Organization

BM:Institute of Biomaterials and Bioengineering
MR:Medical Research Institute
MT:Biomedical Laboratory Sciences
DS:M&D Data Science Center
OH:Oral Health Care Sciences
OE:Oral Health Engineering
IR:Institute of Research
※1:Institute of Physical and Chemical Research (Riken)
※2:National Cancer Center

Department Supervisor Affiliation Research subject
Biomedical Devices and Instrumentation
*Not recruiting this year		 MITSUBAYASHI Kohji BM
  1. Basic and applied research on "BioMedical Sensing" (integration with various engineering technologies)
  2. Wearable devices and artificial organs with MEMS-tech and biocompatible polymers
  3. Bio-fluorometric sensing of disease-based breath chemicals
  4. Real-time imaging of transcutaneous volatiles for metabolic evaluation
  5. Novel wearable biosensors (i.e. Head-set type gas-sensing system for transcutaneous blood volatiles)
Biomedical Informatics NAKAJIMA Yoshikazu BM
  1. Fundamental and applied researches on bio-imaging
  2. Research on high-dimensionalization of medical images and data
  3. Research on computer analysis and diagnosis of medical data
  4. Research on description of biological information, human-body modeling, human-body simulation and their application formedicine
  5. Research on computer-integrated surgical assistance systems
Precision Biomedical Engineering IKEUCHI Masashi BM
  1. Polymer 3-D micro/nano fabrication technology
  2. Micro-scale soft robotics
  3. Integrated microdevice for mechanobiology study
  4. Medical microsystem for assisted reproductive technology
  5. Automatic micro-fluidic tissue culture system
Material-Based Medical Engineering
*Not recruiting this year		 KISHIDA Akio BM
  1. Research on the materials and the engineering for tissue engineering and regenerative medicine
  2. Research on the processing and high functionality of biological materials
  3. Research on the novel method for evaluating inflammatory responses on medical materials in vitro
  4. Research on the control technology of cellular functions by extracellular matrix-bounded nanovesicles
  5. Research on the high selective cell capture devices for immunomodulation
Organic and Medicinal Chemistry
*Not recruiting this year		 KAGECHIKA Hiroyuki BM
  1. Medicinal chemistry of retinoid and nuclear receptors
  2. Development of novel modulators of gene transcription or signaling pathway for clinical application toward intractable diseases
  3. Development of functional fluorescent molecules for elucidation of cellular signaling pathway
  4. Aromatic architecture based on the amide conformational properties
Chemical Bioscience HOSOYA Takamitsu BM
  1. Drug seed development based on new synthetic methodologies
  2. Development of new methods to connect molecules based on strained molecules
  3. Probe synthesis for target protein identification of bioactive compounds
  4. Probe design and synthesis for in vivo molecular imaging
Medicinal Chemistry TAMAMURA Hirokazu BM
  1. Development of bifunctional molecules using organic synthesis
  2. Development of peptidomimetics and drug discovery templates
  3. Development of antiviral agents and anti-cancer agents
  4. Development of bioprobes and chemical biology
Metallic Biomaterials
*Not recruiting this year		 Under Selection BM
  1. Development of zirconium alloys for minimizing MRI artifacts
  2. Bio-functionalization of metals by electrochemical surface treatment and modification techniques
  3. Strengthening of titanium alloys by severe working
  4. Control of differentiation of stem cells on nanometer-level surface topography
  5. Elucidation of interfacial reaction between materials and tissues
Organic Biomaterials MATSUMOTO Akira BM
  1. "On-skin-pancreas" technology for precision medicine in diabetes
  2. Boronic acids-based molecular-recognition chemistry as a platform for diagnostic and therapeutic applications
  3. Development of stimulus-cleavable chemistry and its application to biomaterials science and engineering
  4. Next-era microneedle materials technology for home-use multidrug administration
Diagnostic and Therapeutic Systems Engineering KAJI Hirokazu BM
  1. Biofabrication technology
  2. Implantable drug delivery devices
  3. Minimally invasive cell delivery system
  4. Micropysiological systems
Ceramic Biomaterials YOKOI Taishi BM
  1. Development of layered calcium phosphate based-materials for hard tissue regeneration
  2. Development of ultra-tough artificial bone
  3. Biomedical application of inorganic materials responding to biomolecules
  4. Design of ceramic materials compatible with therapy and diagnosis
  5. Development of ceramic micro/nano-particles for intra-arterial therapy of deep-seated cancer
Advanced Bio-molecular Design
*Not recruiting this year		 KAGECHIKA Hiroyuki
(currently assigned)		 BM
  1. Development of mRNA therapeutics
  2. Technology on cell fate determination
  3. Molecular biology associated with applications of mRNA therapeutics
  4. Molecular design for advanced nucleic acid medicine
Molecular Cell Biology
*Not recruiting this year		 SHIBUYA Hiroshi MR
  1. Molecular mechanism in cellular signaling of growth and differential factors
  2. Molecular mechanism in the onset and progress of diseases
  3. Molecular mechanism in the early deveopment
Developmental and Regenerative Biology
*Not recruiting for 2024 October enrollment		 NISHINA Hiroshi MR
  1. Study on signaling pathways that regulate cell survial and death
  2. Study on signaling pathways that regulate embryonic stem cell proliferation and diffferentiation
  3. Study on liver formation and regeneration using mice and fish
  4. Study on molecular mechanisms regulating circadain clock
Homeostatic Medicine TOYOSHIMA Fumiko MR
  1. Study on physiological organ remodeling and plasticity on life stages
  2. Maternal organ remodling during pregnancy and maternal-fetal crosstalk
  3. Development of regenerative medicine based on physiological organ remodeling
Advanced Nanomedical Engineering UCHIDA Satoshi MR
  1. Development of nano DDS for mRNA, nucleic acids, and gene therapeutics
  2. Molecular designing and engineering of mRNA for the delivery and therapeutic use
  3. Development of mRNA vaccines for infectious disease prevention and cancer therapy
  4. Disease treatment using mRNA therapeutics
Structural Biology ITO Nobutoshi MR
  1. Structural biology by X-ray crystallography and cryo-electron microscopy
  2. Structural and kinetic analyses of protein-protein interactions
  3. Molecular recognition of small-molecule ligands (drugs) by proteins
  4. Computational biology of biological macromolecules using structural information
Biomolecular Pathogenesis MATSUDA Noriyuki MR
  1. Elucidation of molecular function of causative genes for hereditary Parkinson's disease, i.e., PINK1, Parkin, and DJ-1
    1. Study on the function of DJ-1 focusing on a novel post-translational modification
    2. Study on the function of PINK1 and Parkin during mitophagy (process for selective mitochondrial degradation)
  2. Elucidation of the intracellular role of ubiquitin-mediated selective autophagy and mitophagy
  3. Identification of novel factors involved in membrane traffic during selective organelle degradation, and elucidation of their functions
Bio-informational Pharmacology
*Not recruiting this year		 Under Selection MR
  1. Understanding the molecular mechanisms of the transcriptional and epigenetic regulators for mesodermal cells specification during development
  2. Understanding congenital heart-hand syndromes
  3. Epigenome and proteome analysis during the heart regeneration
  4. Bioinformatics analysis in cardiovascular development
  5. Reprogramming/transdifferentiation in development
Disease Functional Genomics Under Selection MR
Epigenetic Epidemiology
*Not recruiting this year		 Under Selection MR
  1. Effects of intrauterine environment on neonate epigenome
  2. The molecular mechanisms underpin DOHaD phenomena (animal experiment)
  3. Gene-environment interaction in common diseases
  4. Integrated personal disease risk assessment system
Functional Genome Informatics NIKAIDO Itoshi MR
  1. Development of data science technologies for large-scale genome analysis using machine learning and computer science
  2. Development of new experimental techniques for large-scale genome science
  3. Study of the development of regenerative medicine and drug discovery using large-scale genome analysis
Medical Chemistry SEGAWA Katsumori MR
  1. Identification of factors responsible for cellular membrane dynamics
  2. Aberrant membrane dynamics and associated diseases
  3. Identification of factors responsible for cellular homeostasis
RIKEN Molecular and Chemical Somatology TANIUCHI Ichiro
SODEOKA Mikiko
ISHIGAKI Kazuyoshi
TANAKA Motomasa
WATANABE Rikiya
HAGIHARA Shinya		 ※1
  1. Regulatory mechanisms for the lymphocyte development (Ichiro Taniuchi)
  2. Design and synthesis of bioactive molecules based on synthetic organic chemistry and chemical biology research (Mikiko Sodeoka)
  3. Discovery, target identification and analyses of mechanism of action of bioactive compounds that regulate biological function (Nobumoto Watanabe)
  4. Molecular basis of psychiatric diseases and neurodegenerative disorders (Motomasa Tanaka)
  5. Development of digital detection technology for disease-biomarkers based on single molecule biophysics (Rikiya Watanabe)
  6. Regulation of physiological function of plants with synthetic molecules
NCC Cancer Science ARAKAWA Hirofumi
MASUTOMI Kenkichi
HAMAMOTO Ryuji
YASUNAGA Masahiro
KOGA Yoshikatsu
UEMURA Yasushi		 ※2
  1. Carcinogenesis and molecular mechanism
  2. Functions of cancer-associated genes and their alterations
  3. Genomic, epigenomic and proteomic analysis of cancer and personalized medicine
  4. Tumor microenvironment/cancer stem cells/non-coding RNA/signaling pathway
  5. Molecular target/drug delivery/diagnosis and therapy
Cellular and Molecular Medicine SASAKI Junko MR
  1. Molecular mechanism of sex reversal induced by lipid metabolism
  2. Malignant tumor and lipid metabolism
  3. Biological significance of phospholipid acyl-chain composition
Interdisciplinary Sciences HIEDA Mitsunori
NAKABAYASHI Jun
YAGISHITA Kazuyoshi
NARA Masayuki
TOKUNAGA Shin-ichi
  1. Histopathological image analysis of hepatocellular carcinoma by artificial intelligence
  2. The effects of hyperbaric oxygen environment on healing acceleration in soft tissue injuries
  3. Spectroscopic analysis for molecules of life
  4. Problems of graph theory as the basis of network structure in life science
Data Science Algorithm Design and Analysis BANNAI Hideo DS
  1. Algorithms and data structures for matching, searching, and discovering patterns
  2. Algorithms and data structures for compression and compressed data processing
  3. Combinatorics on strings
AI Technology Development
*Not recruiting this year		 BANNAI Hideo
(Currently assigned)		 DS
  1. Statistical theory and data-analytic approaches
  2. Explanable AI technologies for systematic understanding of diseases
  3. Analysis of omics data for healthcare
  4. Network biology for uncovering gene regulatory networks
Molecular and Mechanistic Immunology Under Selection IR
  1. Mechanism of anti-viral immune innate immune response
  2. Mechanism of autoimmune disease caused by self-attacking immune response
  3. Development of drugs targeting autoimmune and cancer disease
  4. Development of novel cell manipulation technology by using the CRISPR-Cas system, adaptive immune systems in prokaryotes
Anatomical and Pathological Sciences HOSHI Osamu MT
  1. Application of atomic force microscopy to biological fields
  2. Analysis of high-order structure of human chromosomes
  3. Analysis of dynamics of growth cones of neuron
  4. Molecular pathological study of biliary tract cancer and development of a novel therapy
  5. Creation of digital content using cytological images, AI imaging diagnosis
  6. Development of pathological diagnosis and pathological technology in developing coutries
Hematological and Biophysical System Sciences ITO Minami
Associate Professor: NISHIO Miwako
*Prof Ito: Not recruiting this year		 MT
  1. Laboratory molecular and genetic analyses on hematologic neoplasms
  2. Epstein-Barr virus positive T- or NK-cell neoplasms: Clarification of the onset mechanisms and development of the new treatment strategies
  3. Development of brown adipocytes detection method using human ES/iPS cells
  4. Elucidation of the activation mechanism in brown adipocytes
Clinical Information Applied Sciences
*Not recruiting for 2024 October enrollment		 SUMI Yuki MT
  1. Pathogenic mechanisms of bronchial asthma, COPD, interstitial pneumonia
  2. Gene therapy and immunotherapy for lung diseases
  3. Pathogenesis of neuropsychiatric disease using non-invasive brain function tests and image analyses
  4. Investigation of epilepsy using EEG
  5. Evaluation of brain function using the event-related potential analysys
Clinical and Diagnostic Laboratory Science KAKINUMA Sei MT
  1. Development of novel disease models using human iPS cells and organoids to elucidate the pathophysiology of hepatobiliary diseases
  2. Analysis of cell-to-cell interaction regulating development and progression of hepatobiliary diseases
  3. Molecular mechanisms regulating homeostasis of stem/progenitor cells in hepatobiliary and pancreatic tissues
  4. Research on molecular mechanisms regulating hepatic fibrosis and liver regeneration
  5. Analysis on cell communication and signaling in the process of myocardial remodeling
Clinical Bioanalysis and Molecular Biology OHKAWA Ryunosuke
SUZUKI Yoshinobu		 MT
  1. Development of a new biomarker to estimate residual risk for cardiovascular disease
  2. Mechanism of HDL diversification and its effect on the character and function
  3. Molecular mechanism of red blood cell-related lipids metabolism
  4. Development of new models of neurological and mental disorders using genetically engineered mice
  5. Study on molecular mechanisms of myelination in the central nervous system
  6. Functional and structural analysis of cell adhesion molecules and extracellular matrix molecules
Molecular Microbiology and Immunology SAITO Ryoichi MT
  1. Research on the evolution and diversity of multidrug-resistant bacteria
  2. Research on the regulation system of virulence in pathogenic bacteria
  3. Research on environmental microbiota dynamics and their interactions
  4. Long-term immunity of virus-specific memory T cells
  5. Hematopoietic stem cell mobilization and transplantation immunity
  6. Immunotherapy and the molecular pathogenesis of leukemia
Lifetime Oral Health Care Science
*Not recruiting this year		 ARAKAWA Shinichi OH
  1. Basic and clinical studies oｆ the effects of ozone Ultrafine bubble water：Wound healing, Tratment for oral mucositis in patients, Periodontal therapy, Prevention of bacteremia and aspiration pneumonia, Preventing DUWL (Dental Unit Water Lines) contamination
  2. Clinical evaluation regarding Slight Acidic Electrolytic Water（SAEW）：Prevention of bacteremia and aspiration pneumonia, Preventing DUWL (Dental Unit Water Lines) contamination
  3. Development and evaluation of the education system for denta hygienists in perioperative oral care
Oral Care for Systemic Health Support KABASAWA Yuhji OH
  1. Research on oral management and multidisciplinary collaboration during cancer treatment and perioperative period
  2. Research on the relationship between systemic disease and oral health
  3. Development of the new methods for oral care, oral mucositis prevention and oral mucosal disease treatment
  4. Research on social inequalities in oral health
Preventive Oral Health Care Science
*Not recruiting this year		 SHINADA Kayoko OH
  1. Oral Health strategy for preventive methods on oral diseases
  2. Studys on preventive oral health care and oral health promotion
  3. Development or assessment of oral care goods, materials and substances
  4. Development and assessment of new programs in basic or clinical education for dental hygien students
  5. Development of education system for dental hygiene process or assessment
Oral Health Sciences for Community Welfare MATSUO Koichiro OH
  1. Invention of oral frail preventive program for community dwelling older adults
  2. Invention of monitoring system for eating behavior in dependent older adults
  3. Innovative food technology systems for independent senior living
  4. Establishment of oral management system during stroke recovery
  5. Invention of perioperative oral management system for cancer patients
Oral Health Care Education
*Not recruiting this year		 YOSHIDA Naomi OH
  1. Research and development of oral health education methods
  2. Research and development of assessment tool for oral health
  3. Development and evaluation of dental hygiene education system
  4. Role of dental hygienists in team approaches to care of patients
Basic Oral Health Engineering
*Not recruiting for 2024 October enrollment		 AOKI Kazuhiro OE
  1. Development of novel bone anabolic reagents with suitable scaffold by interdisciplinary research among medical, dental, and engineering toward clinical applications
  2. Relationship between oral bacteria and systemic diseases - Interdisciplinary research toward improvement of lifestyle-related diseases
  3. Study on the quality of life related to functional restoration by dental prostheses
  4. Research on the oral and maxillofacial prosthetic rehabilitation
  5. Research on the role of dental technicians in team approaches
Digital Dentistry KANAZAWA Manabu OE
  1. The applications of the digital densitry for the dental practice
  2. The development of methods for fully digital removable dentures
  3. Development of medical device software applying machine learning
  4. The methods for the digitalized dental educations
Oral Biomedical Engineering IKEDA Masaomi OE
  1. Study on evaluation, improvement and development of CAD/CAM dental technology
  2. Revaluation of conventional analog techniques in dental laboratory
  3. Application of dental technology by dental technician to various medical fields
  4. Improvement of work environment and expansion of job categories for dental technicians
  5. Study on international standardization of the dental technology in dental laboratory

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