Original Article 2011

Original Article 2011

1. Staffs and Students 2011

ProfessorKeiichi OHYA
Associate ProfessorKazuhiro AOKI
Assistant ProfessorYukihiko TAMURA
TechnologistMariko TAKAHASHI
Researcher (JSPS)Noriko KOMATSU
Foreign Researcher (JSPS)Neil Chrisman Roshan Alexander ALLES
ResearcherMari HARAMOTO (~May)
Miki MAEDA (May~)
Graduate StudentKenichi NAGANO (~Mar)
Hiroyuki NAKACHI (Maxillofacial Surgery) (~Mar)
Naoki HAYASHI (Dentistry for Persons with Disabilities) (~Mar)
Toshimi SATO
Kengo FUJIKI (Removable Prosthodontics)
Md. Abdulla Al Masud KHAN(GCOE Advanced Super Student)
Md. Abdullah Al MAMUN (Apr~)
Atsushi KIMURA (Oral and Maxillofacial Surgery)(Aug~)
Genki KATO (Apr~)

2. Purpose of Education

Pharmacology is situated between the basic and clinical sciences and is important for dental students. There is a growing demand on the dental clinicians to know huge knowledge of drugs and how to use them for patients. For these purpose, the first lecture is aimed to teach the scientific aspects of pharmacology and how drugs act on the various body system. The second lecture deals with drugs of medical and dental fields and the last with drugs of special importance of dentistry. Dental students learn the principle of pharmacology through laboratory practice. Following these learning, they must acquire an adequate background for drug use in general practice.

3. Research Subjects

1)Pharmacological analysis of the formation and resorption mechanisms of teeth and bone
2)Drug effects on the differentiation of the cells that participate formation and resorption process of the hard tissues
3)Identification of the new drug targets for hard tissue diseases
4)Translational research for the hard tissue regeneration
5)Analysis of side effects of the drug that appear in oral tissues

4. Publications

Original Article

1. N. S. Soysa, N. Alles, M. Takahashi, A. Aoki, K. Ohya. Defective nuclear factor-κB-inducing kinase in aly/aly mice prevents bone resorption induced by local injection of lipopolysaccharide. J Periodont Res, Vol.46, pp280-284, 2011
2. K. Nagano, N. Alles, A. H. Mian, A. Shimoda, N. Morimoto, Y. Tamura, H. Shimokawa, K. Akiyoshi, K. Ohya, K. Aoki. The tumor necrosis factor type 2 receptor plays a protective role in tumor necrosis factor-α-induced bone resorption lacunae on mouse calvatiae. J Bone Miner Metab, Vol.29, pp671-681, 2011
3. K. Miyagawa, Y. Kozai, Y. Ito, T. Furuhama, K. Naruse, K. Nonaka, Y. Nagai, H. Yamato, I. Kashima, K. Ohya, K. Aoki, Y. Mikuni-Takagaki. A novel underuse model shows that inactivity but not ovariectomy determines the deteriorated material properties and geometry of cortical bone in the tibia of adult rats. J Bone Miner Metab, Vol.29, pp422-436, 2011
4. Bakry AS, Tamura Y, Otsuki M, Kasugai S, Ohya K, Tagami J. Cytotoxicity of 45S5 bioglass paste used for dentine hypersensitivity treatment. J Dent. Vol.39(9), pp599-603, 2011
5. Rojbani H, Nyan M, Ohya K, Kasugai S. Evaluation of the osteoconductivity of α-tricalcium phosphate, β-tricalcium phosphate, and hydroxyapatite combined with or without simvastatin in rat calvarial defect. J Biomed Mater Res A. Vol.98(4), pp488-98, 2011
6. Rodriguez R, Kondo H, Nyan M, Hao J, Miyahara T, Ohya K, Kasugai S. Implantation of green tea catechin α-tricalcium phosphate combination enhances bone repair in rat skull defects. J Biomed Mater Res B Appl Biomater. Vol.98B(2), pp263-71. 2011
7. Hao J, Kuroda S, Ohya K, Bartakova S, Aoki H, Kasugai S. Enhanced osteoblast and osteoclast responses to a thin film sputtered hydroxyapatite coating. J Mater Sci Mater Med.Vol. 22(6), pp1489-99, 2011
8. Date Y, Yokoyama Y, Kondo H, Kuroda S, Ohya K, Ota MS, Iseki S, Kasugai S. Restricted expression of chromatin remodeling associated factor Chd3 during tooth root development. J Periodontal Res. doi: 10.1111/j.1600-0765.2011.01419.x, 2011