研究室案内 業績

業績(2000年から2018年)

  • Matsumoto T, Matsui T, Hirano F, Tohma S, Mori M. Disease activity, treatment and long-term prognosis of adult juvenile idiopathic arthritis patients compared with rheumatoid arthritis patients. Mod Rheumatol. 2018
  • Nakaseko H, Iwata N, Yasuoka R, Kohagura T, Abe N, Kawabe S, Mori M. Pharmacokinetics of mycophenolate mofetil in juvenile patients with autoimmune diseases. Mod Rheumatol. 2018
  • Okamoto N, Yokota S, Takei S, Okura Y, Kubota T, Shimizu M, Nozawa T, Iwata N, Umebayashi H, Kinjo N, Kunishima T, Yasumura J, Mori M. Clinical practice guidance for juvenile idiopathic arthritis (JIA) 2018. Mod Rheumatol. 2018
  • Okumura A, Ida S, Ito S, Oguni T, Suzuki M, Mori M, Shimizu T; Committee on Pediatric Nutrition of the Japanese Pediatric Society. Parental awareness of young children's pattern of ionic beverage consumption. Pediatr Int. 2018
  • Kawakami C, Sato A, Sumita H, Isozaki A, Shimizu H, Kanetaka T, Maehara K, Ao K, Nariai A, Takeshita F, Kizu R, Mori M. Fever Responses Are Enhanced with Advancing Age during Respiratory Syncytial Virus Infection among Children under 24 Months Old. Tohoku J Exp Med. 2018
  • Okumura A, Ida S, Mori M, Shimizu T; Committee on Pediatric Nutrition of The Japanese Pediatric Society. Attitudes of pediatricians toward Children's consumption of ionic beverages. BMC Pediatr. 2018
  • Mori M, Hara T, Kikuchi M, Shimizu H, Miyamoto T, Iwashima S, Oonishi T, Hashimoto K, Kobayashi N, Waki K, Suzuki Y, Otsubo Y, Yamada H, Ishikawa C, Kato T, Fuse S. Infliximab versus intravenous immunoglobulin for refractory Kawasaki disease: a phase 3, randomized, open-label, active-controlled, parallel-group, multicenter trial. Sci Rep. 2018
  • Sakurai N, Hino-Shishikura A, Nozawa T, Kamide H, Ohara A, Nishimura K, Kikuchi M, Hara R, Mori M, Ito S. Clinical significance of subcutaneous fat and fascial involvement in juvenile dermatomyositis. Mod Rheumatol. 2018
  • Donlin LT, Rao DA, Wei K, Slowikowski K, McGeachy MJ, Turner JD, Meednu N, Mizoguchi F, Gutierrez-Arcelus M, Lieb DJ, Keegan J, Muskat K, Hillman J, Rozo C, Ricker E, Eisenhaure TM, Li S, Browne EP, Chicoine A, Sutherby D, Noma A; Accelerating Medicines Partnership RA/SLE Network, Nusbaum C, Kelly S, Pernis AB, Ivashkiv LB, Goodman SM, Robinson WH, Utz PJ, Lederer JA, Gravallese EM, Boyce BF, Hacohen N, Pitzalis C, Gregersen PK, Firestein GS, Raychaudhuri S, Moreland LW, Holers VM, Bykerk VP, Filer A, Boyle DL, Brenner MB, Anolik JH. Methods for high-dimensonal analysis of cells dissociated from cyropreserved synovial tissue. Arthritis Res Ther. 2018
  • Mizoguchi F, Slowikowski K, Wei K, Marshall JL, Rao DA, Chang SK, Nguyen HN, Noss EH, Turner JD, Earp BE, Blazar PE, Wright J, Simmons BP, Donlin LT, Kalliolias GD, Goodman SM, Bykerk VP, Ivashkiv LB, Lederer JA, Hacohen N, Nigrovic PA, Filer A, Buckley CD, Raychaudhuri S, Brenner MB. Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis. Nat Commun. 2018
  • Sato-Kaneko F, Wang X, Yao S, Hosoya T, Lao FS, Messer K, Pu M, Shukla NM, Cottam HB, Chan M, Carson DA, Corr M, Hayashi T. Discovery of a Novel Microtubule Targeting Agent as an Adjuvant for Cancer Immunotherapy. Biomed Res Int. 2018
  • Hosoya T, Sato-Kaneko F, Ahmadi A, Yao S, Lao F, Kitaura K, Matsutani T, Carson DA, Hayashi T. Induction of oligoclonal CD8 T cell responses against pulmonary metastatic cancer by a phospholipid-conjugated TLR7 agonist. Proc Natl Acad Sci U S A. 2018
  • Sasaki H, Takamura A, Kawahata K, Takashima T, Imai K, Morio T, Kohsaka H. Peripheral blood lymphocyte subset repertoires are biased and reflect clinical features in patients with dermatomyositis. Scand J Rheumatol. 2018
  • Kasai S, Sakai R, Koike R, Kohsaka H, Miyasaka N, Harigai M. Higher risk of hospitalized infection, cardiovascular disease, and fracture in patients with rheumatoid arthritis determined using the Japanese health insurance database. Mod Rheumatol. 2018
  • Tanaka Y, Kameda H, Saito K, Kaneko Y, Tanaka E, Yasuda S, Tamura N, Fujio K, Fujii T, Kojima T, Anzai T, Hamada C, Fujino Y, Matsuda S, Kohsaka H. Effect of subcutaneous tocilizumab treatment on work/housework status in biologic-naïve rheumatoid arthritis patients using inverse probability of treatment weighting: FIRST ACT-SC study. Arthritis Res Ther. 2018
  • Sasaki H, Kohsaka H. Current diagnosis and treatment of polymyositis and dermatomyositis. Mod Rheumatol. 2018
  • Umezawa N, Kawahata K, Mizoguchi F, Kimura N, Yoshihashi-Nakazato Y, Miyasaka N, Kohsaka H. Interleukin-23 as a therapeutic target for inflammatory myopathy. Sci Rep. 2018
  • Matsui T, Matsumoto T, Hirano F, Tokunaga F, Okamoto K, Tohma S, Morio T, Kohsaka H, Mori M. Survey of the awareness of adult rheumatologists regarding transitional care for patients with juvenile idiopathic arthritis in Japan. Mod Rheumatol. 2018
  • Mori M, Nakagawa M, Tsuchida N, Kawada K, Sato J, Sakiyama M, Hirano S, Sato K, Nakamura H. Proposal for the development of biologics in pediatric rheumatology. Pediatr Int. 2018
  • Nakano N, Mori M, Umebayashi H, Iwata N, Kobayashi N, Masunaga K, Imagawa T, Murata T, Kinjo N, Nagai K, Miyoshi M, Takei S, Yokota S, Ishii E. Characteristics and outcome of intractable vasculitis syndrome in children: Nation-wide survey in Japan. Mod Rheumatol. 2018
  • Shimizu M, Mizuta M, Yasumi T, Iwata N, Okura Y, Kinjo N, Umebayashi H, Kubota T, Nakagishi Y, Nishimura K, Yashiro M, Yasumura J, Yamazaki K, Wakiguchi H, Okamoto N, Mori M. Validation of Classification Criteria of Macrophage Activation Syndrome in Japanese Patients With Systemic Juvenile Idiopathic Arthritis. Arthritis Care Res (Hoboken). 2018
  • Shukla NM, Arimoto KI, Yao S, Fan JB, Zhang Y, Sato-Kaneko F, Lao FS, Hosoya T, Messer K, Pu M, Cottam HB, Carson DA, Hayashi T, Zhang DE, Corr M. Identification of Compounds That Prolong Type I Interferon Signaling as Potential Vaccine Adjuvants. SLAS Discov. 2018
  • Shimizu H, Mori M. Usefulness of the Combination of Tuberculin Skin Test and Interferon-Gamma Release Assay in Diagnosing Children with Tuberculosis. Tohoku J Exp Med. 2017
  • Mori M, Sugiyama N, Morishima Y, Sugiyama N, Kokubo T, Takei S, Yokota S. Safety and effectiveness of etanercept for treatment of juvenile idiopathic arthritis: Results from a postmarketing surveillance. Mod Rheumatol. 2018
  • Kochi Y, Kamatani Y, Kondo Y, Suzuki A, Kawakami E, Hiwa R, Momozawa Y, Fujimoto M, Jinnin M, Tanaka Y, Kanda T, Cooper RG, Chinoy H, Rothwell S, Lamb JA, Vencovský J, Mann H, Ohmura K, Myouzen K, Ishigaki K, Nakashima R, Hosono Y, Tsuboi H, Kawasumi H, Iwasaki Y, Kajiyama H, Horita T, Ogawa-Momohara M, Takamura A, Tsunoda S, Shimizu J, Fujio K, Amano H, Mimori A, Kawakami A, Umehara H, Takeuchi T, Sano H, Muro Y, Atsumi T, Mimura T, Kawaguchi Y, Mimori T, Takahashi A, Kubo M, Kohsaka H, Sumida T, Yamamoto K. Splicing variant of WDFY4 augments MDA5 signalling and the risk of clinically amyopathic dermatomyositis. Ann Rheum Dis. 2018
  • Bottai M, Tjärnlund A, Santoni G, Werth VP, Pilkington C, de Visser M, Alfredsson L, Amato AA, Barohn RJ, Liang MH, Singh JA, Aggarwal R, Arnardottir S, Chinoy H, Cooper RG, Danko K, Dimachkie MM, Feldman BM, García-De La Torre I, Gordon P, Hayashi T, Katz JD, Kohsaka H, Lachenbruch PA, Lang BA, Li Y, Oddis CV, Olesinka M, Reed AM, Rutkowska-Sak L, Sanner H, Selva-O'Callaghan A, Wook Song Y, Vencovsky J, Ytterberg SR, Miller FW, Rider LG, Lundberg IE; International Myositis Classification Criteria Project consortium, the Euromyositis register and the Juvenile Dermatomyositis Cohort Biomarker Study and Repository (JDRG) (UK and Ireland). EULAR/ACR classification criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups: a methodology report. RMD Open. 2017
  • Oku K, Atsumi T, Akiyama Y, Amano H, Azuma N, Bohgaki T, Asanuma YF, Horita T, Hosoya T, Ichinose K, Kato M, Katsumata Y, Kawaguchi Y, Kawakami A, Koga T, Kohsaka H, Kondo Y, Kubo K, Kuwana M, Mimori A, Mimori T, Mimura T, Murakami K, Nakano K, Nakayamada S, Ogishima H, Ohmura K, Saito K, Sano H, Shibuya M, Takahashi Y, Takasaki Y, Takeuchi T, Tamura N, Tanaka Y, Tsuboi H, Tsunoda S, Yukawa N, Yamakawa N, Yamamoto K, Sumida T. Evaluation of the alternative classification criteria of systemic lupus erythematosus established by Systemic Lupus International Collaborating Clinics (SLICC). Mod Rheumatol. 2018
  • Kimura Y, Yanagimachi M, Ino Y, Aketagawa M, Matsuo M, Okayama A, Shimizu H, Oba K, Morioka I, Imagawa T, Kaneko T, Yokota S, Hirano H, Mori M. Identification of candidate diagnostic serum biomarkers for Kawasaki disease using proteomic analysis. Sci Rep. 2017
  • Hisa K, Yanagimachi MD, Naruto T, Miyamae T, Kikuchi M, Hara R, Imagawa T, Yokota S, Mori M. PADI4 and the HLA-DRB1 shared epitope in juvenile idiopathic arthritis. PLoS One. 2017
  • Lundberg IE, Tjärnlund A, Bottai M, Werth VP, Pilkington C, de Visser M, Alfredsson L, Amato AA, Barohn RJ, Liang MH, Singh JA, Aggarwal R, Arnardottir S, Chinoy H, Cooper RG, Dankó K, Dimachkie MM, Feldman BM, Garcia-De La Torre I, Gordon P, Hayashi T, Katz JD, Kohsaka H, Lachenbruch PA, Lang BA, Li Y, Oddis CV, Olesinska M, Reed AM, Rutkowska-Sak L, Sanner H, Selva-O'Callaghan A, Song YW, Vencovsky J, Ytterberg SR, Miller FW, Rider LG; International Myositis Classification Criteria Project Consortium, the Euromyositis Register, and the Juvenile Dermatomyositis Cohort Biomarker Study and Repository (UK and Ireland). 2017 European League Against Rheumatism/American College of Rheumatology Classification Criteria for Adult and Juvenile Idiopathic Inflammatory Myopathies and Their Major Subgroups. Arthritis Rheumatol. 2017
  • Lundberg IE, Tjärnlund A, Bottai M, Werth VP, Pilkington C, Visser M, Alfredsson L, Amato AA, Barohn RJ, Liang MH, Singh JA, Aggarwal R, Arnardottir S, Chinoy H, Cooper RG, Dankó K, Dimachkie MM, Feldman BM, Torre IG, Gordon P, Hayashi T, Katz JD, Kohsaka H, Lachenbruch PA, Lang BA, Li Y, Oddis CV, Olesinska M, Reed AM, Rutkowska-Sak L, Sanner H, Selva-O'Callaghan A, Song YW, Vencovsky J, Ytterberg SR, Miller FW, Rider LG; International Myositis Classification Criteria Project consortium, The Euromyositis register and The Juvenile Dermatomyositis Cohort Biomarker Study and Repository (JDRG) (UK and Ireland). 2017 European League Against Rheumatism/American College of Rheumatology classification criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups. Ann Rheum Dis. 2017
  • Matsuo Y, Saito T, Yamamoto A, Kohsaka H. Origins of fibroblasts in rheumatoid synovial tissues: Implications from organ fibrotic models. Mod Rheumatol. 2018
  • Honda S, Hirano F, Mouri M, Hasegawa H, Kohsaka H. Aneurysm formation after stent grafting in vascular Behçet's disease. Arthritis Rheumatol. 2018
  • Chang SK, Kohlgruber AC, Mizoguchi F, Michelet X, Wolf BJ, Wei K, Lee PY, Lynch L, Duquette D, Ceperuelo-Mallafré V, Banks AS, Brenner MB. Stromal cell cadherin-11 regulates adipose tissue inflammation and diabetes. J Clin Invest. 2017
  • Nguyen HN, Noss EH, Mizoguchi F, Huppertz C, Wei KS, Watts GFM, Brenner MB. Autocrine Loop Involving IL-6 Family Member LIF, LIF Receptor, and STAT4 Drives Sustained Fibroblast Production of Inflammatory Mediators. Immunity. 2017
  • Rao DA, Gurish MF, Marshall JL, Slowikowski K, Fonseka CY, Liu Y, Donlin LT, Henderson LA, Wei K, Mizoguchi F, Teslovich NC, Weinblatt ME, Massarotti EM, Coblyn JS, Helfgott SM, Lee YC, Todd DJ, Bykerk VP, Goodman SM, Pernis AB, Ivashkiv LB, Karlson EW, Nigrovic PA, Filer A, Buckley CD, Lederer JA, Raychaudhuri S, Brenner MB. Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis. Nature. 2017
  • Hasegawa H, Kawahata K, Mizoguchi F, Okiyama N, Miyasaka N, Kohsaka H. Direct suppression of autoaggressive CD8+ T cells with CD80/86 blockade in CD8+ T cell-mediated polymyositis models of mice.Clin Exp Rheumatol. 2017.
  • Sato-Kaneko F, Yao S, Ahmadi A, Zhang SS, Hosoya T, Kaneda MM, Varner JA, Pu M, Messer KS, Guiducci C, Coffman RL, Kitaura K, Matsutani T, Suzuki R, Carson DA, Hayashi T, Cohen EE. Combination immunotherapy with TLR agonists and checkpoint inhibitors suppresses head and neck cancer. JCI Insight. 2017
  • Utsunomiya M, Dobashi H, Odani T, Saito K, Yokogawa N, Nagasaka K, Takenaka K, Soejima M, Sugihara T, Hagiyama H, Hirata S, Matsui K, Nonomura Y, Kondo M, Suzuki F, Tomita M, Kihara M, Yokoyama W, Hirano F, Yamazaki H, Sakai R, Nanki T, Koike R, Kohsaka H, Miyasaka N, Harigai M. Optimal regimens of sulfamethoxazole-trimethoprim for chemoprophylaxis of Pneumocystis pneumonia in patients with systemic rheumatic diseases: results from a non-blinded, randomized controlled trial. Arthritis Res Ther. 19(1):7, 2017
  • Ge X, Tsang K, He L, Garcia RA, Ermann J, Mizoguchi F, Zhang M, Zhou B, Zhou B, Aliprantis AO. NFAT restricts osteochondroma formation from entheseal progenitors. JCI Insight. 2016
  • Hirano F, Yokoyama W, Yamazaki H, Amano K, Kawakami A, Hayashi T, Tamura N, Yasuda S, Dobashi H, Fujii T, Ito S, Kaneko Y, Matsui T, Okuda Y, Saito K, Suzuki F, Yoshimi R, Sakai R, Koike R, Kohsaka H, Miyasaka N, Harigai M. Achieving simplified disease activity index remission in patients with active rheumatoid arthritis is associated with subsequent good functional and structural outcomes in a real-world clinical setting under a treat-to-target strategy. Mod Rheumatol. 21:1-9,2016
  • Yamazaki H, Hirano F, Takeuchi T, Amano K, Kikuchi J, Kihara M, Yokoyama W, Sugihara T, Nagasaka K, Hagiyama H, Nonomura Y, Sakai R, Tanaka M, Koike R, Nanki T, Kohsaka H, Miyasaka N, Harigai M. Simplified Disease Activity Index remission at month 6 is an independent predictor of functional and structural remissions at month 12 during abatacept treatment in patients with rheumatoid arthritis: A multi-center, prospective cohort study in Japan.Mod Rheumatol. 15:1-8, 2016
  • Yoshihashi-Nakazato Y, Kiumura N, Kawahata K, Miyasaka N, Kohsaka H. Interferon-gamma but not interleukin-4 restrains experimental polymyositis. Arthritis Rheumatol 27. doi: 10.1002/art.39592, 2016.
  • Matsuo Y, Mizoguchi F, Saito T, Kawahata K, Ueha S, Matsushima K, Inagaki Y, Miyasaka N, Kohsaka H. Local fibroblast proliferation but not influx is responsible for synovial hyperplasia in a murine model of rheumatoid arthritis. Biochem Biophys Res Commun 470(3):504-9, 2016.
  • Okiyama N, Hasegawa H, Oida T, Hirata S, Yokozeki H, Fujimoto M, Miyasaka N, Kohsaka H. Experimental myositis inducible with transfer of dendritic cells presenting a skeletal muscle C protein-derived CD8 epitope peptide. Int Immunol 27(7):327-32, 2015.
  • Kimura N, Hirata S, Miyasaka N, Kawahata K, Kohsaka H. Injury and subsequent regeneration of muscles for activation of local innate immunity to facilitate the development and relapse of autoimmune myositis in C57BL/6 mice. Arthritis Rheumatol 67(4):1107-16, 2015
  • Hosoya T, Iwai H, Yamaguchi Y, Kawahata K, Miyasaka N, Kohsaka H. Cell cycle regulation therapy combined with cytokine blockade enhances antiarthritic effects without increasing immune suppression. Ann Rheum Dis 75(1):253-9, 2016.
  • Fukuda S, Kohsaka H, Takayasu A, Yokoyama W, Miyabe C, Miyabe Y, Harigai M, Miyasaka N, Nanki T. Cannabinoid receptor 2 as a potential therapeutic target in rheumatoid arthritis. BMC Musculoskelet Disord 12;15:275, 2014.
  • Yokoyama W, Kohsaka H, Kaneko K, Walters M, Takayasu A, Fukuda S, Miyabe C, Miyabe Y, Love PE, Nakamoto N, Kanai T, Watanabe-Imai K, Charvat TT, Penfold ME, Jaen J, Schall TJ, Harigai M, Miyasaka N, Nanki T. Abrogation of CC chemokine receptor 9 ameliorates collagen-induced arthritis of mice. Arthritis Res Ther 16(5):445, 2014
  • Okiyama N, Sugihara T, Oida T, Ohata J, Yokozeki H, Miyasaka N, Kohsaka H. T lymphocytes and muscle condition act like seeds and soil in a murine polymyositis model. Arthritis Rheum 64(11):3741-9, 2012.
  • Sugihara T, Okiyama N, Suzuki M, Kohyama K, Matsumoto Y, Miyasaka N, Kohsaka H. Definitive engagement of cytotoxic CD8 T cells in C protein-induced myositis, a murine model of polymyositis. Arthritis Rheum 62(10):3088-92, 2010.
  • Mizoguchi F, Murakami Y, Saito T, Miyasaka N, Kohsaka H. miR-31 controls osteoclast formation and bone resorption by targeting RhoA. Arthritis Res Ther 15(5):R102, 2013.
  • Murakami Y, Mizoguchi F, Saito T, Miyasaka N, Kohsaka H. p16(INK4a) exerts an anti-inflammatory effect through accelerated IRAK1 degradation in macrophages. J Immunol 15;189(10):5066-72, 2012.
  • Toyomoto M, Ishido S, Miyasaka N, Sugimoto H, Kohsaka H. Anti-arthritic effect of E3 ubiquitin ligase, c-MIR, expression in the joints. Int Immunol 23(3):177-83, 2011.
  • Okiyama N, Kitajima T, Ito Y, Yokozeki H, Miyasaka N, Kohsaka H. Addition of the collagen binding domain of fibronectin potentiates the biochemical availability of hepatocyte growth factor for cutaneous wound healing. J Dermatol Sci 61(3):215-7, 2011.
  • Nakashioya H, Nakano K, Watanabe N, Miyasaka N, Matsushita S, Kohsaka H. Therapeutic effect of D1-like dopamine receptor antagonist on collagen-induced arthritis of mice. Mod Rheumatol 21(3):260-6, 2011.
  • Sugihara T, Okiyama N, Watanabe N, Miyasaka N, Kohsaka H. Interleukin-1 and tumor necrosis factor α blockade treatment of experimental polymyositis in mice.

    Arthritis Rheum 64(8):2655-62, 2012. 

  • Iwai H, Abe M, Hirose S, Tsushima F, Tezuka K, Akiba H, Yagita H, Okumura K, Kohsaka H, Miyasaka N, Azuma M. Involvement of inducible costimulator-B7 homologous protein costimulatory pathway in murine lupus nephritis. J Immunol 171(6): 2848-2854, 2003.
  • Nonomura Y, Kohsaka H*, Nagasaka K, Miyasaka N. Gene transfer of a cell cycle modulator exerts anti-inflammatory effects in the treatment of arthritis. J Immunol 171(9):4913-4919, 2003.
  • Hagiyama H, Koike R, Nagasaka K, Nononmura Y, Nishio J, Nanki T, Kohsaka H, Kubota T, and Miyasaka N. Two cases of acute respiratory distress syndrome resulting from adult onset Still's disease. Mod Rheumatol 13: 76-80, 2003
  • Iwai H, Kozono Y, Hirose S, Akiba H, Yagita H, Okumura K, Kohsaka H, Miyasaka N, and Azuma M. Amelioration of Collagen-induced Arthritis by Blockade of ICOS-B7h Costimulation. J Immunol 169(8): 4332-4339, 2002
  • Kohsaka H, Nasu K, Matsushita S, and Miyasaka N. Complete cDNA coding sequence of the HLA-DRB1*1405 allele. DNA Sequence 13 (6): 359-361, 2002
  • Nanki T, Imai T, Nagasaka K, Urasaki Y, Nonomura Y, Taniguchi K, Hayashida K, Hasegawa J, Yoshie O, Miyasaka N. Migration of CX3CR1-positive T cells producing type 1 cytokines and cytotoxic molecules into the synovium of patients with rheumatoid arthritis. Arthritis Rheum 46(11): 2878-2883, 2002.
  • Girschick HJ, Grammer AC, Nanki T, Vazquez E, Lipsky PE. Expression of recombination activating genes 1 and 2 in peripheral B cells of patients with systemic lupus erythematosus. Arthritis Rheum 46(5):1255-1263, 2002.
  • Nonomura Y, Koike R, Nishio J, Tsubata R, Kohsaka H, Kubota T, Miyasaka N: Overlap syndrome with cerebral hemorrhage caused by prostaglandin E1 infusion. Int Med 40(3): 265-266, 2001.
  • Hayashida K, Nanki T, Girschick H, Yavuz S, Ochi T, Lipsky PE. Synovial stromal cells from rheumatoid arthritis patients attract monocytes by producing MCP-1and IL-8. Arthritis Res. 3(2): 118-126, 2001.
  • Hermann J. Girschick H, Grammer AC, Nanki T, Mayo M, Lipsky PE. RAG1 and RAG2 expression by B cell subsets from human tonsil and peripheral blood. J Immunol 166(1): 377-386, 2001.
  • Nonomura Y, Kohsaka H, Nasu K, Terada Y, Ikeda M, Miyasaka N. Suppression of arthritis by forced expression of cyclin-dependent kinase Inhibitor p21Cip1 gene into the joints. Int Immunol 13(6): 723-731, 2001.
  • Yavuz S, Grammer AC, Yavuz AS, Nanki T, Lipsky PE. Comparative characteristics of m chain and a chain transcripts expressed by individual tonsil plasma cells. Mol Immunol 38(1): 19-34, 2001.
  • Koike R, Iizuka T, Watanabe T, Miyasaka N: The GOR gene product cannot cross -react with hepatitis C virus in humans. Clin Exp Immunol 124(3): 429-434, 2001
  • Nishio J, Suzuki M, Miyasaka N and Kohsaka H. Clonal bases of peripheral CD8 T cell repertoire directly reflect local inflammation in polymyositis. J Immunol 167(7): 4051-4058, 2001
  • Nanki T, Nagasaka K, Hayashida K, Saita Y, Miyasaka N. Chemokines regulate IL-6 and IL-8 production by fibroblast-like synoviocytes from patients with rheumatoid arthritis. J Immunol 167(9):5381-5385, 2001
  • Nanki T, Lipsky PE. Stimulation of T cell activation by CXCL12/stromal cell derived factor-1 involves a G-protein mediated signaling pathway. Cell Immunol 214(2): 145-154, 2001.
  • Kohsaka H. Gene therapy for arthritis. Modern Rheumatol 10(2), 78-82, 2000.
  • Nasu K, Kohsaka H, Nonomura Y, Terada Y, Ito H, Hirokawa K, Miyasaka N. Adenoviral transfer of cyclin-dependent kinase inhibitor genes suppresses collagen-induced arthritis in mice. J Immunol 165(12): 7246-7252, 2000.
  • Kohsaka H, Nasu K, Nonomura Y, Miyasaka N. Treatment of arthritis with cyclin-dependent kinase inhibitor gene. Jpn J Clin Immunol 23(6): 550-552, 2000.
  • Nishio J, Kohsaka H, Shimamura T, Hamuro J, Miyasaka N. Abundant expression of common cytokine receptor gamma chain (CD132) in the rheumatoid joints. J Rheumatol 28(2): 240-244, 2000.
  • Nishimura T, Koike R, Miyasaka M: Mammary gland of ALY mice: Developmental changes and lactation-related expression of specific proteins, a-casein, GlyCAM-1 and MAdCAM-1. Am J Reprod Immunol 43: 351-358, 2000
  • Iizuka T, Tanaka T, Suematsu M, Miura S, Watanabe T, Koike R, Ishimura Y, Ishii H, Miyasaka N, Miyasaka M: Stage-specific expression of mucosal addressin cell adhesion molecule-1 during embryogenesis in rats. J Immunol 164: 2463 -2471, 2000.
  • Nanki T, Lipsky PE. Lack of Correlation between chemokine receptor and Th1/Th2 cytokine expression by individual memory T cells. Int Immunol 12(12): 1659-1667, 2000.
  • Nanki T, Hayashida K, El-Gabalawy HS, Suson S, Shi K, Girschick HJ, Yavuz S, Lipsky PE. Stromal cell-derived factor-1-CXC chemokine receptor 4 interactions play a central role in CD4+ T cell accumulation in rheumatoid arthritis Synovium. J Immunol 165(11): 6590-6598, 2000.
  • Nanki T, Lipsky PE. Cytokine, Activation marker, and chemokine receptor expression by individual CD4+ memory T cells in rheumatoid arthritis synovium. Arthrits Res. 2(5): 415-423, 2000.
  • Nanki T, Lipsky PE. Stromal cell derived factor-1 Is a co-stimulator for CD4+ T cell activation. J Immunol 164(10): 5010-5014, 2000.
  • Yoshida T, Higuchi T, Hagiyama H, Strasser A, Nishioka K, Tsubata T. Rapid B cell apoptosis induced by antigen receptor ligation does not require Fas (CD95/APO-1), the adaptor protein FADD/MORT1 or CrmA-sensitive caspases but is defective in both MRL-+/+ and MRL-lpr/lpr mice. Int Immunol 12(4):517-526, 2000
  • Okiyama N, Sugihara T, Iwakura Y, Yokozeki H, Miyasaka N, Kohsaka H. Therapeutic effects of IL-6 blockade on a murine model of polymyositis that does not require IL-17A. Arthritis Rheum 60 (8), 2505-2512, 2009.
  • Murakami Y, Akahoshi T, Aoki N, Toyomoto M, Miyasaka N, Kohsaka H. Intervention of an Inflammation Amplifier, Triggering Receptor Expressed on Myeloid Cells 1, for Treatment of Autoimmune Arthritis. Arthritis Rheum 60 (6), 1615-1623, 2009
  • Kaneko K, Nonomura Y, Watanabe K, Koike R, Kubota T, Harigai M, Inoue Y, Iwai T, Miyasaka N. Infected abdominal aortic aneurysm caused by nontyphoid Salmonella in an immunocompromised patient with rheumatoid arthritis. J Infect Chemother. 15(5):312-315, 2009.
  • Nanki T, Takada K, Komano Y, Morio T, Kanegane H, Nakajima A, Lipsky PE, Miyasaka N. Chemokine receptor expression and functional effects of chemokines on B cells: implication in the pathogenesis of rheumatoid arthritis. Arthritis Res Ther. 11(5):R149, 2009.
  • Ohyanagi N, Ishido M, Suzuki F, Kaneko K, Kubota T, Miyasaka N, Nanki T. Retinoid ameliorates experimental autoimmune myositis, with modulation of Th cell differentiation and antibody production in vivo. Arthritis Rheum. 60(10):3118-3127, 2009.
  • Ochi S, Nanki T, Kaneko H, Honne K, Miyazaki Y, Komano Y, Miyasaka N. Successful treatment of ankylosing spondylitis coexisting with pulmonary sarcoidosis by infliximab. Clin Exp Rheumatol. 27(4):698-699, 2009.
  • Kubota T, Fukuya Y, Hashimoto R, Kanda T, Suzuki H, Okamura Y, Nanki T, Miyasaka N, Umezawa K. Possible involvement of chemokine-induced platelet activation in thrombophilic diathesis of antiphospholipid syndrome. Ann N Y Acad Sci. 1173:137-145, 2009.
  • Miyasaka N, Kawai S, Hashimoto H. Efficacy and safety of tacrolimus for lupus nephritis: a placebo-controlled double-blind multicenter study. Mod Rheumatol. 19(6):606-615, 2009.
  • Takeuchi T, Miyasaka N, Inoue K, Abe T, Koike T; RISING study. Impact of trough serum level on radiographic and clinical response to infliximab plus methotrexate in patients with rheumatoid arthritis: results from the RISING study. Mod Rheumatol. 19(5):478-487, 2009.
  • Koike R, Harigai M, Atsumi T, Amano K, Kawai S, Saito K, Saito T, Yamamura M, Matsubara T, Miyasaka N. Japan College of Rheumatology 2009 guidelines for the use of tocilizumab, a humanized anti-interleukin-6 receptor monoclonal antibody, in rheumatoid arthritis. Mod Rheumatol. 19(4):351-357, 2009.
  • Hashimoto J, Garnero P, van der Heijde D, Miyasaka N, Yamamoto K, Kawai S, Takeuchi T, Yoshikawa H, Nishimoto N. A combination of biochemical markers of cartilage and bone turnover, radiographic damage and body mass index to predict the progression of joint destruction in patients with rheumatoid arthritis treated with disease-modifying anti-rheumatic drugs. Mod Rheumatol. 19(3):273-282, 2009.
  • Takahashi N, Matsumoto K, Saito H, Nanki T, Miyasaka N, Kobata T, Azuma M, Lee SK, Mizutani S, Morio T. Impaired CD4 and CD8 effector function and decreased memory T cell populations in ICOS-deficient patients. J Immunol. 182(9):5515-5527, 2009.
  • Komano Y, Harigai M, Koike R, Sugiyama H, Ogawa J, Saito K, Sekiguchi N, Inoo M, Onishi I, Ohashi H, Amamoto F, Miyata M, Ohtsubo H, Hiramatsu K, Iwamoto M, Minota S, Matsuoka N, Kageyama G, Imaizumi K, Tokuda H, Okochi Y, Kudo K, Tanaka Y, Takeuchi T, Miyasaka N. Pneumocystis jiroveci pneumonia in patients with rheumatoid arthritis treated with infliximab: a retrospective review and case-control study of 21 patients. Arthritis Rheum. 61(3):305-312, 2009.
  • Kishi J, Nanki T, Watanabe K, Takamura A, Miyasaka N. A case of rituximab-induced interstitial pneumonitis observed in systemic lupus erythematosus. Rheumatology .48(4):447-448, 2009.
  • Nishimoto N, Miyasaka N, Yamamoto K, Kawai S, Takeuchi T, Azuma J. Long-term safety and efficacy of tocilizumab, an anti-IL-6 receptor monoclonal antibody, in monotherapy, in patients with rheumatoid arthritis (the STREAM study): evidence of safety and efficacy in a 5-year extension study. Ann Rheum Dis. 68(10):1580-1584, 2009.
  • Nishimoto N, Miyasaka N, Yamamoto K, Kawai S, Takeuchi T, Azuma J, Kishimoto T. Study of active controlled tocilizumab monotherapy for rheumatoid arthritis patients with an inadequate response to methotrexate (SATORI): significant reduction in disease activity and serum vascular endothelial growth factor by IL-6 receptor inhibition therapy. Mod Rheumatol. 19(1):12-19, 2009
  • Nii T, Kubota T, Nanki T, Komano Y, Harigai M, Kohsaka H, Hirose W, Nagasaka K, Sakurai T, Miyasaka N. Reevaluation of antibody titers one year after influenza vaccination in patients with rheumatoid arthritis receiving TNF blockers. Modern Rheumatol 19(2)、216-218, 2009.
  • Nonomura Y, Mizoguchi F, Suzuki A, Nanki T, Kato H, Miyasaka N, Kohsaka H. Hypoxia-induced abrogation of contact-dependent inhibition of rheumatoid arthritis synovial fibroblast proliferation. J Rheumatol. 36(4):698-705, 2009.
  • Mizoguchi F, Izu Y, Hayata T, Hemmi H, Nakashima K, Nakamura T, Kato S, Miyasaka N, Ezura Y, Noda M. Osteoclast-specific Dicer gene deficiency suppresses osteoclastic bone resorption. J Cell Biochem. 109(5):866-875, 2009.
  • Mizoguchi F, Mizuno A, Hayata T, Nakashima K, Heller S, Ushida T, Sokabe M, Miyasaka N, Suzuki M, Ezura Y, Noda M. Transient receptor potential vanilloid 4 deficiency suppresses unloading-induced bone loss. J Cell Physiol. 216(1):47-53, 2008.
  • Matsudaira T, Tsuzuki S, Wada A, Suwa A, Kohsaka H, Tomida M, and Ito Y. Automated microfluidic assay system for autoantibodies causing autoimmune diseases using a photoimmobilized autoantigen microarray Biotechnology Progress 24(6):1384-1392, 2008
  • Mizoguchi F, Nakamura S, Iwai H, Kubota T, Miyasaka N. Varicella-zoster virus hepatitis in polymyositis. Mod Rheumatol. 18(3):301-305, 2008.
  • Okiyama N, Kohsaka H, Ueda N, Satoh T, Katayama I, Nishioka K, and Yokozeki H Seborrhic area erythema as a common skin manifestation in Japanese patients with dermatomyositis. Dermatology 217 (4):374-377, 2008.
  • Harigai M, Kawamoto M, Hara M, Kubota T, Kamatani N, Miyasaka N. Excessive production of IFN-gamma in patients with systemic lupus erythematosus and its contribution to induction of B lymphocyte stimulator/B cell-activating factor/TNF ligand superfamily-13B. J Immunol. 181(3):2211-2219, 2008
  • Nakamoto T, Seo S, Sakai R, Kato T, Kutsuna H, Kurokawa M, Noda M, Miyasaka N, Kitagawa S. Expression and tyrosine phosphorylation of Crk-associated substrate lymphocyte type (Cas-L) protein in human neutrophils. J Cell Biochem. 105(1):121-128, 2008.
  • Watanabe K, Nanki T, Sugihara T, Miyasaka N. A case of polyarteritis nodosa with periurethralaseptic abscesses and testicular lesions. Clin Exp Rheumatol. 26(6):1113-1115, 2008.
  • Miyasaka N; CHANGE Study Investigators. Clinical investigation in highly disease-affected rheumatoid arthritis patients in Japan with adalimumab applying standard and general evaluation: the CHANGE study. Mod Rheumatol. 18(3):252-262, 2008.
  • Mizoguchi F, Nanki T, Miyasaka N. Pneumatosis cystoides intestinalis following lupus enteritis and peritonitis. Intern Med 47(13):1267-1271, 2008
  • Mizoguchi F, Nanki T, Takada K, Miyasaka N. Recurrent pulmonary embolism due to intracardiac thrombi in systemic sclerosis. Clin Exp Rheumatol 26(1): 157, 2008.
  • Sekine C, Sugihara T, Miyake S, Hirai H, Yoshida M, Miyasaka N, Kohsaka H Successful treatment of animal models of rheumatoid arthritis with smallmolecule cyclin-dependent kinase inhibitors. J Immunol 180(3):1954-61, 2008.
  • Kubota T, Nii T, Nanki T, Kohsaka H, Harigai M, Komano Y, Sugihara T, Nonomura Y, Hirose W, Nagasaka K, Sakurai T, Miyasaka N. Anti-TNF therapy does not diminish the immune response to influenza vaccine in Japanese patients with rheumatoid arthritis. Modern Rheumatol 17(6): 531-533, 2007.
  • Ohata J, Miura T, Hori S, Ziegler SF, Kohsaka H Enhanced efficacy of regulatory T cell transfer against increasing resistance, by elevated Foxp3 expression induced in arthritic murine hosts Arthritis Rheum 56(9):2947-2956, 2007.
  • Ochi S, Shinohara M, Sato K, Gober HJ, Koga T, Kodama T, Takai T, Miyasaka N, Takayanagi H. Pathological role of osteoclast costimulation in arthritis-induced bone loss. Proc Natl Acad Sci USA. 104(27):11394-9, 2007.
  • Tanaka Y, Yamamoto K, Takeuchi T, Nishimoto N, Miyasaka N, Sumida T, Shima Y, Takada K, Matsumoto I, Saito K, Koike T. A multicenter phase I/II trial of rituximab for refractory systemic lupus erythematosus. Mod Rheumatol 17(3):191-7, 2007
  • Nishimoto N, Hashimoto J, Miyasaka N, Yamamoto K, Kawai S, Takeuchi T, Murata N, van der Heijde D, Kishimoto T. Study of active controlled monotherapy used for rheumatoid arthritis, an IL-6 inhibitor (SAMURAI): evidence of clinical and radiographic benefit from an x ray reader-blinded randomised controlled trial of tocilizumab. Ann Rheum Dis 66(9):1162-7, 2007.
  • Takada K, Kishi J, Miyasaka N. Step-up versus primary intensive approach to the treatment of interstitial pneumonia associated with dermatomyositis/polymyositis: a retrospective study. Mod Rheumatol 17(2):123-30, 2007
  • Sugihara T, Sekine C, Nakae T, Kohyama K, Harigai M, Iwakura Y, Matsumoto Y, Miyasaka N, and Kohsaka H. A new murine model defines critical mediators in the pathology and treatment of polymyositis Arthritis Rheum 56(4):1304-1314, 2007
  • Murakami Y, Kohsaka H, Kitasato H, and Akahoshi T. Lipopolysaccharide-induced up-regulation of triggering receptor expressed on myeloid cells-1 expression on macrophages is regulated by endogenous Prostaglandin E2. J Immunol 178(2): 1144-1150, 2007
  • Cravens PD, Hayashida K, Davis LS, Nanki T, Lipsky PE. Human peripheral blood dendritic cells and monocyte subsets display similar chemokine receptor expression profiles with differential migratory responses. Scand J Immunol 65(6): 514-524, 2007.
  • Kubota T, Hoshino M, Aoki K, Ohya K, Komano Y, Nanki T, Miyasaka N, Umezawa K. NF-kappa B inhibitor DHMEQ suppresses osteoclastogenesis and expression of NFATc1 in mouse arthritis without affecting expression of RANKL, OPG or M-CSF. Arthritis Res Ther 9(5): R97, 2007.
  • Sugihara T, Sekine C, Nakae T, Kohyama K, Harigai M, Iwakura Y, Matsumoto Y, Miyasaka N, and Kohsaka H. A new murine model to define critical pathologic and therapeutic of polymyositis Arthritis Rheum 56(4):1304-1314, 2007
  • Nonomura Y, Nagasaka K, Hagiyama H, Sekine C, Nanki T, Tamamori-Adachi M, Miyasaka, N and Kohsaka H Cyclin-dependent kinase 4/6 directly modulates expression of rheumatoid inflammatory mediators in retinoblastoma protein-dependent and independent pathways Arthritis Rheum 54(7): 2074-2083, 2006
  • Ogawa J, Harigai M, Akashi T, Nagasaka K, Suzuki F, Tominaga S, Miyasaka N. Exacerbation of chronic active Epstein-Barr virus infection in a patient with rheumatoid arthritis receiving humanised anti-interleukin-6 receptor monoclonal antibody. Ann Rheum Dis 65(12):1667-9, 2006
  • Ochi S, Harigai M, Mizoguchi F, Iwai H, Hagiyama H, Oka T, Miyasaka N. Leflunomide-related acute interstitial pneumonia in two patients with rheumatoid arthritis: autopsy findings with a mosaic pattern of acute and organizing diffuse alveolar damage. Mod Rheumatol 16(5):316-20, 2006
  • Komano Y, Nanki T, Hayashida K, Taniguchi K, Miyasaka N. Identification of a human peripheral blood monocyte subset that differentiates into osteoclasts. Arthritis Res Ther 8(5): R152, 2006.
  • Suzuki F, Nanki T, Imai T, Kikuchi H, Hirohata S, Kohsaka H, Miyasaka N. Inhibition of CX3CL1 (fractalkine) improves experimental autoimmune myositis in SJL/J mice. J Immunol 175 (10): 6987-6996, 2005
  • Wakamatsu K, Nanki T, Miyasaka N, Umezawa K, Kubota T. Effect of a small molecule inhibitor of nuclear factor-kB nuclear translocation in a murine model of arthritis and cultured human synovial cells. Arthritis Res Ther 7(6): R1348-R1359, 2005.
  • Ochi S, Nanki T, Takada K, Suzuki F, Komano Y, Kubota T, Miyasaka N. Favorable outcomes with tacrolimus in two patients with refractory interstitial lung disease associated with polymyositis/dermatomyositis. Clin Exp Rheumatol 23(5): 707-710, 2005.
  • Nanki T, Shimaoka T, Hayashida K, Taniguchi K, Yonehara S, Miyasaka N. Pathogenic role of CXCL16-CXCR6 pathway in rheumatoid arthritis. Arthritis Rheum 52(10): 3004-3014, 2005.
  • Singh SK, Morbach H, Nanki T, Girschick HJ. Differential expression of chemokines in synovial cells exposed to different Borrelia burgdorferi isolates. Clin Exp Rheumatol 23(3): 311-322, 2005.
  • Arai A, Jin A, Yan W, Mizuchi D, Yamamoto K, Nanki T, Miura O. SDF-1 synergistically enhances IL-3-induced activation of the Raf-1/MEK/Erk signaling pathway through activation of Rac and its effector Pak kinases to promote hematopoiesis and chemotaxis. Cell Signal 17(4): 497-506, 2005.
  • Liu T, Kohsaka H, Suzuki M, Takagi R, hashimoto K, Uemura Y, Ohyama H, and Matsushita S. Positional effect of amino acid replacement on peptide antigens for the increased IFN-gamma production from CD4 T cells. Allergol Int 54 (1), 117-122, 2005
  • Ogawa J, Harigai M, Nagasaka K, Nakamura T, Miyasaka N. Prediction of and prophylaxis against Pneumocystis pneumonia in patients with connective tissue diseases undergoing medium- or high-dose corticosteroid therapy. Mod Rheumatol 15(2):91-6, 2005
  • Miyasaka N, Takeuchi T, Eguchi K. Proposed Japanese guidelines for the use of infliximab for rheumatoid arthritis. Mod Rheumatol 15(1):4-8, 2005.
  • Nishio J, Suzuki M, Nanki T, Miyasaka N, Kohsaka H. Development of TCRB CDR3 length repertoire of human T lymphocytes. Int Immunol 16(3): 423-431, 2004.
  • Komano Y, Kubota T, Wakabayashi S, Ochi S, Nonomura Y, Hagiyama H, Nanki T, Kohsaka H, Miyasaka N. A case of paraneoplastic syndrome minicking adult-onset Still's disease. Mod Rheumatol 14(5): 410-413, 2004.
  • Singh SK, Morbach H, Nanki T, Faber C, Baar V, Girschick HJ. Differential expression of matrix metalloproteinases and cyclooxygenases in synovial cells exposed to Borrelia burgdorferi. Inflamm Res 53(12): 689-696, 2004.
  • Nanki T, Urasaki Y, Imai T, Nishimura M, Muramoto K, Kubota T, Miyasaka N. Inhibition of fractalkine ameliorates murine collagen-induced arthritis. J Immunol 173(11): 7010-7016, 2004.
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