Publications

Publications

2024

Homma, H., Ngo, K. X., Yoshioka, Y., Tanaka, H., Inotsume, M., Fujita, K., Ando, T. & Okazawa, H. (2024)
PQBP3/NOL7 is an intrinsically disordered protein.
Biochem. Biophys. Res. Commun. 3 December 2024, 736, 150453. doi: 10.1016/j.bbrc.2024.150453

Yoshioka, Y., Huang, Y., Jin, X., Ngo, K. X., Kumaki, T., Jin, M., Toyoda, S., Takayama, S., Inotsume, M., Fujita, K., Homma, H., Ando, T., Tanaka, H. & Okazawa, H. (2024)
PQBP3 prevents senescence by suppressing PSME3-mediated proteasomal Lamin B1 degradation
EMBO J. 5 August 2024, 1–32. doi: 10.1038/s44318-024-00192-4

Homma, H., Yoshioka, Y., Fujita, K., Shirai, S., Hama, Y., Komano, H., Saito, Y., Yabe, I., Okano, H., Sasaki, H., Tanaka, H. & Okazawa, H. (2024)
Dynamic molecular network analysis of iPSC-Purkinje cells differentiation delineates roles of ISG15 in SCA1 at the earliest stage.
Commun. Biol. 9 April 2024, 7 (1), 413. doi: 10.1038/s42003-024-06066-z

Homma, H., Tanaka, H., Fujita, K. & Okazawa, H. (2024)
Necrosis Links Neurodegeneration and Neuroinflammation in Neurodegenerative Disease.
Int. J. Mol. Sci. 24 March 2024, 25 (7). doi: 10.3390/ijms25073636

2023

 Yoshioka, Y., Taniguchi, J. B., Homma, H., Tamura, T., Fujita, K., Inotsume, M., Tagawa, K., Misawa, K., Matsumoto, N., Nakagawa, M., Inoue, H., Tanaka, H. & Okazawa, H. (2023)
AAV-mediated editing of PMP22 rescues Charcot-Marie-Tooth disease type 1A features in patient-derived iPS Schwann cells.
Commun Med 28 November 2023, 3 (1), 1–15. doi: 10.1038/s43856-023-00400-y

Gall-Duncan, T., Luo, J., Jurkovic, C.-M., Fischer, L. A., Fujita, K., Deshmukh, A. L., Harding, R. J., Tran, S., Mehkary, M., Li, V., Leib, D. E., Chen, R., Tanaka, H., Mason, A. G., Lévesque, D., Khan, M., Razzaghi, M., Prasolava, T., Lanni, S., Sato, N., Caron, M.-C., Panigrahi, G. B., Wang, P., Lau, R., Castel, A. L., Masson, J.-Y., Tippett, L., Turner, C., Spies, M., La Spada, A. R., Campos, E. I., Curtis, M. A., Boisvert, F.-M., Faull, R. L. M., Davidson, B. L., Nakamori, M., Okazawa, H., Wold, M. S. & Pearson, C. E. (2023)
Antagonistic roles of canonical and Alternative-RPA in disease-associated tandem CAG repeat instability.
Cell 26 October 2023, 186 (22), 4898-4919.e25. doi: 10.1016/j.cell.2023.09.008

Fujita, K., Homma, H., Jin, M., Yoshioka, Y., Jin, X., Saito, Y., Tanaka, H. & Okazawa, H. (2023)
Mutant α-synuclein propagates via the lymphatic system of the brain in the monomeric state.
Cell Rep 29 Aug 2023, 42 (8), 112962. doi: 10.1016/j.celrep.2023.112962

Shiwaku, H., Katayama, S., Gao, M., Kondo, K., Nakano, Y., Motokawa, Y., Toyoda, S., Yoshida, F., Hori, H., Kubota, T., Ishikawa, K., Kunugi, H., Ikegaya, Y., Okazawa, H. & Takahashi, H. (2023)
Analyzing schizophrenia-related phenotypes in mice caused by autoantibodies against NRXN1α in schizophrenia.
Brain, Behavior, and Immunity 1 July 2023, 111, 32–45. doi: 10.1016/j.bbi.2023.03.028

Jin, X., Tanaka, H., Jin, M., Fujita, K., Homma, H., Inotsume, M., Yong, H., Umeda, K., Kodera, N., Ando, T. & Okazawa, H. (2023)
PQBP5/NOL10 maintains and anchors the nucleolus under physiological and osmotic stress conditions.
Nat Commun 4 Jan 2023, 14 (1), 9. doi: 10.1038/s41467-022-35602-w

2022

Tanaka, H. & Okazawa, H. (2022)
PQBP1: The Key to Intellectual Disability, Neurodegenerative Diseases, and Innate Immunity.
Int. J. Mol. Sci. 2022, Vol. 23, Page 6227 2 June 2022, 23 (11), 6227. doi: 10.3390/IJMS23116227

Shiwaku, H., Katayama, S., Kondo, K., Nakano, Y., Tanaka, H., Yoshioka, Y., Fujita, K., Tamaki, H., Takebayashi, H., Terasaki, O., Nagase, Y., Nagase, T., Kubota, T., Ishikawa, K., Okazawa, H. & Takahashi, H. (2022)
Autoantibodies against NCAM1 from patients with schizophrenia cause schizophrenia-related behavior and changes in synapses in mice.
Cell Reports Med. 19 April 2022, 3 (4), 100597. doi: 10.1016/J.XCRM.2022.100597


Okazawa, H. (2022)
[Career Path and Leadership of Basic Researchers Based on Clinical Medicine].
Brain Nerve January 2022, 74 (1), 59–62. doi:
10.11477/mf.1416201980 8.

望月秀樹, 青木正志, 池中建介, 井上治久, 岩坪威, 宇川義一, 岡澤均, 小野賢二郎, 小野寺理, 北川一夫, 齊藤祐子, 下畑享良, 髙橋良輔, 戸田達史, 中原仁, 松本理器, 水澤英洋, 三井純, 村山繁雄, 勝野雅央, 日本神経学会将来構想委員会, 青木吉嗣, 石浦浩之, 和泉唯信, 小池春樹, 島田斉, 髙橋祐二, 徳田隆彦, 中嶋秀人, 波田野琢, 三澤園子 & 渡辺宏久. (2022)
脳神経疾患克服に向けた研究推進の提言2020,各論II(疾患群別).
臨床神経学 2022, 62 (6), 443–457. doi: 10.5692/clinicalneurol.cn-001696 9.

望月秀樹, 青木正志, 池中建介, 井上治久, 岩坪威, 宇川義一, 岡澤均, 小野賢二郎, 小野寺理, 北川一夫, 齊藤祐子, 下畑享良, 髙橋良輔, 戸田達史, 中原仁, 松本理器, 水澤英洋, 三井純, 村山繁雄, 勝野雅央, 日本神経学会将来構想委員会, 青木吉嗣, 石浦浩之, 和泉唯信, 小池春樹, 島田斉, 髙橋祐二, 徳田隆彦, 中嶋秀人, 波田野琢, 三澤園子 & 渡辺宏久. (2022)
脳神経疾患克服に向けた研究推進の提言2020,各論I(方法論別).
臨床神経学 2022, 62 (6), 429–442. doi: 10.5692/clinicalneurol.cn-001695

2021

Jin, M., Shiwaku, H., Tanaka, H., Obita, T., Ohuchi, S., Yoshioka, Y., Jin, X., Kondo, K., Fujita, K., Homma, H., Nakajima, K., Mizuguchi, M. & Okazawa, H. (2021)
Tau activates microglia via the PQBP1-cGAS-STING pathway to promote brain inflammation.
Nat. Commun. 15 November 2021, 12 (1), 6565. doi: 10.1038/s41467-021-26851-2

Tanaka, H., Kondo, K., Fujita, K., Homma, H., Tagawa, K., Jin, X., Jin, M., Yoshioka, Y., Takayama, S., Masuda, H., Tokuyama, R., Nakazaki, Y., Saito, T., Saido, T., Murayama, S., Ikura, T., Ito, N., Yamamori, Y., Tomii, K., Bianchi, M. E. & Okazawa, H. (2021)
HMGB1 signaling phosphorylates Ku70 and impairs DNA damage repair in Alzheimer’s disease pathology.
Commun. Biol. 11 October 2021, 4 (1), 1–23. doi: 10.1038/s42003-021-02671-4

Jin, M., Jin, X., Homma, H., Fujita, K., Tanaka, H., Murayama, S., Akatsu, H., Tagawa, K. & Okazawa, H. (2021)
Prediction and verification of the AD-FTLD common pathomechanism based on dynamic molecular network analysis.
Commun. Biol. 4 12 August 2021 (1), 961. doi: 10.1038/s42003-021-02475-6

Kondo, K., Ikura, T., Tanaka, H., Fujita, K., Takayama, S., Yoshioka, Y., Tagawa, K., Homma, H., Liu, S., Kawasaki, R., Huang, Y., Ito, N., Tate, S. & Okazawa, H. (2021)
Hepta-Histidine Inhibits Tau Aggregation.
ACS Chem. Neurosci. 28 July 2021, 12 (16), 3015–3027. doi: 10.1021/acschemneuro.1c00164

Homma, H., Tanaka, H., Jin, M., Jin, X., Huang, Y., Yoshioka, Y., Bertens, C. J., Tsumaki, K., Kondo, K., Shiwaku, H., Tagawa, K., Akatsu, H., Atsuta, N., Katsuno, M., Furukawa, K., Ishiki, A., Waragai, M., Ohtomo, G., Iwata, A., Yokota, T., Inoue, H., Arai, H., Sobue, G., Sone, M., Fujita, K. & Okazawa, H. (2021)
DNA damage in embryonic neural stem cell determines FTLDs’ fate via early-stage neuronal necrosis.
Life Sci. Alliance 15 June 2021, 4 (7), e202101022. doi: 10.26508/lsa.202101022

Okazawa, H. (2021)
Intracellular amyloid hypothesis for ultra-early phase pathology of Alzheimer's disease. 
Neuropathology : official journal of the Japanese Society of Neuropathology, 20 April 2021, 41(2) 93-98. doi: 10.1111/neup.12738

Saito, M., Nakayama, M., Fujita, K., Uchida, A., Yano, H., Goto, S., Okazawa, H., Sone, M. (2021)
Role of the Drosophila YATA protein in the proper subcellular localization of COPI revealed by in vivo analysis. 
Genes Genet. Syst., 13 February 2021, 95(6):303-314. doi: 10.1266/ggs.20-00027

Klionsky, DJ., et al. (2021)
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1. 
Autophagy, January 2021, 17(1) 1-382. doi: 10.1080/15548627.2020.1797280

 

2020

Yang, S. S., Ishida, T., Fujita, K., Nakai, Y., Ono, T. & Okazawa, H. (2020)
PQBP1, an intellectual disability causative gene, affects bone development and growth.
Biochem. Biophys. Res. Commun. 19 March 2020, 523 (4), 894–899. doi: 10.1016/j.bbrc.2019.12.097

Tanaka, H., Homma, H., Fujita, K., Kondo, K., Yamada, S., Jin, X., Waragai, M., Ohtomo, G., Iwata, A., Tagawa, K., Atsuta, N., Katsuno, M., Tomita, N., Furukawa, K., Saito, Y., Saito, T., Ichise, A., Shibata, S., Arai, H., Saido, T., Sudol, M., Muramatsu, S., Okano, H., Mufson, E. J., Sobue, G., Murayama, S. & Okazawa, H. (2020)
YAP-dependent necrosis occurs in early stages of Alzheimer’s disease and regulates mouse model pathology.
Nat. Commun. 24 January 2020, 11 (1), 507. doi: 10.1038/s41467-020-14353-6

2019

Rahman, S. K., Okazawa, H. & Chen, Y. W. (2019)
Frameshift PQBP-1 mutants K192Sfs*7 and R153Sfs*41 implicated in X-linked intellectual disability form stable dimers.
J. Struct. Biol. 1 June 2019, 206 (3), 305–313. doi: 10.1016/J.JSB.2019.04.003

Bannai, T., Mano, T., Chen, X., Ohtomo, G., Ohtomo, R., Tsuchida, T., Koshi-Mano, K., Hashimoto, T., Okazawa, H., Iwatsubo, T., Tsuji, S., Toda, T. & Iwata, A. (2019)
Chronic cerebral hypoperfusion shifts the equilibrium of amyloid β oligomers to aggregation-prone species with higher molecular weight.
Sci. Rep. 26 February 2019, 9 (1), 2827. doi: 10.1038/s41598-019-39494-7

Inoue, S., Hayashi, K., Fujita, K., Tagawa, K., Okazawa, H., Kubo, K.-I. & Nakajima, K. (2019)
Drebrin-like (Dbnl) Controls Neuronal Migration via Regulating N-Cadherin Expression in the Developing Cerebral Cortex.
J. Neurosci. 23 January 2019, 39 (4), 678–691. doi: 10.1523/JNEUROSCI.1634-18.2018

Chen, X., Kondo, K. & Okazawa, H. (2019).
Methods to Image Macroautophagy in the Brain In Vivo.
Methods in Molecular Biology, 2019, 1880, 529–534. doi: 10.1007/978-1-4939-8873-0_33

2018

Tanaka, H., Kondo, K., Chen, X., Homma, H., Tagawa, K., Kerever, A., Aoki, S., Saito, T., Saido, T., Muramatsu, S., Fujita, K. & Okazawa, H. (2018)
The intellectual disability gene PQBP1 rescues Alzheimer’s disease pathology.
Mol. Psychiatry 3 October 2018, 1. doi: 10.1038/s41380-018-0253-8

Furotani, K., Kamimura, K., Yajima, T., Nakayama, M., Enomoto, R., Tamura, T., Okazawa, H. & Sone, M. (2018)
Suppression of the synaptic localization of a subset of proteins including APP partially ameliorates phenotypes of the Drosophila Alzheimer’s disease model.
PLoS One 18 September 2018, 13 (9), e0204048. doi: 10.1371/journal.pone.0204048

Fujita, K., Homma, H., Kondo, K., Ikuno, M., Yamakado, H., Tagawa, K., Murayama, S., Takahashi, R. & Okazawa, H. (2018)
Ser46-Phosphorylated MARCKS Is a Marker of Neurite Degeneration at the Pre-Aggregation Stage in PD/DLB Pathology.
eNeuro 16 August 2018, 5 (4), ENEURO.0217-18.2018. doi: 10.1523/ENEURO.0217-18.2018

Okazawa, H. (2018)
Bridging Multiple Dementias.
ACS Chem. Neurosci. 18 April 2018, 9 (4), 636–638. doi: 10.1021/acschemneuro.8b00119

Kawahori, K., Hashimoto, K., Yuan, X., Tsujimoto, K., Hanzawa, N., Hamaguchi, M., Kase, S., Fujita, K., Tagawa, K., Okazawa, H., Nakajima, Y., Shibusawa, N., Yamada, M. & Ogawa, Y. (2018)
Mild Maternal Hypothyroxinemia During Pregnancy Induces Persistent DNA Hypermethylation in the Hippocampal Brain-Derived Neurotrophic Factor Gene in Mouse Offspring.
Thyroid 1 March 2018, 28 (3), 395–406. doi: 10.1089/thy.2017.0331

Fujita, K., Chen, X., Homma, H., Tagawa, K., Amano, M., Saito, A., Imoto, S., Akatsu, H., Hashizume, Y., Kaibuchi, K., Miyano, S. & Okazawa, H. (2018)
Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology.
Nat. Commun. 30 January 2018, 9 (1), 433. doi: 10.1038/s41467-018-02821-z

2017

Fujita, K., Mao, Y., Uchida, S., Chen, X., Shiwaku, H., Tamura, T., Ito, H., Watase, K., Homma, H., Tagawa, K., Sudol, M. & Okazawa, H. (2017)
Developmental YAPdeltaC determines adult pathology in a model of spinocerebellar ataxia type 1.
Nat. Commun. 8, 1864. doi: 10.1038/s41467-017-01790-z

Okazawa, H. (2017)
Ultra-Early Phase pathologies of Alzheimer’s disease and other neurodegenerative diseases.
Proc. Japan Acad. Ser. B, Physical and biological sciences 93(6), 361–377. doi: 10.2183/pjab.93.022

Okazawa, H. (2017)
PQBP1, an intrinsically disordered/denatured protein at the crossroad of intellectual disability and neurodegenerative diseases.
Neurochem. Int. S0197–0186(17)30213–9. doi: 10.1016/j.neuint.2017.06.005

Sato, K., Kerever, A., Kamagata, K., Tsuruta, K., Irie, R., Tagawa, K., Okazawa, H., Arikawa-Hirasawa, E., Nitta, N., Aoki, I. & Aoki, S. (2017)
Understanding microstructure of the brain by comparison of neurite orientation dispersion and density imaging (NODDI) with transparent mouse brain.
Acta Radiol. open 6(4), 2058460117703816. doi: 10.1177/2058460117703816

Yamanishi, E., Hasegawa, K., Fujita, K., Ichinose, S., Yagishita, S., Murata, M., Tagawa, K., Akashi, T., Eishi, Y. & Okazawa, H. (2017)
A novel form of necrosis, TRIAD, occurs in human Huntington’s disease.
Acta Neuropathol. Commun. 5, 19. doi: 10.1186/s40478-017-0420-1

2016

Imamura, T., Fujita, K., Tagawa, K., Ikura, T., Chen, X., Homma, H., Tamura, T., Mao, Y., Taniguchi, J. B., Motoki, K., Nakabayashi, M., Ito, N., Yamada, K., Tomii, K., Okano, H., Kaye, J., Finkbeiner, S. & Okazawa, H. (2016)
Identification of hepta-histidine as a candidate drug for Huntington’s disease by in silico-in vitro- in vivo-integrated screens of chemical libraries.
Sci. Rep. 6, 33861. doi: 10.1038/srep33861

Mao, Y., Chen, X., Xu, M., Fujita, K., Motoki, K., Sasabe, T., Homma, H., Murata, M., Tagawa, K., Tamura, T., Kaye, J., Finkbeiner, S., Blandino, G., Sudol, M. & Okazawa, H. (2016)
Targeting TEAD/YAP-transcription-dependent necrosis, TRIAD, ameliorates Huntington’s disease pathology.
Hum. Mol. Genet. 25, 4749–4770. doi: 10.1093/hmg/ddw303

Fujita, K., Motoki, K., Tagawa, K., Chen, X., Hama, H., Nakajima, K., Homma, H., Tamura, T., Watanabe, H., Katsuno, M., Matsumi, C., Kajikawa, M., Saito, T., Saido, T., Sobue, G., Miyawaki, A. & Okazawa, H. (2016)
HMGB1, a pathogenic molecule that induces neurite degeneration via TLR4-MARCKS, is a potential therapeutic target for Alzheimer’s disease.
Sci. Rep. 6, 31895. doi: 10.1038/srep31895

Taniguchi, J. B., Kondo, K., Fujita, K., Chen, X., Homma, H., Sudo, T., Mao, Y., Watase, K., Tanaka, T., Tagawa, K., Tamura, T., Muramatsu, S.-I. & Okazawa, H. (2016)
RpA1 ameliorates symptoms of mutant ataxin-1 knock-in mice and enhances DNA damage repair.
Hum. Mol. Genet. 25, 4432–4447. doi: 10.1093/hmg/ddw272

Mao, Y., Tamura, T., Yuki, Y., Abe, D., Tamada, Y., Imoto, S., Tanaka, H., Homma, H., Tagawa, K., Miyano, S. & Okazawa, H. (2016)
The hnRNP-Htt axis regulates necrotic cell death induced by transcriptional repression through impaired RNA splicing.
Cell Death Dis. 7, e2207. doi: 10.1038/cddis.2016.101

Mizuguchi, M., Obita, T., Kajiyama, A., Kozakai, Y., Nakai, T., Nabeshima, Y. & Okazawa, H. (2016)
Allosteric modulation of the binding affinity between PQBP1 and the spliceosomal protein U5-15kD.
FEBS Lett. 590, 2221–2231. doi: 10.1002/1873-3468.12256

Kamagata, K., Kerever, A., Yokosawa, S., Otake, Y., Ochi, H., Hori, M., Kamiya, K., Tsuruta, K., Tagawa, K., Okazawa, H., Aoki, S. & Arikawa-Hirasawa, E. (2016)
Quantitative Histological Validation of Diffusion Tensor MRI with Two-Photon Microscopy of Cleared Mouse Brain.
Magn. Reson. Med. Sci. 15 (4), 416–421. doi: 10.2463/mrms.bc.2015-0148

2015

Chen, X., Kondo, K., Motoki, K., Homma, H. & Okazawa, H. (2015)
Fasting activates macroautophagy in neurons of Alzheimer’s disease mouse model but is insufficient to degrade amyloid-beta.
Sci. Rep. 5, 12115. doi: 10.1038/srep12115

Shiwaku, H. & Okazawa, H. (2015)
Impaired DNA damage repair as a common feature of neurodegenerative diseases and psychiatric disorders.
Curr. Mol. Med. 15 (2), 119–128. 10.2174/1566524015666150303002556 (review)

Tagawa, K., Homma, H., Saito, A., Fujita, K., Chen, X., Imoto, S., Oka, T., Ito, H., Motoki, K., Yoshida, C., Hatsuta, H., Murayama, S., Iwatsubo, T., Miyano, S. & Okazawa, H. (2015)
Comprehensive phosphoproteome analysis unravels the core signaling network that initiates the earliest synapse pathology in preclinical Alzheimer’s disease brain.
Hum. Mol. Genet. 24 (2), 540–558. doi: 10.1093/hmg/ddu475

Ito, H., Shiwaku, H., Yoshida, C., Homma, H., Luo, H., Chen, X., Fujita, K., Musante, L., Fischer, U., Frints, S. G. M., Romano, C., Ikeuchi, Y., Shimamura, T., Imoto, S., Miyano, S., Muramatsu, S., Kawauchi, T., Hoshino, M., Sudol, M., Arumughan, A., Wanker, E. E., Rich, T., Schwartz, C., Matsuzaki, F., Bonni, A., Kalscheuer, V. M. & Okazawa, H. (2015)
In utero gene therapy rescues microcephaly caused by Pqbp1-hypofunction in neural stem progenitor cells.
Mol. Psychiatry 20 (4), 459–471. doi: 10.1038/mp.2014.69

Ito, H., Fujita, K., Tagawa, K., Chen, X., Homma, H., Sasabe, T., Shimizu, J., Shimizu, S., Tamura, T., Muramatsu, S. & Okazawa, H. (2015)
HMGB1 facilitates repair of mitochondrial DNA damage and extends the lifespan of mutant ataxin-1 knock-in mice.
EMBO Mol. Med. 7 (1), 78–101. doi: 10.15252/emmm.201404392

2014

Mizuguchi, M., Obita, T., Serita, T., Kojima, R., Nabeshima, Y. & Okazawa, H. (2014)
Mutations in the PQBP1 gene prevent its interaction with the spliceosomal protein U5-15 kD.
Nat. Commun. 5 (1), 3822. doi: 10.1038/ncomms4822

Nabeshima, Y., Mizuguchi, M., Kajiyama, A. & Okazawa, H. (2014)
Segmental isotope-labeling of the intrinsically disordered protein PQBP1.
FEBS Lett. 588 (24), 4583–4589. doi: 10.1016/j.febslet.2014.10.028

Shiraishi, R., Tamura, T., Sone, M. & Okazawa, H. (2014)
Systematic analysis of fly models with multiple drivers reveals different effects of ataxin-1 and huntingtin in neuron subtype-specific expression.
PLoS One 9 (12), e116567. doi: 10.1371/journal.pone.0116567

2013

Barclay, S. S., Tamura, T., Ito, H., Fujita, K., Tagawa, K., Shimamura, T., Katsuta, A., Shiwaku, H., Sone, M., Imoto, S., Miyano, S. & Okazawa, H. (2013)
Systems biology analysis of Drosophila in vivo screen data elucidates core networks for DNA damage repair in SCA1.
Hum. Mol. Genet. 23 (5), 1345–1364. doi: 10.1093/hmg/ddt524

Ikeuchi, Y., de la Torre-Ubieta, L., Matsuda, T., Steen, H., Okazawa, H. & Bonni, A. (2013)
The XLID protein PQBP1 and the GTPase Dynamin 2 define a signaling link that orchestrates ciliary morphogenesis in postmitotic neurons.
Cell Rep. 4 (5), 879–889. doi: 10.1016/j.celrep.2013.07.042

Shiwaku, H., Yagishita, S., Eishi, Y. & Okazawa, H. (2013)
Bergmann glia are reduced in spinocerebellar ataxia type 1.
Neuroreport 24 (11), 620–625. doi: 10.1097/WNR.0b013e32836347b7

Li, C., Ito, H., Fujita, K., Shiwaku, H., Qi, Y., Tagawa, K., Tamura, T. & Okazawa, H. (2013)
Sox2 Transcriptionally Regulates Pqbp1, an Intellectual Disability-Microcephaly Causative Gene, in Neural Stem Progenitor Cells.
PLoS One 8 (7), e68627. doi: 10.1371/journal.pone.0068627

Fujita, K., Nakamura, Y., Oka, T., Ito, H., Tamura, T., Tagawa, K., Sasabe, T., Katsuta, A., Motoki, K., Shiwaku, H., Sone, M., Yoshida, C., Katsuno, M., Eishi, Y., Murata, M., Taylor, J. P., Wanker, E. E., Kono, K., Tashiro, S., Sobue, G., La Spada, A. R. & Okazawa, H. (2013)
A functional deficiency of TERA/VCP/p97 contributes to impaired DNA repair in multiple polyglutamine diseases.
Nat. Commun. 4, 1816. doi: 10.1038/ncomms2828

Tamura, T., Sone, M., Nakamura, Y., Shimamura, T., Imoto, S., Miyano, S. & Okazawa, H. (2013)
A restricted level of PQBP1 is needed for the best longevity of Drosophila.
Neurobiol. Aging 34 (1), 356.e11-20. doi: 10.1016/j.neurobiolaging.2012.07.015

Okazawa, H. (2013)
HD Research Around the World: Japan. Past, Present, Future.
HD Insights 4, 7–8. link
 

2012

Rees, M., Gorba, C., de Chiara, C., Bui, T. T. T., Garcia-Maya, M., Drake, A. F., Okazawa, H., Pastore, A., Svergun, D. & Chen, Y. W. (2012)
Solution model of the intrinsically disordered polyglutamine tract-binding protein-1.
Biophys. J. 102 (7), 1608–1616. doi: 10.1016/j.bpj.2012.02.047

Enokido, Y. & Okazawa, H. (2012)
DNA repair in the nervous system: A new research for neurological disorders.
DNA Repair New Res. 79–106. Edited by Kimura, S. and Shimizu, S. Nova Science. (ISBN: 978-1-62100-756-2)

Nakamura, Y., Tagawa, K., Oka, T., Sasabe, T., Ito, H., Shiwaku, H., La Spada, A. R. & Okazawa, H. (2012)
Ataxin-7 associates with microtubules and stabilizes the cytoskeletal network.
Hum. Mol. Genet. 21 (5), 1099–1110. doi: 10.1093/hmg/ddr539

 

2011

Tamura, T., Sone, M., Iwatsubo, T., Tagawa, K., Wanker, E. E. & Okazawa, H. (2011)
Ku70 Alleviates Neurodegeneration in Drosophila Models of Huntington’s Disease.
PLoS One 6 (11), e27408. doi: 10.1371/journal.pone.0027408

Oka, T., Tagawa, K., Ito, H. & Okazawa, H. (2011)
Dynamic changes of the phosphoproteome in postmortem mouse brains.
PLoS One 6 (6), e21405. doi: 10.1371/journal.pone.0021405