グローバルナビゲーションへ

ローカルナビゲーションへ

フッターへ



先進倫理医科学開発学分野

業績リスト

我々のグループが中心となって行った研究業績です。


重要な論文(PDFあり)

2012年

R. Nohara, H. Daida, M. Hata, K. Kaku, R. Kawamori, J. Kishimoto, M. Kurabayashi, I. Masuda, I. Sakuma, T. Yamazaki, H. Yokoi, M. Yoshida Effect of Intensive Lipid-Lowering Therapy With Rosuvastatin on Progression of Carotid Intima-Media Thickness in Japanese Patients. Circ J. 76: 221-229 ( 2012)

2011年

K. Gomita, K. Sato, M. Yoshida, N. Hagiwara PSGL-1-Expressing CD4 T Cells Induce Endothelial Cell Apoptosis in Perimenopausal Women J Atheroscler Thromb 18: 698-704 (2011)

H. Kuwahara, K. Nishina, K. Yoshida, T. Nishina, M. Yamamoto, Y. Saito, W. Piao, M. Yoshida, H. Mizusawa, T. Yokota Efficient In Vivo Delivery of siRNA Into Brain Capillary Endothelial Cells Along With Endogenous Lipoprotein. Mol Ther. 19: 2213-2221 (2011)

S. Hagita, M. Osaka, K. Shimokado, M. Yoshida Adipose inflammation initiates recruitment of leukocytes to mouse femoral artery: Role of adipovascular axis in chronic inflammation PLoS One 6:e19871 (2011)

M. Tani, A. Kawakami, Y. Mizuno, R. Imase, Y. Ito, K. Kondo, H. Ishii, M. Yoshida Small dense LDL enhances THP-1 macrophage foam cell formation J Atheroscler Thromb 18: 698-704 (2011)

S. Hagita, M. Osaka, K. Shimokado, M. Yoshida Combination of amlodipine and atorvastatin synergistically reduces leukocyte recruitment to mechanically injured mouse femoral artery Hypertens Res 34:450-455 (2011)

M. Yoshida Novel Role of NPC1L1 in the Regulation of Hepatic Metabolism: Potential Contribution of Ezetimibe in NAFLD/NASH Treatment. Curr Vasc Pharmacol. 9:121-123 (2011)

2010年

S. Ito, M. Osaka, Y. Higuchi, F. Nishijima, H. Ishii, M. Yoshida Indoxyl sulfate induces leukocyte-endothelial interactions through upregulation of E-selectin J. Biol. Chem. 285:38869-38875 (2010)

M. Kurabayashi, I. Sakuma, R. Kawamori, H. Daida, T. Yamazaki, M. Yoshida, M. Hata, I. Masuda, K. Kaku, H. Yokoi, J. Kishimoto, R. Nohara Can intensive lipid-lowering therapy with statins ameliorate atherosclerosis in Japanese patients? Rationale and design of the JART study. J Atheroscler Thromb. 17: 416-422 (2010)

M. Yoshida  Not sleeping well can damage your heart Hypertens Res 33:535-536 (2010)

S. Sharma, M. Yoshida. Gene silencing of E-selectin block recruitment of endothelial progenitor cell to vascular endothelium under flow J. Biomedical Science and Engineering 3: 550-555 (2010)

C. Kojima, J. Ino, H. Ishii, K. Nitta, M. Yoshida.  MMP-9 inhibition by ACE inhibitor reduces Oxidized LDL-mediated foam cell formation J Atheroscler Thromb. 17: 97-105(2010)

2009年

J. Ino, C. Kojima, M. Osaka, K. Nitta, M. Yoshida.  Dynamic Observation of Mechanically-injured Mouse Femoral Artery Reveals an Anti-inflammatory Effect of Renin Inhibitor. Arterioscler. Thromb. Vasc. Biol. 29: 1858-1863 (2009)

M. Yoshida  Critical balance of dendritic cells is destined for plaque rupture Circ J 73:1799-800 (2009)

M. Nomura, H. Ishii, A. Kawakami, M. Yoshida. Inhibition of Hepatic Neiman-Pick C1-Like 1 Improves Hepatic Insulin Resistance. Am J. Physiol. Endocrinol. Metab. 297: 1030-1038 (2009)

N. Sermsathanasawadi, H. Ishii, K. Igarashi, M. Miura, M. Yoshida, Y. Inoue, T. Iwai. Enhanced Adhesion of Early Endothelial Progenitor Cells to Radiation-induced Senescence-like Vascular Endothelial Cells in vitro. J. Radiat. Res. 50: 469-475 (2009)

K. Aihara, H. Ishii, M. YoshidaCasein derived tripeptide, Val-Pro-Pro (VPP), modulates monocyte adhesion to vascular endothelium. J Atheroscler Thromb. 16: 594-603(2009)

A. Kawakami, M. Yoshida, Apolipoprotein CIII Links Dyslipidemia with Atherosclerosis. J Atheroscler Thromb. 16: 6-11 (2009)

2008年

H. Yamada, M. Yoshida, Y. Nakano, T. Suganami, N. Satoh, T. Mita, K. Azuma, M. Itoh, Y. Yamamoto, Y. Kamei, M. Horie, H. Watada, Y. Ogawa  In Vivo and In Vitro Inhibition of Monocyte Adhesion to Endothelial Cells and Endothelial Adhesion Molecules by Eicosapentaenoic Acid   Arterioscler. Thromb. Vasc. Biol. 12: 2173-2179 (2008)

H. Ishii, T. Tsukada, M. Yoshida Angiotensin II type-I receptor blocker, candesartan, improves brachial-ankle pulse wave velocity independently from its blood pressure lowering effects in type 2 diabetes patients. Internal Medicine 47: 2013-2018 (2008)

M. Yoshida Regulation of cholesterl biosynthesis and absorption: ultimate management of dyslipidemia with statin and ezetimibe Immun. Endoc. & Metab. Agents in Med. Chem. 8: 177-182 (2008)

G. Haraguchi, H. Kosuge, Y. Maejima, J. Suzuki, T. Imai, M. Yoshida, M. Isobe Pioglitazone reduces systematic inflammation and improves mortality in apolipoprotein E knockout mice with sepsis Intensive Care Med. 34:1304-1312 (2008)

Y. Tsujimura, K. Obata, K. Mukai, H. Shindou, M. Yoshida, H. Nishikado, Y. Kawano, Y. Minegishi, T. Shimizu, H. Karasuyama Basophils play a pivotal role in IgG- but not IgE-mediated systemic anaphylaxis in contrast to mast cells Immunity 28:581-589 (2008)

S. Hagita, M. Osaka, K. Shimokado, M. Yoshida Oxidative stress in mononuclear plays a dominant role in their adhesion to mouse femoral artery after injury Hypertension 51: 797-802 (2008)

N. Nakamura, M. Yoshida, M. Umeda, Y. Huang, S. Kitajima, Y. Inoue, I. Ishikawa, T. Iwai Extended exposure of lipopolysaccharide fraction from Porphyromonas gingivalis facilitates mononuclear cell adhesion to vascular endothelium via Toll-like receptor-2 dependent mechanism Atherosclerosis 196: 59-67 (2008)

2007年

M. Deushi*, M. Nomura*, A. Kawakami, M. Haraguchi, M. Ito, M. Okazaki, H. Ishii, M. Yoshida Ezetimibe improves liver steatosis and insulin resistance in obese rat model of metabolic syndrome. FEBS Letters 581: 5664-5670 (2007) * Equal contribution

C. Kojima, A. Kawakami, T. Takei, K. Nitta, M. Yoshida. Angiotensin converting enzyme inhibitor attenuates monocyte adhesion to vascular endothelium through modulation of intracellular zinc. J Pharmacol Exp Ther 323: 855-860 (2007)

D. Mori, H. Ishii, C. Kojima, N. Nitta, K. Nakajima, M. Yoshida. Cilostazol inhibits monocytic cell adhesion to vascular endothelium via upregulation of cAMP. J. Atheroscler Thromb. 14: 213-218 (2007)

M. Tani, A. Kawakami, M. Nagai, K. Shimokado, K. Kondo, M. Yoshida. Sphingosine 1-phosphate (S1P) inhibits monocyte-endothelial cell interaction by regulating of RhoA activity. FEBS Letters 581: 4621-4626 (2007)

Y. Tanaka, H. Ishii, M. Hiraoka, N. Miyasaka, T. Kuroiwa, KA Hajjar, T. Nagaoka, TQ Duong, K. Ohno, M. Yoshida. Efficacy of Recombinant Annexin-2 for Fibrinolytic Therapy in a Rat Embolic Stroke Model: A Magnetic Resonance Imaging Study. Brain Research 1165: 135-143 (2007)

S. Shinozaki, T. Chiba, K. Kokame, T. Miyata, M. Ai, A. Kawakami, E. Kaneko, M. Yoshida, K. Shimokado Site-specific effect of estradiol on gene expression in the adipose tissue of ob/ob mice. Horm Metab Res. 39:192-196 (2007)

Y. Takano, K. Shimokado, Y. Hata, M. Yoshida HIV envelope protein gp120-triggered CD4+ T-cell adhesion to vascular endothelium is regulated via CD4 and CXCR4 receptors Biochem. Biophys. Acta Molecular Basis of Disease 1772: 549-555 (2007)

M. Osaka, S. Hagita, M. Haraguchi, M. Kajimura, M. Suematsu, M. Yoshida Real time imaging of mechanically injured-femoral artery in mouse revealed a biphasic pattern of leukocyte accumulation Am. J. Physiol. 292:H1876-H1882 (2007)

Y. Nishiwaki, M. Yoshida, H. Iwaguro, H. Masuda, N. Nitta, T. Asahara, M. Isobe Endothelial E-selectin potentiates neovascularization via endothelial progenitor cells dependent and independent mechanisms Arterioscler. Thromb. Vasc. Biol. 27: 512-518 (2007)

A. Kawakami, M. Aikawa, N. Nitta, M. Yoshida, P. Libby, FM Sacks ApolipoproteinCIII-induced THP-1 cell adhesion to endothelial cells involves pertussis toxin-sensitive G-protein- and protein kinase Cα-mediated nuclear factor-κB activation Arterioscler. Thromb. Vasc. Biol. 27: 219-225 (2007)

H. Ishii, M. Hiraoka, A. Tanaka, K. Shimokado, M. Yoshida Recombinant Annexin II inhibits the progress of diabetic nephropathy in diabetic model mice via recovery of hypercoagulation Thromb. Hemostasis 97: 124-128 (2007)

2006年

K. Takahashi, K. Shimokado, M. Yoshida SDF-1-Triggered recruitment of purified human monocytes to vascular endothelium is modulated by a novel dihydroptridine derivative via inhibition of protein kinase C dependent mechanism Eur J. Pharmacol. 552: 162-169 (2006)

T. Takei, M. Hiraoka, K. Nitta, K. Uchida, M. Deushi, T. Yu, N. Nitta, K. Tsuchiya, W. Yumura, H. Nihei, Y. Nakamura, M. Yoshida Functional impact of IgA nephropathy-associated selectin gene haplotype on leukocyte-endothelial interaction Immunogentics 58:355-61 (2006)

N. Kasuya, Y. Kishi, M. Isobe, M. Yoshida, F. Numano P-Selectin Expression, but not GPIIb/IIIa Activation, is Enhanced in the Inflammatory Stage of Takayasu's Arteritis Circ J. 70: 600-604 (2006)

2005年

T. Nakazawa, T. Chiba, E. Kaneko, K. Yui, M. Yoshida, K. Shimokado Insulin Signaling in Arteries Prevents Smooth Muscle Apoptosis.  Arterioscler. Thromb. Vasc. Biol. 25: 760-765 (2005)

A. Kawakami, M. Tani, A. T. Chiba, K. Yui, S. Shinozaki, K. Nakajima, Tanaka, K. Shimokado, M. Yoshida. Pitavastatin inhibits remnant lipoprotein-induced macrophage foam cell formation via apoB48 receptor-dependent mechanism  Arterioscler. Thromb. Vasc. Biol. 25: 424-429 (2005)

T. Imada, T. Tatsumi, Y. Mori, T. Nishiue, M. Yoshida, H. Masaki, M. Okigaki, H. Kojima, Y. Nozawa, Y. Nishiwaki, N. Nitta, T. Iwasaka, H. Matsubara. Targeted delivery of bone marrow mononuclear cells by ultrasound destruction of microbubbles induces both angiogenesis and arteriogenesis response.  Arterioscler Thromb Vasc Biol. 25: 2128-34 (2005)

2004年

M. Hiraoka, N. Nitta, M. Nagai, K. Shimokado, M. Yoshida MCP-1-induced enhancement of THP-1 adhesion to vascular endothelium was modulated by HMG-CoA reductase inhibitor through RhoA GTPase-, but not ERK1/2-dependent pathway Life Sci 75: 1333-1341 (2004)

R. Gotoh, J. Suzuki, H. Kosuge, T. Kakuta, S. Sakamoto, M. Yoshida, M. Isobe E-Selectin Blockade Decreases Adventitial Inflammation and Attenuates Intimal Hyperplasia in Rat Carotid Arteries After Balloon Injury. Arterioscler. Thromb. Vasc. Biol. 24: 1-7 (2004)

2003年

M. Yoshida,T. Sasaoka, Y.Takano, T. Izumi, A. Kimura. E-selectin polymorphism associated with myocardial infarction causes enhanced leukocyte-endothelial interactions under flow conditions. Arterioscler. Thromb. Vasc. Biol. 23: 783-788 (2003)

T. Yu, I. Morita, K. Shimokado, T. Iwai, M. Yoshida. Amlodipine modulates THP-1 cell adhesion to vascular endothelium under flow via inhibition of protein kinase C - dependent signal transduction Hypertension 42: 329-334 (2003)

Y. Nishiwaki, T. Yokota, M. Hiraoka, M. Miyagishi, K. Taira, M. Isobe, H. Mizusawa, M. Yoshida. Introduction of short interfering RNA to silence endogeneous E-selectin in vascular endothelium leads to successful inhibition of leukocyte adhesion. Biochem. Biophys. Res. Com. 310: 1070-1074 (2003)

Y. Toriumi, M. Hiraoka, M. Watanabe, M. Yoshida. Pioglitazone reduces monocyte adhesion to vascular endothelium under physiological flow conditions by modilating RhoA GTPase and focal adhesion kinase. FEBS Letters 553: 419-422 (2003)

A. Kawakami, A. Tanaka, K. Nakajima, K. Shimokado, M. Yoshida. Remnant lipoprotein-induced smooth muscle cell proliferation involves EGF receptor transactivation Circulation 108: 2679-2688 (2003)

S. Fujiyama, K. Amano, K. Uehira, M. Yoshida, Y. Nishiwaki, Y. Nozawa, D. Jin, S. Takai, M. Miyazaki, K. Egashira, T. Imada, T. Iwasaka, H. Matsubara. Bone Marrow Monocyte-Lineage Cells Adhere on Injured Endothelium by MCP-1-Dependent Manner and Accelerate Reendothelialization as Endothelial Progenitor Cells. Circ Res. 93: 980-989 (2003)

M. Yoshida. Potential role of statins in inflammation and atherosclerosis J. Atheroscler. Thromb. 10: 140-144 (2003)

Y. Onai, J. Suzuki, Y. Nishiwaki, R. Gotoh, K. Berens, R. Dixon, M. Yoshida, H. Ito, M. Isobe. Blockade of cell adhesion by a small molecule selectin antagonist attenuates myocardial ischemia/reperfusion injury. Eur J Pharmacol. 481:217-25 (2003)

2002年以前

A. Kawakami, A. Tanaka, K. Nakajima, Y. Yasukochi, K. Shimokado, M. Yoshida. Atorvastatin Attenuates Remnant Lipoprotein-Induced Monocyte Adhesion to Vascular Endothelium under Physiological Flow Conditions. Circ. Res. 91: 263 - 271 (2002)

M. Jibiki, M. Yoshida, Y. Inoue, L-J. Chien, T. Iwai, Y. Yasukochi. Hypoxia-induced upregulation of CD11b in granulocytes. Int. J. Angiol. 11: 102-106 (2002)

M. Yoshida, T. Sawada, H. Ishii, R. E. Gerszten, A. Rosenzweig, M. A. Gimbrone, Jr., Y. Yasukochi, F. Numano HMG-CoA reductase inhibitor modulates monocyte endothelial interaction under physiologic flow condition in vitro: involvement of Rho GTPase dependent mechanism Arterioscler. Thromb. Vasc. Biol. 21: 1165-1171 (2001)

T. Sawada, M. Yoshida, Y. Yasukochi, M. Watanabe and F. Numano. Colon cancer cell adhesion to endothelial E-selectin inhibits detachment of endothelial cells through b1-integrin. Biochem. Biophys. Res. Com. 286: 20-27 (2001)

H. Ishii, M. Yoshida, M. Hiraoka, KA. Hajjar, A. Tanaka, Y. Yasukochi, F. Numano Recombinant annexin II modulates impaired fibrinolytic activity in vitro and in rat carotid artery. Circ. Res. 89 : 1240-1245 (2001)

Kawakami, M. Yoshida, A. Tanaka, K. Nakajima, Y. Yasukochi, K. Shimokado, F. Numano. Remnant lipoprotein and atherogenesis Ann. N. Y. Acad. Sci. 947 : 366-369 (2001)

H. Ishii, M. Yoshida, KA. Hajjar, A. Tanaka, Y. Yasukochi, F. Numano. Potential role of recombinant annexin II in diabetic vascular injury. Ann. N. Y. Acad. Sci. 947 : 306-310 (2001)

F.W. Luscinskas, R.E. Gerszten, E.A. Garcia-Zepeda, Y.-C. Lim, M. Yoshida, H. Ding, M.A. Gimbrone,Jr., A.D. Luster, A. Rosenzweig C-C and C-X-C chemokine trigger firm adhesion of monocytes to vascular endothelium under flow conditions. Ann. N.Y. Acad. Sci. 902, 288-293, (2000)

Y. Fujii, M. Yoshida, L. Chien, K. Kihara, Y. Kageyama, Y. Yasukochi, H. Oshima. Significance of Carbohydrate Antigen Sialyl-Lewis X, Sialyl-Lewis A, and Possible Unknown Ligands to Adhesion of Human Urothelial Cancer Cells to Activated Endothelium Urol. Int. 64, 129-133 (2000)

H. Ishii, M. Yoshida, A. Rosenzweig, M.A. Gimbrone,Jr., Y. Yasukochi, F. Numano. Adenoviral transduction of human E-selectin into isolated, perfused rat aortic segments: an ex vivo model for studying leukocyte-endothelial interactions. J. Leukocyte Biol. 68, 687-692 (2000)

Y. Fukuda, N. Kurihara, I. Imoto, K. Yasui, M. Yoshida, K. Yanagihara, JG. Park, Y. Nakamura, J. Inazawa. CD44 is a potential target of amplification within the 11p13 amplicon detected in gastric cancer cell lines. Genes, Chromosomes and Cancer 29: 315-324 (2000)

M. Doi, M. Shichiri, M. Yoshida, F. Marumo, Y. Hirata. Suppression of integrin alpha(v) expression by endothelin-1 in vascular smooth muscle cells. Hypertens Res 23:643-649 (2000)

M. Yoshida, L-J Chen, Y. Yasukochi, F. Numano. Differentiation induced transmigration of HL60 cells across activated HUVEC monolayer involves E-selectin-dependent mechanism. Ann. N.Y. Acad. Sci.902, 307-310, (2000)

H. Ishii, M. Yoshida, K.A. Hajjar, Y. Yasukochi, F. Numano. Construction of recomninant adenovial vector of annexin II. Ann. N.Y. Acad. Sci.902, 311-314, (2000)

R.E. Gerszten, E.A. Garcia-Zepeda, Y.-C. Lim, M. Yoshida, H. Ding, M.A. Gimbrone,Jr., A.D. Luster, A. F.W. Luscinskas, Rosenzweig MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions. Nature 398, 718-723 (1999)

M.Yoshida, B.E. Szente, J-M. Kiely, A. Rosenzweig, M.A. Gimbrone,Jr. Phosphorylation of the cytoplasmic domain of E-selectin is regulated during leukocyte-endothelial adhesion. J. Immunol. 161, 933-941, (1998)

M. Yoshida, M.A. Gimbrone,Jr. Novel roles for E-selectin in endothelial-leukocyte adhesion. Ann. N.Y. Acad. Sci. 811, 493-497, (1997)

M. Yoshida, W. F. Westlin, N. Wang, D. E. Ingber, A. Rosenzweig, N. Resnick, M. A. Gimbrone,Jr. Leukocyte adhesion to vascular endothelium induces E-selectin linkage to the actin-cytoskeleton. J. Cell Biol. 133, 145-155 (1996)

M. Yoshida, H. Nonoguchi, A. Owada, S. Ishiyama, Y. Maeda, K. Ando, H. Iwamoto, T. Shiigai, F. Marumo, K. Tomita. Three cases of malignant hypertension: the roles of endothelin-1 and the renin-angiotensin-aldosterone system. Clinical Nephrology 42, 295-299 (1994)

M. Yoshida, A. Kimura, K. Katsuragi, F. Numano, T. Sasazuki. DNA typing of HLA-B gene in Takayasu's arteritis. Tissue Antigens 42, 87-90 (1993)

M. Yoshida, A. Kimura, F. Numano, T. Sasazuki. Polymerase chain reaction based analysis of the HLA-B gene. Human Immunology 34, 257-266 (1992)

M. Yoshida, A. Kimura, F. Numano, T. Sasazuki. Analysis of polymorphism in exon 2 of the HLA-B gene. in HLA1991 K. Tsuji, M. Aizawa, T. Sasazuki, Eds. (Oxford Science Publications, 1991), vol. 2, pp. 215-218.

Kimura, S. Hoshino, M. Yoshida, H. Harada, T. Sasazuki. Polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) analysis of HLA genes: a practical HLA-matching system. in HLA1991 K. Tsuji, M. Aizawa, T. Sasazuki, Eds. (Oxford Science Publications, 1991), vol. 1, pp. 511-514.