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Home  > Department of Neuropathology  > Research Activities  > Ser46-Phosphorylated MARCKS Is a Marker of Neurite Degeneration at the Pre-Aggregation Stage in PD/DLB Pathology

Ser46-Phosphorylated MARCKS Is a Marker of Neurite Degeneration at the Pre-Aggregation Stage in PD/DLB Pathology

MARCKS Phosphorylation at Ser46 reflects neurite degeneration and is a candidate marker for presymptomatic and preaggretaion pathology of Alzheimer’s disease. Here, we demonstrate the similar change in Parkinson’s disease and Dementia with Lewy body prior to alpha-synuclein aggregation, and suggest an ultra-early stage pathology shared by different groups of neurodegenerative diseases.

Publications

Fujita, K., Homma, H., Kondo, K., Ikuno, M., Yamakado, H., Tagawa, K., Murayama, S., Takahashi, R. & Okazawa, H. (2018)
Ser46-Phosphorylated MARCKS Is a Marker of Neurite Degeneration at the Pre-Aggregation Stage in PD/DLB Pathology.
eNeuro ENEURO.0217-18.2018. doi: 10.1523/ENEURO.0217-18.2018