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ホーム  > 分子遺伝分野  > 研究業績

研究業績

2018

Shigeaki Sunada, Akira Nakanishi, Yoshio Miki. Crosstalk of DNA double-strand break repair pathways in poly(ADP-ribose) polymerase inhibitor treatment of breast cancer susceptibility gene 1/2-mutated cancer. Cancer Science. 2018 Apr; 109(4): 893–899.

2017

Shigeaki Sunada, Hirokazu Hirakawa, Akira Fujimori, Mitsuru Uesaka, Ryuichi Okayasu, Oxygen Enhancement Ratio in Radiation-Induced Initial DSBs by an Optimized Flow Cytometry-based Gamma-H2AX Analysis in A549 Human Cancer Cells. Radiation Research. 2017 Nov; 188 (5): 591-594.

Miho Takaoka, Shun Ito, Yoshio Miki*, Akira Nakanishi, FKBP51 regulates cell motility and invasion via RhoA signaling. Cancer Science. 2017 Mar; 108(3):380-389.

2016

Torii S, Yoshida T, Arakawa S, Honda S, Nakanishi A, Shimizu S.: Identification of PPM1D as an essential Ulk1 phosphatase for genotoxic stress-induced autophagy. EMBO Reports. 2016 Nov; 17 (11): 1552-1564.

Shigeaki Sunada, Hideki Kanai, Younghyun Lee, Takeshi Yasuda, Hirokazu Hirakawa, Cuihua Liu, Akira Fujimori, Mitsuru Uesaka, Ryuichi Okayasu: Nontoxic concentration of DNA-PK inhibitor NU7441 radio-sensitizes lung tumor cells with little effect on double strand break repair. Cancer Sci. 2016 Sep; 107 (9): 1250-1255.

Sadiya Malik, Hiroko Saito, Miho Takaoka, Yoshio Miki*, Akira Nakanishi, BRCA2 mediates centrosome cohesion via an interaction with cytoplasmic dynein. Cell Cycle. 2016 Aug 17;15(16):2145-2156.

Hiroki Osumi, Eiji Shinozaki, Mitsukuni Suenaga, Satoshi Matsusaka, Tsuyoshi Konishi, Takashi Akiyoshi, Yoshiya Fujimoto, Satoshi Nagayama, Yosuke Fukunaga, Masashi Ueno, Yoshihiro Mise, Takeaki Ishizawa, Yosuke Inoue, Yu Takahashi, Akio Saiura, Hirohumi Uehara, Mingyon Mun, Sakae Okumura, Nobuyuki Mizunuma, Yoshio Miki, Toshiharu Yamaguchi: RAS mutation is a prognostic biomarker in colorectal cancer patients with metastasectomy. Int. J. Cancer. 2016 Mar

Junhui Wang, Qianshan Ding, Hiroaki Fujimori, Akira Motegi, Yoshio Miki, Mitsuko Masutani: Loss of CtIP disturbs homologous recombination repair and sensitizes breast cancer cells to PARP inhibitors. Oncotarget. 2016 Feb; 7 (7): 7701-7714.

Samir Kumar Pal, Chi Thi Kim Nguyen, Kei-Ichi Morita, Yoshio Miki, Kou Kayamori, Akira Yamaguchi, Kei Sakamoto: THBS1 is induced by TGFB1 in the cancer stroma and promotes invasion of oral squamous cell carcinoma. J. Oral Pathol. Med. 2016 Feb

2015

Nakamura S, Takahashi M, Tozaki M, Nakayama T, Nomizu T, Miki Y, Murakami Y, Aoki D, Iwase T, Nishimura S, Yamauchi H, Ohsumi S, Baba S, Shimizu T. Prevalence and differentiation of hereditary breast and ovarian cancers in japan. Breast Cancer 2015 Sep;22(5):462-8.

2014

Ishiba T, Nagahara M, Nakagawa T, Sato T, Ishikawa T, Uetake H, Sugihara K, Miki Y, Nakanishi A. Periostin suppression induces decorin secretion leading to reduced breast cancer cell motility and invasion. Scientific Reports. 2014 Nov 17;4:7069.

Kimura H, Miki Y, Nakanishi A. Centrosomes at M phase act as a scaffold for the accumulation of intracellular ubiquitinated proteins. Cell Cycle. 13, 1928-1937 (2014)

Takaoka M, Saito H, Takenaka K, Miki Y, Nakanishi A. BRCA2 phosphorylated by PLK1 moves to the midbody to regulate cytokinesis mediated by nonmuscle myosin IIC. Cancer Res. 74, 1518-1528 (2014)

Wali N, Hosokawa K, Malik S, Saito H, Miyaguchi K, Imajoh-Ohmi S, Miki Y, Nakanishi A. Centrosomal BRCA2 is a target protein of membrane type-1 matrix metalloproteinase (MT1-MMP). Biochem Biophys Res Commun. 443, 1148-1154 (2014)

Wada Y, Matsuura M, Sugawara M, Ushijima M, Miyata S, Nagasaki K, Noda T, Miki Y. Development of detection method for novel fusion gene using genechip exon array. J Clin Bioinforma 2014; 4(1): 3.

Tan TZ, Miow QH, Miki Y, Noda T, Mori S, Huang RY, Thiery JP. Epithelial-mesenchymal transition spectrum quantification and its efficacy in deciphering survival and drug responses of cancer patients. EMBO Mol Med 2014; 6(10): 1279-93.

2013

Nakamura S, Takahashi M, Tozaki M, Nakayama T, Nomizu T, Miki Y, Murakami Y, Aoki D, Iwase T, Nishimura S, Yamauchi H, Ohsumi S, Baba S, Shimizu T. Prevalence and differentiation of hereditary breast and ovarian cancers in japan. Breast Cancer 2013.

Mimoto R, Taira N, Takahashi H, Yamaguchi T, Okabe M, Uchida K, Miki Y*, Yoshida K. Dyrk2 controls the epithelial-mesenchymal transition in breast cancer by degrading snail. Cancer Lett 2013; 339(2): 214-25.

Low SK, Takahashi A, Ashikawa K, Inazawa J, Miki Y, Kubo M, Nakamura Y, Katagiri T. Genome-wide association study of breast cancer in the japanese population. PLoS One 2013; 8(10): e76463.

Kawazu M, Ueno T, Kontani K, Ogita Y, Ando M, Fukumura K, Yamato A, Soda M, Takeuchi K, Miki Y, Yamaguchi H, Yasuda T, Naoe T, Yamashita Y, Katada T, Choi YL, Mano H. Transforming mutations of rac guanosine triphosphatases in human cancers. Proc Natl Acad Sci U S A 2013; 110(8): 3029-34.

2012

Wang L, Tsutsumi S, Kawaguchi T, Nagasaki K, Tatsuno K, Yamamoto S, Sang F, Sonoda K, Sugawara M, Saiura A, Hirono S, Yamaue H, Miki Y, Isomura M, Totoki Y, Nagae G, Isagawa T, Ueda H, Murayama-Hosokawa S, Shibata T, Sakamoto H, Kanai Y, Kaneda A, Noda T, Aburatani H. Whole-exome sequencing of human pancreatic cancers and characterization of genomic instability caused by mlh1 haploinsufficiency and complete deficiency. Genome Res 2012; 22(2): 208-19.

Taira N, Mimoto R, Kurata M, Yamaguchi T, Kitagawa M, Miki Y*, Yoshida K. Dyrk2 priming phosphorylation of c-jun and c-myc modulates cell cycle progression in human cancer cells. J Clin Invest 2012; 122(3): 859-72.

Suzuki K, Dashzeveg N, Lu ZG, Taira N, Miki Y*, Yoshida K. Programmed cell death 6, a novel p53-responsive gene, targets to the nucleus in the apoptotic response to DNA damage. Cancer Sci 2012; 103(10): 1788-94.

Satoh Y, Sugai S, Uehara H, Mun M, Sakao Y, Okumura S, Nakagawa K, Ishikawa Y, Miki Y, Miyata S. Clinical impact of intraoperative detection of carcinoembryonic antigen mrna in pleural lavage specimens from nonsmall cell lung cancer patients. Thorac Cardiovasc Surg 2012; 60(8): 533-40.

Sakamoto K, Fujii T, Kawachi H, Miki Y, Omura K, Morita K, Kayamori K, Katsube K, Yamaguchi A. Reduction of notch1 expression pertains to maturation abnormalities of keratinocytes in squamous neoplasms. Lab Invest 2012; 92(5): 688-702.

Khanom R, Sakamoto K, Pal SK, Shimada Y, Morita K, Omura K, Miki Y, Yamaguchi A. Expression of basal cell keratin 15 and keratin 19 in oral squamous neoplasms represents diverse pathophysiologies. Histol Histopathol 2012; 27(7): 949-59.

2011

Wang, HF., Takenaka, K., Nakanishi, A. and Miki Y. BRCA2 and nucleophosmin coregulate centrosome amplification and form a complex with the Rho effector kinase ROCK2. Cancer Res. 71, 68-77 (2011)

Sakamoto K, Aragaki T, Morita K, Kawachi H, Kayamori K, Nakanishi S, Omura K, Miki Y, Okada N, Katsube K, Takizawa T, Yamaguchi A. Down-regulation of keratin 4 and keratin 13 expression in oral squamous cell carcinoma and epithelial dysplasia: A clue for histopathogenesis. Histopathology 2011; 58(4): 531-42.

Kimura J, Kudoh T, Miki Y*, Yoshida K. Identification of dihydropyrimidinase-related protein 4 as a novel target of the p53 tumor suppressor in the apoptotic response to DNA damage. Int J Cancer 2011; 128(7): 1524-31.

Ito Y, Nagasaki K, Miki Y, Iwase T, Akiyama F, Matsuura M, Horii R, Makita M, Tokudome N, Ushijima M, Yoshimoto M, Takahashi S, Noda T, Hatake K. Prospective randomized phase ii study determines the clinical usefulness of genetic biomarkers for sensitivity to primary chemotherapy with paclitaxel in breast cancer. Cancer Sci 2011; 102(1): 130-6.

Hew HC, Liu H, Miki Y*, Yoshida K. Pkcdelta regulates mdm2 independently of p53 in the apoptotic response to DNA damage. Mol Carcinog 2011; 50(9): 719-31.

Hew HC, Liu H, Lu ZG, Kimura J, Miki Y*, Yoshida K. Identification of evi-1 as a novel effector of pkcdelta in the apoptotic response to DNA damage. Biochim Biophys Acta 2011; 1809(7): 285-94.