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研究業績

2018

Hideo Jinnou, Masato Sawada, Koya Kawase, Naoko Kaneko, Vicente Herranz-Pérez, Takuya Miyamoto, Takumi Kawaue, Takaki Miyata, Yasuhiko Tabata, Toshihiro Akaike, José Manuel García-Verdugo, Itsuki Ajioka, Shinji Saitoh, Kazunobu Sawamoto*
"Radial glial fibers promote neuronal migration and functional recovery after neonatal brain injury"
Cell Stem Cell 22, 128-137 (2018)

味岡逸樹
"損傷大脳皮質の再生治療を目指したバイオマテリアル"
バイオマテリアルー生体材料ー 36, 190-195 (2018)

酒井崇匡、味岡逸樹、鄭 雄一
"再生医療や立体組織培養のための高分子足場材料"
再生医療 17, 279-292 (2018)

2017

Mio Oshikawa, Kei Okada, Hidenori Tabata, Koh-ichi Nagata, and Itsuki Ajioka# (# corresponding author)
“Dnmt1-dependent Chk1 pathway suppression is protective against neuron division”
Development 144, 3303-3314 (2017)

Mio Oshikawa, Kei Okada, Naoko Kaneko, Kazunobu Sawamoto, and Itsuki Ajioka# (# corresponding author)
“Affinity-Immobilization of VEGF on Laminin Porous Sponge Enhances Angiogenesis in the Ischemic Brain”
Adv Healthc Mater 1700183 (2017)

Teppei Fujioka, Naoko Kaneko, Itsuki Ajioka, Kanako Nakaguchi, Taichi Omata, Honoka Ohba, Reinhard Fässler, José Manuel García-Verdugo, Kiyotoshi Sekiguchi, Noriyuki Matsukawa, Kazunobu Sawamoto.
“β1 integrin signaling promotes neuronal migration along vascular scaffolds in the post-stroke brain”
EBioMedicine 16, 195-203 (2017)

味岡逸樹
"大脳皮質の再生ー分子技術と神経発生生物学の融合によるアプローチ"
生体の科学 68, 38-42 (2017)

味岡逸樹
"中枢神経系の発生・再生研究においてバイオマテリアルの果たす役割"
バイオマテリアルー生体材料ー 35, 32-35 (2017)

2016

Itsuki Ajioka# (# corresponding author)
“Biomaterial-engineering and neurobiological approaches for regenerating the injured cerebral cortex"
Regenerative Therapy 3, 63-67 (2016) (review)

Nobutaka Ishizu, Daishi Yui, Akira Hebisawa, Hidenori Aizawa, Wanpeng Cui, Yuko Fujita, Kenji Hashimoto, Itsuki Ajioka, Hidehiro Mizusawa, Takanori Yokota, and Kei Watase.
“Impaired striatal dopamine release in homozygous Vps35 D620N knock-in mice”
Hum Mol Genet 25, 4507-4517 (2016)

2015

Issam Aldiri*, Itsuki Ajioka*, Beisi Xu, Jiakun Zhang, Xiang Chen, Claudia Benavente, David Finkelstein, Dianna Johnson, Jennifer Akiyama, Len A. Pennacchio, and Michael A. Dyer (*co-first author)
“Brg1 coordinates multiple processes during retinogenesis and is a tumor suppressor in retinoblastoma”
Development 142, 4092-4106 (2015)

Itsuki Ajioka#*, Hideo Jinnou*, Kei Okada, Masato Sawada, Shinji Saitoh, and Kazunobu Sawamoto# (# co-corresponding author, *co-first author)
"Enhancement of neuroblast migrationinto the injured cerebral cortex using laminin-containing porous sponge"
Tissue Eng Part A 21, 193-201 (2015)

Daishi Yui, Yoichiro Nishida, Tomoko Nishina, Kaoru Mogushi, Mio Tajiri, Satoru Ishibashi, Itsuki Ajioka, Kinya Ishikawa, Hidehiro Mizusawa, Shigeo Murayama, and Takanori Yokota.
“Enhanced phospholipase A2 group 3 expression by oxidative stress decreases the insulin-degrading enzyme”
PLoS ONE 10, e0143518 (2015)

2014

Itsuki Ajioka# (# corresponding author)
“Coordination of proliferation and differentiation by the retinoblastoma protein family"
Dev Growth Differ 56, 324-334 (2014) (review)

Hirofumi Fujita, Hanako Aoki, Itsuki Ajioka, Maya Yamazaki, Manabu Abe, Arata Oh-Nishi, Kenji Sakimura, Izumi Sugihara.
“Detailed expression pattern of Aldolase C (Aldoc) in the cerebellum, retina and other areas of the CNS studied in Aldoc-Venus knock-in mice”
PLoS ONE 9, e86679, (2014)

味岡逸樹
“神経前駆細胞において増殖と分化の協調を制御するRbファミリータンパク質の役割”
生化学 86, 489-492 (2014)

2013

Mio Oshikawa, Kei Okada, Kazunori Nakajima, and Itsuki Ajioka# (# corresponding author)
“Cortical excitatory neurons become protected from cell division during neurogenesis in an Rb family-dependent manner”
Development 140, 2310-2320 (2013)

2011

Itsuki Ajioka#, Shizuko Ichinose, Kazunori Nakajima, and Hidehiro Mizusawa (# corresponding author)
“Basement membrane-like matrix sponge for the three-dimensional proliferation culture of differentiated retinal horizontal interneurons”
Biomaterials 32, 5765-5772 (2011)

- 2010

Nikia Laurie, Adithi Mohan, Justina McEvoy, Damon Reed, Jiakun Zhang, Brett Schweers, Itsuki Ajioka, Virginia Valentine, Dianna Johnson, David Ellison, and Michael A. Dyer.
“Changes in retinoblastoma cell adhesion associated with optic nerve invasion”
Mol. Cell. Biol., 29, 6268-6282 (2009)

Itsuki Ajioka and Michael A. Dyer
“A new model of tumor susceptibility following tumor suppressor gene inactivation”
Cell Cycle, 7, 735-740 (2008) (review)

Itsuki Ajioka, Rodrigo Martins, Ildar T. Bayazitov, Stacy Donovan, Dianna A. Johnson, Sharon Frase, Samantha Cicero, Kelli Boyd, Stanislav S. Zakharenko, and Michael A. Dyer
“Differentiated horizontal interneurons clonally expand to form metastatic retinoblastoma in mice”
Cell, 131, 378-390 (2007)

Takuya T Maeda, Itsuki Ajioka, and Kazunori Nakajima.
“Computational cell model based on autonomous cell movement regulated by cell-cell signalling successfully recapitulates the inside and outside pattern of cell sorting”
BMC Syst. Biol., 1, 43 (2007)

Yuko Gonda, Hitoshi Sakurai, Yukio Hirata, Hidenori Tabata, Itsuki Ajioka, and Kazunori Nakajima.
“Expression profiles of Insulin-like growth factor binding protein-like 1 in the developing mouse forebrain”
Gene Expr. Patterns, 7, 431-440 (2007)

Itsuki Ajioka*, Takuya Maeda*, and Kazunori Nakajima. (*co-first author)
“Large-scale correlation of DNA accession numbers to the cDNAs in the FANTOM full-length mouse cDNA clone set”
Keio J. Med., 55, 107-110 (2006)

Itsuki Ajioka, Takuya Maeda, and Kazunori Nakajima.
“Identification of ventricular-side-enriched molecules regulated in a stage-dependent manner during cerebral cortical development”
Eur. J. Neurosci., 23, 296-308 (2006)

Itsuki Ajioka and Kazunori Nakajima.
“Switching of α-catenin from αE-catenin in the cortical ventricular zone to αN-catenin II in the intermediate zone”
Dev. Brain Res., 160, 106-110 (2005)

Itsuki Ajioka and Kazunori Nakajima.
“Birth-date-dependent segregation of the mouse cerebral cortical neurons in the reaggregation cultures”
Eur. J. Neurosci., 22, 331-342 (2005)

Chikako Kudo, Itsuki Ajioka, Yukio Hirata, and Kazunori Nakajima.
“Expression profiles of EphA3 at both the RNA and protein level in the developing mammalian forebrain”
J. Comp. Neurol., 487, 255-269 (2005)

Itsuki Ajioka, Toshihiro Akaike, and Yoshifumi Watanabe.
“Ethanolamine is a co-mitogenic factor for proliferation of primary hepatocytes”
J. Cell. Biochem., 84, 249-263 (2002)

Itsuki Ajioka*, Reiji Nishio*, Masahiko Ikekita, Toshihiro Akaike, Masato Sasaki, Jumpei Enami, and Yoshifumi Watanabe. (*co-first author)
“Establishment of heterotropic liver tissue mass with direct link to the host liver following implantation of hepatocytes transfected with vascular endothelial growth factor gene in mice”
Tissue Eng., 7, 335-344 (2001)

Takahiro Haruyama, Itsuki Ajioka, Toshihiro Akaike, and Yoshifumi Watanabe.
“Regulation and significance of hepatocyte-derived matrix metalloproteases (MMP) in liver remodeling”
Biochem. Biophys. Res. Com., 272, 681-686 (2000).

Itsuki Ajioka, Toshihiro Akaike, and Yoshifumi Watanabe.
“Expression of vascular endothelial growth factor promotes colonization, vascularization, and growth of transplanted hepatic tissues in the mouse”
Hepatology, 29, 396-402 (1999).

Yoshifumi Watanabe*, Itsuki Ajioka*, and Toshihiro Akaike. (*co-first author)
“Gene transfection of multicellular spheroid of hepatocytes on an artificial substrate”
Cytotechnology, 26, 65-78 (1998).

Yoshifumi Watanabe, Sam W. Lee, Michael Detmer, Itsuki Ajioka, and Harold F. Dvorak.
“Vascular permeability factor / vascular endothelial growth factor (VPF/VEGF) delays and induces escape from senescence in human dermal microvascular endothelial cells”
Oncogene, 14, 2025-2032 (1997).