Changes in the oral microbiota can occur due to factors such as the host's diet, medication, oral hygiene, inflammation of the oral mucosa, and variations in saliva quantity and quality. This can lead to localized dysbiosis of the oral microbiota, which is believed to impact various systemic diseases.

In this project, we will conduct integrative research combining clinical epidemiology with basic cellular and molecular studies to investigate how dysbiosis of the oral microbiota alters local oral responses and affects systemic organs and diseases. Additionally, we aim to build evidence that evaluating and diagnosing the oral condition and the oral microbiota can predict and prevent systemic diseases, and that improving oral health can contribute to the prevention and management of systemic conditions. Ultimately, we aim to advance proactive healthcare that predicts and prevents systemic conditions through the assessment of oral and overall health.

The mucosal tissues in the head and neck region have unique physiological functions and are exposed to various external stimuli from daily activities such as breathing and eating, as well as lifestyle habits like smoking.

The mechanisms of head and neck cancer and refractory mucosal diseases are complex. Despite advances in surgery and neoadjuvant therapy, controlling recurrence and metastasis remains challenging. This project aims to clarify the unique characteristics of the head and neck region by identifying key genes and molecules involved in these conditions and understanding the cancer microenvironment. Our goal is to develop minimally invasive treatments for head and neck cancer to improve quality of life and address unmet medical needs.

Declines in oral functions such as chewing and swallowing have garnered significant attention from society, as evidenced by the 2018 inclusion of 'Oral Function Development Disorder' in insurance coverage. Additionally, declines in brain functions associated with aging and disabilities, such as dementia, pose major challenges in healthcare within our aging and shrinking population.

"Recent studies have revealed that issues within the oral system, such as tooth loss, reduced chewing ability, and periodontal disease, may be risk factors for declines in brain function. This evidence suggests that viewing brain diseases from the perspective of oral system-brain connections could lead to the development of innovative prevention and treatment methods for such diseases. This project aims to elucidate the neural mechanisms underlying the healthy development and maintenance of the oral system and the impact of oral system dysfunction due to disease and aging on the brain. By improving and maintaining oral functions such as eating and swallowing across all generations, and enhancing the enjoyment of eating and motivation to live, we seek to significantly contribute to the promotion of a society of healthy longevity.

Traditional dental treatments using precious metals have significant material consumption and environmental impact, and price fluctuations due to social conditions have put pressure on medical costs. Additionally, the manufacturing methods for conventional dental materials and equipment are not compatible with digitalization, making it challenging to adequately respond to the accumulation and utilization of medical big data.

Recent advancements in digital manufacturing techniques not only effectively utilize medical big data but also reduce intermediate material consumption, minimizing environmental impact and conserving resources. However, the speed and precision of these methods, as well as the development of specialized materials, are still evolving. This research aims to develop new dental materials compatible with digital manufacturing, ensuring stable performance and cost. The goal is to establish resource-efficient dental technologies that contribute to SDGs and reduce dental healthcare costs.