Organelle zones for the Golgi stress response

Research abstract

When the capacity of the Golgi function becomes insufficient (Golgi stress), eukaryotic cells increase Golgi capacity by activating the homeostatic mechanism called the Golgi stress response. We are studying organelle zones in the Golgi apparatus, which transmit stress signals to the nucleus upon detection of Golgi stress. Since the function of the Golgi is quite diverse, several organelle zones for the Golgi stress response may exist, corresponding to each Golgi function. In detail, we are analyzing (1) the TFE3 zone for N-glycosylation, Golgi structure and vesicular transport, (2) the proteoglycan zone for proteoglycan-type glycosylation, (3) the mucin zone for mucin-type glycosylation and (4) the lipid pathway for lipid transport and glycosylation.

Original papers

1. Kimura M, Sasaki K, Fukutani Y, Yoshida H, Ohsawa I, Yohda M, Sakurai K. (2019) Anticancer saponin OSW-1 is a novel class of selective Golgi stress inducer, Bioorg Med Chem Lett. 29, 1732-1736. doi: 10.1016/j.bmcl.2019.05.022s
2. Sasaki K, Komori R, Taniguchi M, Shimaoka A, Midori S, Yamamoto M, Okuda C, Tanaka R, Sakamoto M, Wakabayashi S, Yoshida H. (2019) PGSE Is a Novel Enhancer Regulating the Proteoglycan Pathway of the Mammalian Golgi Stress Response, Cell Struct Funct. 44, 1-19. doi: 10.1247/csf.18031.
3. Oku, M., Tanakura, S., Uemura, A., Sohda, M., Misumi, Y., Taniguchi, M., Wakabayashi, S., and Yoshida, H. (2011) Novel cis-acting element GASE regulates transcriptional induction by the Golgi stress response. Cell Struct Funct 36, 1-12
4. Taniguchi, M., Nadanaka, S., Tanakura, S., Sawaguchi, S., Midori, S., Kawai, Y., Yamaguchi, S., Shimada, Y., Nakamura, Y., Matsumura, Y., Fujita, N., Araki, N., Yamamoto, M., Oku, M., Wakabayashi, S., Kitagawa, H., and Yoshida, H. (2015) TFE3 Is a bHLH-ZIP-type Transcription Factor that Regulates the Mammalian Golgi Stress Response. Cell Struct Funct 40, 13-30
5. Taniguchi, M., Sasaki-Osugi, K., Oku, M., Sawaguchi, S., Tanakura, S., Kawai, Y., Wakabayashi, S., and Yoshida, H. (2016) MLX Is a Transcriptional Repressor of the Mammalian Golgi Stress Response. Cell Struct Funct 41, 93-10

Reviews

1. Sasaki K, Yoshida H. (2019) Organelle Zones, Cell Struct Funct. 44, 85-94. doi: 10.1247/csf.19010
2. Sasaki K, Yoshida H. (2019) Golgi stress response and organelle zones, FEBS Lett., in press. doi: 10.1002/1873-3468.13554
3. Sasaki, K., and Yoshida, H. (2015) Organelle autoregulation-stress responses in the ER, Golgi, mitochondria and lysosome. Journal of biochemistry 157, 185-195