News

May 16, 2025	The collaborative research conducted by Dr. Le Bui Thao Nguyen, Professor Uchida, Professor Teiji Sawa (Kyoto Prefectural University of Medicine), and Professor Hiroshi Abe (Nagoya University) has been published in the Journal of Controlled Release. Ken Kawaguchi#, Le Bui Thao Nguyen#, Mao Kinoshita, Naoko Abe, Makoto Oba, Hiroshi Abe, Kazuki Sudo, Keita Inoue, Satoshi Uchida, Teiji Sawa, Highly pure mRNA vaccine provides robust immunization against P. aeruginosa by minimizing type I interferon responses, Journal of Controlled Release in press doi: 10.1016/j.jconrel.2025.113860
May 1, 2025	The paper by Assistant Professor Norimatsu and colleagues was published in the journal ACS Applied Nano Materials. It will be featured in the special issue "Commemorate the Establishment of the Institute of Science Tokyo" Jumpei Norimatsu, Rashida Hashim, Theofilus A. Tockary, Muhammad Shahid Nazir, Yuki Mochida, Satoshi Uchida,Polycations Improve Intracellular Stability of mRNA Delivered Using Lipid Nanoparticles for Prolonged Protein Expression, ACS Applied Nano Materials in press doi: 10.1021/acsanm.5c00633
April 1, 2025	Our new PhD students,Chen Xianyi and Zhu Xueyang, and our new Master student, Haruto Yamashita, have joined our lab.
February 19, 2025	Collaborative research, conducted by Prof. Abe, Prof. Uchida, et al., has been published in Nature Biotechnology. Kosuke Fukuchi, Yuko Nakashima, Naoko Abe, Seigo Kimura, Fumitaka Hashiya, Yuichi Shichino, Yiwei Liu, Ryoko Ogisu, Satomi Sugiyama, Daisuke Kawaguchi, Masahito Inagaki, Zheyu Meng, Shiryu Kajihara, Mizuki Tada, Satoshi Uchida, Ting-Ting Li, Ramkrishna Maity, Tairin Kawasaki, Yasuaki Kimura, Shintaro Iwasaki, Hiroshi Abe, Internal cap-initiated translation for efficient protein production from circular mRNA, Nature Biotechnology in press doi: 10.1038/s41587-025-02561-8
February 10, 2025	Research on the impact of secondary structures on polymeric micelle-type drug delivery systems (DDSs), conducted by Prof. Mochida, has been published in Chemistry of Materials. Yuki Mochida, Horacio Cabral, Yutaka Miura, Kensuke Osada, Nobuhiro Nishiyama, Kazunori Kataoka, Secondary Structure-Guided Assembly of Uniform Disk-Like Polymeric Micelles Incorporating Hydrophobic Platinum Drugs for Improved Tumor Targeting, Chemistry of Materials* in press doi: 10.1021/acs.chemmater.4c02734
October 1, 2024	Junpei Norimatsu (research assistant) has been appointed as Assistant Professor.
October 1, 2024	Our new PhD students, Muhammad Salman and Meng Yue, our new Master students, Bhaskar Chatterjee and Huang Mian, and our new Graduate Research Students, Zhang Shuyuan, Chen Xinyu and Guo Yuqi, have joined our lab.
October 1, 2024	The Department of Advanced Nano-Medical Engineering, Medical Research Institute, Tokyo Medical and Dental University has become Department of Advanced Nanomedical Engineering, Medical Research Laboratory, Institute of Integrated Research, Institute of Science Tokyo through university integration.
July 10, 2024	Research about mRNA delivery systems, conducted by Jumpei Norimatsu (research assistant),. has published a paper in Materials Horizons. Jumpei Norimatsu, Hayato L. Mizuno, Takayoshi Watanabe, Takumi Obara, Makoto Nakakido, Kouhei Tsumoto, Horacio Cabral, Daisuke Kuroda, Yasutaka Anraku,Triphenylphosphonium-modified catiomers enhance in vivo mRNA delivery through stabilized polyion complexation, Materials Horizons in press doi: 10.1039/D4MH00325J
July 11, 2024	The member pages of Project Assistant Professor Ishikawa and Post-doc Le Bui Thao Nguyen are now available.
July 3, 2024	Collaborative research, conducted by Prof. Mochida, Prof. Naito, and Prof. Miyata, has been published in Bioconjugate Chemistry. Yukine Ishibashi, Mitsuru Naito, Yusuke Watanuki, Mao Hori, Satomi Ogura, Kaori Taniwaki, Masaru Cho, Ryosuke Komiya, Yuki Mochida, Kanjiro Miyata, Size-Dependent Glioblastoma Targeting by Polymeric Nanoruler with Prolonged Blood Circulation , Bioconjugate Chemistry in press doi: 10.1021/acs.bioconjchem.4c00235
July 1, 2024	Our new project assistant professor, Junichi Ishikawa, has joined our Lab.
June 10, 2024	The annual report for 2024 has been published.
May 6, 2024	We issued a press release regarding the paper published in Angewandte Chemie International Edition (EurekAlert).
May 1, 2024	Our paper is highlighted in “In This Issue” in Molecular Therapy.
Apr 23, 2024	Collaborative research, conducted by Dr. Guyse and Prof. Uchida, has been published in Angewandte Chemie International Edition. Joachim F. R. Van Guyse#,, Saed Abbasi#, Kazuko Toh, Zlata Nagorna, Junjie Li, Anjaneyulu Dirisala, Sabina Quader, Satoshi Uchida, Kazunori Kataoka, Facile generation of heterotelechelic poly(2-oxazoline)s towards accelerated exploration of poly(2-oxazoline)-based nanomedicine, Angewandte Chemie International Edition e202404972, (2024) in press
Apr 15, 2024	Our paper published in Small Science has been selected as Inside Front Cover.
Apr 2, 2024	Research about mRNA vaccines against COVID-19, conducted by Prof. Uchida, et al., has been published in Molecular therapy, along with a press release on EurekAlert. Saed Abbasi, Miki Matsui-Masai, Fumihiko Yasui, Akimasa Hayashi, Theofilus A. Tockary, Yuki Mochida, Shiro Akinaga, Michinori Kohara, Kazunori Kataoka, Satoshi Uchida, Carrier-free mRNA vaccine induces robust immunity against SARS-CoV-2 in mice and non-human primates without systemic reactogenicity, Molecular Therapy in press doi: 10.1016/j.ymthe.2024.03.022
Apr 1, 2024	Our new research assistant, Jumpei Norimatsu, our new post-doc, Le Bui Thao Nguyen, and our new master's student, Sae Takagi, have joined our Lab.
Mar 26, 2024	A review paper authored by Prof. Mochida and Prof. Uchida has been published in RNA Biology. Yuki Mochida, Satoshi Uchida, mRNA vaccine designs for optimal adjuvanticity and delivery, RNA Biology* 21, 1-27, (2024)
Feb 22, 2024	Research about spleen targeting of mRNA polyplexes, conducted by Prof. Mochida, Mr. Marx, and Prof. Uchida, et al. has been published in Small Science. Miki Suzuki#, Yuki Mochida#, Mao Hori, Akimasa Hayashi, Kazuko Toh, Theofilus A. Tockary, Xueying Liu, Victor Marx, Hidetomo Yokoo, Kanjiro Miyata, Makoto Oba, Satoshi Uchida, Poly(ethylene Glycol) (PEG)–OligoRNA Hybridization to mRNA Enables Fine‐Tuned Polyplex PEGylation for Spleen‐Targeted mRNA Delivery, Small Science* in press doi: 10.1002/smsc.202300258
Feb 14, 2024	Research video of our laboratory has been released.
Feb 1, 2024	Our new short-term exchange student, Rashida Hashim, and our new research assistant, Nan Qiao, have joined our Lab.
Jan 5, 2024	Collaborative research, conducted by Prof. Uchida and Prof. Cabral, et al., has been published in Biomacromolecules. Lucas Mixich, Eger Boonstra, Keita Masuda, Shang-Wei Li, Yuki Nakashima, Fanlu Meng, Momoko Sakata, Tatsuro Goda, Satoshi Uchida, Horacio Cabral, Ionizable Polymeric Micelles with Phenylalanine Moieties Enhance Intracellular Delivery of Self-Replicating RNA for Long-Lasting Protein Expression In Vivo, Biomacromolecules* in press doi: 10.1021/acs.biomac.3c01102
Dec 30, 2023	Collaborative research, conducted by Prof. Uchida, Prof. Oba, and Dr. Yokoo, has been published in ACS Biomaterials Science & Engineering. Hidetomo Yokoo, Anjaneyulu Dirisala, Satoshi Uchida, Makoto Oba, Oligosarcosine Conjugation of Arginine-Rich Peptides Improves the Intracellular Delivery of Peptide/pDNA Complexes, ACS Biomaterials Science & Engineering in press doi: 10.1021/acsbiomaterials.3c01542
Dec 26, 2023	The website of Crafton Biotechnology Co., Ltd., where Prof. Uchida serves as the Chief Medical Officer, has been released.
Dec 21, 2023	Our new short-term exchange students, Bao Wenjing and Zhao Xin, have joined our Lab.
Dec 8, 2023	Our new short-term exchange student, Wang Rui, has joined our Lab.
Nov. 11, 2023	The review paper, ”Multifunctional Immunoadjuvants for Use in Minimalist Nucleic Acid Vaccines”, authored by S. Abbasi and S. Uchida, was chosen as one of the Selected Papers in 2021 in the Section "Gene and Cell Therapy in Pharmaceutics".
Oct. 30, 2023	Prof. Uchida delivered an oral presentation, titled “Naked mRNA Jet Injection into the Skin Enables the Robust Vaccination against SARS-CoV-2 in Mice and Cynomolgus Monkeys”, at 11th International mRNA Health Conference.
Oct 1, 2023	Our new research assistant, Victor Marx, and our new master's student, Naiya Ruzzama, have joined our Lab.
Sep 1, 2023	Our new research assistant, Reiko Shiratori, has joined our Lab.
Aug 30, 2023	The research about COVID-19 mRNA vaccines based on mRNA has been posted in bioRxiv. Saed Abbasi, Miki Matsui-Masai, Fumihiko Yasui, Akimasa Hayashi, Theofilus Tockary, Shiro Akinaga, Michinori Kohara, Kazunori Kataoka, Satoshi Uchida, Jet injection potentiates naked mRNA SARS-CoV-2 vaccine in mice and non-human primates by adding physical stress to the skin, bioRxiv DOI: 10.1101/2023.02.27.530188
July 12, 2023	Research about cancer vaccines based on mRNA engineering, conducted by Prof. Uchida and Ms. Masai, et al. has been published in PNAS, along with a press release on EurekAlert. Theofilus A. Tockary#, Saed Abbasi#, Miki Matsui-Masai, Akimasa Hayashi, Naoto Yoshinaga, Eger Boonstra, Zheng Wang, Shigeto Fukushima, Kazunori Kataoka, Satoshi Uchida, Comb-structured mRNA vaccine tethered with short double-stranded RNA adjuvants maximizes cellular immunity for cancer treatment, Proceedings of the National Academy of Sciences 120, e2214320120, (2023)
July 6, 2023	Prof. Uchida obtained a Grant-in-Aid for Challenging Research (Pioneering) as a principal investigator (ref).
June 26, 2023	A review authored by Prof. Uchida, Prof. Miyata (the University of Tokyo) has been published in Advanced Drug Delivery Review. Satoshi Uchida, Chun Yin Jerry Lau, Makoto Oba, Kanjiro Miyata, Polyplex Designs for Improving the Stability and Safety of RNA Therapeutics, Advanced Drug Delivery Reviews 199, 114972 (2023)
June 11, 2023	Collaborative research on the mRNA vaccine against Pseudomonas aeruginosa, conducted by Prof. Uchida, Prof. Sawa, at Kyoto Prefectural University of Medicine, et al., has been posted as a preprint. Ken Kawaguchi, Mao Kinoshita, Kazuki Sudo, Keita Inoue, Yoshifumi Naito, Makoto Oba, Satoshi Uchida, Teiji Sawa, mRNA vaccine induces protective immunity against the type III secretory virulence of Pseudomonas aeruginosa, bioRxiv DOI: 10.1101/2023.06.09.544431
May 12, 2023	Collaborative research with Prof. Uchida and Prof. Abe et al. at Nagoya University has been published in Nature Communications. M Inagaki, N Abe, Z Li, Y Nakashima, S Acharyya, K Ogawa, D Kawaguchi, H Hiraoka, A Banno, Z Meng, M Tada, T Ishida, P Lyu, K Kokubo, H Murase, F Hashiya, Y Kimura, S Uchida, H Abe,Cap analogs with a hydrophobic photocleavable tag enable facile purification of fully capped mRNA with various cap structures, Nature Communications 14, 2657, (2023)
April 29, 2023	Prof. Uchida gave an invited lecture titled "Basics of mRNA Vaccine," at a seminar co-sponsored by Moderna Japan, Co., Ltd. at the 97th Annual Meeting of the Japanese Association for Infectious Diseases, the 71st Annual Meeting of the Japanese Society of Chemotherapy, Joint Conference.
April 27, 2023	Prof. Uchida will give an online presentation titled "Nano-DDS Development for mRNA Vaccines and Drugs" at iSeminar on Wednesday, May 17, at 16:30. Everyone is welcome to join. [Registration]
April 20, 2023	We have launched our website.