Original Article 2008

Original Article 2008

1. Staffs and Students 2008

ProfessorKeiichi OHYA
Associate ProfessorHitoyata SHIMOKAWA
Assistant ProfessorYukihiko TAMURA
Kazuhiro AOKI
TechnologistMariko TAKAHASHI
Researcher (JSPS)Kazuo OKAMOTO
Graduate StudentHennadige Niroshani Surangika SOYSA (~Sep)
Chrisman Neil Roshan Alexander ALLES
Wantida SRIARJ (Developmental Oral Health Science)
Nobuyoshi TOMOMATSU (Maxillofacial Surgery)
Kenichi NAGANO
Hiroyuki NAKACHI (Maxillofacial Surgery) (Apr~)
Naoki HAYASHI >(Dentistry for Persons with Disabilities) (Apr~)
Toshimi SATO (Apr~)

2. Purpose of Education

Pharmacology is situated between the basic and clinical sciences and is important for dental students. There is a growing demand on the dental clinicians to know huge knowledge of drugs and how to use them for patients. For these purpose, the first lecture is aimed to teach the scientific aspects of pharmacology and how drugs act on the various body system. The second lecture deals with drugs of medical and dental fields and the last with drugs of special importance of dentistry. Dental students learn the principle of pharmacology through laboratory practice. Following these learning, they must acquire an adequate background for drug use in general practice.

3. Research Subjects

1)Pharmacological analysis of the formation and resorption mechanisms of teeth and bone
2)Drug effects on the differentiation of the cells that participate formation and resorption process of the hard tissues
3)Identification of the new drug targets for hard tissue diseases
4)Translational research for the hard tissue regeneration
5)Analysis of side effects of the drug that appear in oral tissues

4. Publications

Original Article

1. Yokota T, Shimokawa H, Shibata S, Itoh K, Baba Y, Ohya K, Ohyama K, Suzuki S. Insulin-like Growth Factor I Regulates Apoptosis in Condylar Cartilage. J Dent Res Vol.87(2), pp159-163, 2008

2. Asagiri M, Hirai T, Kunigami T, Kamano S, Gober H-J, Okamoto K, Nishikawa K, Latz E, Golenbock D.T, Aoki K, Ohya K, Imai Y, Morishita Y, Miyazono K, Kato S, Saftig P, Takayanagi H. Cathepsin K-Dependent Toll-Like Receptor 9 Signaling Revealed in Experimental Arthritis. Science Vol.319, pp.624-627, February 2008

3. Mian MD, Saito H, Alles N, Shimokawa H, Aoki K, Ohya K. Lipopolysaccharide-induced bone resorption is increased in TNF type 2 receptor-deficient mice in vivo. J Bone Miner Metab Vol.26, pp469-477, 2008

4. Yokoyama Y, Damrongrungruang T, Kuroda S, Takano Y, Ohya K, Kasugai S, Kondo H. Comparative Analysis of Gene Expression by cDNA Microarray between Cementoblasts and Periodontal Ligament Cells in the Murine Mandible. J Oral Biosci Vol.50(3), pp183-193, 2008

5. Samee M, Kasugai S, Kondo H, Ohya K, Shimokawa H, Kuroda S. Bone Morphogenetic Protein-2(BMP-2) and Vascular Endothelial Growth Factor (VEGF) Transfection to Human Periosteal Cells Enhances Osteoblast Differentiation and Bone Formation. J Pharmacol Sci Vol.108, pp18-31, 2008