業績

2020年度

  1. Sayuri Nitta, Kazuaki Takahashi, Fukiko Kawai-Kitahata, Jun Tsuchiya, Ayako Sato, Masato Miyoshi, Miyako Murakawa, Yasuhiro Istui, Mina Nakagawa, Seishin Azuma, Sei Kakinuma, Mamoru Watanabe, Yasuhiro Asahina. Time course alterations of virus sequences and immunoglobulin titers in a chronic hepatitis E patient Hepatol Res. 2020; Apr;50(4):524-531. PMID: 31883166 DOI: 10.1111/hepr.13480

  2. Kana Otsubo, Chiaki Maeyashiki, Yoichi Nibe, Akiko Tamura, Emi Aonuma, Hiroki Matsuda, Masanori Kobayashi, Michio Onizawa, Yasuhiro Nemoto, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Satoru Torii, Eisuke Itakura, Mamoru Watanabe, Shigeru Oshima. Receptor-Interacting Protein Kinase 3 (RIPK3) inhibits autophagic flux during necroptosis in intestinal epithelial cells. FEBS Letters. 2020.01; 594; 1586-1595 , PMID: 31997355 DOI: 10.1002/1873-3468.13748

  3. Toshifumi Hibi, Makoto Naganuma, Eisei Oda, Yoji Yamada, Yoshitomo Chujoh, Ryoichi Yoshihara, Mamoru Watanabe. Predictive factors for achievement of mucosal healing by budesonide 2-mg foam in ulcerative colitis: a pooled analysis of data from two clinical trials. Intest Res. 2020.01; 18(1); 56-68, PMID: 31813214 PMCID: PMC7000644 DOI: 10.5217/ir.2019.00064

  4. Shohei Tanaka, Yasuhiro Nemoto, Yuria Takei, Ryo Morikawa, Shigeru Oshima, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Susanne Stutte, Mamoru Watanabe. High-fat diet-derived free fatty acids impair the intestinal immune system and increase sensitivity to intestinal epithelial damage. Biochem Biophys Res Commun. 2020.02; 522(4); 971-977 PMID: 31810607 DOI: 10.1016/j.bbrc.2019.11.158

  5. Kento Takenaka, Kazuo Ohtsuka, Toshimitsu Fujii, Mariko Negi, Kohei Suzuki, Hiromichi Shimizu, Shiori Oshima, Shintaro Akiyama, Maiko Motobayashi, Masakazu Nagahori, Eiko Saito, Katsuyoshi Matsuoka, Mamoru Watanabe. Development and Validation of a Deep Neural Network for Accurate Evaluation of Endoscopic Images From Patients With Ulcerative Colitis. Gastroenterology. 2020.02; PMID: 32060000 DOI: 10.1053/j.gastro.2020.02.012

  6. Ryuichi Okamoto, Hiromichi Shimizu, Kohei Suzuki, Ami Kawamoto, Junichi Takahashi, Mao Kawai, Sayaka Nagata, Yui Hiraguri, Sayaka Takeoka, Hady Yuki Sugihara, Shiro Yui, Mamoru Watanabe. Organoid-based regenerative medicine for inflammatory bowel disease. Regen Ther. 2020.03; 13; 1-6, PMID: 31970266 PMCID: PMC6961757 DOI: 10.1016/j.reth.2019.11.004

  7. Yuria Takei, Yasuhiro Nemoto, Ryo Morikawa, Shohei Tanaka, Shigeru Oshima, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe. T cells show amoeboid shape and frequent morphological change in vitro, and localize to small intestinal intraepithelial region in vivo. Biochem Biophys Res Commun. 2020.03; 523(2); 328-335 PMID: 31864702 DOI: 10.1016/j.bbrc.2019.12.021

  8. Kento Takenaka, Yoshio Kitazume, Toshimitsu Fujii, Kiichiro Tsuchiya, Mamoru Watanabe, Kazuo Ohtsuka. Objective evaluation for treat to target in Crohn’s disease. J Gastroenterol. 2020.03; 55(3); 579-587 PMID: 32130521 PMCID: PMC7242491 DOI: 10.1007/s00535-020-01678-8

  9. Sho Anzai, Ami Kawamoto, Sayaka Nagata, Junichi Takahashi, Mao Kawai, Reiko Kuno, Sakurako Kobayashi, Satoshi Watanabe, Kohei Suzuki, Hiromichi Shimizu, Yui Hiraguri, Sayaka Takeoka, Hady Yuki Sugihara, Shiro Yui, Shigeru Oshima, Mamoru Watanabe, Ryuichi Okamoto. TGF-β promotes fetal gene expression and cell migration velocity in a wound repair model of untransformed intestinal epithelial cells. Biochem Biophys Res Commun. 2020.04; 524(3); 533-541 PMID: 32014254 DOI: 10.1016/j.bbrc.2020.01.108

  10. Kento Takenaka, Toshimitsu Fujii, Kohei Suzuki, Hiromichi Shimizu, Maiko Motobayashi, Shuji Hibiya, Eiko Saito, Masakazu Nagahori, Mamoru Watanabe, Kazuo Ohtsuka. Small bowel healing detected by endoscopy in patients with Crohn’s disease after treatment with antibodies against tumor necrosis factor. Clin Gastroenterol Hepatol. 2020.06; 18(7); 1545-1552 PMID: 31442600 DOI: 10.1016/j.cgh.2019.08.024

  11. Hiromichi Shimizu, Toshimitsu Fujii, Shuji Hibiya, Maiko Motobayashi, Kohei Suzuki, Kento Takenaka, Eiko Saito, Masakazu Nagahori, Kazuo Ohtsuka, Mamoru Watanabe. Rapid prediction of 1-year efficacy of tofacitinib for treating refractory ulcerative colitis. Intest Res. 2020.06; Online ahead of print. PMID: 32516866 PMCID: PMC7873398 DOI: 10.5217/ir.2020.00030

  12. Yasuhiro Asahina, and Drafting Committee for Hepatitis Management Guidelines, the Japan Society of Hepatology. JSH guidelines for the management of hepatitis C virus infection, 2019 update; protective effect of antiviral therapy against hepatocarcinogenesis. Hepatol Res. 2020.07; 50(7); 775-790 PMID: 32298527 DOI: 10.1111/hepr.13501

  13. Mina Nakagawa, Nobutoshi Nawa, Eiko Takeichi, Taro Shimizu, Jun Tsuchiya, Ayako Sato, Masato Miyoshi, Fukiko Kawai-Kitahata, Miyako Murakawa, Sayuri Nitta, Yasuhiro Itsui, Seishin Azuma, Sei Kakinuma, Takeo Fujiwara, Mamoru Watanabe, Yujiro Tanaka, Yasuhiro Asahina. Mac-2 binding protein glycosylation isomer as a novel predictive biomarker for patient survival after hepatitis C virus eradication by DAAs. J Gastroenterol. 2020.08; 55; 990-999 PMID: 32770465 DOI: 10.1007/s00535-020-01715-6

  14. Kento Takenaka, Kazuo Ohtsuka, Kohei Suzuki, Mamoru Watanabe. Reply to GASTRO-D- 20-00591 Gastroenterology. 2020.10; 159(4); 1626-1627

  15. Yasuhiro Asahina, Chun-Jen Liu, Edward Gane, Yoshito Itoh, Norifumi Kawada, Yoshiyuki Ueno, Jin Youn, Chen-Yu Wang, Joe Llewellyn, Takuma Matsuda, Anuj Gaggar, Hongmei Mo, Hadas Dvory-Sobol, Gerald Crans, Wan-Long Chuang, Pei-Jer Chen, Nobuyuki Enomoto. Twelve weeks of ledipasvir/sofosbuvir all-oral regimen for patients with chronic hepatitis C genotype 2 infection: Integrated analysis of three clinical trials. Hepatol Res. 2020.10; 50(10); 1109-1117 PMID: 32614468 DOI: 10.1111/hepr.13546

  16. Yasuharu Maeda, Shin-Ei Kudo, Noriyuki Ogata, Yuichi Mori, Masashi Misawa, Mayumi Homma, Tetsuo Nemoto, Masataka Ogawa, Seiko Sasanuma, Yuta Sato, Shinichi Kataoka, Yuta Kouyama, Tatsuya Sakurai, Kenta Igarashi, Yushi Ogawa, Kazuki Kato, Katsuro Ichimasa, Hiroki Nakamura, Toyoki Kudo, Takemasa Hayashi, Kunihiko Wakamura, Toshiyuki Baba, Haruhiro Inoue, Kazuo Ohtsuka. Endocytoscopic intramucosal capillary network changes and crypt architecture abnormalities can predict relapse in patients with an ulcerative colitis Mayo endoscopic score of 1. Dig Endosc. 2020.11; 32(7); 1082-1091 PMID: 32073691DOI: 10.1111/den.13655

  17. Asakawa T, Onizawa M, Saito C, Hikichi R, Yamada D, Minamidate A, Mochimaru T, Asahara SI, Kido Y, Oshima S, Nagaishi T, Tsuchiya K, Ohira H, Okamoto R, Watanabe M. Oral administration of D-serine prevents the onset and progression of colitis in mice. J Gastroenterol. 2021 Jun 20. PMID: 34148144 DOI: 10.1007/s00535-021-01792-1

  18. Kuno R, Ito G, Kawamoto A, Hiraguri Y, Sugihara HY, Takeoka S, Nagata S, Takahashi J, Tsuchiya M, Anzai S, Mizutani T, Shimizu H, Yui S, Oshima S, Tsuchiya K, Watanabe M, Okamoto R. Notch and TNF-α signaling promote cytoplasmic accumulation of OLFM4 in intestinal epithelium cells and exhibit a cell protective role in the inflamed mucosa of IBD patients. Biochem Biophys Rep. 2021 Jan11;25:100906. PMID: 33490652 PMCID: PMC7808948 DOI: 10.1016/j.bbrep.2020.100906

  19. Tsuchiya M, Ito G, Hama M, Nagata S, Kawamoto A, Suzuki K, Shimizu H, Anzai S, Takahashi J, Kuno R, Takeoka S, Hiraguri Y, Sugihara HY, Mizutani T, Yui S, Oshima S, Tsuchiya K, Watanabe M, Okamoto R. Functional analysis of isoflavones using patient-derived human colonic organoids. Biochem Biophys Res Commun. 2021 Jan 20;542:40-47. PMID: 33486190 DOI: 10.1016/j.bbrc.2021.01.021

  20. Naoya Tsugawa, Daiki Yamada, Taro Watabe, Michio Onizawa, Shuang Wang, Yasuhiro Nemoto, Shigeru Oshima, Takeshi Tsubata, Takahiro Adachi, Yohei Kawano, Mamoru Watanabe, Richard S. Blumberg, Ryuichi Okamoto, Takashi Nagaishi. CEACAM1 specifically suppresses B cell receptor signaling-mediated activation. Biochemical and Biophysical Research Communications. Biochem Biophys Res Commun. 2021 Jan 8;535:99-105. PMID: 33352461 DOI: 10.1016/j.bbrc.2020.11.126

  21. Nobuhiro Katsukura, Sho Watanabe, Tomoaki Shirasaki, Shuji Hibiya, Yoshihito Kano, Keiichi Akahoshi, Minoru Tanabe, Susumu Kirimura, Takumi Akashi, Masanobu Kitagawa, Ryuichi Okamoto, Mamoru Watanabe, Kiichiro Tsuchiya. Intestinal phenotype is maintained by Atoh1 in the cancer region of intraductal papillary mucinous neoplasm. Cancer Science. 2021 Feb;112(2):932-944. PMID: 33275808 PMCID: PMC7894004 DOI: 10.1111/cas.14755

  22. Morikawa R, Nemoto Y, Yonemoto Y, Tanaka S, Takei Y, Oshima S, Nagaishi T, Tsuchiya K, Nozaki K, Mizutani T, Nakamura T, Watanabe M, Okamoto R. Intraepithelial Lymphocytes Suppress Intestinal Tumor Growth by Cell-to-Cell Contact via CD103/E-Cadherin Signal. Cell Mol Gastroenterol Hepatol. 2021;11(5):1483-1503. PMID: 33515805 PMCID: PMC8025200 DOI: 10.1016/j.jcmgh.2021.01.014

  23. Shimizu H, Fujii T, Hibiya S, Motobayashi M, Suzuki K, Takenaka K, Saito E, Nagahori M, Ohtsuka K, Watanabe M. Rapid prediction of 1-year efficacy of tofacitinib for treating refractory ulcerative colitis. Intest Res. 2021 Jan;19(1):115-118. doi: 10.5217/ir.2020.00030. Epub 2020 Jun 11. PMID: 32516866 PMCID: PMC7873398 DOI: 10.5217/ir.2020.00030