I, Kawano H, Nakagawa M, Okazawa H
Human molecular genetics 12 711-725 Apr 2003

Interaction between mutant ataxin-1 and PQBP-1 affects transcription and cell death.
Okazawa H, Rich T, Chang A, Lin X, Waragai M, Kajikawa M, Enokido Y, Komuro A, Kato S, Shibata M, Hatanaka H, Mouradian MM, Sudol M, Kanazawa I
Neuron 34(5) 701-713 May 2002

Enhanced SUMOylation in polyglutamine diseases.
Ueda H, Goto J, Hashida H, Lin X, Oyanagi K, Kawano H, Zoghbi HY, Kanazawa I, Okazawa H
Biochemical and biophysical research communications 293(1) 307-313 Apr 2002

PQBP-1 increases vulnerability to low potassium stress and represses transcription in primary cerebellar neurons.
Enokido Y, Maruoka H, Hatanaka H, Kanazawa I, Okazawa H.
Biochemical and Biophysical Research Communications 294(2) 268-271 2002

JNK activation is associated with intracellular beta-amyloid accumulation.
Shoji M, Iwakami N, Takeuchi S, Waragai M, Suzuki M, Kanazawa I, Lippa CF, Ono S, Okazawa H.
Molecular Brain Research 85(1-2) 221-233 2000

PQBP-1/Npw38, a nuclear protein binding to the polyglutamine tract, interacts with U5-15kD/dim1p via the carboxyl-terminal domain.
Waragai M, Junn E, Kajikawa M, Takeuchi S, Kanazawa I, Shibata M, Mouradian MM, Okazawa H.
Biochemical and Biophysical Research Communications 273(2) 592-595 2000

AP-2beta represses D(1A) dopamine receptor gene transcription in neuro2a cells.
Takeuchi S, Imafuku I, Waragai M, Roth C, Kanazawa I, Buettner R, Mouradian MM, Okazawa H.
Molecular Brain Research 74(1/2) 208-216 1999

Presenilin 1 suppresses the function of c-Jun homodimers via interaction with QM/Jif-1.
Imafuku I, Masaki T, Waragai M, Takeuchi S, Kawabata M, Hirai S, Ohno S, Nee LE, Lippa CF, Kanazawa I, Imagawa M, Okazawa H.
Journal of Cell Biology 147(1) 121-133 1999

PQBP-1, a novel polyglutamine tract-binding protein, inhibits transcription activation by Brn-2 and affects cell survival.
Waragai M, Lammers CH, Takeuchi S, Imafuku I, Udagawa Y, Kanazawa I, Kawabata M, Mouradian MM, Okazawa H.
Hum Mol Genet. 8(6) 977-987 1999

Polar amino acid-rich sequences bind to polyglutamine tracts.
Imafuku I, Waragai M, Takeuchi S, Kanazawa I, Kawabata M, Mouradian MM, Okazawa H.
Biochemical and Biophysical Research Communications 253(1) 16-20 1998

Upstream elements involved in vivo in activation of the brain-specific rat aldolase C gene. Role of binding sites for POU and winged helix proteins.
Skala H, Porteu A, Thomas M, Szajnert MF, Okazawa H, Kahn A, Phan-Dinh-Tuy F.
Journal of Biological Chemistry 273(48) 31806-31814 1998

Presenilin 1 binds to amyloid precursor protein directly.
Waragai M, Imafuku I, Takeuchi S, Kanazawa I, Oyama F, Udagawa Y, Kawabata M, Okazawa H.
Biochemical and Biophysical Research Communications 239(2) 480-482 1997

Regulation of striatal D1A dopamine receptor gene transcription by Brn-4.
Okazawa H, Imafuku I, Minowa MT, Kanazawa I, Hamada H, Mouradian MM.
Proceedings of the National Academy of Sciences, USA 93(21) 11933-11938 1996

POU transcription factors differentially regulate the D1A dopamine receptor gene in cultured cells.
Imafuku I, Kamei M, Kanazawa I, Mouradian MM, Okazawa H.
Biochemical and Biophysical Research Communications 222(3) 736-741 1996

Bcl-2 inhibits retinoic acid-induced apoptosis during the neural differentiation of embryonal stem cells.
Okazawa H, Shimizu J, Kamei M, Imafuku I, Hamada H, Kanazawa I.
Journal of Cell Biology 132(5) 955-968 1996

Gene regulation of trkB and trkC in the chick retina by light/darkness exposure.
Okazawa H, Kamei M, Imafuku I, Kanazawa I.
Oncogene. 9(7) 1813-1818 1994

Hybrid cell extinction and re-expression of Oct-3 function correlates with differentiation potential.
Shimazaki T, Okazawa H, Fujii H, Ikeda M, Tamai K, McKay RD, Muramatsu M, Hamada H.
EMBO Journal 12(12) 4489-4498 1993

Expression and binding characteristics of the BDNF receptor chick trkB.
Dechant G, Biffo S, Okazawa H, Kolbeck R, Pottgiesser J, Barde YA.
Development. 119(2) 545-558 1993

Molecular cloning and expression of a novel truncated form of chicken trkC.
Okazawa H, Kamei M, Kanazawa I.
FEBS Letters 329((1-2)) 171-177 1993

trk immunoreactivity at neuronal dendrite and cell body.
Okazawa H, Nishiyama K, Kamei M, Washizaki K, Murayama S, Kwak S, Kanazawa I.
Biochemical and Biophysical Research Communications 194(2) 683-690 1993

Dopaminergic stimulation up-regulates the in vivo expression of brain-derived neurotrophic factor (BDNF) in the striatum.
Okazawa H, Murata M, Watanabe M, Kamei M, Kanazawa I.
FEBS Letters 313(2) 138-142 1992

The oct3 gene, a gene for an embryonic transcription factor, is controlled by a retinoic acid repressible enhancer.
Okazawa H, Okamoto K, Ishino F, Ishino-Kaneko T, Takeda S, Toyoda Y, Muramatsu M, Hamada H.
EMBO Journal 10(10) 2997-3005 1991

A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells.
Okamoto K, Okazawa H, Okuda A, Sakai M, Muramatsu M, Hamada H.
Cell. 60(3) 461-472 1990