Original Article 2012

Original Article 2012

1. Staffs and Students 2012

ProfessorKeiichi OHYA
Associate ProfessorKazuhiro AOKI
Assistant ProfessorYukihiko TAMURA
TechnologistMariko TAKAHASHI
Researcher (JSPS)Noriko KOMATSU
Foreign Researcher (JSPS)Neil Chrisman Roshan Alexander ALLES (~Nov)
ResearcherMiki MAEDA (~May)
Kenichi NAGANO (~Dec)
Kengo FUJIKI (Removable Prosthodontics) (~Oct)
Nobuyoshi TOMOMATSU (Maxillofacial Surgery) (Apr~)
Yasuhiro SHIMIZU (Orthodontic Science) (Apr~)
Graduate StudentToshimi SATO
Md. Abdulla Al Masud KHAN (GCOE Advanced Super Student)
Md. Abdullah Al MAMUN
Natsuki SUZUK I(Removable Prosthodontics) (Nov~)
Atsushi KIMURA (Oral and Maxillofacial Surgery)
Genki KATO
Yasutaka SUGAMORI (Apr~)
Makiri KAWASAKI (~Mar)

2. Purpose of Education

Pharmacology is situated between the basic and clinical sciences and is important for dental students. There is a growing demand on the dental clinicians to know huge knowledge of drugs and how to use them for patients. For these purpose, the first lecture is aimed to teach the scientific aspects of pharmacology and how drugs act on the various body system. The second lecture deals with drugs of medical and dental fields and the last with drugs of special importance of dentistry. Dental students learn the principle of pharmacology through laboratory practice. Following these learning, they must acquire an adequate background for drug use in general practice.

3. Research Subjects

1)Pharmacological analysis of the formation and resorption mechanisms of teeth and bone
2)Drug effects on the differentiation of the cells that participate formation and resorption process of the hard tissues
3)Identification of the new drug targets for hard tissue diseases
4)Translational research for the hard tissue regeneration
5)Analysis of side effects of the drug that appear in oral tissues

4. Publications

Original Article

1. Hayashi N, Tamura Y, Kusumoto Y, Shimokawa H, Aoki K, Ohya K, YamazakiT, Shinozuka O. Gingival overgrowth induced by phenytoin-study of the human gingival overgrowth tissues and clonal gingival cells-. Disability and Oral Health 33, 16-25, 2012
2. Seo Y, Fukushima H, Maruyama T, Kuroishi KN, Osawa K, Nagana K, Aoki K, Wejh F, Doi T, Zhang M, Ohya K, Katagiri T, Hosokawa R, Jimi E. Accumulation of p100, a precursor of NF-kB2, enhances osteoblastic differentiation in vitro and bone formation in vivo in aly/aly mice. Mol Endocrinol 26, 414-422, 2012
3. Aoki K, Alles N, Soysa N, Ohya K. Peptide-based delivery to bone. Advanced Drug Delivery Reviews 64, 1220-1238, 2012
4. Nakachi H, Aoki K, Tomomatsu N, Alles N, Nagano K, Yamashiro M, Zhang H, Merali R, Greene M.I, Ohya K, Amagasa T. A structural modulator of tumor necrosis factor type 1 receptor promotes bone formation under lipopolysaccharide-induced inflammation in a murine tooth extraction model. European J Pharmacology 679, 132–138, 2012
5. Soysa N.S, Alles N, Aoki K, Ohya K. Osteoclast formation and differentiation: An overview. J Med Dent Sci 59, 65-74, 2012
6. Muguruma M, Ahhmed A.M, Kawahara A, Kusumegi K, Hishinuma T, Ohya K, Nakamura T. A combination of soybean and skimmed milk reduces osteoporosis in rats. J Functional Foods 4, 810-818, 2012
7. Oue E, Lee J-W, Sakamoto K, Iimura T, Aoki K, Kayamori K, Michi Y, Yamashiro M, Harada K, Amagasa T, Yamaguchi A. CXCL2 synthesized by oral squamous cell carcinoma is involved in cancer-associated bone destruction. Biochemical and Biophysical Research Communications 424, 456-461, 2012
8. Furuta H, Osawa K, Shin M, Ishikawa A, Matsuo K, Khan M, Aoki K, Ohya K, Okamoto M, Tominaga K, Takahashi T, Nakahashi O, Jimi E. Selective inhibition of NF-kB suppresses bone invasion by oral squamous cell carcinoma in vivo. Int J Cancer 131 E625–E635, 2012