Publications
Kodaka M, Mao F, Arimoto-Matsuzaki K, Kitamura M, Xu X, Yang Z, Nakagawa K, Maruyama J, Ishii K, Akazawa C, Oyaizu T, Yamamoto N, Ishigami-Yuasa M, Tsuemoto N, Ito S, Kagechika H, Nishina H, Hata Y. Characterization of a novel compound that promotes myogenesis via Akt and transcriptional co-activator with PDZ-binding motif (TAZ) in mouse C2C12 cells. PLoS One. 2020 Apr 8;15(4):e0231265. doi: 10.1371/journal.pone.0231265. eCollection 2020.
Watanabe N, Morimatsu M, Fujita A, Teranishi M, Sudevan S, Watanabe M, Iwasa H, Hata Y, Kagi H, Nishiyama M, Naruse K, Higashitani A. Increased hydrostatic pressure induces nuclear translocation of DAF-16/FOXO in C. elegans. Biochem Biophys Res Commun. 2020 Mar 19;523(4):853-858. doi: 10.1016/j.bbrc.2020.01.047. Epub 2020 Jan 15.
Ito M, Hara H, Takeda N, Naito AT, Nomura S, Kondo M, Hata Y, Uchiyama M, Morita H, Komuro I. Characterization of a small molecule that promotes cell cycle activation of human induced pluripotent stem cell-derived cardiomyocytes. J Mol Cell Cardiol. 2019 Jan 23;128:90-95. doi: 10.1016/j.yjmcc.2019.01.020. [Epub ahead of print]
Hara H, Takeda N, Kondo M, Kubota M, Saito T, Maruyama J, Fujiwara T, Maemura S, Ito M, Naito AT, Harada M, Toko H, Nomura S, Kumagai H, Ikeda Y, Ueno H, Takimoto E, Akazawa H, Morita H, Aburatani H, Hata Y, Uchiyama M, Komuro I. Discovery of a Small Molecule to Increase Cardiomyocytes and Protect the Heart After Ischemic Injury. JACC Basic Transl Sci. 2018 Nov 12;3(5):639-653. doi: 10.1016/j.jacbts.2018.07.005. eCollection 2018 Oct.]
Hata Y. Hippo Pathway in Cancer, towards the Realization of Hippo-Targeted Therapy. Cancers (Basel). 2018 Oct 12;10(10). pii: E383. doi: 10.3390/cancers10100383
Timalsina S, Arimoto-Matsuzaki K, Kitamura M, Xu X, Wenzhe Q, Ishigami-Yuasa M, Kagechika H, Hata Y. Chemical compounds that suppress hypoxia-induced stress granule formation enhance cancer drug sensitivity of human cervical cancer HeLa cells. J Biochem. 2018 Nov 1;164(5):381-391. doi: 10.1093/jb/mvy062.
Iwasa H, Sarkar A, Shimizu T, Sawada T, Hossain S, Xu X, Maruyama J, Arimoto-Matsuzaki K, Withanage K, Nakagawa K, Kurihara H, Kuroyanagi H, Hata Y. UNC119 is a binding partner of a tumor suppressor RASSF6 and induces apoptosis and cell cycle arrest via MDM2 and p53. Cancer Sci. 2018 Sep;109(9):2767-2780. doi: 10.1111/cas.13706.
Li Q, Yoshimura H, Komiya M,Tajiri K, Uesugi M, Hata Y, Ozawa T. A Robust Split-Luciferase-Based Cell Fusion Screening for Discovering Myogenesis-Promoting Molecules. Analyst 2018 Jul 9;143(14):3472-3480. doi: 10.1039/c8an00285a.
Hossain S, Iwasa H, Sarkar A, Maruyama J, Arimoto-Matsuzaki K, Hata Y.The RASSF6 tumor suppressor protein regulates apoptosis and the cell cycle via Retinoblastoma protein. Mol Cell Biol. 2018 Jun 11. pii: MCB.00046-18. doi: 10.1128/MCB.00046-18.
Iwasa H, Hossain S, Hata Y. Tumor suppressor C-RASSF proteins. Cellular and Molecular Life Sciences 2018 May;75(10):1773-1787. doi: 10.1007/s00018-018-2756-5.
Xu X, Iwasa H, Hossain S, Sarkar A, Maruyama J, Arimoto-Matsuzaki K, Hata Y. BCL-XL binds and antagonizes RASSF6 tumor suppressor to suppress p53 expression. Genes Cells. 2017 Dec;22(12):993-1003. doi: 10.1111/gtc.12541.
Maruyama J, Inami K, Michishita F, Jiang X, Iwasa H, Nakagawa K, Ishigami-Yuasa M, Kagechika H, Miyamura N, Hirayama J, Nishina H, Nogawa D, Yamamoto K, Hata Y. Novel YAP1 Activator, Identified by Transcription-Based Functional Screen, Limits Multiple Myeloma Growth. Mol Cancer Res. 2017 Oct 23. doi: 10.1158/1541-7786.MCR-17-0382. [Epub ahead of print]
Sarkar A, Iwasa H, Hossain S, Xu X, Sawada T, Shimizu T, Maruyama J, Arimoto-Matsuzaki K, Hata Y. Domain analysis of Ras-association domain family member 6 upon interaction with MDM2. FEBS Lett. 591, 260-272. 2017 doi: 10.1002/1873-3468.12551.
Kodaka M, Xu X, Yang Z, Maruyama J, Hata Y. Application of split-GFP reassembly assay to study myogenesis and myofution in vitro. Methods Mol Bio. 1668, 127-134. 2017. doi: 10.1007/978-1-4939-7283-8_9.
Nagashima S, Bao Y, Hata Y. The Hippo pathway as drug targets in cancer therapy and regenerative medicine. Current Drug Targets. 18, 447-454. 2017 doi: 10.2174/1389450117666160112115641.
Nagashima S, Maruyama J, Kawano S, Iwasa H, Nakagawa K, Ishigami-Yuasa M, Kagechika H, Nishina H, Hata Y. Validation of the chemical compound library screening for TAZ inhibitors by use of green fluorescence protein-fused TAZ. Cancer Sci. 107, 791-802. 2016
Katano T, Fukuda M, Furue H, Yamazaki M, Abe M, Watanabe M, Nishida K, Yao I, Yamada A, Hata Y, Okumura N, Nakazawa T, Yamamoto T, Sakimura K, Takano T, Ito S. Invovlement of brain-enriched guanylate kinase-assoicated protein (BEGAIN) in chronic pain ater peripheral nerve injury. eNeuro 17, 3. pii: ENEURO.0110-16.2016. eCollection 2016 Sep-Oct.
Iwasa H, Jiang X, Hata Y. RASSF6; the Putative Tumor Suppressor of the RASSF Family. Cancers (Basel). 9, 2415-2426. 2015
Kodaka M, Yang Z, Nakagawa K, Maruyama J, Xu X, Sarkar A, Ichimura A, Nasu Y, Ozawa T, Iwasa H, Ishigami-Yuasa M, Ito S, Kagechika H, Hata Y. A new cell-based assay to evaluate myogenesis in mouse myoblast C2C12 cells. Exp Cell Res. 336, 171-181. 2015
Kawano S, Maruyama J, Nagashima S, Inami K, Qiu W, Iwasa H, Nakagawa K, Ishigami-Yuasa M, Kagechika H, Nishina H, Hata Y. A cell-based screening for TAZ activators identifies ethacridine, a widely used antiseptic and abortifacient, as a compound that promotes dephosphorylation of TAZ and inhibits adipogenesis in C3H10T1/2 cells. J Biochem. 158, 413-423. 2015
Lefebvre J, Clarkson M, Massa F, Bradford ST, Charlet A, Buske F, Lacas-Gervais S, Schulz H, Gimpel C, Hata Y, Schaefer F, Schedl A. Alternatively spliced isoforms of WT1 control podocyte-specific gene expression. Kidney Int. 88, 321-331. 2015
Nagashma S, Kodaka M, Iwasa H, Hata Y. MAGI2/S-SCAM outside brain. J Biochem. 157, 177-184. 2015
Kodaka M, Hata Y. The mammalian Hippo pathway: regulation and function of YAP1 and TAZ. Cell Mol Life Sci. 72, 285-306. 2015
Yang Z, Nakagawa K, Sarkar A, Maruyama J, Iwasa H, Bao Y, Ishigami-Yuasa M, Ito S, Kagechika H, Hata S, Nishina H, Abe S, Kitagawa M, Hata Y. Screening with a novel cell-based assay for TAZ activators identifies a compound that enhances myogenesis in C2C12 cells and facilitates muscle repair in the muscle injury model. Mol Cell Biol. 34, 1607-1621. 2014
Iwasa H, Kudo T, Maimait S, Ikeda M, Maruyama J, Nakagawa K, Hata Y. The RASSF6 tumor suppressor protein regulates apoptosis an the cell cycle via MDM2 protein and p53 protein. J Biol Chem 288, 30320-30329. 2013
Yang Z, Hata Y. What is the Hippo pathway?: Is the Hippo pathway conserved in Caenorhabditis elegans? J Biochem. 154, 207-209. 2013
Hata Y, Timalsina S, Maimaitia S. Okadaic acid: a tool to study the Hippo pathway. Marine Drugs 11, 896-902. 2013
Sanada Y, Kumoto T, Suehiro H, Nishimura F, Kato N, Hata Y, Sorisky A, Yanaka N. RASSF6 expression in adipocytes down-regulated by interaction with macrophages. PLoS One 8, e61931. 2013
Iwasa H, Maimaitia S, Kuroyanagi H, Kawano S, Inami K, Timalsina S, Ikeda M, Nakagawa K, Hata Y. Yes-associated protein homolog, YAP-1, is involved in the thermotolerance and aging in the nematode Caenorhabditis elegans, Exp. Cell Res. 319, 931-945. 2013
Iwasa H, Kuroyanagi H, Maimaiti S, Ikeda M, Nakagawa K, Hata Y. Characterization of RSF-1, the Caenorhabditis elegans homolog of the Ras-association domain family protein 1. Exp. Cell Res. 319, 1-11. 2013
Kudo T, Ikeda M, Nishikawa M, Yang Z, Ohno K, Nakagawa K, Hata Y. The RASSF3 candidate tumor suppressor induces apoptosis and G1/S cell cycle arrest via p53. Cancer Res. 72, 2901-2911. 2012
Nishio M, Hamada K, Kawahara K, Sasaki M, Noguchi F, Chiba S, Mizuno K, Suzuki S, Dong Y, Tokuda M, Morikawa T, Hikasa H, Eggenschwiler J, Yabuta N, Nojima H, Nakagawa K, Hata Y, Nishina H, Mimori K, Mori M, Sasaki T, Mak TW, Nakano T, Itami S, Suzuki A. Cancer susceptibility and embryonic lethality in Mob1A/1B double mutant mice. J Clin Invest. 122,4505-4518. 2012
Hata S, Hirayama J, Kajiho H, Nakagawa K, Hata Y, Katada T, Furutani-Seiki M, Nishina H. A novel acetylation cycle of transcription co-activator Yes-associated protein that is downstream of Hippo pathway is triggered in response to SN2 alkylating agents. J Biol Chem. 287, 22089-22098. 2012
Withanage K, Nakagawa K, Ikeda M, Kurihahara H, Kudo T, Yang Z, Sakanae A, Sasaki T, Hata Y. Expression of RASSF6 in kidney and the implication of RASSF6 and the Hippo pathway in the sorbitol-induced apoptosis in renal proximal tubular epithelial cells. J Biochem. 152, 111-119. 2012
Hirai S, Miwa A, Ohtaka-Maruyama C, Kasai M, Okabe S, Hata Y, Okado H. RP58 controls neuron and astrocyte differentiation by downregulating the expression of Id1-4 genes in the developing cortex. EMBO J. 31, 1190-1202. 2012
Bao Y, Nakagawa K, Yang Z, Ikeda M, Withanage K, Ishigami-Yuasa M, Okuno Y, Hata S, Nishina H, Hata Y. A cell-based assay to screen stimulators of the Hippo pathway reveals the inhibitory effect of dobutamine on the YAP-dependent gene transcription. J Biochem. 150, 199-208. 2011. (日本生化学会JB論文賞)
Bao Y, Hata Y, Ikeda M, Withanage K. Mammlian Hippo pathway:from development to cancer and beyond. J Biochem. 149, 361-379. 2011
Fukaya M, Kamata A, Hara Y, Tamaki H, Katsumata O, Ito N, Takeda S, Hata Y, Suzuki T, Watanabe M, Harvey RJ, Sakagami H. SynArfGEF is a guanine nucleotide exchange factor for Arf6 and localizes preferentially at post-synaptic specializations of inhibitory synapse. J Neurochem. 116, 1122-1137. 2011
Kaufman L, Potla U, Coleman S, Dikiy S, Hata Y, Kurihara H, He JC, D’Agati VD, Klotman PE. Upregulation of the homophilic adhesion molecule Sidekick-1 in podocytes contributes to glomeruloscrelosis. J Biol Chem.285, 25677-25685. 2010
Nakagawa K, Sugahara M, Yamasaki T, Kajiho H, Takahashi S, Hirayama J, Minami Y, Ohta Y, Watanabe T, Hata Y, Katada T, Nishina H. Filamin associates with stress signaling kinases MKK7 and MKK4 and regulates JNK activation. Biochem J. 427(2), 237-245. 2010
Bao Y, Sumita K, Kudo T, Withanage K, Nakagawa K, Ikeda M, Ohno K, Wang Y, Hata Y. Roles of mammalian sterile 20-like kinase 2-dependent phosphorylations of Mps one binder 1B in the activation of nuclear Dbf2-related kinases. Genes Cells 14: 1369-1381. 2009
Ikeda M, Kawata A, Nishikawa M, Tateishi Y, Yamaguchi M, Nakagawa K, Hirabayashi S, Bao Y, Hidaka S, Hirata Y, Hata Y. Hippo pathway-dependent and -independent roles of RASSF6. Sci Signal. 2: ra59 2009
Hirabayashi S, Nakagawa K, Sumita K, Hidaka S, Kawai T, Ikeda M, Kawata A, Ohno K, Hata Y. Threonine 74 of MOB1 is a putative key phosphorylation site by MST2 to form the scaffold to activate nuclear Dbf2-related kinase 1. Oncogene 27: 4281-4292. 2008
Takahashi A, Hirai S, Ohtaka-Maruyama C, Miwa A, Hata Y, Okabe S, Okado H. Co-localization of a novel transcriptional repressor simiRP58 with RP58. Biochem Biophys Res Commun. 368: 637-642. 2008
Iida J, Ishizaki H, Okamoto-Tanaka M, Kawata A, Sumita K, Ohgake S, Sato Y, Yorifuji H, Nukina,N, Ohashi K, Mizuno K, Tsutsumi T, Mizoguchi A, Miyoshi J, Takai Y, Hata Y. S-SCAMalpha is a scaffold to mediate NMDA receptor-dependent RhoA activation in dendrites. Mol Cell Biol. 27: 4388-4405. 2007
Ikeda M, Hirabayashi S, Fujiwara N, Mori H, Kawata A, Iida J, Bao Y, Sato Y, Iida T, Sugimura H, Hata Y. Ras-association domain family protein 6 induces apoptosis via both caspase-dependent and caspase-independent pathways. Exp Cell Res. 313: 1484-1495. 2007
Sumita K, Sato Y, Iida J, Kawata A, Hamano M, Hirabayashi S, Ohno K, Peles E, Hata Y. S-SCAM/MAGI-2 is associated with cell adhesion molecules at inhibitory synapses at rat hippocampal, neurons. J Neurochem. 100: 154-166. 2007
Fujiwara N, Ikeda M Hirabayashi S, Mori H, Shirasawa M, Kansaku A, Sunamori M, Hata Y. Monoclonal antibody 7F9 recognizes rat protein homologous to human carboxypeptidase-M in rat developing and adult lung. Respirology 12: 54-62. 2007
Nagamatsu G, Ohmura M, Mizukami T, Hamaguchi I, Hirabayashi S, Yoshida S, Hata Y, Suda T, Ohbo K. CTX family cell adhesion molecule, JAM4, expresses in stem cell- and progenitor cell populations of both male germ cell and hematopoietic cell lineages. Mol Cell.Biol. 24: 8498-8506. 2006
Kansaku A, Hirabayashi S, Mori H, Fujiwara N, Kawata A, Ikeda M, Rokukawa C, Kurihara H, Hata Y. Ligand-of-Numb protein X is an endocytic scaffold for junctional adhesion molecule 4. Oncogene 25: 5071-5084. 2006
Kawata A, Iida J, Ikeda M, Sato Y, Mori H, Kansaku A, Sumita K, Fujiwara N, Rokukawa C, Hamano M, Hirabayashi S, Hata Y. CIN85 is localized at synapses and forms a complex with S-SCAM via Dendrin. J. Biochem. 139: 931-939. 2006
Uchida T, Shirasawa M, Ware LB, Kojima K, Hata Y, Makita K, Mednick G, Matthay ZA, Matthay MA. Receptor for advanced glycation end-products is a marker of type I cell injury in acute lung injury. Am J Respir Crit. Care Med. 173: 1008-1015. 2006
Hirabayashi S, Mori H, Kansaku A, Sakai H, Shimizu F, Kawachi H, Hata Y. MAGI-1 is a component of the glomerular slit diaphragm that is tightly associated with nephrin. Lab Invest. 85: 1528-1543. 2005
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Watanabe N, Morimatsu M, Fujita A, Teranishi M, Sudevan S, Watanabe M, Iwasa H, Hata Y, Kagi H, Nishiyama M, Naruse K, Higashitani A. Increased hydrostatic pressure induces nuclear translocation of DAF-16/FOXO in C. elegans. Biochem Biophys Res Commun. 2020 Mar 19;523(4):853-858. doi: 10.1016/j.bbrc.2020.01.047. Epub 2020 Jan 15.
Ito M, Hara H, Takeda N, Naito AT, Nomura S, Kondo M, Hata Y, Uchiyama M, Morita H, Komuro I. Characterization of a small molecule that promotes cell cycle activation of human induced pluripotent stem cell-derived cardiomyocytes. J Mol Cell Cardiol. 2019 Jan 23;128:90-95. doi: 10.1016/j.yjmcc.2019.01.020. [Epub ahead of print]
Hara H, Takeda N, Kondo M, Kubota M, Saito T, Maruyama J, Fujiwara T, Maemura S, Ito M, Naito AT, Harada M, Toko H, Nomura S, Kumagai H, Ikeda Y, Ueno H, Takimoto E, Akazawa H, Morita H, Aburatani H, Hata Y, Uchiyama M, Komuro I. Discovery of a Small Molecule to Increase Cardiomyocytes and Protect the Heart After Ischemic Injury. JACC Basic Transl Sci. 2018 Nov 12;3(5):639-653. doi: 10.1016/j.jacbts.2018.07.005. eCollection 2018 Oct.]
Hata Y. Hippo Pathway in Cancer, towards the Realization of Hippo-Targeted Therapy. Cancers (Basel). 2018 Oct 12;10(10). pii: E383. doi: 10.3390/cancers10100383
Timalsina S, Arimoto-Matsuzaki K, Kitamura M, Xu X, Wenzhe Q, Ishigami-Yuasa M, Kagechika H, Hata Y. Chemical compounds that suppress hypoxia-induced stress granule formation enhance cancer drug sensitivity of human cervical cancer HeLa cells. J Biochem. 2018 Nov 1;164(5):381-391. doi: 10.1093/jb/mvy062.
Iwasa H, Sarkar A, Shimizu T, Sawada T, Hossain S, Xu X, Maruyama J, Arimoto-Matsuzaki K, Withanage K, Nakagawa K, Kurihara H, Kuroyanagi H, Hata Y. UNC119 is a binding partner of a tumor suppressor RASSF6 and induces apoptosis and cell cycle arrest via MDM2 and p53. Cancer Sci. 2018 Sep;109(9):2767-2780. doi: 10.1111/cas.13706.
Li Q, Yoshimura H, Komiya M,Tajiri K, Uesugi M, Hata Y, Ozawa T. A Robust Split-Luciferase-Based Cell Fusion Screening for Discovering Myogenesis-Promoting Molecules. Analyst 2018 Jul 9;143(14):3472-3480. doi: 10.1039/c8an00285a.
Hossain S, Iwasa H, Sarkar A, Maruyama J, Arimoto-Matsuzaki K, Hata Y.The RASSF6 tumor suppressor protein regulates apoptosis and the cell cycle via Retinoblastoma protein. Mol Cell Biol. 2018 Jun 11. pii: MCB.00046-18. doi: 10.1128/MCB.00046-18.
Iwasa H, Hossain S, Hata Y. Tumor suppressor C-RASSF proteins. Cellular and Molecular Life Sciences 2018 May;75(10):1773-1787. doi: 10.1007/s00018-018-2756-5.
Xu X, Iwasa H, Hossain S, Sarkar A, Maruyama J, Arimoto-Matsuzaki K, Hata Y. BCL-XL binds and antagonizes RASSF6 tumor suppressor to suppress p53 expression. Genes Cells. 2017 Dec;22(12):993-1003. doi: 10.1111/gtc.12541.
Maruyama J, Inami K, Michishita F, Jiang X, Iwasa H, Nakagawa K, Ishigami-Yuasa M, Kagechika H, Miyamura N, Hirayama J, Nishina H, Nogawa D, Yamamoto K, Hata Y. Novel YAP1 Activator, Identified by Transcription-Based Functional Screen, Limits Multiple Myeloma Growth. Mol Cancer Res. 2017 Oct 23. doi: 10.1158/1541-7786.MCR-17-0382. [Epub ahead of print]
Sarkar A, Iwasa H, Hossain S, Xu X, Sawada T, Shimizu T, Maruyama J, Arimoto-Matsuzaki K, Hata Y. Domain analysis of Ras-association domain family member 6 upon interaction with MDM2. FEBS Lett. 591, 260-272. 2017 doi: 10.1002/1873-3468.12551.
Kodaka M, Xu X, Yang Z, Maruyama J, Hata Y. Application of split-GFP reassembly assay to study myogenesis and myofution in vitro. Methods Mol Bio. 1668, 127-134. 2017. doi: 10.1007/978-1-4939-7283-8_9.
Nagashima S, Bao Y, Hata Y. The Hippo pathway as drug targets in cancer therapy and regenerative medicine. Current Drug Targets. 18, 447-454. 2017 doi: 10.2174/1389450117666160112115641.
Nagashima S, Maruyama J, Kawano S, Iwasa H, Nakagawa K, Ishigami-Yuasa M, Kagechika H, Nishina H, Hata Y. Validation of the chemical compound library screening for TAZ inhibitors by use of green fluorescence protein-fused TAZ. Cancer Sci. 107, 791-802. 2016
Katano T, Fukuda M, Furue H, Yamazaki M, Abe M, Watanabe M, Nishida K, Yao I, Yamada A, Hata Y, Okumura N, Nakazawa T, Yamamoto T, Sakimura K, Takano T, Ito S. Invovlement of brain-enriched guanylate kinase-assoicated protein (BEGAIN) in chronic pain ater peripheral nerve injury. eNeuro 17, 3. pii: ENEURO.0110-16.2016. eCollection 2016 Sep-Oct.
Iwasa H, Jiang X, Hata Y. RASSF6; the Putative Tumor Suppressor of the RASSF Family. Cancers (Basel). 9, 2415-2426. 2015
Kodaka M, Yang Z, Nakagawa K, Maruyama J, Xu X, Sarkar A, Ichimura A, Nasu Y, Ozawa T, Iwasa H, Ishigami-Yuasa M, Ito S, Kagechika H, Hata Y. A new cell-based assay to evaluate myogenesis in mouse myoblast C2C12 cells. Exp Cell Res. 336, 171-181. 2015
Kawano S, Maruyama J, Nagashima S, Inami K, Qiu W, Iwasa H, Nakagawa K, Ishigami-Yuasa M, Kagechika H, Nishina H, Hata Y. A cell-based screening for TAZ activators identifies ethacridine, a widely used antiseptic and abortifacient, as a compound that promotes dephosphorylation of TAZ and inhibits adipogenesis in C3H10T1/2 cells. J Biochem. 158, 413-423. 2015
Lefebvre J, Clarkson M, Massa F, Bradford ST, Charlet A, Buske F, Lacas-Gervais S, Schulz H, Gimpel C, Hata Y, Schaefer F, Schedl A. Alternatively spliced isoforms of WT1 control podocyte-specific gene expression. Kidney Int. 88, 321-331. 2015
Nagashma S, Kodaka M, Iwasa H, Hata Y. MAGI2/S-SCAM outside brain. J Biochem. 157, 177-184. 2015
Kodaka M, Hata Y. The mammalian Hippo pathway: regulation and function of YAP1 and TAZ. Cell Mol Life Sci. 72, 285-306. 2015
Yang Z, Nakagawa K, Sarkar A, Maruyama J, Iwasa H, Bao Y, Ishigami-Yuasa M, Ito S, Kagechika H, Hata S, Nishina H, Abe S, Kitagawa M, Hata Y. Screening with a novel cell-based assay for TAZ activators identifies a compound that enhances myogenesis in C2C12 cells and facilitates muscle repair in the muscle injury model. Mol Cell Biol. 34, 1607-1621. 2014
Iwasa H, Kudo T, Maimait S, Ikeda M, Maruyama J, Nakagawa K, Hata Y. The RASSF6 tumor suppressor protein regulates apoptosis an the cell cycle via MDM2 protein and p53 protein. J Biol Chem 288, 30320-30329. 2013
Yang Z, Hata Y. What is the Hippo pathway?: Is the Hippo pathway conserved in Caenorhabditis elegans? J Biochem. 154, 207-209. 2013
Hata Y, Timalsina S, Maimaitia S. Okadaic acid: a tool to study the Hippo pathway. Marine Drugs 11, 896-902. 2013
Sanada Y, Kumoto T, Suehiro H, Nishimura F, Kato N, Hata Y, Sorisky A, Yanaka N. RASSF6 expression in adipocytes down-regulated by interaction with macrophages. PLoS One 8, e61931. 2013
Iwasa H, Maimaitia S, Kuroyanagi H, Kawano S, Inami K, Timalsina S, Ikeda M, Nakagawa K, Hata Y. Yes-associated protein homolog, YAP-1, is involved in the thermotolerance and aging in the nematode Caenorhabditis elegans, Exp. Cell Res. 319, 931-945. 2013
Iwasa H, Kuroyanagi H, Maimaiti S, Ikeda M, Nakagawa K, Hata Y. Characterization of RSF-1, the Caenorhabditis elegans homolog of the Ras-association domain family protein 1. Exp. Cell Res. 319, 1-11. 2013
Kudo T, Ikeda M, Nishikawa M, Yang Z, Ohno K, Nakagawa K, Hata Y. The RASSF3 candidate tumor suppressor induces apoptosis and G1/S cell cycle arrest via p53. Cancer Res. 72, 2901-2911. 2012
Nishio M, Hamada K, Kawahara K, Sasaki M, Noguchi F, Chiba S, Mizuno K, Suzuki S, Dong Y, Tokuda M, Morikawa T, Hikasa H, Eggenschwiler J, Yabuta N, Nojima H, Nakagawa K, Hata Y, Nishina H, Mimori K, Mori M, Sasaki T, Mak TW, Nakano T, Itami S, Suzuki A. Cancer susceptibility and embryonic lethality in Mob1A/1B double mutant mice. J Clin Invest. 122,4505-4518. 2012
Hata S, Hirayama J, Kajiho H, Nakagawa K, Hata Y, Katada T, Furutani-Seiki M, Nishina H. A novel acetylation cycle of transcription co-activator Yes-associated protein that is downstream of Hippo pathway is triggered in response to SN2 alkylating agents. J Biol Chem. 287, 22089-22098. 2012
Withanage K, Nakagawa K, Ikeda M, Kurihahara H, Kudo T, Yang Z, Sakanae A, Sasaki T, Hata Y. Expression of RASSF6 in kidney and the implication of RASSF6 and the Hippo pathway in the sorbitol-induced apoptosis in renal proximal tubular epithelial cells. J Biochem. 152, 111-119. 2012
Hirai S, Miwa A, Ohtaka-Maruyama C, Kasai M, Okabe S, Hata Y, Okado H. RP58 controls neuron and astrocyte differentiation by downregulating the expression of Id1-4 genes in the developing cortex. EMBO J. 31, 1190-1202. 2012
Bao Y, Nakagawa K, Yang Z, Ikeda M, Withanage K, Ishigami-Yuasa M, Okuno Y, Hata S, Nishina H, Hata Y. A cell-based assay to screen stimulators of the Hippo pathway reveals the inhibitory effect of dobutamine on the YAP-dependent gene transcription. J Biochem. 150, 199-208. 2011. (日本生化学会JB論文賞)
Bao Y, Hata Y, Ikeda M, Withanage K. Mammlian Hippo pathway:from development to cancer and beyond. J Biochem. 149, 361-379. 2011
Fukaya M, Kamata A, Hara Y, Tamaki H, Katsumata O, Ito N, Takeda S, Hata Y, Suzuki T, Watanabe M, Harvey RJ, Sakagami H. SynArfGEF is a guanine nucleotide exchange factor for Arf6 and localizes preferentially at post-synaptic specializations of inhibitory synapse. J Neurochem. 116, 1122-1137. 2011
Kaufman L, Potla U, Coleman S, Dikiy S, Hata Y, Kurihara H, He JC, D’Agati VD, Klotman PE. Upregulation of the homophilic adhesion molecule Sidekick-1 in podocytes contributes to glomeruloscrelosis. J Biol Chem.285, 25677-25685. 2010
Nakagawa K, Sugahara M, Yamasaki T, Kajiho H, Takahashi S, Hirayama J, Minami Y, Ohta Y, Watanabe T, Hata Y, Katada T, Nishina H. Filamin associates with stress signaling kinases MKK7 and MKK4 and regulates JNK activation. Biochem J. 427(2), 237-245. 2010
Bao Y, Sumita K, Kudo T, Withanage K, Nakagawa K, Ikeda M, Ohno K, Wang Y, Hata Y. Roles of mammalian sterile 20-like kinase 2-dependent phosphorylations of Mps one binder 1B in the activation of nuclear Dbf2-related kinases. Genes Cells 14: 1369-1381. 2009
Ikeda M, Kawata A, Nishikawa M, Tateishi Y, Yamaguchi M, Nakagawa K, Hirabayashi S, Bao Y, Hidaka S, Hirata Y, Hata Y. Hippo pathway-dependent and -independent roles of RASSF6. Sci Signal. 2: ra59 2009
Hirabayashi S, Nakagawa K, Sumita K, Hidaka S, Kawai T, Ikeda M, Kawata A, Ohno K, Hata Y. Threonine 74 of MOB1 is a putative key phosphorylation site by MST2 to form the scaffold to activate nuclear Dbf2-related kinase 1. Oncogene 27: 4281-4292. 2008
Takahashi A, Hirai S, Ohtaka-Maruyama C, Miwa A, Hata Y, Okabe S, Okado H. Co-localization of a novel transcriptional repressor simiRP58 with RP58. Biochem Biophys Res Commun. 368: 637-642. 2008
Iida J, Ishizaki H, Okamoto-Tanaka M, Kawata A, Sumita K, Ohgake S, Sato Y, Yorifuji H, Nukina,N, Ohashi K, Mizuno K, Tsutsumi T, Mizoguchi A, Miyoshi J, Takai Y, Hata Y. S-SCAMalpha is a scaffold to mediate NMDA receptor-dependent RhoA activation in dendrites. Mol Cell Biol. 27: 4388-4405. 2007
Ikeda M, Hirabayashi S, Fujiwara N, Mori H, Kawata A, Iida J, Bao Y, Sato Y, Iida T, Sugimura H, Hata Y. Ras-association domain family protein 6 induces apoptosis via both caspase-dependent and caspase-independent pathways. Exp Cell Res. 313: 1484-1495. 2007
Sumita K, Sato Y, Iida J, Kawata A, Hamano M, Hirabayashi S, Ohno K, Peles E, Hata Y. S-SCAM/MAGI-2 is associated with cell adhesion molecules at inhibitory synapses at rat hippocampal, neurons. J Neurochem. 100: 154-166. 2007
Fujiwara N, Ikeda M Hirabayashi S, Mori H, Shirasawa M, Kansaku A, Sunamori M, Hata Y. Monoclonal antibody 7F9 recognizes rat protein homologous to human carboxypeptidase-M in rat developing and adult lung. Respirology 12: 54-62. 2007
Nagamatsu G, Ohmura M, Mizukami T, Hamaguchi I, Hirabayashi S, Yoshida S, Hata Y, Suda T, Ohbo K. CTX family cell adhesion molecule, JAM4, expresses in stem cell- and progenitor cell populations of both male germ cell and hematopoietic cell lineages. Mol Cell.Biol. 24: 8498-8506. 2006
Kansaku A, Hirabayashi S, Mori H, Fujiwara N, Kawata A, Ikeda M, Rokukawa C, Kurihara H, Hata Y. Ligand-of-Numb protein X is an endocytic scaffold for junctional adhesion molecule 4. Oncogene 25: 5071-5084. 2006
Kawata A, Iida J, Ikeda M, Sato Y, Mori H, Kansaku A, Sumita K, Fujiwara N, Rokukawa C, Hamano M, Hirabayashi S, Hata Y. CIN85 is localized at synapses and forms a complex with S-SCAM via Dendrin. J. Biochem. 139: 931-939. 2006
Uchida T, Shirasawa M, Ware LB, Kojima K, Hata Y, Makita K, Mednick G, Matthay ZA, Matthay MA. Receptor for advanced glycation end-products is a marker of type I cell injury in acute lung injury. Am J Respir Crit. Care Med. 173: 1008-1015. 2006
Hirabayashi S, Mori H, Kansaku A, Sakai H, Shimizu F, Kawachi H, Hata Y. MAGI-1 is a component of the glomerular slit diaphragm that is tightly associated with nephrin. Lab Invest. 85: 1528-1543. 2005
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