教室のご案内

Research

Our scientific and academic activities encompass a wide spectrum, from basic to clinical research. Our goal is a comprehensive resolution of childhood health issues through the development of innovative diagnostic, therapeutic, and preventive strategies.

Hematology/ Oncology/Immunology Cardiology Neurology Endocrinology and Metabolism Rheumatology/Nephrology Neonatology Allergy

Hematology/ Oncology/Immunology

  • Pathophysiological Analysis of Infant Acute Lymphoblastic Leukemia
  • Pathogenesis and Therapeutic Development for Neuroblastoma
  • Development of Gene Therapy for Ataxia–Telangiectasia
  • Development of Diagnostic Methods for Leukemia Based on 3D Genome Architecture and Nuclear Localization
  • Development of Virus-Specific T-Cell Therapy and CAR-NK Cell Therapy
  • Identification of Causative Genes in Primary Immunodeficiency Diseases

Cardiology

  • Elucidation of the Pathophysiology of Pulmonary Hypertension and Development of Novel Therapeutic Strategies
  • Clinical Research on Pulmonary Hypertension
  • AI-Based Imaging Diagnosis for Cardiovascular Diseases

Neurology

  • Establishment of Newborn Screening Methods for Spinal Muscular Atrophy (SMA) and Longitudinal Changes in Electrophysiological Findings in Treated SMA Patients
  • Evaluation of Adrenocortical Function in Patients with West Syndrome Undergoing ACTH Therapy
  • Establishment of Pediatric Reference Values and Clinical Application in Central Nervous System Disorders for a Cerebellar Motor-Learning Assessment System Using Prism Adaptation
  • Study on the Association Between Serum Copper and Zinc Levels and Epilepsy Severity

Endocrinology and Metabolism

  • Elucidation of the Molecular Mechanisms of Sex Differentiation and Gonadal Development
  • Establishment of Novel Diagnostic and Therapeutic Strategies and Biomarkers for 21-Hydroxylase Deficiency (21OHD)
  • Molecular Pathophysiology of Congenital Endocrine Disorders
  • Elucidating the Mechanisms Linking the Intrauterine Environment to Disease Development Using Umbilical Cord–Derived Mesenchymal Stem Cells

Rheumatology/Nephrology

  • Molecular Immunological Analysis of Pediatric Rheumatic Diseases
  • Data Analysis of Pediatric Rheumatic Diseases Using an Immunodeficiency Registry
  • Immunological Evaluation of Infants Born to Mothers With Immune-Mediated Diseases to Establish Safe and Effective Vaccination Guidelines
  • Pathophysiological Analysis of Juvenile Idiopathic Arthritis Toward Personalized Medicine
  • Immunological Pathogenesis of Pediatric Kidney Diseases
  • Pathophysiological Analysis of TINU Syndrome

Neonatology

  • Basic Research on Changes in the Profiles of Umbilical Cord Blood and Umbilical Cord–Derived Mesenchymal Stem Cells Influenced by the Intrauterine Environment
  • Analysis of Changes in Deciduous Tooth Pulp Stem Cell Profiles in Children With Cerebral Palsy Caused by Periventricular Leukomalacia
  • Basic Research on the Relationship Between Physical Growth in Infancy and the Gene Expression Profiles of Umbilical Cord–Derived Mesenchymal Stem Cells

Allergy

  • Clinical Characteristics and Pathophysiology of Allergic Diseases Associated With Primary Immunodeficiency Diseases and Inflammatory/Immune Dysregulation Disorders

Principal investigators

Department of Pediatrics and Developmental Biology

All medical staffs are Board certified pediatrician

Professor Masatoshi Takagi, PhD., MD. (Hematology/ Oncology/Immunology) m.takagi.ped(at)tmd.ac.jp
Associate Professor Takeshi Isoda, PhD., MD. (Hematology/ Oncology/Immunology) tisoda.ped@md.isct.ac.jp
Junior Associate Professor Takahiro Kamiya, PhD., MD. (Hematology/ Oncology/Immunology) kamiya.ped(at)tmd.ac.jp
Assistant Professor Kei Takasawa, PhD., MD. (Endocrinology) ktakasawa.ped(at)tmd.ac.jp

Department of Child Health and Development

Professor Hirokazu Kanegane, PhD., MD. (Hematology/ Oncology/Immunology) hkanegane.ped(at)tmd.ac.jp

Department of Pediatrics, Neonatal and Maternal Medicine

Professor Masaki Shimizu, PhD., MD. (Rheumatology/Nephrology) mshimizu.ped(at)tmd.ac.jp