咬合機能低下と歯周組織

• 咀嚼筋機能低下と顎関節
• 加齢に伴う顎口腔の形態および機能の変化
• 咬合と頭頚部および全身との関係
• 咬合と顎関節症状との関係
• 咬合・咀嚼の生力学的解析

 

• 移植歯に対する矯正力や咬合による機械的刺激の影響（基礎および臨床研究）

 
 

 

 

• 実験的歯の移動における各種タンパク、ホルモンの影響
• 機械的刺激に対する歯根膜細胞および骨系細胞の反応

 
 
 

 

 

• 超弾性型チタンニッケル合金角型ワイヤーの改良および臨床応用
• 強化プラスチックワイヤーの開発
• MRIにおける金属アーチファクト

 

 

• 抜歯と味覚の関連
• 口呼吸と味覚の関連
  
  
  
  
   

 

 
 
 
 
 

 

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〇研究業績
〇研究発表
〇著作・受賞歴等
 

研究業績

2024

• Original Articles

• Koji Honda, Toshinori Iwai, Satomi Sugiyama, Kenji Mitsudo. Transantral apicoectomy for radicular cyst of maxillary molar following downfracture in Le Fort I osteotomy. J Dent Sci. 2024.01; 19 (1): 684-685. ( PubMed, DOI )
   

• 2023

• Original Articles

• Haruki Imai, Yosuke Yamashita, Hikaru Takasu, Koichi Fujita, Takashi Ono, Makoto Hirota, Kenji Mitsudo. Accuracy and influencing factors of maxillary and mandibular repositioning using pre-bent locking plates: a prospective study. Br J Oral Maxillofac Surg. 2023.12; 61 (10): 659-665. ( PubMed, DOI )

• Eri Misawa-Omori, Hidemasa Okihara, Takuya Ogawa, Yasunori Abe, Chiho Kato, Hideyuki Ishidori, Akiyo Fujita, Satoshi Kokai, Takashi Ono. Reduced mastication during growth inhibits cognitive function by affecting trigeminal ganglia and modulating Wnt signaling pathway and ARHGAP33 molecular transmission. Neuropeptides. 2023.12; 102 102370. ( PubMed, DOI )

• Hao Guan, Ikuo Yonemitsu, Yuhei Ikeda, Takashi Ono. Reversible Effects of Functional Mandibular Lateral Shift on Masticatory Muscles in Growing Rats. Biomedicines. 2023.07; 11 (8): 2126. ( PubMed, DOI )

• Ruixin Li, Chiho Kato, Akiyo Fujita, Yasunori Abe, Takuya Ogawa, Hideyuki Ishidori, Eri Misawa, Hidemasa Okihara, Satoshi Kokai, Takashi Ono. Effect of Obesity on Masticatory Muscle Activity and Rhythmic Jaw Movements Evoked by Electrical Stimulation of Different Cortical Masticatory Areas. J Clin Med. 2023.06; 12 (11): 3856. ( PubMed, DOI )

• Cangyou Xie, Fatma Rashed, Yosuke Sasaki, Masud Khan, Jia Qi, Yuri Kubo, Yoshiro Matsumoto, Shinichi Sawada, Yoshihiro Sasaki, Takashi Ono, Tohru Ikeda, Kazunari Akiyoshi, Kazuhiro Aoki. Comparison of Osteoconductive Ability of Two Types of Cholesterol-Bearing Pullulan (CHP) Nanogel-Hydrogels Impregnated with BMP-2 and RANKL-Binding Peptide: Bone Histomorphometric Study in a Murine Calvarial Defect Model. Int J Mol Sci. 2023.06; 24 (11): 9751. ( PubMed, DOI )

• Takashi Ono. Pediatric obstructive sleep apnea: Insights and current research Seminars in Orthodontics. 2023.06; 29 (2): 204-206. ( DOI )

• Sasin Sritara, Yoshiro Matsumoto, Yixin Lou, Jia Qi, Jun Aida, Takashi Ono. Association between the Temporomandibular Joint Morphology and Chewing Pattern. Diagnostics (Basel). 2023.06; 13 (13): 2177. ( PubMed, DOI )

• Naoaki Mikami ,Ikuo Yonemitsu,Hiroshi Takemura,Mark Kondou,Kouhei Soga,Kazuhiro Suga,Zuisei Kanno, WeiJen Lai, Motohiro Uo,Takashi Ono. Mechanical analysis of the improved superelastic Ni-Ti alloy wire using the orthodontic simulator with high-precision sensors J Mech Behav Biomed Mater. 2023.06; 142 105861. ( PubMed, DOI )

• Takumi Suzuki, Jun Hosomichi, Naoyuki Miyasaka, Yasunari Miyazaki, Atsuko Taki, Takashi Zaitsu, Chikako Morioka, Noriko Sato, Manaka Moro, Takashi Ono. Characteristics of obstructive sleep apnea among pregnant Japanese woman and their birth outcomes SLEEP. 2023.05; 46 A229.

• Wenqian Sun, Hidemasa Okihara, Takuya Ogawa, Hideyuki Ishidori, Eri Misawa, Chiho Kato, Takashi Ono. Pre-Adolescent Diet Normalization Restores Cognitive Function in Young Mice. J Clin Med. 2023.05; 12 (11): 3642. ( PubMed, DOI )

• Karin Harumi Uchima Koecklin, Chiho Kato, Yasunori Abe, Tadachika Yabushita, Satoshi Kokai, Takashi Ono. Histological and contractile changes in the genioglossus muscle after nasal obstruction in growing rats. Sci Rep. 2023.04; 13 (1): 6245. ( PubMed, DOI )

• Takashi Ono, Valmy Pangrazio-Kulbersh, Letizia Perillo, Flavia Artese, Ewa Czochrowska, M Ali Darendeliler, Steven Dugoni, William E Fayad Bajaire, Eric Liou, Jae Hyun Park, David Rice, Abbas Zaher, Athanasios E Athanasiou, Lee W Graber, Nikhilesh R Vaid. World Federation of Orthodontists guidelines for postgraduate orthodontic education. J World Fed Orthod. 2023.04; 12 (2): 41-49. ( PubMed, DOI )

• Saranya Serirukchutarungsee, Ippei Watari, Masataka Narukawa, Katarzyna Anna Podyma-Inoue, Pornchanok Sangsuriyothai, Takashi Ono. Two-generation exposure to a high-fat diet induces the change of salty taste preference in rats. Sci Rep. 2023.04; 13 (1): 5742. ( PubMed, DOI )

• Seiko Ishihara, Risa Usumi-Fujita, Yuki Kasahara, Shuji Oishi, Kana Shibata, Yasuhiro Shimizu, Yuji Ishida, Sawa Kaneko, Makoto Sugiura-Nakazato, Makoto J Tabata, Jun Hosomichi, Yoshiaki Taniyama, Takashi Ono. Periostin splice variants affect craniofacial growth by influencing chondrocyte hypertrophy. J Bone Miner Metab. 2023.03; 41 (2): 171-181. ( PubMed, DOI )

• Ikuo Yonemitsu, Shusaku Ozaki, Takashi Ono. The Improved Superelastic Ni-Ti Alloy Wire in Orthodontic Treatment: Characteristics and Clinical Application SEMINARS IN ORTHODONTICS. 2023.03; 29 (1): 43-50. ( DOI )

• Saranya Serirukchutarungsee, Ippei Watari, Pornchanok Sangsuriyothai, Masato Akakura, Takashi Ono. The Effect of Two-Generation Exposure to a High-Fat Diet on Craniofacial Morphology in Rats. J Clin Med. 2023.02; 12 (5): 1903. ( PubMed, DOI )

• Albert Chun-Shuo Huang, Yuji Ishida, Kai Li, Duantawan Rintanalert, Kasumi Hatano-Sato, Shuji Oishi, Jun Hosomichi, Risa Usumi-Fujita, Hiroyuki Yamaguchi, Hiroyuki Tsujimoto, Aiko Sasai, Ayaka Ochi, Hajime Watanabe, Takashi Ono. NF-κB Decoy ODN-Loaded Poly(Lactic-co-glycolic Acid) Nanospheres Inhibit Alveolar Ridge Resorption. Int J Mol Sci. 2023.02; 24 (4): 3699. ( PubMed, DOI )

• Wirongrong Wongkitikamjorn, Eiji Wada, Jun Hosomichi, Hideyuki Maeda, Sirichom Satrawaha, Haixin Hong, Ken-Ichi Yoshida, Takashi Ono, Yukiko K Hayashi. Metabolic dysregulation and decreased capillarization in skeletal muscles of male adolescent offspring rats exposed to gestational intermittent hypoxia. Front Physiol. 2023; 14 1067683. ( PubMed, DOI )

• Yixin Lou, Yoshiro Matsumoto, Sachiko Iseki, Takashi Ono. Difference in apical resorption activity during rat molar root formation in response to mechanical force. Eur J Orthod. 2023.02;(PubMed, DOI)

  Yuna Kanamori, Naoko Seki, Richard Foxton, Janelle Moross, Yuriko Komagamine, Koji Mizutani, Keiichi Hosaka, Manabu Kanazawa, Takashi Hatayama, Wataru Komada, Ikuo Yonemitsu, Masako Akiyama, Paramaporn Chiewpattanakul Kaewmanee, Nathawut Kaewsutha, Hiroshi Nitta, Noriyuki Wakabayashi, Ikuko Morio. Fostering globally competent dental students through virtual team-working, problem-solving and person-centred multi-disciplinary care planning. J Dent Sci. 2023.01;18(1):95-104.(PubMed, DOI)

2022

• Original Articles

  Lu Zhao, Yoshiro Matsumoto, Sachiko Iseki, Takashi Ono. Effects of short-term orthodontic force application on the root at different developmental stages in rat maxillary molars. Am J Orthod Dentofacial Orthop. 2022.12;(PubMed, DOI)

  Mirei Keitoku, Ikuo Yonemitsu, Yuhei Ikeda, Huan Tang, Takashi Ono. Differential Recovery Patterns of the Maxilla and Mandible after Eliminating Nasal Obstruction in Growing Rats. J Clin Med. 2022.12;11 (24):(PubMed, DOI)

  Narubhorn Ongprakobkul, Yuji Ishida, Sirima Petdachai, Aiko Ishizaki, Chiyo Shimizu, Paiboon Techalertpaisarn, Takashi Ono. Morphometric and volumetric analysis of the proximity between the incisive canal and maxillary central incisors during anterior retraction: a retrospective cone-beam computed tomography study. Angle Orthod. 2022.11;93(2):159-167. (PubMed, DOI)

  Hiroko Ohmori,Hiroaki Kirimoto,Anindya Kamaratih,Jun Aida ,Takashi Ono. Associations among temporomandibular disorder, headache, shoulder pain, craniofacial morphology, and premature contacts in female children and adolescents with malocclusion Clinical and Investigative Orthodontics. 2022.10;81(4):202-208. ( DOI)

  Shuko Arai, Chiho Kato, Ippei Watari, Takashi Ono. Does Orthodontic Treatment Change the Preferred Chewing Side of Patients with Malocclusion? J Clin Med. 2022.10;11 (21):( PubMed, DOI)

  Shuji Oishi, Takashi Ono. A Case Treated with Maxillary Molar Distalization through the Maxillary Sinus: Three-Dimensional Assessment with a Cone-Beam Computed Tomography Superimposition Applied Sciences. 2022.09; 12 9494. ( DOI )

  Shahriar Mohd Shams, Ippei Watari​, Eri Saito, Takashi Ono. Molar extraction alters gastric mucosa and ghrelin expression in rat stomach: A preliminary study APOS Trends in Orthodontics. 2022.08; 12(2): 86-93. ( DOI )

  Anindya Kamaratih, Hiroko Ohmori​, Misaki Aoyagi, Zuisei Kanno, Takashi Ono. Gastric emptying rate of a solid meal in patients with anterior open bite malocclusion: A preliminary study APOS Trends in Orthodontics. 2022.08; 12(2): 77-85. ( DOI )

  Masako Kawada, Yasuhiro Shimizu, Eisaku Kanazawa, Takashi Ono. Samurai in Japan: Class System-Related Morphological Differences in Maxillofacial Regions in the Edo Period. Int J Environ Res Public Health. 2022.07; 19 (15): ( PubMed, DOI )

  Akiyo Fujita, Chiho Kato, Yasunori Abe, Hideyuki Ishidori, Ruixin Li, Phyo Thura Aung, Takuya Ogawa, Hidemasa Okihara, Satoshi Kokai, Takashi Ono. Unilateral nasal obstruction affects development of cortical orofacial motor representation in the cortical masticatory area of growing rats. Neurosci Lett. 2022.07; 783 136700. ( PubMed, DOI )

  Wirongrong Wongkitikamjorn, Jun Hosomichi, Eiji Wada, Hideyuki Maeda, Sirichom Satrawaha, Haixin Hong, Yukiko K Hayashi, Ken-Ichi Yoshida, Takashi Ono. Gestational Intermittent Hypoxia Induces Mitochondrial Impairment in the Geniohyoid Muscle of Offspring Rats. Cureus. 2022.05; 14(5): e25088. ( PubMed, DOI )

  Sunmin Kim, Ikuo Yonemitsu, Hiroshi Takemura, Kunio Shimoda, Kazuhiro Suga, Kohei Soga, Takashi Ono, Motohiro Uo. Influence of different ligation methods on force and moment generation in a simulated condition of the maxillary crowded anterior dentition with linguo-version and rotation. Biomed Mater Eng. 2022.05; ( PubMed, DOI )

  Misaki Aoyagi, Marie Oshima, Masamichi Oishi, Soma Kita, Koichi Fujita, Haruki Imai, Shuji Oishi, Hiroko Ohmori, Takashi Ono. Computational fluid dynamic analysis of the nasal respiratory function before and after postero-superior repositioning of the maxilla. PLoS One. 2022.04; 17(4): e0267677. ( PubMed, DOI )

  Kai Li, Yuji Ishida, Kasumi Hatano-Sato, Narubhorn Ongprakobkul, Jun Hosomichi, Risa Usumi-Fujita, Sawa Kaneko, Hiroyuki Yamaguchi, Takashi Ono. Nuclear factor-kappa B decoy oligodeoxynucleotide-loaded poly lactic-co-glycolic acid nanospheres promote periodontal tissue healing after tooth replantation in rats. J Periodontol. 2022.03; 93(3): 458-470. ( PubMed, DOI )

  Ishidori Hideyuki, Okihara Hidemasa, Ogawa Takuya, Abe Yasunori, Kato Chiho, Aung Phyo Thura, Fujita Akiyo, Kokai Satoshi, Ono Takashi. Nasal obstruction during the growth period modulates the Wnt/beta-catenin pathway and brain-derived neurotrophic factor production in association with tyrosine kinase receptor B mRNA reduction in mouse hippocampus EUROPEAN JOURNAL OF NEUROSCIENCE. 2022.01; 55(1): 5-17. ( PubMed, DOI )

  Asuka Manabe, Takayoshi Ishida, Eiichiro Kanda, Takashi Ono. Evaluation of maxillary and mandibular growth patterns with cephalometric analysis based on cervical vertebral maturation: A Japanese cross-sectional study. PLoS One. 2022; 17(4): e0265272. ( PubMed, DOI )

  Kato C, Watari I, Aida J, Ono T: Factors associated with the eruption of the impacted maxillary third molars after second molar extraction. American Journal of Orthodontics and Dentofacial Orthopedics. 2022.07 (PubMed)

2021

Original Articles
Abe Y, Ozaki S, Matsubara N, Kirimoto H, Ono T: Treatment of Class II malocclusion with the improved superelastic nickel-titanium alloy wire and long hooks for mandibular molar protraction American Journal of Orthodontics and Dentofacial Orthopedics Clinical Companion. 2021.08; 1 (2): 136-153.

Li K, Ishida Y, Hatano-Sato K, Ongprakobkul N, Hosomichi J, Usumi-Fujita R, Kaneko S, Yamaguchi H, Ono T: Nuclear factor-kappa B decoy oligodeoxynucleotide-loaded poly lactic-co-glycolic acid nanospheres promote periodontal tissue healing after tooth replantation in rats. J Periodontol. 2021.07

Keiko Fukino, Masahiro Tsutsumi, Akimoto Nimura, Koh Miwa, Takashi Ono, Keiichi Akita: Reply to "Palatopharyngeus muscle in pharyngoplasty surgery for OSAS: cut or not to cut?" Eur Arch Otorhinolaryngol. 2021.07; 278 (7): 2659-2660.

Kuma Y, Hosomichi J, Maeda H, Oishi S, Usumi-Fujita R, Shimizu Y, Kaneko S, Suzuki J, Yoshida K, Ono T: Intermittent hypoxia induces turbinate mucosal hypertrophy via upregulating the gene expression related to inflammation and EMT in rats Sleep and Breathing. 2021.06; 25 (2): 677-684.

Hong H, Hosomichi J, Maeda H, Ishida Y, Usumi-Fujita R, Yoshida K, Ono T: Selective β2-adrenoceptor blockade rescues mandibular growth retardation in adolescent rats exposed to chronic intermittent hypoxia Front Physiol. 2021.06; 12 676270.

Koike S, Hamba H, Tagami J, Ono T: Effect of fluoride-releasing 4-META/MMA-TBB resin on enamel demineralization around orthodontic brackets: An in vitro µCT analysis. Dental Materials Journal. 2021.06

Sasin Sritara, Masahiro Tsutsumi, Keiko Fukino, Yoshiro Matsumoto, Takashi Ono, Keiichi Akita: Evaluating the morphological features of the lateral pterygoid insertion into the medial surface of the condylar process. Clinical and Experimental Dental Research. 2021.04; 7 (2): 219-225.

Ozawa E, Honda E, Tomizato H, Kurabayashi T, Nunthayanon K, Ohmori H, Shimazaki K, Ono T: Preliminary study of articulatory characteristics in open bite subjects revealed by 3T magnetic resonance imaging movies APOS Trends in Orthodontics. 2021.04; 11 (1): 14-22.

Sritara S, Tsutsuni M, Fukino K, Matsumoto Y, Ono T, Akita K: Evaluating the morphological features of the lateral pterygoid insertion into the medial surface of the condylar process Clinical and Experimental Dental Research. 2021.04; 7 (2): 219-225.

Fukino K, Tsutsumi M, Nimura A, Miwa K, Ono T, Akita K: Anatomy of inferior end of palatopharyngeus: Its contribution to upper esophageal sphincter opening European Archives of Oto-Rhino-Laryngology. 2021.03; 278 (3): 749-754.

Fujita K, Minamiyama S; Usumi-Fujita R; Omura S, Takasu H, Yamashita Y, Honda K Imai H, Iwai T, Hirota M Ono T, Mitsudo K: Examination of the temporomandibular joint stability after two types of maxillary impaction surgery in patients with skeletal Class II open bites due to condylar deformations: A preliminary study Orthodontic Waves. 2021.03; 80 47-54.

Keiko Fukino, Masahiro Tsutsumi, Akimoto Nimura, Koh Miwa, Takashi Ono, Keiichi Akita: Anatomy of inferior end of palatopharyngeus: its contribution to upper esophageal sphincter opening. Eur Arch Otorhinolaryngol. 2021.03; 278 (3): 749-754.

Ongprakobkul N, Ishida Y, Hatano-Sato K, Li K, Petdachai S, Usumi-Fujita R ,Hosomichi J, Mahatumarat K, Ono T: Effects of local versus systemic administration of CXCR4 inhibitor AMD3100 on orthodontic tooth movement in rats American Journal of Orthodontics & Dentofacial Orthopedics. 2021.03;

Fujita K, Minamiyama S, Usumi-Fujita R, Omura S, Takasu H, Yamashita Y, Honda K, Imai H, Iwai T, Hirota M, Ono T, Mitsudo K: Temporomandibular joint stability after two types of maxillary impaction surgery in patients with skeletal class II open bite due to condylar deformations: a preliminary study Orthodontic Waves. 2021.03; 80 (1): 47-54.

Aung P T, Kato C, Fujita A, Abe Y, Ogawa T, Ishidori H, Okihara H, Kokai S, Ono T: Effects of low occlusal loading on the neuromuscular behavioral development of cortically-elicited jaw movements in growing rats Sci Rep. 2021.03; 11 (1): 7175. 

Hong H, Hosomichi J, Maeda H, Lekvijittada K, Oishi S, Ishida Y, Usumi-Fujita R, Kaneko S, Suzuki J, Yoshida K, Ono T: Intermittent hypoxia retards mandibular growth and alters RANKL expression in adolescent and juvenile rats European Journal of Orthodontics. 2021.02; 43 94-103.

Keo P, Matsumoto Y, Shimizu Y, Nagahiro S, Ono T, Aoki K: A pilot study to investigate the histomorphometric changes of murine maxillary bone around the site of mini-screw insertion in the regenerated bone induced by anabolic reagents European Journal of Orthodontics. 2021.02; 43 86-93.

Lekvijittada K, Hosomichi J, Maeda H, Hong H, Changsiripun C, Kuma Y, Oishi S, Suzuki J,Yoshida K, Ono T: Intermittent hypoxia inhibits mandibular cartilage growth with reduced TGF-β and SOX9 expressions in neonatal rats Sci Rep. 2021.01; 11 (1): 1140.

Okihara H, Ono T: Authors' response. American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics. 2021.01; 159 (1): e3-e5.

Ongprakobkul N, Hatano-Sato K, Li K, Petdachai S, Usumi-Fujita R, Hosomichi J, Mahatumarat K, Ono T.: Effects of AMD3100 on orthodontic tooth movement in rats Am J Orthod Dentofacial Orthop.. 2021 in press
 

2020

Original Articles
Guo X, Watari I, Ikeda Y, Yang W, Ono T: Effect of functional lateral shift of the mandible on hyaluronic acid metabolism related to lubrication of temporomandibular joint in growing rats. European Journal of Orthodontics. 2020.12

Naito S, Kato C, Yabushita T, Ono T: Functional changes in the temporomandibular joint mechanoreceptors associated with experimentally induced condylar resorption in rats. Angle Orthodontist. 2020.11; 90 (6): 831-836.

Takayuki Suga, Trang Thi Huyen Tu, Miho Takenoshita, Norihisa Higashihori, Yuji Kabasawa, Takashi Ono, Keiji Moriyama, Akira Toyofuku: Psychosocial indication for orthognathic surgery in patients with psychiatric comorbidities. Psychiatry Clin Neurosci. 2020.11; 74 (11): 621-623.

Shima Y, Takemoto K, Koyama A, Uo M, Ono T: Comparative evaluation of square and rectangular slot three-point play behavior. Dental Materials Journal. 2020.10; 39 (5): 735-741.

Miwa K, Tsutsumi M, Fukino K, Eguchi K, Okada R, Akita K: An anatomical atudy of the anterior wall of the hypopharyngeal and the cervical esophageal junction. Auris Nasus Larynx. 2020.10; 47 (5): 849-855.

Ono T: Should the "envelope of discrepancy" be revised in the era of three-dimensional imaging? Journal of the World Federation of Orthodontists. 2020.10; 9 (3S): S59-S66.
Miki H, Okito A, Akiyama M, Ono T, Tachikawa N, Nakahama KI: Genetic and epigenetic regulation of osteopontin by cyclic adenosine 3' 5'-monophosphate in osteoblasts. Gene. 2020.08; (763): 145059. 

Suga T, Tu TTH, Takenoshita M, Higashihori N, Kabasawa Y, Ono T, Moriyama K, Toyofuku A: Psychosocial Indication for Orthognathic Surgery in Patients with Psychiatric Comorbidities. Psychiatry and clinical neurosciences. 2020.08

Kuma YI, Hosomichi J, Maeda H, Oishi S, Usumi-Fujita R, Shimizu Y, Kaneko S, Suzuki JI, Yoshida KI, Ono T: Intermittent hypoxia induces turbinate mucosal hypertrophy via upregulating the gene expression related to inflammation and EMT in rats. Sleep and Breathing. 2020.08

Okihara H, Ono T: Correction of bilateral heavily impacted second molar with improved super-elastic nickel-titanium alloy wires. American Journal of Orthodontics and Dentofacial Orthopedics. 2020.07; 158 (1): 114-125.

Okuzawa-Iwasaki M, Ishida Y, Ikeda Y, Imamura T, Oishi S, Kita S, Matsumura T, Sakaguchi-Kuma T, Ono T: Alveolar bone morphology in patients with a unilateral palatally displaced maxillary lateral incisor: A cone-beam computed tomography study. American Journal of Orthodontics and Dentofacial Orthopedics. 2020.07; 158 (1): 28-34.

Imai H, Fujita K, Yamashita Y, Yajima Y, Takasu H, Takeda A, Honda K, Iwai T., Mitsudo K., Ono T, Omura S: Accuracy of mandible-independent maxillary repositioning using pre-bent locking plates: a pilot study International Journal of Oral and Maxillofacial Surgery. 2020.07; 49 (7): 901-907.

Saito E, Watari I, Mizumachi-Kubono M, Hsu-Hayashi S, Ono T: Occlusional modifications reversibly alter aquaporin 5 expression and localization in rat salivary glands. Frontiers in Physiology. 2020.06; 11 528.

Oishi S, Ishida Y, Matsumura T, Kita S, Sakaguchi-Kuma T, Imamura T, Ikeda Y, Kawabe A, Okuzawa M, Ono T: A cone-beam computed tomographic assessment of the proximity of the maxillary canine and posterior teeth to the maxillary sinus floor: Lessons from 4778 roots. American Journal of Orthodontics and Dentofacial Orthopedics. 2020.06; 157 (6): 792-802.

Imamura T, Uesugi S, Ono T: Unilateral maxillary central incisor root resorption after orthodontic treatment for Angle Class II, division 1 malocclusion with significant maxillary midline deviation: A possible correlation with root proximity to the incisive canal. Korean Journal of Orthodontics. 2020.05; 50 (3): 216-226.

Yang SS, Ishida T, Fujita K, Nakai Y, Ono T, Okazawa H: PQBP1, an intellectual disability causative gene, affects bone development and growth. Biochem Biophys Res Commun. 2020.03; 523 (4): 894-899. 

Kato C, Kokai S, Ono T: Orthodontic movement of a contralateral maxillary central incisor across the midpalatal suture. APOS Trends in Orthodontics. 2020.03; 10 (1): 50-59.

Sakaguchi-Kuma T, Ishida Y, Oishi S, Kurabayashi T, Ono T: Cone-beam computed tomography-based quantitative analysis of the thickness of mandibular alveolar bone in adult females with different vertical facial patterns. APOS Trends in Orthodontics. 2020.03; 10 25-31.

Hong H, Hosomichi J, Maeda H, Lekvijittada K, Oishi S, Ishida Y, Usumi-Fujita R, Kaneko S, Suzuki JI, Yoshida KI, Ono T: Intermittent hypoxia retards mandibular growth and alters RANKL expression in adolescent and juvenile rats. European Journal of Orthodontics. 2020.03

Koyama A, Ono T, Uo M, Kiyokawa H, Ohira N, Shima Y, Kanno Z: Improvement of binding friction between stainless steel orthodontic wire and bracket by performing Rh-PTFE composite plating on the wire. Orthodontic Waves. 2020.03; 79 (1): 39-47.

Keo P, Matsumoto Y, Shimizu Y, Nagahiro S, Ikeda M, Aoki K, Ono T: A pilot study to investigate the histomorphometric changes of murine maxillary bone around the site of mini-screw insertion in regenerated bone induced by anabolic reagents. European journal of orthodontics. 2020.03

Yang W, Podyma-Inoue KA, Yonemitsu I, Watari I, Ikeda Y, Guo X, Watabe T, Ono T: Mechanoresponsive and lubricating changes of mandibular condylar cartilage associated with mandibular lateral shift and recovery in the growing rat. Clinical Oral Investigations. 2020.02

Aung PT, Kato C, Abe Y, Ogawa T, Ishidori H, Fujita A, Okihara H, Kokai S, Ono T: Functional analysis of rhythmic jaw movements evoked by electrical stimulation of the cortical masticatory area during low occlusal loading in growing rats. Frontiers in Physiology. 2020.01; 11 34. 

Kita S, Fujita K, Imai H, Aoyagi M, Shimazaki K, Yonemitsu I, Omura S, Ono T: Postoperative stability of conventional bimaxillary surgery compared with maxillary impaction surgery with mandibular autorotation for patients with skeletal class II retrognathia. British Journal of Oral and Maxillofacial Surgery. 2020.01; 58 (1): 57-61. 

Satokawa C, Nishiyama A, Suzuki K, Uesugi S, Kokai S, Ono T: Evaluation of tissue oxygen saturation of the masseter muscle during standardised teeth clenching. Journal of oral rehabilitation. 2020.01; 47 (1): 19-26.

2019

Original Articles

Ishida Takayoshi, Manabe Asuka, Yang Shin-Sheng, Watakabe Kenzo, Abe Yasunori, Ono Takashi: An orthodontic-orthognathic patient with obstructive sleep apnea treated with Le Fort I osteotomy advancement and alar cinch suture combined with a muco-musculo-periosteal V-Y closure to minimize nose deformity ANGLE ORTHODONTIST. 2019.11; 89 (6): 946-952.

Preksa Keo, 松本 芳郎, 長弘 茂樹, 青木 和広, 小野 卓史: RANKL結合ペプチドとBMP-2との注射により誘導されたマウス上顎骨の経時的変化とスクリュー植立の影響(Time-course study of bones induced by the co-injection of RANKL-binding peptide and BMP-2 and the effects of subsequent screw placement in murine maxilla) Journal of Oral Biosciences Supplement. 2019.10; 2019 270.

Kawabata Iku, Imai Haruki, Kanno Zuisei, Tetsumura Akemi, Tsutsumi Yusuke, Doi Hisashi, Ashida Maki, Kurabayashi Tohru, Hanawa Takao, Yamamoto Toru, Ono Takashi: Three-dimensional quantification of magnetic resonance imaging artifacts associated with shape factors DENTAL MATERIALS JOURNAL. 2019.08; 38 (4): 638-645. 

Yoshida M, Honda E, Ozawa E, Inoue-Arai SM, Ohmori H, Moriyama K, Ono T, Kurabayashi T, Yoshihara H, Nunthayanon Parakonthun K: Principles of the magnetic resonance imaging movie method for articulatory movement. Oral Radiology. 2019.05; 35 (2): 91-100. 

Zhao L, Matsumoto Y, Ono T, Iseki S.: Effects of mechanical force application on the developing root apex in rat maxillary molars. Arch Oral Biol.. 2019.05; 101 64-76.

Yoshida Midori, Honda Eiichi, Ozawa Erika, Inoue-Arai Sayuri Maristela, Ohmori Hiroko, Moriyama Keiji, Ono Takashi, Kurabayashi Tohru, Yoshihara Hozumi, Parakonthun Kulthida Nunthayanon: 構音運動に対するMRI動画撮像法の原理(Principles of the magnetic resonance imaging movie method for articulatory movement) Oral Radiology. 2019.05; 35 (2): 91-100.
 
Inoue M, Ono T, Kameo Y, Sasaki F, Ono T, Adachi T, Nakashima T: Forceful mastication activates osteocytes and builds a stout jawbone. Scientific reports. 2019.03; 9 (1): 4404. 
Ren E, Watari I, Jui-Chin H, Mizumachi-Kubono M, Podyma-Inoue KA, Narukawa M, Misaka T, Watabe T, Ono T: Unilateral nasal obstruction alters sweet taste preference and sweet taste receptors in rat circumvallate papillae. Acta histochemica. 2019.02; 121 (2): 135-142. 

Velusamy Pavethynath, Shimada Yasushi, Kanno Zuisei, Ono Takashi, Tagami Junji: Optical evaluation of enamel white spot lesions around orthodontic brackets using swept-source optical coherence tomography (SS-OCT): An in vitro study DENTAL MATERIALS JOURNAL. 2019.02; 38 (1): 22-27.

Uchikawa Y, Hosomichi J, Suzuki JI, Yamaguchi H, Ishida Y, Hatano K, Usumi-Fujita R, Shimizu Y, Kaneko S, Uesugi S, Ono T.: Differential growth of craniofacial and tibial bones to sympathetic hyperactivity-related hypertension in rats. Archives of Oral Biology. 2019.01; 99 73-81. 

Nakai Yuta, Okamoto Kazuo, Terashima Asuka, Ehata Shogo, Nishida Jun, Imamura Takeshi, Ono Takashi, Takayanagi Hiroshi: Efficacy of an orally active small-molecule inhibitor of RANKL in bone metastasis BONE RESEARCH. 2019.01; 7 1.

Kokai S, Fukuyama E, Omura S, Kimizuka S, Yonemitsu I, Fujita K, Ono T: Long-term stability after multidisciplinary treatment involving maxillary distraction osteogenesis, and sagittal split ramus osteotomy for unilateral cleft lip and palate with severe occlusal collapse and gingival recession: A case report. Korean Journal of Orthodontics. 2019.01; 49 (1): 59-69.

Beauboeuf R, Watari I, Saito E, Jui-Chin H, Kubono-Mizumachi M, Ono T: Alterations in the gustatory papillae after anterior bite plate insertion in growing rats. Journal of orthodontic science. 2019; 8 4.

Uesugi S, Imamura T, Yonemitsu I, Ono T: Surgical-Orthodontic Treatment of Adults with Mandibular Retrognathism and Obstructive Sleep Apnea. Journal of clinical orthodontics : JCO. 2019; 53 (9): 521-534.


2018

Original Articles

Kato Chiho, Ono Takashi: Anterior open bite due to temporomandibular joint osteoarthrosis with muscle dysfunction treated with temporary anchorage devices AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS. 2018.12; 154 (6): 848-859.

Hosomichi J, Shibutani N, Yamaguchi H, Hatano K, Kuma Y, Suzuki T, Kaneko S, Ono T: Localization of leucine-rich repeat-containing G-protein-coupled receptor 5- and Ki67-positive periodontal cells expressing runt-related transcription factor 2 during tooth movement. Orthodontic Waves. 2018.12; 77 (4): 197-208. 

Moe Sato, Toshifumi Asano, Jun Hosomichi, Takashi Ono, Takao Nakata: Optogenetic manipulation of intracellular calcium by BACCS promotes differentiation of MC3T3-E1 cells. Biochemical and Biophysical Research Communications. 2018.11; 506 (3): 716-722. 

Keiko Fukino, Masahiro Tsutsumi, Jose Sanudo, Takashi Ono, Keiichi Akita: Anatomical Significance of the Spatial Distribution of the Palatopharyngeus With Regard to Velopharyngeal Closure. Cleft Palate Craniofac. J.. 2018.11; 1055665618813082.

Ishida Takayoshi, Manabe Asuka, Yang Shin-Sheng, Yoon Hyung Sik, Kanda Eiichiro, Ono Takashi: Patterns of adenoid and tonsil growth in Japanese children and adolescents: A longitudinal study SCIENTIFIC REPORTS. 2018.11; 8 (1): 17088.

Keiichi Akita, Tomomi Sakaguchi-Kuma, Keiko Fukino, Takashi Ono: Masticatory Muscles and Branches of Mandibular Nerve: Positional Relationships between Various Muscle Bundles and Their Innervating Branches. Anat Rec (Hoboken). 2018.10; 302 (4): 609-619. ( PubMed , DOI )

Sato M, Asano T, Hosomichi J, Ono T, Nakata T: Optogenetic manipulation of intracellular calcium by BACCS promotes differentiation of MC3T3-E1 cells. Biochemical and biophysical research communications. 2018.10; 506 (3): 716-722.

Watakabe K, Yonemitsu I, Ikeda Y, Tang H, Ono T: Unilateral nasal obstruction induces morphological changes of the mandibular condyle in growing rats. Orthodontic Waves. 2018.09; 77 (3): 157-168. 

Matsumoto Yoshiro, Sringkarnboriboon Siripen, Ono Takashi: Effects of continuous force application for extrusive tipping movement on periapical root resorption in the rat mandibular first molar KOREAN JOURNAL OF ORTHODONTICS. 2018.09; 48 (5): 339-345. 

Hiyama G, Mizushima S, Matsuzaki M, Tobari Y, Choi JH, Ono T, Tsudzuki M, Makino S, Tamiya G, Tsukahara N, Sugita S, Sasanami T: Female Japanese quail visually differentiate testosterone-dependent male attractiveness for mating preferences. Scientific reports. 2018.07; 8 (1): 10012.

Uesugi Shunsuke, Imamura Toshihiro, Kokai Satoshi, Ono Takashi: Cone-beam computed tomography-based diagnosis and treatment simulation for a patient with a protrusive profile and a gummy smile KOREAN JOURNAL OF ORTHODONTICS. 2018.05; 48 (3): 189-199.

Honda Koji, Hirota Makoto, Iwai Toshinori, Fujita Koichi, Omura Susumu, Ono Takashi, Tohnai Iwai: Orthognathic Surgery and Implant-Supported Bridge in a Class III Patient Injured in a Motor Vehicle Accident JOURNAL OF CRANIOFACIAL SURGERY. 2018.05; 29 (3): E296-E298. 

Takada JI, Ono T, Miyamoto JJ, Yokota T, Moriyama K: Corrigendum: Association between intraoral pressure and molar position and inclination in subjects with facial asymmetry. European journal of orthodontics. 2018.04; 40 (2): 225. 

Hsu Jui-Chin, Watari Ippei, Funaki Yukiha, Kokai Satoshi, Ono Takashi: Unilateral nasal obstruction induces degeneration of fungiform and circumvallate papillae in rats JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION. 2018.03; 117 (3): 220-226.

Ono T, Iida M, Sakisaka T, Minami K, Miyata K: Effect of laser peripheral iridotomy using argon and neodymium-YAG lasers on corneal endothelial cell density: 7-year longitudinal evaluation. Japanese journal of ophthalmology. 2018.03; 62 (2): 216-220.

Shimizu Y, Khan M, Kato G, Aoki K, Ono T: Occlusal disharmony-induced stress causes osteopenia of the lumbar vertebrae and long bones in mice. Scientific Reports. 2018.01; 8 (1): 173.

Ikeda Yuhei, Kokai Satoshi, Ono Takashi: A patient with mandibular deviation and 3 mandibular incisors treated with asymmetrically bent improved superelastic nickel-titanium alloy wires AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS. 2018.01; 153 (1): 131-143. 

Yasuhiro Shimizu, Masud Khan, Genki Kato, Kazuhiro Aoki & Takashi Ono: Occlusal disharmony-induced stress causes osteopenia of the lumbar vertebrae and long bones in mice. Scientific Reports. 2018.01; 8 (173): 1-9. 
 

• Ogawa T, Okihara H*, Kokai S, Abe Y, Karin Harumi UK, Makiguchi M, Kato C, Yabushita T, Michikawa M, Ono T. Nasal obstruction during adolescence induces memory/learning impairments associated with BDNF/TrkB signaling pathway hypofunction and high corticosterone levels. J Neurosci Res. 2018;96(6):1056-1065.
• Usumi-Fujita R, Nakakuki K, Fujita K, Kosugi M, Yonemitus I, Fukuyama E, Ono T. Collaborative treatment for a case of condylar hyperplastic facial asymmetry. Angle Orthod. 2018;88(4):503-517.
• Uesugi S, Imamura T, Kokai S, Ono T. Cone-beam computed tomography-based diagnosis and treatment simulation for a patient with a protrusive profile and a gummy smile. Korean J Orthod. 2018;48(3):189-199.
• Honda K, Hirota M, Iwai T, Fujita K, Omura S, Ono T, Tohnai I. Orthognathic Surgery and Implant-Supported Bridge in a Class III Patient Injured in a Motor Vehicle Accident. J Craniofac Surg. 2018;29(3):296-298.
• Kanaguchi-Arita A, Yonemitsu I, Ikeda Y, Miyazaki M, Ono T. Low-intensity pulsed ultrasound stimulation for mandibular condyle osteoarthritis lesions in rats. Oral Dis. 2018;24(4):600-610.
• Hsu JC, Watari I, Funaki Y, Kokai S, Ono T. Unilateral nasal obstruction induces degeneration of fungiform and circumvallate papillae in rats. J Form Med Assoc. 2018;117(3):220-226.
• Kimura-Ueda K, Shimazaki K, Sugimoto K, Ono T. Influence of habitual mouth breathing on taste sensation. Orthodontic Waves. 2018;77(1)：24-30.
• Suzuki J, Shimazaki K, Koike S, Ono T. Gastric emptying rate before and after orthodontic treatm ent examined with the [13C] breath test: A pilot study. Am J Orthod Dentofacial Orthop. 2018;153(3):347-354.
• Hatano K, Ishida Y, Yamaguchi H, Hosomichi J, Suzuki JI, Usumi-Fujita R, Shimizu Y, Shibutani N, Kaneko S, Ono T. The chemokine receptor type 4 antagonist, AMD3100, interrupts experimental tooth movement in rats. Arch Oral Biol. 2018;86:35-39.
• Ozawa E, Honda EI, Parakonthun KN, Ohmori H, Shimazaki K, Kurabayashi T, Ono T. Influence of orthodontic appliance-derived artifacts on 3-T MRI movies. Prog Orthod. 2018;19(1):7.
• Ikeda Y, Kokai S, Ono T. A patient with mandibular deviation and 3 mandibular incisors treated with asymmetrically bent improved superelastic nickel-titanium alloy wires. Am J Orthod Dentofacial Orthop. 2018;153(1):131-143.
• Uesugi S, Kokai S, Kanno Z, Ono T. Stability of secondarily inserted orthodontic miniscrews after failure of the primary insertion for maxillary anchorage: Maxillary buccal area vs midpalatal suture area. Am J Orthod Dentofacial Orthop. 2018;153(1):54-60.
• Shimizu Y, Khan M, Kato G, Aoki K, Ono T. Occlusal disharmony-induced stress causes osteopenia of the lumbar vertebrae and long bones in mice. Sci Rep. 2018;8(9):173.
• Lai WJ, Midorikawa Y, Kanno Z, Takemura H, Suga K, Soga K, Ono T, Uo M. A new orthodontic force system for moment control utilizing the flexibility of common wires: Evaluation of the effect of contractile force and hook length. J Form Med Assoc. 2018;117(1):71-79.
   

外部資金獲得

平成29年度
 

科学研究費助成事業（学術研究助成基金助成金）基盤研究（B）
呼吸様式の変化に伴う味覚情報処理機構の破綻と回復に関するメカニズムの解明
課題番号26293434
3,770千円 (直接経費 : 2,900千円、間接経費 : 870千円)
 
科学研究費助成事業（学術研究助成基金助成金）基盤研究（B）海外学術
ASEAN地域における顎口腔機能に関する国際調査：形態との関連性の解明
課題番号15H05299
2,080千円 (直接経費 : 1,600千円、間接経費 : 480千円)
 
科学研究費助成事業（学術研究助成基金助成金）挑戦的萌芽研究
中枢性骨形成シグナルによる小児閉塞性睡眠時無呼吸症候群の顎顔面成長障害機構の解明
課題番号15K15753
910千円 (直接経費 : 700千円、間接経費 : 210千円)
 
科学研究費助成事業（学術研究助成基金助成金）挑戦的萌芽研究
咀嚼機能低下に起因する認知症発症の分子機構解明に関する先駆的研究
課題番号15K15712
910千円 (直接経費 : 700千円、間接経費 : 210千円)
 
科学研究費助成事業（学術研究助成基金助成金）基盤研究（C）
歯の移動に伴う歯根吸収重篤化に関わる好塩基球性免疫機構の解明と修復活性化の検討
課題番号15K15712
1,560千円 (直接経費 : 1,200千円、間接経費 : 360千円)
 
科学研究費助成事業（学術研究助成基金助成金）基盤研究（C）
SR-XRFおよびICP-MSを用い微量金属元素の口腔粘膜沈着メカニズムを探る
課題番号15K11343
910千円 (直接経費 : 700千円、間接経費 : 210千円)
 
科学研究費助成事業（学術研究助成基金助成金）基盤研究（C）
セロトニン受容体障害を介した小児睡眠時無呼吸症候群における上気道閉塞機構の解明
課題番号16K11778
1,690千円 (直接経費 : 1,300千円、間接経費 : 390千円)
 
科学研究費助成事業（学術研究助成基金助成金）基盤研究（C）
外科的矯正治療における上気道閉塞部位診断評価システムと治療予測モデルの構築
課題番号15K11361
1,430千円 (直接経費 : 1,100千円、間接経費 : 330千円)
 
科学研究費助成事業（学術研究助成基金助成金）基盤研究（C）
GLUT4およびHIF-1αを介した鼻呼吸障害に伴う不正咬合の新たな発現機序解明
課題番号16K11782
1,040千円 (直接経費 : 800千円、間接経費 : 240千円)
 
科学研究費助成事業（学術研究助成基金助成金）基盤研究（C）
GPCR転写ネットワーク制御と骨再生を目指したRNA核酸医療への挑戦
課題番号16K11781
1,040千円 (直接経費 : 800千円、間接経費 : 240千円)
 
科学研究費助成事業（学術研究助成基金助成金）若手研究（B）
VEGF/VEGFRに着目した咬合刺激低下歯の効率的な矯正学的移動システムの構築
課題番号15K20582
1,170千円 (直接経費 : 900千円、間接経費 : 270千円)
 
科学研究費助成事業（学術研究助成基金助成金）基盤研究（C）
歯の移動を促進する骨代謝活性化制御の新戦略：ナノ粒子を利用したDDSアプローチ
課題番号15K11342
1,040千円 (直接経費 : 900千円、間接経費 : 270千円)
 
科学研究費助成事業（学術研究助成基金助成金）若手研究（B）
よく噛むことは大脳皮質一次運動野・感覚野ホムンクルスの生後発達に影響を与えるか
課題番号15K20581
650千円 (直接経費 : 500千円、間接経費 : 150千円)
 
科学研究費助成事業（学術研究助成基金助成金）研究活動スタート支援
ルブリシン産生能の変調が顎関節OAを誘発する新規メカニズムの解明
課題番号15K20581
1,300千円 (直接経費 : 1,000千円、間接経費 : 300千円)
 
科学研究費助成事業（学術研究助成基金助成金）研究活動スタート支援
アンジオテンシン受容体亢進を介した小児高血圧症における骨代謝変調の解明
課題番号17H06661
1,430千円 (直接経費 : 1,100千円、間接経費 : 330千円)
 
科学研究費助成事業（学術研究助成基金助成金）基盤研究（C）
NFκBデコイ核酸の超音波マイクロバブル導入による変形性顎関節症の新規治療の開発
課題番号16K11777
1,950千円 (直接経費 : 1,500千円、間接経費 : 450千円)
 
科学研究費助成事業（学術研究助成基金助成金）基盤研究（C）
呼吸様式の変化が海馬BDNF/TrkBシグナル制御に与える影響
課題番号15K11339
650千円 (直接経費 : 500千円、間接経費 : 150千円)
 
科学研究費助成事業（学術研究助成基金助成金）基盤研究（C）
成長期鼻呼吸障害に伴う舌運動制御メカニズムの変調に関する末梢中枢連関の包括的解析
課題番号15K11338
780千円 (直接経費 : 600千円、間接経費 : 180千円)
 
科学研究費助成事業（学術研究助成基金助成金）若手研究（B）
身体運動と顎骨成長の関連：ヒト標本およびマウス運動刺激モデルを用いた骨形態解析
課題番号16K20639
1,170千円 (直接経費 : 900千円、間接経費 : 270千円)