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Add：1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan
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Recent years have witnessed growing clinical approvals of new drug classes, including nucleic acid therapeutics, gene therapy, and mRNA vaccines, changing the concept of drugs. These new classes of drugs control the functionalities of target genes and proteins to treat diseases at molecular levels, providing hopeful options for intractable disease treatment with reduced adverse effects. Developing such new drugs requires interdisciplinary research. For example, mRNA vaccine development involves chemistry and engineering for mRNA manufacturing and nano-drug delivery systems (DDS), molecular biology and immunology of mRNA, and medical research on vaccine effects and adverse outcomes. In this interdisciplinary field, our laboratory develops nano DDSs, evaluates their biological properties, and applies them to disease treatment, focusing on mRNA vaccines and therapeutics. Moreover, we attempt clinical translation in collaboration with companies. Notably, our research interests include basic research for understanding biological processes we observe in application studies.
Join Our Laboratory: Opportunities for Master's, Doctoral, and Postdoctoral Researchers
Graduate Students
Are you a motivated graduate student looking for an exciting research opportunity? Our laboratory is seeking talented individuals to join our team. We offer graduate programs for both master's and doctoral students, covering a wide range of topics from nano DDS technology development to biological evaluation and therapeutic applications. Regardless of your academic background, we welcome applicants from any field. You will have the flexibility to choose a research theme aligned with your academic interests. We are also happy to arrange laboratory tours, including online options, at your convenience. Feel free to contact us for more information and application details. (Detailed information )
Postdoctoral Researchers
Are you a postdoctoral researcher seeking a collaborative research environment? Look no further! Our laboratory welcomes postdocs to join our team. We provide a supportive atmosphere where you can further your research and contribute to cutting-edge discoveries. We encourage you to explore the JSPS Postdoctoral Fellowships.
News
The collaborative research conducted by Dr. Le Bui Thao Nguyen, Professor Uchida, Professor Teiji Sawa (Kyoto Prefectural University of Medicine), and Professor Hiroshi Abe (Nagoya University) has been published in the Journal of Controlled Release.
Ken Kawaguchi#, Le Bui Thao Nguyen#, Mao Kinoshita, Naoko Abe, Makoto Oba, Hiroshi Abe, Kazuki Sudo, Keita Inoue, Satoshi Uchida*, Teiji Sawa*, Highly pure mRNA vaccine provides robust immunization against P. aeruginosa by minimizing type I interferon responses, Journal of Controlled Release in press doi: 10.1016/j.jconrel.2025.113860
The paper by Assistant Professor Norimatsu and colleagues was published in the journal ACS Applied Nano Materials. It will be featured in the special issue "Commemorate the Establishment of the Institute of Science Tokyo"
Jumpei Norimatsu, Rashida Hashim, Theofilus A. Tockary, Muhammad Shahid Nazir, Yuki Mochida*, Satoshi Uchida*,Polycations Improve Intracellular Stability of mRNA Delivered Using Lipid Nanoparticles for Prolonged Protein Expression, ACS Applied Nano Materials in press doi: 10.1021/acsanm.5c00633
Our new PhD students, Chen Xianyi and Zhu Xueyang, and our new Master student, Haruto Yamashita, have joined our lab.
Collaborative research, conducted by Prof. Abe, Prof. Uchida, et al., has been published in Nature Biotechnology.
Kosuke Fukuchi, Yuko Nakashima, Naoko Abe*, Seigo Kimura, Fumitaka Hashiya, Yuichi Shichino, Yiwei Liu, Ryoko Ogisu, Satomi Sugiyama, Daisuke Kawaguchi, Masahito Inagaki, Zheyu Meng, Shiryu Kajihara, Mizuki Tada, Satoshi Uchida, Ting-Ting Li, Ramkrishna Maity, Tairin Kawasaki, Yasuaki Kimura, Shintaro Iwasaki, Hiroshi Abe*, Internal cap-initiated translation for efficient protein production from circular mRNA, Nature Biotechnology in press doi: 10.1038/s41587-025-02561-8
Research on the impact of secondary structures on polymeric micelle-type drug delivery systems (DDSs), conducted by Prof. Mochida, has been published in Chemistry of Materials.
Yuki Mochida, Horacio Cabral, Yutaka Miura, Kensuke Osada, Nobuhiro Nishiyama, Kazunori Kataoka*, Secondary Structure-Guided Assembly of Uniform Disk-Like Polymeric Micelles Incorporating Hydrophobic Platinum Drugs for Improved Tumor Targeting, Chemistry of Materials in press doi: 10.1021/acs.chemmater.4c02734
Junpei Norimatsu (research assistant) has been appointed as Assistant Professor.
Our new PhD students, Muhammad Salman and Meng Yue, our new Master students, Bhaskar Chatterjee and Huang Mian, and our new Graduate Research Students, Zhang Shuyuan, Chen Xinyu and Guo Yuqi, have joined our lab.
The Department of Advanced Nano-Medical Engineering, Medical Research Institute, Tokyo Medical and Dental University has become Department of Advanced Nanomedical Engineering, Medical Research Laboratory, Institute of Integrated Research, Institute of Science Tokyo through university integration.
Research about mRNA delivery systems, conducted by Jumpei Norimatsu (research assistant),. has published a paper in Materials Horizons.
Jumpei Norimatsu, Hayato L. Mizuno, Takayoshi Watanabe, Takumi Obara, Makoto Nakakido, Kouhei Tsumoto, Horacio Cabral, Daisuke Kuroda, Yasutaka Anraku,Triphenylphosphonium-modified catiomers enhance in vivo mRNA delivery through stabilized polyion complexation, Materials Horizons in press doi: 10.1039/D4MH00325J
The memeber pages of Project Assistant Professor Ishikawa and Post-doc Le Bui Thao Nguyen are now available.
Collaborative research, conducted by Prof. Mochida, Prof. Naito, and Prof. Miyata, has been published in Bioconjugate Chemistry.
Yukine Ishibashi, Mitsuru Naito*, Yusuke Watanuki, Mao Hori, Satomi Ogura, Kaori Taniwaki, Masaru Cho, Ryosuke Komiya, Yuki Mochida, Kanjiro Miyata*, Size-Dependent Glioblastoma Targeting by Polymeric Nanoruler with Prolonged Blood Circulation , Bioconjugate Chemistry in press doi: 10.1021/acs.bioconjchem.4c00235
Our new project assistant professor, Junichi Ishikawa, has joined our Lab.
The annual report for 2024 has been published.
We issued a press release regarding the paper published in Angewandte Chemie International Edition (EurekAlert).
Our paper is highlighted in “In This Issue” in Molecular Therapy.
Collaborative research, conducted by Dr. Guyse and Prof. Uchida, has been published in Angewandte Chemie International Edition.
Joachim F. R. Van Guyse#,*, Saed Abbasi#, Kazuko Toh, Zlata Nagorna, Junjie Li, Anjaneyulu Dirisala, Sabina Quader, Satoshi Uchida, Kazunori Kataoka*,
Facile generation of heterotelechelic poly(2-oxazoline)s towards accelerated exploration of poly(2-oxazoline)-based nanomedicine, Angewandte Chemie International Edition e202404972, (2024) in press
Our paper published in Small Science has been selected as Inside Front Cover.
Research about mRNA vaccines against COVID-19, conducted by Prof. Uchida, et al., has been published in Molecular therapy, along with a press release on EurekAlert.
Saed Abbasi, Miki Matsui-Masai, Fumihiko Yasui, Akimasa Hayashi, Theofilus A. Tockary, Yuki Mochida, Shiro Akinaga, Michinori Kohara, Kazunori Kataoka*, Satoshi Uchida*,
Carrier-free mRNA vaccine induces robust immunity against SARS-CoV-2 in mice and non-human primates without systemic reactogenicity, Molecular Therapy in press doi: 10.1016/j.ymthe.2024.03.022
Our new research assistant, Jumpei Norimatsu, our new post-doc, Le Bui Thao Nguyen, and our new master's student, Sae Takagi, have joined our Lab.