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Recent years have witnessed growing clinical approvals of new drug classes, including nucleic acid therapeutics, gene therapy, and mRNA vaccines, changing the concept of drugs. These new classes of drugs control the functionalities of target genes and proteins to treat diseases at molecular levels, providing hopeful options for intractable disease treatment with reduced adverse effects. Developing such new drugs requires interdisciplinary research. For example, mRNA vaccine development involves chemistry and engineering for mRNA manufacturing and nano-drug delivery systems (DDS), molecular biology and immunology of mRNA, and medical research on vaccine effects and adverse outcomes. In this interdisciplinary field, our laboratory develops nano DDSs, evaluates their biological properties, and applies them to disease treatment, focusing on mRNA vaccines and therapeutics. Moreover, we attempt clinical translation in collaboration with companies. Notably, our research interests include basic research for understanding biological processes we observe in application studies.
Join Our Laboratory: Opportunities for Master's, Doctoral, and Postdoctoral Researchers
Graduate Students
Are you a motivated graduate student looking for an exciting research opportunity? Our laboratory is seeking talented individuals to join our team. We offer graduate programs for both master's and doctoral students, covering a wide range of topics from nano DDS technology development to biological evaluation and therapeutic applications. Regardless of your academic background, we welcome applicants from any field. You will have the flexibility to choose a research theme aligned with your academic interests. We are also happy to arrange laboratory tours, including online options, at your convenience. Feel free to contact us for more information and application details. (Detailed information )
Postdoctoral Researchers
Are you a postdoctoral researcher seeking a collaborative research environment? Look no further! Our laboratory welcomes postdocs to join our team. We provide a supportive atmosphere where you can further your research and contribute to cutting-edge discoveries. We encourage you to explore the JSPS Postdoctoral Fellowships.
News
The collaborative research conducted by Prof. Yasuo Yanagi and Prof. Satoshi Uchida has been published in Vaccine.
Yasuo Yanagi*, Hinako Ichikawa, Le Bui Thao Nguyen, Akimasa Hayashi, Naoko Abe, Hiroshi Abe, Satoshi Uchida*, mRNA vaccination mitigates pathological retinochoroidal neovascularization in animal models, Vaccine 61, 127451, (2025)
The research conducted by Victor Marx, Dr. Mochida, Prof. Uchida has been published in ACS Applied Nano Materials.
Victor Marx, Yuki Mochida*, Shigehito Osawa, Theofilus A. Tockary, Jumpei Norimatsu, Hidetomo Yokoo, Makoto Oba, Satoshi Uchida*, Poly(sarcosine) and Poly(2-ethyl-2-oxazoline) Tethered To mRNA Provide Stealth Properties To mRNA Polyplexes, ACS Applied Nano Materials in press doi: 10.1021/acsanm.5c00636
Our research, titled 'Polycations Enhance the Intracellular Stability of mRNA Delivered via Lipid Nanoparticles for Sustained Protein Expression' presented by Assistant Professor Norimatsu, received the Materials Advances Oral Presentation Award at the 41st Annual Meeting of the DDS Society.
The collaborative research conducted by Nan Qiao, Professor Satoshi Uchida, and Professor Kanjiro Miyata (The University of Tokyo) has been published in Biomaterials.
Nan Qiao, Mao Hori*, Mitsuru Naito, Heemin Chang, Satomi Ogura, Mika Suzuki, Tsuyoshi Kimura, Shigeto Fukushima, Hyun Jin Kim, Satoshi Uchida*, Kanjiro Miyata*, Increasing polycation hydrophobicity in mRNA polyplex vaccines enhances the efficacy of humoral and cellular immunity induction, Biomaterials in press doi: 10.1016/j.biomaterials.2025.123515
A paper by Professor Uchida and Prof. Kazunori Kataoka (iCONM) has been published in the Journal of Controlled Release.
Anjaneyulu Dirisala, Satoshi Uchida*, Kazuko Toh, Junjie Li, Xueying Liu, Panyue Wen, Shigeto Fukushima, Kazunori Kataoka*, Structural stability and RNase resistance of mRNA Polyplex micelles for systemic delivery, Journal of Controlled Release in press doi: 10.1016/j.jconrel.2025.113935
Our paper published in ACS Applied Nano Materials has been selected as the journal cover.
The collaborative research conducted by Dr. Le Bui Thao Nguyen, Professor Uchida, Professor Teiji Sawa (Kyoto Prefectural University of Medicine), and Professor Hiroshi Abe (Nagoya University) has been published in the Journal of Controlled Release.
Ken Kawaguchi#, Le Bui Thao Nguyen#, Mao Kinoshita, Naoko Abe, Makoto Oba, Hiroshi Abe, Kazuki Sudo, Keita Inoue, Satoshi Uchida*, Teiji Sawa*, Highly pure mRNA vaccine provides robust immunization against P. aeruginosa by minimizing type I interferon responses, Journal of Controlled Release in press doi: 10.1016/j.jconrel.2025.113860
The paper by Assistant Professor Norimatsu and colleagues was published in the journal ACS Applied Nano Materials. It will be featured in the special issue "Commemorate the Establishment of the Institute of Science Tokyo"
Jumpei Norimatsu, Rashida Hashim, Theofilus A. Tockary, Muhammad Shahid Nazir, Yuki Mochida*, Satoshi Uchida*,Polycations Improve Intracellular Stability of mRNA Delivered Using Lipid Nanoparticles for Prolonged Protein Expression, ACS Applied Nano Materials in press doi: 10.1021/acsanm.5c00633
Our new PhD students, Chen Xianyi and Zhu Xueyang, and our new Master student, Haruto Yamashita, have joined our lab.