東京科学大学
法医学分野

業績

2025　2024　2023　2022　2021　2020　2019　2018　2017　2016　2015　2014　2013　2012　2011　2010

2025年

原著論文など

  1. Aki T, Funakoshi T, Unuma K. Thallium induces metallothionein gene expression in Huh-7 human hepatoma cells. Toxicology. 2025 Mar 16;514:154121. doi: 10.1016/j.tox.2025.154121. Epub ahead of print. PMID: 40101890.
  2. Aki T, Unuma K. Cocaine abuse and its impact on the thymus and spleen. Histol Histopathol. 2025 Mar 13:18904. doi: 10.14670/HH-18-904. Epub ahead of print. PMID: 40145263.
  3. Komatsu M, Funakoshi T, Aki T, Unuma K. Aristolochic Acid-Induced DNA Adduct Formation Triggers Acute DNA Damage Response in Rat Kidney Proximal Tubular Cells. Toxicol Lett. 2025 Feb 13:S0378-4274(25)00030-X. doi: 10.1016/j.toxlet.2025.02.006. Epub ahead of print. PMID: 39955082.

2024年

原著論文など

  1. Sugahara S, Unuma K, Wen S, Funakoshi T, Aki T, Uemura K. Dissociation of mitochondrial and ribosomal biogenesis during thallium administration in rat kidney. PLoS One. 2024 Dec 4;19(12):e0311884. doi: 10.1371/journal.pone.0311884. PMID: 39630634.
  2. Unuma K, Wen S, Sugahara S, Nagano S, Aki T, Ogawa T, Takeda-Homma S, Oikawa M, Tojo A. Thallium reabsorption via NKCC2 causes severe acute kidney injury with outer medulla-specific calcium crystal casts in rats. Arch Toxicol. 2024 Oct 3. doi: 10.1007/s00204-024-03868-2. Epub ahead of print. PMID: 39361050.

    https://www.isct.ac.jp/ja/news/jjqm0916snc9

  3. Nagano S, Unuma K, Makino Y, Mori H, Uemura K. Acute upper airway obstruction due to cervical hematoma after cervicofacial liposuction. J Forensic Leg Med. 2024 May 16;104:102697. doi: 10.1016/j.jflm.2024.102697.
  4. Nagano S, Unuma K, Aki T, Uemura K. N-acetylcysteine alleviates arsenic trioxide-induced reductions in hepatic catalase gene expression both in vitro and in vivo. Leg Med (Tokyo). 2024 Jul;69:102458. doi: 10.1016/j.legalmed.2024.102458. Epub 2024 May 11. PMID: 38781725.
  5. Wen S, Makino Y, Inaji M, Arai N, Unuma K. Importance of repeated computed tomography on pediatric traumatic acute posterior fossa subdural hematoma: A case study. Leg Med (Tokyo). 2024 Sep;70:102466. doi: 10.1016/j.legalmed.2024.102466. Epub 2024 Jun 4. PMID: 38852472.
  6. Tachibana H, Nomura M, Funakoshi T, Unuma K, Aki T, Uemura K. Incomplete autophagy and increased cholesterol synthesis during neuronal cell death caused by a synthetic cannabinoid, CP-55,940. Neurotoxicology. 2024 Jul;103:215-221. doi: 10.1016/j.neuro.2024.06.013. Epub 2024 Jun 26. PMID: 38942151.
  7. 長野修太郎, 渡邊嶺, 鵜沼香奈. "スワドル"が原因と考えられた乳児窒息死の一剖検例. 法医学の実際と研究 67:35-40. 2024 Nov.
  8. 鵜沼香奈. 真実を探求する:犯罪学 法医鑑定の意義を考える 丁寧な法医解剖により予期せぬ真実を見出すことがある. 犯罪学雑誌. 90(2):35-36. 2024 Nov.
  9. 須賀原翔, 鵜沼香奈, 温書恒, 藤乘嗣泰. 硫酸タリウム中毒における腎障害のメカニズム(Mechanism of Renal Injury in Thallium Sulfate Intoxication). 日本腎臓学会誌. 66(4):593. 2024 Jun.
  10. 上村公一, 鵜沼香奈. 調査法解剖から司法解剖に切り替えになった例. 犯罪学雑誌. 90(2):53. 2024 Nov.
  11. 峰岸沙希, 櫻田宏一, 鵜沼香奈, 上村公一. 身元不明遺体の歯科所見と厚労省歯科疾患実態調査との比較・検討. 犯罪学雑誌. 90(2):52. 2024 Nov.

学会発表など

  1. 長野修太郎, 鵜沼香奈, 秋利彦, 上村公一. Protective effects of N-acetylcysteine on arsenic-induced hepatotoxity in vitro and in vivo. 第108回日本法医学会学術全国集会. 2024 Jun 5.
  2. 鵜沼香奈, 秋利彦, 温書恒, 長野修太郎, 上村公一. タリウム投与によるラット腎臓ミトコンドリア障害とリボソーム生合成の増加. 第108回日本法医学会総会. 2024 Jun 5.
  3. 須賀原翔, 鵜沼香奈, 温書恒, 藤乘嗣泰. Mechanism of Renal Injury in Thallium Sulfate Intoxication. 第67回腎臓学会学術総会. 2024 Jun 28.
  4. 長野修太郎, 渡邊嶺, 鵜沼香奈. スワドル着用中の乳児突然死 -臨床への還元とその課題-. 第93回日本法医学会学術関東地方会. 2024 Oct 12.
  5. 須賀原翔, 鵜沼香奈, 小川覚之, 藤乘嗣泰. LVSEMを用いた硫酸タリウムによる腎毒性部位の同定と治療応用の検討. 第8回腎生検LVSEM研究会 総会・学術集会. 2024 Nov 9. 東京.
  6. 内田佳子, 植松悟子, 小﨑里華, 柳久美子, 要匡, 林紀乃, 槇野陽介, 鵜沼香奈, 垣谷重毅. 多施設で協同した小児不詳死に対する死因究明. 第52回本救急医学会総会・学術集会.
  7. 鵜沼香奈. シンポジウム：今こそ頭部外傷の神経病理について考えよう －司法制度におけるその重要性と将来の展望－ 刑事事件の法医鑑定における神経病理学的検索の実際. 第65回日本神経病理学会総会学術研究会.

その他

  1. 殺人に使われるタリウム 中毒の早期診断法、科学大など. 日本経済新聞掲載 (2024年11月17日)

    https://www.nikkei.com/article/DGXZQOSG3199J0R31C24A0000000/

  2. 鵜沼香奈. 非腫瘍性疾患病理アトラス 中枢神経. 各論. 頭部外傷. Ⅱ-5．脳底部動脈破裂による外傷性くも膜下出血. 文光堂. 2024.

2023年

原著論文など

  1. Aki T, Kukita M, Takata M, Funakoshi T, Unuma K, Uemura K. Induction of filamin-C and its involvement in the regulation of cellular senescence and apoptosis in Huh-7 hepatoma cells during arsenic trioxide exposure. Biochem Biophys Res Commun. 2023 Apr 9;651:92-97. doi: 10.1016/j.bbrc.2023.02.020. Epub 2023 Feb 10. PMID: 36801614.
  2. Komatsu M, Funakoshi T, Aki T, Unuma K, Uemura K. Aristolochic acid induces an inflammatory response with prostaglandin E2 production and apoptosis in NRK-52E proximal tubular cells. Toxicol Lett. 2023 Apr 1;378:39-50. doi: 10.1016/j.toxlet.2023.02.009. Epub 2023 Mar 1. PMID: 36863539.
  3. Unuma K, Sato H, Wen S, Makino Y, Hirakawa A, Uemura K. The proportion of false-positives in positive Seratec® prostate-specific antigen SemiQuant test results in postmortem screening for seminal fluid. Leg Med (Tokyo). 2023 May;62:102243. doi: 10.1016/j.legalmed.2023.102243. Epub 2023 Mar 21. PMID: 36965350.
  4. Unuma K, Tomomasa D, Noma K, Yamamoto K, Matsuyama TA, Makino Y, Hijikata A, Wen S, Ogata T, Okamoto N, Okada S, Ohashi K, Uemura K, Kanegane H. Case Report: Molecular autopsy underlie COVID-19-associated sudden, unexplained child mortality. Front Immunol. 2023 Apr 18;14:1121059. doi: 10.3389/fimmu.2023.1121059. PMID: 37143668; PMCID: PMC10151512.

    https://www.tmd.ac.jp/press-release/20230418-1/

  5. Wen S, Unuma K, Funakoshi T, Aki T, Uemura K. Cocaine induces vascular smooth muscle cells proliferation via DRP1-mediated mitochondrial fission and PI3K/HIF-1α signaling. Biochem Biophys Res Commun. 2023 Oct 8;676:30-35. doi: 10.1016/j.bbrc.2023.07.020. Epub 2023 Jul 14. PMID: 37481940.
  6. Wen S, Unuma K, Uemura K, Harada K. Revisiting the canonical definition of heat hematoma: A rare case of postmortem subdural heat hematoma. J Forensic Leg Med. 2023 Aug;98:102563. doi: 10.1016/j.jflm.2023.102563. Epub 2023 Jul 13. PMID: 37459704.
  7. Aki T, Tanaka H, Funakoshi T, Unuma K, Uemura K. Excessive N-acetylcysteine exaggerates glutathione redox homeostasis and apoptosis during acetaminophen exposure in Huh-7 human hepatoma cells. Biochem Biophys Res Commun. 2023 Oct 8;676:66-72. doi: 10.1016/j.bbrc.2023.07.023. Epub 2023 Jul 20. PMID: 37487439.
  8. Wen S, Unuma K, Inaji M, Makino Y, Nagano S, Harada K, Arai N, Uemura K. Case report: Fatal ischemic stroke induced by unruptured traumatic intracranial vertebral artery dissection. Front Neurol. 2023 Sep 12;14:1202698. doi: 10.3389/fneur.2023.1202698. PMID: 37780720; PMCID: PMC10536137.
  9. Nomura M, Wen S, Unuma K, Funakoshi T, Aki T, Uemura K. Increased fatty acid synthesis and disturbed lipid metabolism in Neuro2a cells after repeated cocaine exposure: A preliminary study. Biochem Biophys Res Commun. 2024 Feb 5;695:149438. doi: 10.1016/j.bbrc.2023.149438. Epub 2023 Dec 27. PMID: 38160532.
  10. Wen S, Unuma K, Hanazawa R, Nagano S, Watanabe R, Hirakawa A, Uemura K. Alcohol and toxicological factors influencing fatal falls from height in the Greater Tokyo Area: a retrospective study. Int J Legal Med. 2024 May;138(3):793-800. doi: 10.1007/s00414-023-03125-8. Epub 2023 Nov 15. PMID: 37968477.
  11. Unuma K, Wen S, Aki T, Uemura K. Ectopic myogenesis and fibrosis accompany adipogenesis during thymic involution induced by repeated cocaine administration. Biochem Biophys Res Commun. 2023 Dec 17;686:149201. doi: 10.1016/j.bbrc.2023.149201. Epub 2023 Oct 31. PMID: 37926043.

学会発表など

  1. 鵜沼香奈, 秋利彦, 温書恒, 船越丈司, 上村公一. コカイン投与によるラット胸腺の組織学的検討. 第107次日本法医学会学術全国集会. 2023 Jun 8.
  2. 鵜沼香奈. 法医鑑定の意義を考える ～丁寧な法医解剖により予期せぬ真実を見出すことがある～ The Significance of Forensic Examinations ~Careful forensic autopsy may reveal unexpected truths~. 第60 回日本犯罪学会総会 シンポジウム. 2023 Nov 25.

2022年

原著論文など

  1. Aki T, Funakoshi T, Unuma K, Uemura K. Inverse regulation of GSDMD and GSDME gene expression during LPS-induced pyroptosis in RAW264.7 macrophage cells. Apoptosis. 2022 Feb;27(1-2):14-21. doi: 10.1007/s10495-022-01708-1. Epub 2022 Jan 10. PMID: 35006493.
  2. Aki T, Unuma K, Uemura K. The Role of Peroxiredoxins in the Regulation of Sepsis. Antioxidants (Basel). 2022 Jan 6;11(1):126. doi: 10.3390/antiox11010126. PMID: 35052630; PMCID: PMC8773135.
  3. Wen S, Unuma K, Makino Y, Mori H, Uemura K. Fatal consequence after MiraDry® treatment: Necrotizing fasciitis complicated with streptococcal toxic shock syndrome. Leg Med (Tokyo). 2022 Sep;58:102095. doi: 10.1016/j.legalmed.2022.102095. Epub 2022 May 30. PMID: 35662070.
  4. Wen S, Aki T, Funakoshi T, Unuma K, Uemura K. Role of Mitochondrial Dynamics in Cocaine's Neurotoxicity. Int J Mol Sci. 2022 May 12;23(10):5418. doi: 10.3390/ijms23105418. PMID: 35628228; PMCID: PMC9145816.
  5. Wen S, Unuma K, Uemura K. Two fatal cases due to inadvertent discharge of carbon dioxide fire suppressant: Intoxication or asphyxiation? J Forensic Leg Med. 2022 Aug;90:102390. doi: 10.1016/j.jflm.2022.102390. Epub 2022 Jun 7. PMID: 35717756.
  6. Wen S, Unuma K, Funakoshi T, Aki T, Uemura K. Contraction Band Necrosis with Dephosphorylated Connexin 43 in Rat Myocardium after Daily Cocaine Administration. Int J Mol Sci. 2022 Oct 9;23(19):11978. doi: 10.3390/ijms231911978. PMID: 36233284; PMCID: PMC9570416.
  7. Makino Y, Unuma K, Nolte KB, Adolphi NL. Accuracy of forensic pathologists in incorporating post-mortem CT (PMCT) in forensic death investigation. J Forensic Sci. 2022 Nov;67(6):2351-2359. doi: 10.1111/1556-4029.15131. Epub 2022 Sep 6. PMID: 36069005.

    https://twitter.com/the_aafs/status/1577690266084859904?s=46&t=DW_r2AGbK42VzyMvlePIjg

  8. Unuma K, Kaga H, Funakoshi T, Nomura M, Aki T, Uemura K. Thymic involution caused by repeated cocaine administration includes apoptotic cell loss followed by ectopic adipogenesis. PLoS One. 2022 Nov 28;17(11):e0277032. doi: 10.1371/journal.pone.0277032. PMID: 36441681; PMCID: PMC9704633.
  9. Aoki S, Funakoshi T, Aki T, Uemura K. Aggregation-prone A53T mutant of α-synuclein exaggerates methamphetamine neurotoxicity in SH-SY5Y cells: Protective role of cellular cholesterol. Toxicol Rep. 2022 Nov 21;9:2020-2029. doi: 10.1016/j.toxrep.2022.11.006. PMID: 36518421; PMCID: PMC9742969.
  10. 稲次基希, 鵜沼香奈, 上村公一, 前原健寿. 脳神経外科救急におけるM＆M. 乳幼児急性硬膜下血腫における眼底所見の意義と原因の相関. Neurosurgical Emergency.26巻3号:288(2022).
  11. Wen S, Unuma K, Watanabe R, Uemura K, Harada K. Fatal subarachnoid hemorrhage due to neglected traumatic exyracranial vertebral artery pseudoaneurysm: forensic assessment in a difficult to diagnosed highly decomposed case. 法医学の実際と研究65: 161-166. 2022.

学会発表など

  1. 鵜沼香奈. アルコール・薬物と事件・事故. 2022年度アルコール・薬物依存関連学会合同学術総会 シンポジウム. 2022 Jun 9.
  2. 鵜沼香奈, 渡邊嶺, 上村公一. 腹部殴打後に腹部大動脈瘤が破裂した1剖検例. 第91回 日本法医学会学術関東地方集会. 2022 Oct 8.

2021年

原著論文など

  1. Norii T, Makino Y, Unuma K, Hatch GM, Adolphi NL, Dallo S, Albright D, Sklar DP, Braude D. Extraglottic Airway Device Misplacement: A Novel Classification System and Findings in Postmortem Computed Tomography. Ann Emerg Med. 2021 Mar;77(3):285-295. doi: 10.1016/j.annemergmed.2020.10.005. Epub 2021 Jan 15. PMID: 33455839.
  2. Norii T, Makino Y, Unuma K, Adolphi NL, Albright D, Sklar DP, Crandall C, Braude D. CT imaging of extraglottic airway device-pictorial review. Emerg Radiol. 2021 Jun;28(3):665-673. doi: 10.1007/s10140-021-01909-2. Epub 2021 Feb 2. PMID: 33532932.
  3. Wen S, Unuma K, Chinuki Y, Hikino H, Uemura K. Fatal anaphylaxis due to alpha-gal syndrome after initial cetuximab administration: The first forensic case report. Leg Med (Tokyo). 2021 Jul;51:101878. doi: 10.1016/j.legalmed.2021.101878. Epub 2021 Apr 7. Erratum in: Leg Med (Tokyo). 2021 Sep;52:101936. doi: 10.1016/j.legalmed.2021.101936. PMID: 33892262.
  4. Wen S, Unuma K, Watanabe R, Uemura K. Diagnosis by forensic autopsy of cannula malposition resulting in fatal tension pneumothorax after attempted percutaneous tracheostomy: A short communication. J Forensic Leg Med. 2021 Jul;81:102177. doi: 10.1016/j.jflm.2021.102177. Epub 2021 May 6. PMID: 34004465.
  5. Murata T, Noritake K, Aki T, Uemura K. Possible roles of AMPK and macropinocytosis in the defense responses against Δ9-THC toxicity on HL-1 cardiomyocytes. Toxicol Rep. 2021 Apr 30;8:980-987. doi: 10.1016/j.toxrep.2021.04.014. PMID: 34026562; PMCID: PMC8131391.
  6. Nomura M, Unuma K, Aki T, Uemura K. Sustained splenic contraction after daily cocaine administration in rats. PLoS One. 2021 Jun 4;16(6):e0252853. doi: 10.1371/journal.pone.0252853. PMID: 34086815; PMCID: PMC8177630.
  7. Yamada A, Unuma K, Arai N, Kitamura O, Uemura K. Inappropriate diet and fatal malnutrition in a 10-year-old child fed only infant formula throughout life: Novel pathological diagnostic criterion for starvation via lipophagy. Forensic Sci Int. 2021 Aug;325:110896. doi: 10.1016/j.forsciint.2021.110896. Epub 2021 Jul 4. PMID: 34243037.
  8. Unuma K, Makino Y, Yamamoto K, Hattori S, Arai N, Sakai K, Kitagawa M, Uemura K, Kanegane H. Fatal intracranial hemorrhage due to infantile acute lymphoblastic leukemia mimicking abusive head trauma. J Forensic Sci. 2021 Nov;66(6):2504-2510. doi: 10.1111/1556-4029.14815. Epub 2021 Jul 23. PMID: 34296766.
  9. Ota M, Funakoshi T, Aki T, Unuma K, Uemura K. Oxcarbazepine induces mitotic catastrophe and apoptosis in NRK-52E proximal tubular cells. Toxicol Lett. 2021 Oct 10;350:240-248. doi: 10.1016/j.toxlet.2021.07.018. Epub 2021 Jul 29. PMID: 34333065.
  10. 秋利彦, 上村公一. 細胞内空胞形成とメスオーシス. 月刊「細胞」 53:33-35. 2021.
  11. Aki T, Uemura K. Cell Death and Survival Pathways Involving ATM Protein Kinase. Genes (Basel). 2021 Oct 7;12(10):1581. doi: 10.3390/genes12101581. PMID: 34680975; PMCID: PMC8535589.
  12. Wen S, Unuma K, Watanabe R, Makino Y, Uemura K. Forensic evaluation of fatal-suffocating retropharyngeal haematoma secondary to cervical fractures: Report of two cases. J Forensic Leg Med. 2022 Jan;85:102274. doi: 10.1016/j.jflm.2021.102274. Epub 2021 Nov 15. PMID: 34800774.
  13. Wen S, Unuma K, Funakoshi T, Aki T, Uemura K. Altered cardiac mitochondrial dynamics and biogenesis in rat after short-term cocaine administration. Sci Rep. 2021 Dec 16;11(1):24129. doi: 10.1038/s41598-021-03631-y. PMID: 34916603; PMCID: PMC8677764.

学会発表など

  1. 鵜沼香奈, 渡邊嶺, 梶原美祐, 松山蓮実, 上村 公一. 死後敗血症診断における血清プレセプシンの有用性の検討. 第105次日本法医学会学術全国集会. 2021 Sep 8.

2020年

原著論文など

  1. Aki T, Funakoshi T, Noritake K, Unuma K, Uemura K. Extracellular glucose is crucially involved in the fate decision of LPS-stimulated RAW264.7 murine macrophage cells. Sci Rep. 2020 Jun 29;10(1):10581. doi: 10.1038/s41598-020-67396-6. PMID: 32601294; PMCID: PMC7324593.
  2. Kitayama T, Fukagawa T, Watahiki H, Mita Y, Fujii K, Unuma K, Sakurada K, Uemura K, Sekiguchi K, Mizuno N. Evaluation of Rapid DNA system for buccal swab and disaster victim identification samples. Leg Med (Tokyo). 2020 Sep;46:101713. doi: 10.1016/j.legalmed.2020.101713. Epub 2020 May 6. PMID: 32442862.
  3. Unuma K, Watanabe R, Hirayama N, Uemura K. Autopsy Identification of Viable Mycobacterium Tuberculosis in the Lungs of a Markedly Decomposed Body. J Forensic Sci. 2020 Nov;65(6):2194-2197. doi: 10.1111/1556-4029.14532. Epub 2020 Aug 31. PMID: 32866302.
  4. Noritake K, Aki T, Isa S, Uemura K. Pyroptotic cell death by exposure to 1-butanol in H9c2 cardiomyoblastoma cells. Heliyon. 2020 Nov 18;6(11):e05503. doi: 10.1016/j.heliyon.2020.e05503. PMID: 33294662; PMCID: PMC7683309.
  5. Wen S, Aki T, Unuma K, Uemura K. Chemically Induced Models of Parkinson's Disease: History and Perspectives for the Involvement of Ferroptosis. Front Cell Neurosci. 2020 Dec 23;14:581191. doi: 10.3389/fncel.2020.581191. PMID: 33424553; PMCID: PMC7786020.
  6. Kunihiro J, Nabeka H, Wakisaka H, Unuma K, Khan MSI, Shimokawa T, Islam F, Doihara T, Yamamiya K, Saito S, Hamada F, Matsuda S. Prosaposin and its receptors GRP37 and GPR37L1 show increased immunoreactivity in the facial nucleus following facial nerve transection. PLoS One. 2020 Dec 1;15(12):e0241315. doi: 10.1371/journal.pone.0241315. PMID: 33259479; PMCID: PMC7707515.
  7. Nagai M, Sakurada K, Imaizumi K, Ogawa Y, Uo M, Funakoshi T, Uemura K. Evaluation of Parameters for Estimating the Postmortem Interval of Skeletal Remains Using Bovine Femurs: A Pilot Study. Diagnostics (Basel). 2020 Dec 9;10(12):1066. doi: 10.3390/diagnostics10121066. PMID: 33317185; PMCID: PMC7764391.

2019年

原著論文など

  1. Unuma K, Aki T, Yamashita A, Yoshikawa A, Uemura K. Hydrogen sulfide donor NaHS causes bronchitis with enhanced respiratory secretion in rats. J Toxicol Sci. 2019;44(2):107-112. doi: 10.2131/jts.44.107. PMID: 30726810.
  2. Aki T, Unuma K, Noritake K, Hirayama N, Funakoshi T, Uemura K. Formation of high molecular weight p62 by CORM-3. PLoS One. 2019 Jan 8;14(1):e0210474. doi: 10.1371/journal.pone.0210474. PMID: 30620762; PMCID: PMC6324786.
  3. Unuma K, Makino Y, Sasaki Y, Iwase H, Uemura K. Presepsin: A potential superior diagnostic biomarker for the postmortem differentiation of sepsis based on the Sepsis-3 criteria. Forensic Sci Int. 2019 Jun;299:17-20. doi: 10.1016/j.forsciint.2019.03.034. Epub 2019 Mar 23. PMID: 30954003.
  4. Unuma K, Yoshikawa A, Aki T, Uemura K. Increased circulating peroxiredoxin-4 in sepsis model rats involves secretion from hepatocytes and is mitigated by GYY4137. J Toxicol Pathol. 2019 Oct;32(4):305-310. doi: 10.1293/tox.2019-0030. Epub 2019 Sep 14. PMID: 31719759; PMCID: PMC6831490.
  5. Funakoshi T, Furukawa M, Aki T, Uemura K. Repeated exposure of cocaine alters mitochondrial dynamics in mouse neuroblastoma Neuro2a. Neurotoxicology. 2019 Dec;75:70-77. doi: 10.1016/j.neuro.2019.09.001. Epub 2019 Sep 5. PMID: 31494168.

学会発表など

  1. 鵜沼香奈, 秋利彦, 吉川綾香, 上村公一. 敗血症性肝障害に対する硫化水素の影響. 第103次日本法医学会学術全国集会. 2019 Jun.

2018年

原著論文など

  1. Aki T, Unuma K, Funakoshi T, Uemura K. Modes of Chemically Induced Cell Death. Comprehensive Toxicology 3rd ed Volume 1 (General subjects), (2018) 229-253, Elsevier UK
  2. Unuma K, Aki T, Nagano S, Watanabe R, Uemura K. The down-regulation of cardiac contractile proteins underlies myocardial depression during sepsis and is mitigated by carbon monoxide. Biochem Biophys Res Commun. 2018 Jan 8;495(2):1668-1674. doi: 10.1016/j.bbrc.2017.12.020. Epub 2017 Dec 5. PMID: 29217190.
  3. Hirayama N, Aki T, Funakoshi T, Noritake K, Unuma K, Uemura K. Necrosis in human neuronal cells exposed to paraquat. J Toxicol Sci. 2018;43(3):193-202. doi: 10.2131/jts.43.193. PMID: 29540653.
  4. Aki T, Unuma K, Noritake K, Kurahashi H, Funakoshi T, Uemura K. Interaction of carbon monoxide-releasing ruthenium carbonyl CORM-3 with plasma fibronectin. Toxicol In Vitro. 2018 Aug;50:201-209. doi: 10.1016/j.tiv.2018.03.010. Epub 2018 Mar 23. PMID: 29580987.
  5. Aki T, Noritake K, Unuma K, Uemura K. Autophagic regulation of cardiomyocyte survival and heart regeneration. “Autophagy in health and disease”, “Stem Cell Biology and Regenerative Medicine” book series, published by Humana press, Springer-Nature, 2018, pp101-118. ISBN 978-3-319-98145-1 ISSN 2196-8985
  6. 佐野智美, 船越丈司, 則竹香菜子, 鵜沼香奈, 上村公一. 危険ドラッグが検出された10剖検例の死因の検討. 法医学の実際と研究 61:71-77. 2018.

学会発表など

  1. Unuma Kana, Aki Toshihiko, Watanabe Ryo, Uemura Koichi. Down-regulation of cardiac contractile protein is involved in cardiac dysfunction during sepsis and is mitigated by carbon monoxide. 24th Congress of the International Academy of Legal Medicine. 2018 May 1.

2017年

原著論文など

  1. Unuma K, Aki T, Noritake K, Funakoshi T, Uemura K. A CO-releasing molecule prevents annexin A2 down-regulation and associated disorders in LPS-administered rat lung. Biochem Biophys Res Commun. 2017 Jun 3;487(3):748-754. doi: 10.1016/j.bbrc.2017.04.131. Epub 2017 Apr 25. PMID: 28450113.
  2. Watanabe R, Unuma K, Noritake K, Funakoshi T, Aki T, Uemura K. Ataxia telangiectasia and rad3 related (ATR)-promyelocytic leukemia protein (PML) pathway of the DNA damage response in the brain of rats administered arsenic trioxide. J Toxicol Pathol. 2017 Oct;30(4):333-337. doi: 10.1293/tox.2017-0020. Epub 2017 Jul 3. PMID: 29097844; PMCID: PMC5660956.
  3. Noritake K, Aki T, Kimura M, Funakoshi T, Unuma K, Uemura K. Restoration of YAP activation rescues HL-1 cardiomyocytes from apoptotic death by ethanol. J Toxicol Sci. 2017;42(5):545-551. doi: 10.2131/jts.42.545. PMID: 28904289.
  4. Aki T, Unuma K, Uemura K. Emerging roles of mitochondria and autophagy in liver injury during sepsis. Cell Stress. 2017 Oct 2;1(2):79-89. doi: 10.15698/cst2017.11.110. PMID: 31225438; PMCID: PMC6551821.
  5. 鵜沼香奈. 危険ドラッグの現状. 日本医事新報. 4864. 54. 2017.
  6. 鵜沼香奈. 法医解剖死亡児から見る児童虐待. 日本医事新報. 4856. 55 .2017.

学会発表など

  1. 鵜沼香奈, 則竹香菜子, 船越丈司, 坂幹樹, 木村遥, 藤井祐介, 上村公一. 乳幼児における薬物分析検査の重要性 ―思いがけず薬物の寄与が明らかになった2剖検例―. 第101次日本法医学会学術全国集会

2016年

原著論文など

  1. Kimura-Kojima H, Unuma K, Funakoshi T, Kato C, Komatsu A, Aki T, Uemura K. Increased MFG-E8 expression and its implications in the vascular pathophysiology of cocaine abuse. J Toxicol Pathol. 2016 Apr;29(2):131-8. doi: 10.1293/tox.2015-0072. Epub 2016 Jan 17. PMID: 27182119; PMCID: PMC4866001.
  2. 鵜沼香奈, 秋利彦. 敗血症における心筋ミトコンドリア障害と一酸化炭素による保護. 月刊「細胞」 48(11): 31-34. 2016.
  3. Fujii Y, Funakoshi T, Unuma K, Noritake K, Aki T, Uemura K. Hydrogen sulfide donor NaHS induces death of alveolar epithelial L2 cells that is associated with cellular shrinkage, transgelin expression and myosin phosphorylation. J Toxicol Sci. 2016;41(5):645-54. doi: 10.2131/jts.41.645. PMID: 27665774.
  4. Funakoshi T, Aki T, Tajiri M, Unuma K, Uemura K. Necroptosis-like Neuronal Cell Death Caused by Cellular Cholesterol Accumulation. J Biol Chem. 2016 Nov 25;291(48):25050-25065. doi: 10.1074/jbc.M116.727404. Epub 2016 Oct 18. PMID: 27756839; PMCID: PMC5122773.

学会発表など

  1. 鵜沼香奈, 原田一樹, 槇野陽介, 小松亜由美, 上村公一. CTにて明らかになった全身死蝋化を伴う頭部銃創の1例. 第100次日本法医学会学術全国集会. 2016 Jun 15.
  2. 鵜沼香奈. エンドトキシン刺激ラット肝細胞における障害ミトコンドリア処理機構の解析. 第25回内毒素・LPS研究会. 2016 Jun 25.
  3. 鵜沼香奈. 法医鑑定は標準化できるか～質の担保のために何が必要か～. 第53回日本犯罪学会総会 シンポジウム. 2015 Dec 3.

2015年

原著論文など

  1. Watanabe M, Unuma K, Fujii Y, Noritake K, Uemura K. An autopsy case of vagus nerve stimulation following acupuncture. Leg Med (Tokyo). 2015 Mar;17(2):120-2. doi: 10.1016/j.legalmed.2014.11.001. Epub 2014 Nov 11. PMID: 25465674.
  2. Okawa S, Unuma K, Yamada A, Aki T, Uemura K. Lipopolysaccharide induces expression of collagen VI in the rat lung. J Toxicol Pathol. 2015 Jan;28(1):37-41. doi: 10.1293/tox.2014-0053. Epub 2014 Dec 27. Erratum in: J Toxicol Pathol. 2016 Jan;29(1):74. PMID: 26023260; PMCID: PMC4337498.
  3. Yamada A, Aki T, Unuma K, Funakoshi T, Uemura K. Paraquat induces epithelial-mesenchymal transition-like cellular response resulting in fibrogenesis and the prevention of apoptosis in human pulmonary epithelial cells. PLoS One. 2015 Mar 23;10(3):e0120192. doi: 10.1371/journal.pone.0120192. PMID: 25799450; PMCID: PMC4370722.
  4. Aki T, Funakoshi T, Uemura K. Regulated necrosis and its implications in toxicology. Toxicology. 2015 Jul 3;333:118-126. doi: 10.1016/j.tox.2015.04.003. Epub 2015 Apr 9. PMID: 25865964.
  5. Watanabe M, Unuma K, Makino Y, Noritake K, Yamada A, Iwase H, Uemura K. An Autopsy Case of Acute Massive Hematochezia Caused by Superior Mesenteric Vein Thrombosis: A First Report in Forensic Medicine. J Forensic Sci. 2016 Jan;61(1):271-3. doi: 10.1111/1556-4029.12903. Epub 2015 Aug 13. PMID: 26268582.
  6. Nagai H, Kuwahira I, Schwenke DO, Tsuchimochi H, Nara A, Ogura S, Sonobe T, Inagaki T, Fujii Y, Yamaguchi R, Wingenfeld L, Umetani K, Shimosawa T, Yoshida K, Uemura K, Pearson JT, Shirai M. Pulmonary Macrophages Attenuate Hypoxic Pulmonary Vasoconstriction via β3AR/iNOS Pathway in Rats Exposed to Chronic Intermittent Hypoxia. PLoS One. 2015 Jul 1;10(7):e0131923. doi: 10.1371/journal.pone.0131923. PMID: 26132492; PMCID: PMC4489089.
  7. Noritake K, Aki T, Funakoshi T, Unuma K, Uemura K. Direct Exposure to Ethanol Disrupts Junctional Cell-Cell Contact and Hippo-YAP Signaling in HL-1 Murine Atrial Cardiomyocytes. PLoS One. 2015 Aug 28;10(8):e0136952. doi: 10.1371/journal.pone.0136952. PMID: 26317911; PMCID: PMC4552866.
  8. Unuma K, Aki T, Funakoshi T, Hashimoto K, Uemura K. Extrusion of mitochondrial contents from lipopolysaccharide-stimulated cells: Involvement of autophagy. Autophagy. 2015;11(9):1520-36. doi: 10.1080/15548627.2015.1063765. PMID: 26102061; PMCID: PMC4590602.
  9. Uchida K, Unuma K, Uemura K. A fatality in a child with severe fatty liver due to n-butane and isopentane poisoning resulting from long-term inhalation of an antiperspirant aerosol. Forensic Sci Med Pathol. 2015 Dec;11(4):631-2. doi: 10.1007/s12024-015-9712-6. Epub 2015 Sep 8. PMID: 26350115.
  10. Kuroda R, Shintani-Ishida K, Unuma K, Yoshida K. Immobilization Stress With α2-Adrenergic Stimulation Induces Regional and Transient Reduction of Cardiac Contraction Through Gi Coupling in Rats. Int Heart J. 2015;56(5):537-43. doi: 10.1536/ihj.15-034. Epub 2015 Sep 4. PMID: 26346517.
  11. Utsuno H, Kageyama T, Uchida K, Kibayashi K, Sakurada K, Uemura K. Pilot study to establish a nasal tip prediction method from unknown human skeletal remains for facial reconstruction and skull photo superimposition as applied to a Japanese male populations. J Forensic Leg Med. 2016 Feb;38:75-80. doi: 10.1016/j.jflm.2015.11.017. Epub 2015 Dec 12. PMID: 26724561.
  12. 則竹香菜子, 秋利彦, 上村 公一. アルコールによる心筋障害とオートファジーの役割. 月刊「細胞」 47(14): 44-47. 2013.

学会発表など

  1. 鵜沼香奈，大川紗由里，秋利彦，山田真嗣，上村公一. 敗血症性肺障害モデルにおけるコラーゲン分子の変動. 第99次日本法医学術全国集会. 2015 Jun 11.

2014年

原著論文など

  1. Yamada A, Unuma K, Kojima H, Uemura K. Subarachnoid hemorrhage caused by a traffic accident: de novo aneurysm ruptured 30 years after surgical neck clipping. J Forensic Leg Med. 2014 Feb;22:90-2. doi: 10.1016/j.jflm.2013.12.015. Epub 2013 Dec 21. PMID: 24485430.
  2. Watanabe M, Funakoshi T, Unuma K, Aki T, Uemura K. Activation of the ubiquitin-proteasome system against arsenic trioxide cardiotoxicity involves ubiquitin ligase Parkin for mitochondrial homeostasis. Toxicology. 2014 Aug 1;322:43-50. doi: 10.1016/j.tox.2014.04.008. Epub 2014 May 4. PMID: 24801902.
  3. Uchida K, Unuma K, Funakoshi T, Aki T, Uemura K. Activation of Master Autophagy Regulator TFEB During Systemic LPS Administration in the Cornea. J Toxicol Pathol. 2014 Jul;27(2):153-8. doi: 10.1293/tox.2014-0004. Epub 2014 Apr 17. PMID: 25352718; PMCID: PMC4110941.
  4. Nagai H, Kuwahira I, Schwenke DO, Tsuchimochi H, Nara A, Inagaki T, Ogura S, Fujii Y, Umetani K, Shimosawa T, Yoshida K, Pearson JT, Uemura K, Shirai M. β2-Adrenergic receptor-dependent attenuation of hypoxic pulmonary vasoconstriction prevents progression of pulmonary arterial hypertension in intermittent hypoxic rats. PLoS One. 2014 Oct 28;9(10):e110693. doi: 10.1371/journal.pone.0110693. PMID: 25350545; PMCID: PMC4211686.

学会発表など

  1. Kana Unuma, Toshihiko Aki, Takeshi Funakoshi, Koichi. Secretion of mitochondrial contents through autophagolysosomal exocytosis from lipopolysaccharide-stimulated hepatocytes and embryonic fibroblasts. 9th International Symposium on Advances in Legal Medicine. 2014 Jun 17.
  2. 鵜沼香奈. 敗血症モデルにおける各種臓器不全の分子学的検討. 第98次日本法医学会学術全国集会. 2014 Jun 19.
  3. 鵜沼香奈. 法医実務ベースに生じた疑問解明へのチャレンジ－敗血症とオートファジー. 第12回医科学研究発表会. 2014 Sep 18.

2013年

原著論文など

  1. Unuma K, Aki T, Matsuda S, Funakoshi T, Yoshida K, Uemura K. Inducer of heme oxygenase-1 cobalt protoporphyrin accelerates autophagy and suppresses oxidative damages during lipopolysaccharide treatment in rat liver. Hepatol Res. 2013 Jan;43(1):91-6. doi: 10.1111/j.1872-034X.2012.01049.x. Epub 2012 Dec 11. PMID: 23231766.
  2. Funakoshi T, Aki T, Unuma K, Uemura K. Lysosome vacuolation disrupts the completion of autophagy during norephedrine exposure in SH-SY5Y human neuroblastoma cells. Brain Res. 2013 Jan 15;1490:9-22. doi: 10.1016/j.brainres.2012.10.056. Epub 2012 Nov 2. PMID: 23123211.
  3. Hirose I, Harada K, Kuroda R, Ishii Y, Nakajima M, Kamei Y, Takazawa Y, Yoshida K. An autopsy report on a ruptured rudimentary horn (uterine anomaly) with ectopic pregnancy. Forensic Sci Int. 2013 Jan 10;224(1-3):e4-6. doi: 10.1016/j.forsciint.2012.10.019. Epub 2012 Dec 20. PMID: 23265443.
  4. Unuma K, Aki T, Funakoshi T, Yoshida K, Uemura K. Cobalt protoporphyrin accelerates TFEB activation and lysosome reformation during LPS-induced septic insults in the rat heart. PLoS One. 2013;8(2):e56526. doi: 10.1371/journal.pone.0056526. Epub 2013 Feb 15. PMID: 23457579; PMCID: PMC3574118.
  5. Sugihara M, Odagiri F, Suzuki T, Murayama T, Nakazato Y, Unuma K, Yoshida K, Daida H, Sakurai T, Morimoto S, Kurebayashi N. Usefulness of running wheel for detection of congestive heart failure in dilated cardiomyopathy mouse model. PLoS One. 2013;8(1):e55514. doi: 10.1371/journal.pone.0055514. Epub 2013 Jan 31. PMID: 23383212; PMCID: PMC3561288.
  6. Unuma K, Harada K, Oka T, Uemura K. Starch accumulation in the lungs of two infants following positive ventilation. Forensic Sci Med Pathol. 2013 Dec;9(4):554-7. doi: 10.1007/s12024-013-9453-3. Epub 2013 May 23. PMID: 23700192; PMCID: PMC3825578.
  7. Fujii Y, Funakoshi T, Uchida K, Watanabe M, Saka K, Uemura K. An autopsy case of acute carbon monoxide poisoning with fatal hypnotic drugs in the blood. Int Med J. 2013;20(5):587-588.
  8. Bessho M, Aki T, Funakoshi T, Unuma K, Noritake K, Kato C, Uemura K. Rho-kinase inhibitor Y-27632 attenuates arsenic trioxide toxicity in H9c2 cardiomyoblastoma cells. Cardiovasc Toxicol. 2013 Sep;13(3):267-77. doi: 10.1007/s12012-013-9206-2. PMID: 23532581.
  9. Aki T, Funakoshi T, Unuma K, Uemura K. Impairment of autophagy: from hereditary disorder to drug intoxication. Toxicology. 2013 Sep 15;311(3):205-15. doi: 10.1016/j.tox.2013.07.001. Epub 2013 Jul 10. PMID: 23851159.
  10. Funakoshi-Hirose I, Aki T, Unuma K, Funakoshi T, Noritake K, Uemura K. Distinct effects of methamphetamine on autophagy-lysosome and ubiquitin-proteasome systems in HL-1 cultured mouse atrial cardiomyocytes. Toxicology. 2013 Oct 4;312:74-82. doi: 10.1016/j.tox.2013.07.016. Epub 2013 Aug 7. PMID: 23933405.
  11. Kashima J, Shintani-Ishida K, Nakajima M, Maeda H, Unuma K, Uchiyama Y, Yoshida K. Immunohistochemical study of the autophagy marker microtubule-associated protein 1 light chain 3 in normal and steatotic human livers. Hepatol Res. 2014 Jul;44(7):779-87. doi: 10.1111/hepr.12183. Epub 2013 Aug 7. PMID: 23773367.

学会発表など

  1. 鵜沼香奈, 秋利彦, 船越丈司, 内田恭子, 則竹香菜子, 藤井祐介, 上村公一. ヘムオキシゲナーゼ誘導剤は敗血症ラットの心筋障害をオートファジー活性化を介して軽減する. 第97次日本法医学会学術全国集会.

2012年

原著論文など

  1. Aki T, Nara A, Uemura K. Cytoplasmic vacuolization during exposure to drugs and other substances. Cell Biol Toxicol. 2012 Jun;28(3):125-31. doi: 10.1007/s10565-012-9212-3. Epub 2012 Mar 7. PMID: 22431173.
  2. Unuma K, Uozaki H, Kuroda R, Uemura K, Yoshida K. Death from axillary haemorrhage during haemodialysis in a patient with a history of microscopic polyangiitis. BMJ Case Rep. 2012 Jan 18;2012:bcr1120115194. doi: 10.1136/bcr.11.2011.5194. PMID: 22665880; PMCID: PMC3263122.
  3. Bessho M, Unuma K, Nara A, Uemura K. A case in which a bone fragment caused by a bullet made a second channel in addition to the bullet channel. Leg Med (Tokyo). 2012 Jul;14(4):188-90. doi: 10.1016/j.legalmed.2012.02.006. Epub 2012 Apr 11. PMID: 22498233.
  4. Noritake K, Aki T, Funakoshi T, Unuma K, Nara A, Kato C, Uemura K. Critical roles of Rho-associated kinase in membrane blebbing and mitochondrial pathway of apoptosis caused by 1-butanol. Toxicol In Vitro. 2012 Sep;26(6):849-55. doi: 10.1016/j.tiv.2012.04.027. Epub 2012 May 4. PMID: 22564901.
  5. Nara A, Aki T, Funakoshi T, Unuma K, Uemura K. Hyperstimulation of macropinocytosis leads to lysosomal dysfunction during exposure to methamphetamine in SH-SY5Y cells. Brain Res. 2012 Jul 23;1466:1-14. doi: 10.1016/j.brainres.2012.05.017. Epub 2012 May 14. PMID: 22613348.
  6. Unuma K, Aki T, Matsuda S, Funakoshi T, Yoshida K, Uemura K. Elimination and active extrusion of liver mitochondrial proteins during lipopolysaccharide administration in rat. Hepatol Res. 2013 May;43(5):526-34. doi: 10.1111/j.1872-034X.2012.01084.x. Epub 2012 Sep 13. PMID: 22971177.
  7. 菊地洋介, 阿部伸幸, 鵜沼香奈, 重田聡男, 福永龍繁. 内視鏡的逆行性胆道ドレナージチューブステントの逸脱によるS状結腸穿孔の一剖検例. 法医学の実際と研究55: 139-144. 2012.

学会発表など

  1. 鵜沼香奈, 秋利彦, 則竹香菜子, 上村公一. プロテオーム及びin vivo系を用いた敗血症における新たなマーカーの同定. 第96次日本法医学会学術全国集会.

2011年

原著論文など

  1. Noritake K, Unuma K, Nara A, Uchida K, Shiratori T, Watanuki Y, Funakoshi T, Uemura K. Autopsy findings of a patient with rapidly progressive massive ascites caused by alcoholic cirrhosis. Leg Med (Tokyo). 2011 May;13(3):148-50. doi: 10.1016/j.legalmed.2010.12.006. Epub 2011 Jan 28. PMID: 21277247.
  2. Funakoshi T, Aki T, Nakayama H, Watanuki Y, Imori S, Uemura K. Reactive oxygen species-independent rapid initiation of mitochondrial apoptotic pathway by chelerythrine. Toxicol In Vitro. 2011 Dec;25(8):1581-7. doi: 10.1016/j.tiv.2011.05.028. Epub 2011 Jun 2. PMID: 21664962.
  3. Unuma K, Harada K, Furutani M, Furutani Y, Nakajima M, Nakanishi T, Matsuoka R, Yoshida K. Multiple stenotic arteriopathy in a 72-year-old female with Williams syndrome. J Clin Pathol. 2011 Apr;64(4):368-70. doi: 10.1136/jcp.2010.085803. Epub 2011 Jan 5. PMID: 21212057.
  4. Unuma K, Harada K, Funakoshi T, Uemura K. Sudden death of an alcoholic elderly man with acute esophageal necrosis (black esophagus). Forensic Sci Int. 2011 Oct 10;212(1-3):e15-7. doi: 10.1016/j.forsciint.2011.05.024. PMID: 21684699.
  5. Kuroda R, Harada K, Kobayashi T, Nagai H, Unuma K, Saka K, Shintani-Ishida K, Yoshida K. Sudden cardiac death caused by the administration of a β₂-agonist for asthma attack. Int J Cardiol. 2011 Dec 15;153(3):e56-8. doi: 10.1016/j.ijcard.2011.02.041. Epub 2011 Mar 10. PMID: 21396727.

2010年

原著論文など

  1. Aki T, Nara A, Funakoshi T, Uemura K. Bifurcate effects of glucose on caspase-independent cell death during hypoxia. Biochem Biophys Res Commun. 2010 Jun 4;396(3):614-8. doi: 10.1016/j.bbrc.2010.04.122. Epub 2010 Apr 24. PMID: 20420806.
  2. Unuma K, Shintani-Ishida K, Yahagi N, Tsushima K, Shimosawa T, Ueyama T, Yoshida K. Restraint stress induces connexin-43 translocation via α-adrenoceptors in rat heart. Circ J. 2010 Nov;74(12):2693-701. doi: 10.1253/circj.cj-10-0529. Epub 2010 Oct 19. PMID: 20966593.
  3. Unuma K, Shintani-Ishida K, Tsushima K, Shimosawa T, Ueyama T, Kuwahara M, Yoshida K. Connexin-43 redistribution and gap junction activation during forced restraint protects against sudden arrhythmic death in rats. Circ J. 2010 Jun;74(6):1087-95. doi: 10.1253/circj.cj-09-1019. Epub 2010 Apr 3. PMID: 20379000.
  4. Tojo A, Unuma K, Harada K, Yoshida K, Fujita T. Localization and mechanism of nephrocalcinosis in pseudo-Bartter's syndrome. Kidney Int. 2010 May;77(9):831; author reply 831. doi: 10.1038/ki.2010.54. PMID: 20393494.
  5. Unuma K, Harada K, Nakajima M, Ito T, Okutsu K, Yoshida K. Unexpected death of a patient with rheumatoid arthritis complicated by a cervical deformity. Leg Med (Tokyo). 2010 Sep;12(5):242-5. doi: 10.1016/j.legalmed.2010.06.001. Epub 2010 Jul 14. PMID: 20634116.
  6. 鵜沼香奈, 藤乘嗣泰, 原田一樹, 中嶋信, 藤田敏郎, 吉田謙一. ダイエット薬乱用による偽性バーター症候群の剖検例における結石形成機序の考察. 臨床体液37; 43-48. 2010.