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原著論文

Eichi Watabe, Shoichiro Ono and Hidehito Kuroyanagi.
Alternative splicing of the Caenorhabditis elegans lev-11 tropomyosin gene is regulated in a tissue-specific manner.
Cytoskeleton. 2018. doi: 10.1002/cm.21489.
PMID:30155988

Hiroaki Iwasa, Aradhan Sarkar, Takanobu Shimizu, Takeru Sawada, Shakhawoat Hossain, Xiaoyin Xu, Junichi Maruyama, Kyoko Arimoto‐Matsuzaki, Kanchanamala Withanage, Kentaro Nakagawa, Hidetake Kurihara, Hidehito Kuroyanagi, Yutaka Hata.
UNC119 is a binding partner of a tumor suppressor RASSF6 and induces apoptosis and cell cycle arrest via MDM2 and p53.
Cancer Science. 109: 2767-2780, 2018.
PMID:29931788

Rie Murayama, Mariko Kimura-Asami, Marina Togo-Ohno, Yumiko Yamasaki-Kato, Taeko K. Naruse, Takeshi Yamamoto, Takeharu Hayashi, Tomohiko Ai, Katherine G. Spoonamore, Richard J. Kovacs, Matteo Vatta, Mai Iizuka, Masumi Saito, Shotaro Wani, Yuichi Hiraoka, Akinori Kimura and Hidehito Kuroyanagi.
Phosphorylation of the RSRSP stretch is critical for splicing regulation by RNA-Binding Motif Protein 20 (RBM20) through nuclear localization.
Scientific Reports. 8: 8970, 2018.
PMID:29895960
プレスリリース:拡張型心筋症の原因変異が分子ばねタンパク質の発現に影響するしくみを解明
日本経済新聞:東京医科歯科大、難治性心臓病 原因遺伝子発見、心筋のばね弱く
日刊工業新聞:拡張型心筋症、たんぱく質の変異起因 東京医科歯科大が発見
EurekAlert!:拡張型心筋症の原因変異が分子ばねタンパク質の発現に影響するしくみを解明
Science Daily: Of hearts and giants: Moving a cardiac regulatory protein to the right place
Technology Networks: Of Hearts and Giants: Biggest Protein Helps Study Cardiac Disease
MedicalXpress: Moving a cardiac regulatory protein to the right place

Dawn E. Barnes, Eichi Watabe, Kanako Ono, Euiyoung Kwak, Hidehito Kuroyanagi, Shoichiro Ono.
Tropomyosin isoforms differentially affect muscle contractility in the head and body regions in the nematode Caenorhabditis elegans.
Molecular Biology of the Cell. 29: 1075-1088, 2018.
PMID:29496965
新学術領域研究「ノンコーディングRNAネオタクソノミ」:線虫も紅をさす!?

Masahiro Tomioka, Yasuki Naito, Hidehito Kuroyanagi & Yuichi Iino.
Splicing factors control C. elegans behavioural learning in a single neuron by producing DAF-2c receptor.
Nature Communications. doi:10.1038/ncomms11645, 2016.
PMID:27198602
UTokyo Research: 飢餓の記憶の形成に必要な分子が作られるしくみ
F1000Prime: Recommended by Yishi Jin
Neuroscience News: Production of a Molecule for Memory of Salt Concentration

Takei S, Togo-Ohno M, Suzuki Y, Kuroyanagi H.
Evolutionarily conserved autoregulation of alternative pre-mRNA splicing by ribosomal protein L10a.
Nucleic Acids Research. 44: 5585-5596, 2016.
PMID:26961311

Kuwasako K, Takahashi M, Unzai S, Tsuda K, Yoshikawa S, He F, Kobayashi N, Güntert P, Shirouzu M, Ito T, Tanaka A, Yokoyama S, Hagiwara M, Kuroyanagi H, Muto Y.
RBFOX and SUP-12 sandwich a G base to cooperatively regulate tissue-specific splicing.
Nature Structural & Molecular Biology. 21: 778–786, 2014.
PMID:25132178
プレスリリース:2つのタンパク質が協働してRNAを認識する新しいしくみの解明
サイエンスポータル:タンパク質が2つ協働してRNA認識
ライフサイエンス 新着論文レビュー:組織特異的にスプライシング反応を制御するRBFOXファミリーRNA結合タンパク質およびSUP-12によるRNAの協働的な認識の機構
MedicalXpress: How pairs of proteins collaborate to splice RNAs into cell-specific products

Kuroyanagi H, Takei S, Suzuki Y.
Comprehensive analysis of mutually exclusive alternative splicing in C. elegans.
Worm. 3: e28459, 2014.
PMID:25254147

Kuroyanagi H, Watanabe Y, Hagiwara M.
CELF family RNA-binding protein UNC-75 regulates two sets of mutually exclusive exons of the unc-32 gene in neuron-specific manners in Caenorhabditis elegans.
PLoS Genetics. 9: e1003337, 2013.
PMID:23468662

Kuroyanagi H, Watanabe Y, Suzuki Y, Hagiwara M.
Position-dependent and neuron-specific splicing regulation by the CELF family RNA-binding protein UNC-75 in Caenorhabditis elegans.
Nucleic Acids Research. 41: 4015-4025, 2013.
PMID:23416545

Iwasa H, Maimaiti S, Kuroyanagi H, Kawano S, Inami T, Ikeda M, Nakagawa K, Hata Y.
Yes-associated protein homolog, YAP-1, is involved in the thermotolerance and aging in the nematode Caenorhabditis elegans.
Experimental Cell Research. 319: 931–945, 2013.
PMID:23396260

Iwasa H, Kuroyanagi H, Maimaiti S, Ikeda M, Nakagawa K, Hata Y.
Characterization of RSF-1, the Caenorhabditis elegans homolog of the Ras-association domain family protein 1.
Experimental Cell Research. 319: 1–11, 2013.
PMID:23103556

Ohno G, Ono K, Togo M, Watanabe Y, Ono S, Hagiwara M, Kuroyanagi H.
Muscle-Specific Splicing Factors ASD-2 and SUP-12 Cooperatively Switch Alternative Pre-mRNA Processing Patterns of the ADF/Cofilin Gene in Caenorhabditis elegans.
PLoS Genetics. 8: e1002991, 2012.
PMID:23071450

Kuroyanagi H, Ohno G, Sakane H, Maruoka H, Hagiwara M.
Visualization and genetic analysis of alternative splicing regulation in vivo using fluorescence reporters in transgenic Caenorhabditis elegans.
Nature Protocols. 5: 1495-1517, 2010.
PMID:20725066

Ohno G, Hagiwara M, Kuroyanagi H.
STAR family RNA-binding protein ASD-2 regulates developmental switching of mutually exclusive alternative splicing in vivo.
Genes & Development. 22: 360-374, 2008.
PMID:18230701
プレスリリース:色でわかる遺伝情報発現の変化
F1000Prime: Recommended by Thomas Blumenthal

Kuroyanagi H, Ohno G, Mitani S, Hagiwara M.
The Fox-1 family and SUP-12 coordinately regulate tissue-specific alternative splicing in vivo.
Molecular and Cellular Biology. 27: 8612-8621, 2007.
PMID:17923701

Gengyo-Ando K, Kuroyanagi H, Kobayashi T, Murate M, Fujimoto K, Okabe S, Mitani S.
The SM protein VPS-45 is required for RAB-5-dependent endocytic transport in Caenorhabditis elegans.
EMBO reports. 8: 152-157, 2007.
PMID:17235359

Kuroyanagi H, Kobayashi T, Mitani S, Hagiwara M.
Transgenic alternative-splicing reporters reveal tissue-specific expression profiles and regulation mechanisms in vivo.
Nature Methods. 3: 909-915, 2006.
PMID:17060915