業績

2021年度

  1. Morikawa R, Nemoto Y, Yonemoto Y, Tanaka S, Takei Y, Oshima S, Nagaishi T, Tsuchiya K, Nozaki K, Mizutani T, Nakamura T, Watanabe M, Okamoto R. Intraepithelial Lymphocytes Suppress Intestinal Tumor Growth by Cell-to-Cell Contact via CD103/E-Cadherin Signal. Cell Mol Gastroenterol Hepatol. 2021; 11(5); 1483-1503. PMID: 33515805 PMCID: PMC8025200 DOI: 10.1016/j.jcmgh.2021.01.014

  2. Hibiya S, Matsuyama Y, Fujii T, Maeyashiki C, Saito E, Ito K, Shimizu H, Kawamoto A, Motobayashi M, Takenaka K, Nagahori M, Kurosaki M, Yauchi T, Ohtsuka K, Fujiwara T, Okamoto R, Watanabe M. 5-aminosalicylate-intolerant patients are at increased risk of colectomy for ulcerative colitis. Aliment Pharmacol Ther. 2021; 53(1); 103-113. PMID: 33159485 DOI: 10.1111/apt.16120

  3. Tsugawa N, Yamada D, Watabe T, Onizawa M, Wang S, Nemoto Y, Oshima S, Tsubata T, Adachi T, Kawano Y, Watanabe M, Blumberg RS, Okamoto R, Nagaishi T. CEACAM1 specifically suppresses B cell receptor signaling-mediated activation. Biochem Biophys Res Commun. 2021; 535; 99-105. PMID: 33352461 DOI: 10.1016/j.bbrc.2020.11.126

  4. Kitazume Y, Takenaka K, Ohtsuka K, Kimura K, Ogihara Y, Fujioka T, Tsuchiya J, Fujii T, Watanabe M, Tateisi U. Crohn disease: magnetic resonance enterocolonography features of endoscopic ulcer stages reclassified with the healing process and the relationships to prognoses. Jpn J Radiol. 2021; 39(5); 459-476. PMID: 33438096 DOI: 10.1007/s11604-020-01082-5

  5. Kato S, Shimizu H, Tomii S, Uchida H, Kawamoto A, Hibiya S, Motobayashi M, Takenaka K, Fujii T, Saito E, Nagahori M, Ohtsuka K, Negi M, Akashi T, Matsuyama T, Kinugasa Y, Watanabe M. Substantial Epstein-Barr virus reactivation in a case of severe refractory ulcerative colitis: a possible role in exacerbation. Clin J Gastroenterol. 2021; 14(2); 584-588. PMID: 33400186 DOI: 10.1007/s12328-020-01319-w

  6. Aonuma E, Tamura A, Matsuda H, Asakawa T, Sakamaki Y, Otsubo K, Nibe Y, Onizawa M, Nemoto Y, Nagaishi T, Tsuchiya K, Nakamura T, Uo M, Watanabe M, Okamoto R, Oshima S. Nickel ions attenuate autophagy flux and induce transglutaminase 2 (TG2) mediated post-translational modification of SQSTM1/p62. Biochem Biophys Res Commun. 2021; 542; 17-23. PMID: 33482469 DOI: 10.1016/j.bbrc.2021.01.023

  7. Tsugeno Y, Kawachi H, Kirimura S, Hirota Y, Shintaku H, Ito T, Kikuchi A, Ohtsuka K, Akashi T, Kitagawa M. Adenocarcinoma arising in the multiple heterotopic submucosal glands of the intestine in a Satoyoshi syndrome patient: A case report. Pathol Int. 2021; 71(2); 147-154. PMID: 33333628 DOI: 10.1111/pin.13053

  8. Tsuchiya M, Ito G, Hama M, Nagata S, Kawamoto A, Suzuki K, Shimizu H, Anzai S, Takahashi J, Kuno R, Takeoka S, Hiraguri Y, Sugihara HY, Mizutani T, Yui S, Oshima S, Tsuchiya K, Watanabe M, Okamoto R. Functional analysis of isoflavones using patient-derived human colonic organoids. Biochem Biophys Res Commun. 2021; 542; 40-47. PMID: 33486190 DOI: 10.1016/j.bbrc.2021.01.021

  9. Kudo SE, Maeda Y, Ogata N, Misawa M, Ogawa Y, Takishima K, Ishiyama M, Mochizuki K, Minegishi Y, Ogura Y, Abe M, Okumura T, Matsudaira S, Ishigaki T, Sasanuma S, Mori Y, Kudo T, Hayashi T, Wakamura K, Miyachi H, Baba T, Ishida F, Nemoto T, Hamatani S, Ohtsuka K. Combined endocytoscopy with pit pattern diagnosis in ulcerative colitis-associated neoplasia: Pilot study. Dig Endosc. 2022 Jan;34(1):133-143. PMID: 33641190 DOI: 10.1111/den.13964

  10. Kuno R, Ito G, Kawamoto A, Hiraguri Y, Sugihara HY, Takeoka S, Nagata S, Takahashi J, Tsuchiya M, Anzai S, Mizutani T, Shimizu H, Yui S, Oshima S, Tsuchiya K, Watanabe M, Okamoto R. Notch and TNF-α signaling promote cytoplasmic accumulation of OLFM4 in intestinal epithelium cells and exhibit a cell protective role in the inflamed mucosa of IBD patients. Biochem Biophys Rep. 2021; 25; 100906. PMID: 33490652 PMCID: PMC7808948 DOI: 10.1016/j.bbrep.2020.100906

  11. Sapena V, Enea M, Torres F, Celsa C, Rios J, Rizzo GEM, Nahon P, Mari˜no Z, Tateishi R, Minami T, Sangiovanni A, Forns X, Toyoda H, Brillanti S, Conti F, Degasperi E, Yu ML, Tsai PC, Jean K, El Kassas M, Shousha HI, Omar A, Zavaglia C, Nagata H, Nakagawa M, Asahina Y, Singal AG, Murphy C, Kohla M, Masetti C, Dufour JF, Merchante N, Cavalletto L, Chemello LL, Pol S, Crespo J, Calleja JL, Villani R, Serviddio G, Zanetto A, Shalaby S, Russo FP, Bielen R, Trevisani F, Camm` C, Bruix J, Cabibbo G, Reig M. Hepatocellular carcinoma recurrence after direct-acting antiviral therapy: an individual patient data meta-analysis. Gut. 2022 Mar;71(3):593-604. PMID: 33741640 DOI: 10.1136/gutjnl-2020-323663

  12. Saito Y, Kodashima S, Matsuda T, Matsuda K, Fujishiro M, Tanaka K, Kobayashi K, Katada C, Horimatsu T, Muto M, Ohtsuka K, Oda I, Kato M, Kida M, Hoteya S, Yamamoto H, Ryozawa S, Iwakiri R, Kutsumi H, Kato M, Haruma K, Fujimoto K, Iishi H, Ogata H, Uemura N, Kaminishi M, Tajiri H, Inoue H. Current status of diagnostic and therapeutic colonoscopy in Japan: The Japan EndoscopicDatabase Project. Dig Endosc. 2022 Jan;34(1):144-152. PMID: 33774877 DOI: 10.1111/den.13980

  13. Kaneshiro M, Takenaka K, Suzuki K, Fujii T, Hibiya S, Kawamoto A, Motobayashi M, Shimizu H, Nagahori M, Saito E, Okamoto R, Ohtsuka K, Watanabe M. Pancolonic endoscopic and histologic evaluation for relapse prediction in patients with ulcerative colitis in clinical remission. Aliment Pharmacol Ther. 2021; 53(8); 900-907. PMID: 33745170 DOI: 10.1111/apt.16302

  14. Maeda Y, Kudo SE, Takishima K, Misawa M, Ogata N, Ohtsuka K. Letter: the combination of histologic remission and Mayo endoscopic score 1 as a suitable therapeutic target in ulcerative colitis. Aliment Pharmacol Ther.  2021; 53(8); 955-956. PMID: 33745170 DOI: 10.1111/apt.16302

  15. Takenaka K, Ohtsuka K, Fujii T, Oshima S, Okamoto R, Watanabe M. Deep Neural Network Accurately Predicts Prognosis of Ulcerative Colitis Using Endoscopic Images. Gastroenterology. 2021; 160(6); 2175-2177. PMID: 33485853 DOI: 10.1053/j.gastro.2021.01.210

  16. Ito G, Yui S, Okamoto R. A Cellular ”Hub” Function to Resolve Colitis. Cell Mol Gastroenterol Hepatol. 2021; 12(2); 789-790. PMID: 33971162 PMCID: PMC8348527 DOI: 10.1016/j.jcmgh.2021.04.008

  17. Nagaishi T, Watabe T, Kotake K, Kumazawa T, Aida T, Tanaka K, Ono R, Ishino F, Usami T, Miura T, Hirakata S, Kawasaki H, Tsugawa N, Yamada D, Hirayama K, Yoshikawa S, Karasuyama H, Okamoto R, Watanabe M, Blumberg RS, Adachi T. Immunoglobulin A-specific deficiency induces spontaneous inflammation specifically in the ileum. Gut. 2022 Mar;71(3):487-496. PMID: 33963042 PMCID: PMC8809603 DOI: 10.1136/gutjnl-2020-322873

  18. Rao C, Frodyma DE, Southekal S, Svoboda RA, Black AR, Guda C, Mizutani T, Clevers H, Johnson KR, Fisher KW, Lewis RE. KSR1- and ERK-dependent translational regulation of the epithelial-to-mesenchymal transition. eLife. 2021; 10; e66608. PMID: 33970103 PMCID: PMC8195604 DOI: 10.7554/eLife.66608

  19. Kawamoto A, Takenaka K, Hibiya S, Ohtsuka K, Okamoto R, Watanabe M. Serum Leucine-Rich α 2 Glycoprotein: A Novel Biomarker For Small Bowel Mucosal Activity in Crohn's Disease. Clin Gastroenterol Hepatol. 2022 May;20(5):e1196-e1200. PMID: 34216822 DOI: 10.1016/j.cgh.2021.06.036

  20. Takenaka K, Kawamoto A, Hibiya S, Suzuki K, Fujii T, Motobayashi M, Shimizu H, Nagahori M, Saito E, Okamoto R, Watanabe M, Ohtsuka K. Higher concentrations of cytokine blockers are needed to obtain small bowel mucosal healing during maintenance therapy in Crohn’s disease. Aliment Pharmacol Ther. 2021; Oct;54(8):1052-1060. PMID: 34323301 DOI: 10.1111/apt.16551

  21. Mori Y, Kudo SE, Misawa M, Hotta K, Kazuo O, Saito S, Ikematsu H, Saito Y, Matsuda T, Kenichi T, Kudo T, Nemoto T, Itoh H, Mori K. Artificial intelligence-assisted colonic endocytoscopy for cancer recognition: a multicenter study. Endosc Int Open. 2021; 9(7); E1004-E1011. PMID: 34222622 PMCID: PMC8211486 DOI: 10.1055/a-1475-3624

  22. Maeda Y, Kudo SE, Ogata N, Misawa M, Mori Y, Mori K, Ohtsuka K. Can artificial intelligence help to detect dysplasia in patients with ulcerative colitis? Endoscopy. 2021; 53(7); E273-E274. PMID: 33003217 DOI: 10.1055/a-1261-2944

  23. Asakawa T, Onizawa M, Saito C, Hikichi R, Yamada D, Minamidate A, Mochimaru T, Asahara S, Kido Y, Oshima S, Nagaishi T, Tsuchiya K, Ohira H, Okamoto R, Watanabe M. Oral administration of D-serine prevents the onset and progression of colitis in mice. J Gastroenterol. 2021; 56(8); 732-745. PMID: 34148144 DOI: 10.1007/s00535-021-01792-1

  24. Ito R, Kobayashi M, Ohtsuka K, Tanabe M, Okamoto R. A rare case of hepatocellular carcinoma with bile duct invasion diagnosed by peroral cholangioscopy. VideoGIE. 2021; 6(8); 354-357. PMID: 34401630 PMCID: PMC8350986 DOI: 10.1016/j.vgie.2021.04.007

  25. Yasutomi Y, Chiba A, Haga K, Murayama G, Makiyama A, Kuga T, Watanabe M, Okamoto R, Nagahara A, Nagaishi T, Miyake S. Activated Mucosal-associated Invariant T Cells Have a Pathogenic Role in a Murine Model of Inflammatory Bowel Disease. Cell Mol Gastroenterol Hepatol.  2022;13(1):81-93. PMID: 34461283 PMCID: PMC8593615 DOI: 10.1016/j.jcmgh.2021.08.018

  26. Minamidate A, Onizawa M, Saito C, Hikichi R, Mochimaru T, Murakami M, Sakuma C, Asakawa T, Hiraoka Y, Oshima S, Nagaishi T, Tsuchiya K, Ohira H, Okamoto R, Watanabe M. A potent endocytosis inhibitor Ikarugamycin up-regulates TNF production. Biochem Biophys Rep. 2021; 27; 101065. PMID: 34286109 PMCID: PMC8274290 DOI: 10.1016/j.bbrep.2021.101065

  27. Hayakawa Y, Tsuchiya K, Kurosaki M, Yasui Y, Kaneko S, Tanaka Y, Ishido S, Inada K, Kirino S, Yamashita K, Nobusawa T, Matsumoto H, Kakegawa T, Higuchi M, Takaura K, Tanaka S, Maeyashiki C, Tamaki N, Nakanishi H, Itakura J, Takahashi Y, Asahina Y, Okamoto R, Izumi N. Early experience of atezolizumab plus bevacizumab therapy in Japanese patients with unresectable hepatocellular carcinoma in real-world practice. Invest New Drugs. 2022 Apr;40(2):392-402. PMID: 34586531 DOI: 10.1007/s10637-021-01185-4

  28. Takenaka K, Kawamoto A, Ohtsuka K. Editorial: higher concentrations of cytokine blockers are needed to obtain small bowel mucosal healing during maintenance therapy in Crohn’s disease-authors’ reply. Aliment Pharmacol Ther. 2021; 54(8); 1087. PMID: 34564889 DOI: 10.1111/apt.16579

  29. Takenaka K, Fujii T, Kawamoto A, Suzuki K, Shimizu H, Maeyashiki C, Yamaji O, Motobayashi M, Igarashi A, Hanazawa R, Hibiya S, Nagahori M, Saito E, Okamoto R, Ohtsuka K, Watanabe M. Deep neural network for video colonoscopy of ulcerative colitis: a cross-sectional study. Lancet Gastroenterol Hepatol. 2022 Mar;7(3):230-237. PMID: 34856196 DOI: 10.1016/S2468-1253(21)00372-1