業績

2023年度

  1. Uojima H, Nakabayashi K, Yamasaki K, Sugiyama M, Ishii N, Shirabe K, Kyoutou T, Ueda K, Takahama Y, Tamaki N, Kurosaki M, Hidaka H, Kusano C, Amano K, Kawaguchi T, Taketomi A, Joshita S, Umemura T, Murakawa M, Asahina Y, Suzuki T, Matsuura K, Nishimura T, Iijima H, Sakamoto K, Ito K, Nishina S, Hino K, Toyoda H, Yatsuhashi H, Kage M, Mizokami M.New chemiluminescent enzyme immunoassay for quantitative measurement of Mac-2 binding protein glycosylation isomer in chronic liver disease. J Gastroenterol. 2023.12; 58(12); 1252-1260. PMID: 37812281 DOI: 10.1007/s00535-023-02043-1

  2. Tahata Y, Hikita H, Mochida S, Enomoto N, Ido A, Kuroda H, Miki D, Kurosaki M, Hiasa Y, Sakamori R, Kawada N, Yamashita T, Suda G, Yatsuhashi H, Yoshiji H, Kato N, Takami T, Nakao K, Matsuura K, Asahina Y, Itoh Y, Tateishi R, Nakamoto Y, Kakazu E, Terai S, Shimizu M, Ueno Y, Akuta N, Miyazaki M, Nozaki Y, Kabayama M, Sobue S, Moriuchi A, Miyaki T, Kodama T, Tatsumi T, Yamada T, Takehara T. Posttreatment liver function, but not baseline liver function stratifies patient survival after direct-acting antiviral treatment in decompensated cirrhosis with hepatitis C virus. J Gastroenterol. 2023.12; 58(12); 1211-1221. PMID: 37831182 DOI: 10.1007/s00535-023-02039-x

  3. Kaneko S, Asahina Y, Murakawa M, Ueyama S, Maeyashiki C, Watanabe H, Kusano-Kitazume A, Sato A, Uchidate K, Asakawa T, Watanabe S, Iizuka Y, Shibata I, Oooka S, Karakama Y, Fujii T, Watabe T, Akahoshi K, Tanabe M, Inada K, Mochida T, Watakabe K, Shimizu T, Tsuchiya J, Miyoshi M, Kitahata-Kawai F, Nitta S, Nakagawa M, Kakinuma S, Okamoto R. Prognostic Significance of C-Reactive Protein in Unresectable Hepatocellular Carcinoma treated with Atezolizumab and Bevacizumab. Hepatol Res. 2024 Jun;54(6):562-574. PMID: 38133587 DOI: 10.1111/hepr.14001

  4. Naganuma M, Kobayashi T, Kunisaki R, Matsuoka K, Yamamoto S, Kawamoto A, Saito D, Nanki K, Narimatsu K, Shiga H, Esaki M, Yoshioka S, Kato S, Saruta M, Tanaka S, Yasutomi E, Yokoyama K, Moriya K, Tsuzuki Y, Ooi M, Fujiya M, Nakazawa A, Abe T, Hisamatsu T. Real-world efficacy and safety of advanced therapies in hospitalized patients with ulcerative colitis. J Gastroenterol. 2023.12; 58(12); 1198-1210. PMID: 37831183 DOI: 10.1007/s00535-023-02048-w

  5. Peyrin-Biroulet L, Allegretti J. R, Rubin D. T, Bressler B, Germinaro M, Huang K.-H. G, Shipitofsky N, Zhang H, Wilson R, Han C, Feagan B. G, Sandborn W. J, Panés J, Hisamatsu T, Lichtenstein G. R, Sands B. E, Dignass A. ; QUASAR Study Group. Guselkumab in Patients With Moderately to Severely Active Ulcerative Colitis: QUASAR Phase 2b Induction Study. Gastroenterology. 2023.12; 165(6); 1443-1457. PMID: 37659673 DOI: 10.1053/j.gastro.2023.08.038

  6. Suwatthanarak T, Tanjak P, Suwatthanarak T, Acharayothin O, Thanormjit K, Chaiboonchoe A, Tawantanakorn T, Phalanusitthepha C, Trakarnsanga A, Methasate A, Pithukpakorn M, Okamoto R, Chinswangwatanakul V. Exploring extracellular matrix and prostaglandin pathway alterations across varying resection margin distances of right-sided colonic adenocarcinoma. BMC Cancer. 2023.12; 23(1); 1202. PMID: 38062443 DOI: 10.1186/s12885-023-11595-7

  7. Hibiya S, Fujii T, Fujii T, Suzuki S, Kondo M, Ooka S, Furumoto Y, Azuma S, Tanaka K, Kurata H, Tanaka S, Kurosaki M, Nagayama K, Kusano F, Iizuka Y, Kawamura T, Ikemiyagi H, Sakita S, Yauchi T, Watanabe H, Kawamoto A, Matsuyama Y, Ohtsuka K, Okamoto R. COVID-19 severity is associated with the risk of gastrointestinal bleeding. BMJ Open Gastroenterol. 2023.11; 10(1):e001199. PMID: 37963649 DOI: 10.1136/bmjgast-2023-001199

  8. Kawamoto A, Takenaka K, Hibiya S, Kitazume Y, Shimizu H, Fujii T, Saito E, Ohtsuka K, Okamoto R. Combination of leucine-rich alpha-2 glycoprotein and fecal markers detect Crohn’s disease activity confirmed by balloon-assisted enteroscopy. Intest Res. 2024 Jan;22(1):65-74. PMID: 37939721 DOI: 10.5217/ir.2023.00092

  9. Himuro M, Wakabayashi Y, Taguchi T, Katahira T, Suzuki L, Iida H, Ogihara T, Nishida Y, Sasaki S, Lynn F C, Hiraoka Y, Oshima S, Okamoto R, Fujitani Y, Watada H, Miyatsuka T. Novel time-resolved reporter mouse reveals spatial and transcriptional heterogeneity during alpha cell differentiation. Diabetologia. 2024 Jan;67(1):156-169. PMID: 37870650 DOI: 10.1007/s00125-023-06028-w

  10. Kobayashi M, Katsuda H, Ohtsuka K, Okamoto R. Comparison of guidewires for successful cannulation of biliary stenosis and targeting of biliary branches in ERCP. Endosc Int Open. 2023.09; 11(9); E805-E810. PMID: 37664788 DOI: 10.1055/a-2131-5145

  11. Morimoto K, Ueda H, Asano D, Ishikawa Y, Watanabe S, Akahoshi K, Ono H, Kobayashi M, Okamoto R, Tanaka S, Tanabe M. Incidence and Mechanism of Refractory Postoperative Cholangitis After Hepatectomy with Hepaticojejunostomy. J Gastrointest Surg. 2023.08; 27(8); 1668-1676. PMID: 37268828 DOI: 10.1007/s11605-023-05724-7

  12. Miyamoto K, Sujino T, Harada Y, Ashida H, Yoshimatsu Y, Yonemoto Y, Nemoto Y, Tomura M, Melhem H, Niess J H, Suzuki T, Suzuki T, Suzuki S, Koda Y, Okamoto R, Mikami Y, Teratani T, Tanaka K F, Yoshimura A, Sato T, Kanai T. The gut microbiota-induced kynurenic acid recruits GPR35-positive macrophages to promote experimental encephalitis. Cell Rep. 2023.08; 42(8); 113005. PMID: 37590143 DOI: 10.1016/j.celrep.2023.113005

  13. Yamamoto T, Nakase H, Watanabe K, Shinzaki S, Takatsu N, Fujii T, Okamoto R, Matsuoka K, Yamada A, Kunisaki R, Matsuura M, Shiga H, Bamba S, Mikami Y, Shimoyama T, Motoya S, Torisu T, Kobayashi T, Ohmiya N, Saruta M, Matsuda K, Matsumoto T, Maemoto A, Murata Y, Yoshigoe S, Nagasaka S, Yajima T, Hisamatsu T. Diagnosis and Clinical Features of Perianal Lesions in Newly Diagnosed Crohn’s Disease: Subgroup Analysis from Inception Cohort Registry Study of Patients with Crohn’s Disease (iCREST-CD). J Crohns Colitis. 2023.08; 17(8); 1193-1206. PMID: 36869815 DOI: 10.1093/ecco-jcc/jjad038

  14. Matsuoka K, Yamazaki H, Nagahori M, Kobayashi T, Omori T, Mikami Y, Fujii T, Shinzaki S, Saruta M, Matsuura M, Yamamoto T, Motoya S, Hibi T, Watanabe M, Fernandez J, Fukuhara S, Hisamatsu T. Association of ulcerative colitis symptom severity and proctocolectomy with multidimensional patient-reported outcomes: a cross-sectional study. J Gastroenterol. 2023.08; 58(8); 751-765. PMID: 37351647 DOI: 10.1007/s00535-023-02005-7

  15. Kitazume Y, Takenaka K, Ohtsuka K, Ozawa Y, Kimura K, Watanabe R, Tsuchiya J, Fujii T, Nagahori M, Watanabe M, Tateishi U. Motility Mapping Quantification Using the Classical Optical Flow Algorithm for Small Bowel Crohn’s Disease: Comparison with Balloon-assisted Enteroscopy Findings. Magn Reson Med Sci. 2023.07; 22(3); 325-334. PMID: 35545505 DOI: 10.2463/mrms.mp.2021-0037

  16. Ueda T, Koyama F, Sugita A, Ikeuchi H, Futami K, Fukushima K, Nezu R, Iijima H, Mizushima T, Itabashi M, Watanabe K, Hata K, Shinagawa T, Matsuoka K, Takenaka K, Sasaki M, Nagayama M, Yamamoto H, Shinozaki M, Fujiya M, Kato J, Ueno Y, Tanaka S, Okita Y, Hashimoto Y, Kobayashi T, Koganei K, Uchino M, Fujii H, Suzuki Y, Hisamatsu T. Endoscopic lesions of postoperative anastomotic area in patients with Crohn’s disease in the biologic era: A Japanese multi-center nationwide cohort study. J Crohns Colitis. 2023 Dec 30;17(12):1968-1979. PMID: 37450892 DOI: 10.1093/ecco-jcc/jjad116

  17. Takahashi J, Sugihara H. Y, Kato S, Nagata S, Okamoto R, Mizutani T.Protocol to generate large human intestinal organoids using a rotating bioreactor. STAR Protocols. 2023.06; 4(3); 102374. PMID: 37352105 DOI: 10.1016/j.xpro.2023.102374

  18. Takenaka K, Kawamoto A, Kitazume Y, Fujii T, Udagawa Y, Shimizu H, Hibiya S, Nagahori M, Ohtsuka K, Watanabe M, Okamoto R. Transmural Remission Characterized by High Biologic Concentrations Demonstrates Better Prognosis in Crohn’s Disease. J Crohns Colitis. 2023.06; 17(6); 855-862. PMID: 36527678 DOI: 10.1093/ecco-jcc/jjac185

  19. Takenaka K, Kitazume Y, Kawamoto A, Fujii T, Udagawa Y, Watanabe R, Shimizu H, Hibiya S, Nagahori M, Ohtsuka K, Sato H, Hirakawa A, Watanabe M, Okamoto R. Serum Leucine-Rich α 2 Glycoprotein: A Novel Biomarker for Transmural Inflammation in Crohn’s Disease. Am J Gastroenterol. 2023.06; 118(6); 1028-1035. PMID: 36571769 DOI: 10.14309/ajg.0000000000002127

  20. Fujiwara S, Kano Y, Maejima Y, Fujioka T, Tamura K, Kirimura S, Miyake S, Okamoto R. Clinical Response of Primary Malignant Pericardial Mesothelioma with Peritoneal Dissemination to Nivolumab. Intern Med. 2024 Feb 15;63(4):513-519. PMID: 37380459 DOI: 10.2169/internalmedicine.1707-23

  21. Matsuoka K, Fujii T, Okamoto R, Yamada A, Kunisaki R, Matsuura M, Watanabe K, Shiga H, Takatsu N, Bamba S, Mikami Y, Yamamoto T, Shimoyama T, Motoya S, Torisu T, Kobayashi T, Ohmiya N, Saruta M, Matsuda K, Matsumoto T, Nakase H, Maemoto A, Shinzaki S, Murata Y, Yoshigoe S, Sasaki A, Yajima T, Hisamatsu T. Correction: Characteristics of adult patients newly diagnosed with Crohn’s disease: interim analysis of the nation-wide inception cohort registry study of patients with Crohn’s disease in Japan (iCREST-CD). J Gastroenterol. 2023.06; 58(6); 602-603. PMID: 35930087 DOI: 10.1007/s00535-022-01907-2

  22. Fujiwara S, Kawamoto A, Motobayashi M, Hibiya S, Takenaka K, Shimizu H, Saito E, Fujii T, Nagahori M, Kawata D, Umezawa N, Hosoya T, Yasuda S, Ohtsuka K, Okamoto R. Hemorrhagic gastric ulcer in a patient with Behcet’s disease successfully treated with infliximab. DEN open. 2023.04; 3(1); e196. PMID: 36540902 DOI: 10.1002/deo2.196

  23. Watanabe S, Ogasawara N, Kobayashi S, Kirino S, Inoue M, Hiraguri Y, Nagata S, Shimizu H, Ito G, Mizutani T, Nemoto Y, Tsuchiya K, Okamoto R, Watanabe M, Yui S. Organoids transplantation as a new modality to design epithelial signature to create a membrane-protective sulfomucin-enriched segment. J Gastroenterol. 2023.04; 58(4); 379-393. PMID: 36745238 DOI: 10.1007/s00535-023-01959-y

  24. Keitoku T, Tamaki N, Kurosaki M, Inada K, Kirino S, Uchihara N, Suzuki K, Tanaka Y, Miyamoto H, Ishido S, Yamada M, Nobusawa T, Matsumoto H, Higuchi M, Takaura K, Tanaka S, Maeyashiki C, Kaneko S, Yasui Y, Takahashi Y, Tsuchiya K, Nakanishi H, Asahina Y, Okamoto R, Izumi N. Effect of fatty liver and fibrosis on hepatocellular carcinoma development in patients with chronic hepatitis B who received nucleic acid analog therapy. J Viral Hepat. 2023.04; 30(4); 297-302. PMID: 36648382 DOI: 10.1111/jvh.13805

  25. Yamada D, Kojima Y, Hosoya A, Suzuki M, Watabe T, Inoue T, Tsugawa N, Asakawa T, Yonemoto Y, Onizawa M, Nemoto Y, Oshima S, Shimonaka M, Kuba K, Ishida J, Fukamizu A, Penninger J M, Watanabe M, Okamoto R, Nagaishi T. Apelin expression is downregulated in T cells in a murine model of chronic colitis. Biochem Biophys Res Commun. 2023.03; 647; 72-79. PMID: 36731336 DOI: 10.1016/j.bbrc.2023.01.068

  26. Ikeda N, Kubota H, Suzuki R, Morita M, Yoshimura A, Osada Y, Kishida K, Kitamura D, Iwata A, Yotsumoto S, Kurotaki D, Nishimura K, Nishiyama A, Tamura T, Kamatani T, Tsunoda T, Murakawa M, Asahina Y, Hayashi Y, Harada H, Harada Y, Yokota A, Hirai H, Seki T, Kuwahara M, Yamashta M, Shichino S, Tanaka M, Asano K. The early neutrophil-committed progenitors aberrantly differentiate into immunoregulatory monocytes during emergency myelopoiesis. CELL REPORTS. 2023.03; 42(3); 112165. PMID: 36862552 DOI: 10.1016/j.celrep.2023.112165

  27. Saito E, Ohtsuka K, Kawamoto A, Fujii T, Takenaka K, Hibiya S, Shimizu H, Nagahori M, Tomii S, Okamoto R. A case of venous stasis colitis possibly caused by eplerenone. Clinical journal of gastroenterology. 2023.02; 16(1); 69-72. PMID: 36319777 DOI: 10.1007/s12328-022-01722-5

  28. Tsuchiya K, Nagahori M, Hanazawa R, Sasaki M, Sato H, Hirakawa A, Anzai T, Takahashi K, Kobayashi Y, Hibiya S, Takenaka K, Watanabe M. Serial daily recording of patient-reported outcomes (PRO2) might predict treatment change in the patients with Ulcerative Colitis. JOURNAL OF CROHNS & COLITIS. 2023.02; 17(1); I316-I317.

  29. Ishido S, Tsuchiya K, Kano Y, Yasui Y, Takaura K, Uchihara N, Suzuki K, Tanaka Y, Miyamoto H, Yamada M, Matsumoto H, Nobusawa T, Keitoku T, Tanaka S, Maeyashiki C, Tamaki N, Takahashi Y, Nakanishi H, Sakurai U, Asahina Y, Okamoto R, Kurosaki M, Izumi N. Clinical Utility of Comprehensive Genomic Profiling in Patients with Unresectable Hepatocellular Carcinoma. CANCERS. 2023.02; 15(3); 719. PMID: 36765676 DOI: 10.3390/cancers15030719

  30. Shibata T, Shinjo D, Takahashi J, Fushimi K. Pandemic-resilient target setting in colorectal cancer screening for vulnerable older population. Cancer Med. 2023.01; 12(1); 619-630. PMID: 35666024 DOI: 10.1002/cam4.4907

  31. Kaneko S, Kurosaki M, Mashiba T, Marusawa H, Kondo M, Kojima Y, Uchida Y, Fujii H, Akahane T, Yagisawa H, Kusakabe A, Kobashi H, Abe T, Yoshida H, Ogawa C, Furuta K, Tamaki N, Tsuji K, Matsushita T, Izumi N. Risk factors for hepatocellular carcinoma at baseline and 1 year after initiation of nucleos(t)ide analog therapy for chronic hepatitis B. J Med Virol. 2023.01; 95(1); e28210. PMID: 36222204 DOI: 10.1002/jmv.28210

  32. Kaneko S, Asahina Y, Nakagawa M, Murakawa M, Miyazaki Y, Asakage T, Fukuda S, Namiki T, Kano Y, Nagata M, Tsuchiya J, Miyoshi M, Kitahata-Kawai F, Nitta S, Itsui Y, Kakinuma S, Okamoto R. Factors associated with liver injury and prognosis in advanced cancer patients treated with immune checkpoint inhibitors. Hepatology research. 2023.05; 53(5); 450-459. PMID: 36626292 DOI: 10.1111/hepr.13878

  33. Shimakami T, Setoyama H, Oza N, Itakura J, Kaneko S, Korenaga M, Toyama T, Tanaka J, Kanto T. Development of performance indicators for hepatitis countermeasures as a tool for the assessment and promotion of liver cancer prevention in Japan. J Gastroenterol. 2023.01; 1-11. PMID: 36645470 DOI: 10.1007/s00535-023-01956-1

  34. Okamoto R, Mizutani T, Shimizu H. Development and Application of Regenerative Medicine in Inflammatory Bowel Disease. Digestion. 2023; 104(1); 24-29. PMID: 36353779 DOI: 10.1159/000527423

  35. Takahama S, Yoshio S, Masuta Y, Murakami H, Sakamori R, Kaneko S, Honda T, Murakawa M, Sugiyama M, Kurosaki M, Asahina Y, Takehara T, Appay V, Kanto T, Yamamoto T. Hepatitis B surface antigen reduction is associated with hepatitis B core-specific CD8+ T cell quality Front Immunol. 2023; 14; 1257113. PMID: 37920475 DOI: 10.3389/fimmu.2023.1257113

  36. Leo S, Kato Y, Wu Y. M, Yokota M, Koike M, Yui S, Tsuchiya K, Shiraki N, Kume S. The effect of Vitamin D3 and Valproic Acid on the maturation of human induced pluripotent stem cell-derived enterocyte-like cells. Stem Cells. 2023 Aug 16;41(8):775-791. PMID: 37228023 DOI: 10.1093/stmcls/sxad042

  37. Kirino S, Tamaki N, Kurosaki M, Takahashi Y, Higuchi M, Itakura Y, Tanaka Y, Inada K, Ishido S, Yamashita K, Nobusawa T, Matsumoto H, Hayakawa Y, Kakegawa T, Takaura K, Tanaka S, Maeyashiki C, Kaneko S, Yasui Y, Tsuchiya K, Nakanishi H, Okamoto R, Izumi N. Detecting advanced liver fibrosis using ultrasound shear wave velocity measurement in the general population QUANTITATIVE IMAGING IN MEDICINE AND SURGERY. 2023.10; 13(10); 6493-6502. PMID: 37869309 DOI: 10.21037/qims-23-511