Institute of Integrated Research, Institute of Science Tokyo

Department of Advanced Nanomedical Engineering,
Medical Research Laboratory
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Yuki MOCHIDA

Research Keywords Biography Achievements Memberships
持田 祐希

Yuki Mochida, Ph.D.

Associate Professor
E-mail:

researchmap, ORCiD

Research Keywords

Drug delivery system (DDS), mRNA therapeutics，Antibody therapeutics, Cancer immunotherapy，Polymer structure, Polymer-metal complex

Biography

Education

2009.3　 B. Eng. Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo
2011.3　 M. Eng. Department of Bioengineering, Graduate School of Engineering, The University of Tokyo
2014.3　 Ph.D. (Eng.) Department of Bioengineering, Graduate School of Engineering, The University of Tokyo
　 "A Study on the Characterization and Biological Activity of Polymeric Micelles Incorporating Platinum Antitumor Agents"

Research History

2011.4-
2013.3　		 JSPS Research Fellow (DC1), The University of Tokyo
2014.4-
2015.3　		 Project Researcher, The University of Tokyo
2015.4-
2015.5　		 Research Scientist, Innovation Center of NanoMedicine (iCONM)
2015.6-
2023.3　		 Senior Research Scientist, Innovation Center of NanoMedicine (iCONM)
2023.4-　 Dupty Principal Research Scientist, Innovation Center of NanoMedicine (iCONM)
2023.4-　 Associate Professor,Department of Advanced Nanomedical Engineering, Medical Research Laboratory, Institute of Integrated Research, Institute of Science Tokyo (former name Tokyo Medical and Dental University)

Achievements

Publications

  1. Yuki Mochida, Horacio Cabral, Yutaka Miura, Kensuke Osada, Nobuhiro Nishiyama, Kazunori Kataoka*, Secondary Structure-Guided Assembly of Uniform Disk-Like Polymeric Micelles Incorporating Hydrophobic Platinum Drugs for Improved Tumor Targeting, Chemistry of Materials in press doi: 10.1021/acs.chemmater.4c02734
  2. S. Abbasi, M. Matsui-Masai, F. Yasui, A. Hayashi, T. A. Tockary, Y. Mochida, S. Akinaga, M. Kohara, K. Kataoka, S. Uchida, Carrier-free mRNA vaccine induces robust immunity against SARS-CoV-2 in mice and non-human primates without systemic reactogenicity. Mol. Ther. 2024, 32, 1266-1283
  3. Y. Mochida, S. Uchida, mRNA vaccine designs for optimal adjuvanticity and delivery. RNA Biol. 2024, 21, 1-27
  4. P. Chen, W. Yang, Y. Mochida, S. Li, T. Hong, H. Kinoh, K. Kataoka, H. Cabral, Selective Intracellular Delivery of Antibodies in Cancer Cells with Nanocarriers Sensing Endo/Lysosomal Enzymatic Activity. Angew. Chem. Int. Ed. 2024, 63, e202317817
  5. M. Suzuki#, Y. Mochida#, M. Hori, A. Hayashi, K. Toh, T. A. Tockary, X. Liu, V. Marx, H. Yokoo, K. Miyata, M. Oba, S. Uchida, Poly(ethylene glycol)(PEG)–oligoRNA hybridization to mRNA enables fine‐tuned polyplex PEGylation for spleen‐targeted mRNA delivery. Small Sci. 2024, 4, 2300258
  6. D. Maiti, H. Yu, Y. Mochida, S. Won, S. Yamashita, M. Naito, K. Miyata, H. J. Kim, Terbium-Rose Bengal Coordination Nanocrystals-Induced ROS Production under Low-Dose X-rays in Cultured Cancer Cells for Photodynamic Therapy. ACS Appl. Bio Mater. 2023, 6, 2505-2513
  7. Y. Mochida, Current Status of Next-Generation Immune Checkpoint Inhibitors for the Treatment of Malignant Brain Tumors. Jpn. J. Cancer Chemother. 2023, 50, 694-700
  8. A. Awaad, H. Takemoto, M. Iizuka, K. Ogi, Y. Mochida, A. H. Ranneh, M. Toyoda, M. Matsui, T. Nomoto, Y. Honda, K. Hayashi, K. Tomoda, T. Ohtake, Y. Miura, N. Nishiyama, Changeable net charge on nanoparticles facilitates intratumor accumulation and penetration. J. Control. Release 2022, 346, 392-404
  9. A. Dirisala, S. Uchida, J. Li, J. F. R. V. Guyse, K. Hayashi, S. V. C. Vummaleti, S. Kaur, Y. Mochida, S. Fukushima, K. Kataoka, Effective mRNA Protection by Poly(L-ornithine) Synergizes with Endosomal Escape Functionality of a Charge-Conversion Polymer toward Maximizing mRNA Introduction Efficiency. Macromol. Rapid Commun. 2022, 43, 2100754
  10. T. Yang, Y. Mochida, X. Liu, H. Zhou, J. Xie, Y. Anraku, H. Kinoh, H. Cabral, K. Kataoka, Conjugation of glucosylated polymer chains to checkpoint blockade antibodies augments their efficacy and specificity for glioblastoma. Nat. Biomed. Eng. 2021, 5, 1274-1287
  11. W. K. D. Paraiso, J. Garcia-Chica, X. Ariza, S. Zagmutt, S. Fukushima, J. Garcia, Y. Mochida, D. Serra, L. Herrero, H. Kinoh, N. Casals, K. Kataoka, R. Rodríguez-Rodríguez, S. Quader, Poly-ion complex micelles effectively deliver CoA-conjugated CPT1A inhibitors to modulate lipid metabolism in brain cells. Biomater. Sci. 2021, 9, 7076-7091.
  12. H. Shibasaki, H. Kinoh, H. Cabral, S. Quader, Y. Mochida, X. Liu, K. Toh, K. Miyano, Y. Matsumoto, T. Yamasoba, K. Kataoka, Efficacy of pH-Sensitive Nanomedicines in Tumors with Different c-MYC Expression Depends on the Intratumoral Activation Profile. ACS Nano 2021, 15, 5545-5559
  13. N. Nakamura#, Y. Mochida#, K. Toh, S. Fukushima, H. Cabral, Y. Anraku, Effect of Mixing Ratio of Oppositely Charged Block Copolymers on Polyion Complex Micelles for In Vivo Application. Polymers 2021, 13, 5
  14. S. Quader, X. Liu, K. Toh, Y.-L. Su, A. R. Maity, A. Tao, W. K. D. Paraiso, Y. Mochida, H. Kinoh, H. Cabral, K. Kataoka, Supramolecularly enabled pH-triggered drug action at tumor microenvironment potentiates nanomedicine efficacy against glioblastoma. Biomaterials 2021, 267, 120463
  15. K. Koji, N. Yoshinaga, Y. Mochida, T. Hong, T. Miyazaki, K. Kataoka, K. Osada, H. Cabral, S. Uchida, Bundling of mRNA strands inside polyion complexes improves mRNA delivery efficiency in vitro and in vivo. Biomaterials 2020, 261, 120332
  16. A. Dirisala, S. Uchida, K. Toh, J. Li, S. Osawa, T. A. Tockary, X. Liu, S. Abbasi, K. Hayashi, Y. Mochida, S. Fukushima, H. Kinoh, K. Osada, K. Kataoka, Transient stealth coating of liver sinusoidal wall by anchoring two-armed PEG for retargeting nanomedicines. Sci. Adv. 2020, 6, eabb8133
  17. T. A. Tockary, W. Foo, A. Dirisala, Q. Chen, S. Uchida, S. Osawa, Y. Mochida, X. Liu, H. Kinoh, H. Cabral, K. Osada, K. Kataoka, Single-Stranded DNA-Packaged Polyplex Micelle as Adeno-Associated-Virus-Inspired Compact Vector to Systemically Target Stroma-Rich Pancreatic Cancer. ACS Nano 2019, 13, 12732-12742
  18. N. Yoshinaga, E. Cho, K. Koji, Y. Mochida, M. Naito, K. Osada, K. Kataoka, H. Cabral, S. Uchida, Bundling mRNA Strands to Prepare Nano‐Assemblies with Enhanced Stability Towards RNase for In Vivo Delivery. Angew. Chem. Int. Ed. 2019, 58, 11360-11363
  19. K. Suzuki, Y. Miura, Y. Mochida, T. Miyazaki, K. Toh, Y. Anraku, V. Melo, X. Liu, T. Ishii, O. Nagano, H. Saya, H. Cabral, K. Kataoka, Glucose transporter 1-mediated vascular translocation of nanomedicines enhances accumulation and efficacy in solid tumors. J. Control. Release 2019, 301, 28-41
  20. Y. Yi, H. -J. Kim, M. Zheng, P. Mi, M. Naito, B. S. Kim, H. S. Min, K. Hayashi, F. Perche, K. Toh, X. Liu, Y. Mochida, H. Kinoh, H. Cabral, K. Miyata, K. Kataoka, Glucose-linked sub-50-nm unimer polyion complex-assembled gold nanoparticles for targeted siRNA delivery to glucose transporter 1-overexpressing breast cancer stem-like cells. J. Control. Release 2019, 295, 268-277
  21. A. H. Ranneh, H. Takemoto, S. Sakuma, A. Awaad, T. Nomoto, Y. Mochida, M. Matsui, K. Tomoda, M. Naito, N. Nishiyama, Ethylenediamine-based betaine structure switches the neutral net harge of polyzwitterion into cationic at tumorous pH for effective tumor accumulation of the coated Nanomaterials. Angew. Chem. Int. Ed. 2018, 57, 5057-5061
  22. K. Miyano, H. Cabral, Y. Miura, Y. Matsumoto, Y. Mochida, H. Kinoh, K. Iwata, O. Nagato, H. Saya, N. Nishiyama, K. Kataoka, T. Yamasoba, cRGD peptide installation on cisplatin-loaded nanomedicines enhances efficacy against locally advanced head and neck squamous cell carcinoma bearing cancer stem-like cells. J. Control. Release 2017, 261, 275-286
  23. Y. Mochida, H. Cabral, K. Kataoka, Polymeric micelles for targeted tumor therapy of platinum anticancer drugs. Expert Opin. Drug Deliv. 2017, 14, 1423-1438
  24. M. Wang, Y. Miura, K. Tsuchihashi, K. Miyano, O. Nagano, M. Yoshikawa, A. Tanabe, J. Makino, Y. Mochida, N. Nishiyama, H. Saya, H. Cabral, K. Kataoka, Eradication of CD44-variant positive population in head and neck tumors through controlled intracellular navigation of cisplatin-loaded nanomedicines. J. Control. Release 2016, 230, 26-33
  25. J. Makino, H. Cabral, Y. Miura, Y. Matsumoto, P. Mi, H. Kinoh, Y. Mochida, N. Nishiyama, K. Kataoka, cRGD-installed polymeric micelles loading platinum anticancer drugs enable cooperative treatment against lymph node metastasis. J. Control. Release 2015, 220 PartB, 783-791
  26. O. F. Mutaf, A. Kishimura, Y. Mochida, A. Kim, K. Kataoka, Induction of secondary structure through micellization of an oppositely charged pair of homochiral block- and homopolypeptides in an aqueous medium. Macromol. Rapid. Commun. 2015, 36, 1958-1964
  27. Y. Mochida, H. Cabral, Y. Miura, F. Albertini, S. Fukushima, K. Osada, N. Nishiyama, K. Kataoka, “Bundled Assembly of Helical Nanostructures in Polymeric Micelles Loaded with Platinum Drugs Enhancing Therapeutic Efficiency against Pancreatic Tumor”, ACS Nano, 2014, 8, 6724-6738
  28. S. Quader, H. Cabral, Y. Mochida, T. Ishii, X. Liu, K. Toh, Y. Miura, N. Nishiyama, K. Kataoka., Selevtive intracellular delivery of proteasome inhibitors through pH-sensitive polymeric micelles directed to efficient antitumor therapy, J. Control. Release 2014, 188, 67-77
  29. K. Osada, H. Cabral, Y. Mochida, S. Lee, K. Nagata, T. Matsuura, M. Yamamoto, Y. Anraku, A. Kishimura, N. Nishiyama, K. Kataoka, Bioactive Polymeric Metallosomes Self-Assembled through Block Copolymer-Metal Complexation, J. Am. Chem. Soc. 2012, 134, 13172-13174
  30. M. Kawahara, Y. Shimo, A. Hitomi, Y. Mochida, T. Sogo, H. Ueda, T. Nagamune, Fluorescein-responsive migration of mammalian cells equipped with an antibody/receptor chimera, J. Biosci. Bioeng. 2009, 108, S33

Books

  1. Y. Mochida, “1. Medicine – Nanomachine developer”. Picture book of works that create future vol. 2 – Create a safe daily life, Tokyo, Gakken Plus, 2021, p. 8-9, ISBN 978-4-05-501338-3.
  2. Y. Mochida, Y. Yamasaki, K. Kataoka, “4. 5. 1 Polymeric micelle”. Colloid and Surface Chemistry, The Chemical Society of Japan ed. 4th ed., Tokyo, Maruzen Publishing., 2018, p. 204-206, ISBN 978-4-621-30291-0.

Awards

2023.7 13th IPC (International Polymer Conference)　 Young Scientist Poster Award
2022.11 17th Nano Biomedical Society Award
2022.3 Best Presentation Award, COI Meetup for Young Scientists
2021.6 Best Presentation Award, 37th Japan DDS conference
2021.1 Best Presentation Award, 15th COINS General meeting
2019.2 Seiichi Tejima Research Awards (Paper Award)
2014.11 Best Presentation Award, The 23th Polymer Materials Forum
2014.7 Best Presentation Award, The 43th Biomedical Polymer Symposium
2014.3 The Dean Award for Academic Excellence from Graduate School of Engineering, The University of Tokyo

Research Fundings

2024-2025 AMED, Project for Cancer Research and Therapeutic Evolution (PI)
2024-2027 JPSP, KAKENHI, Grant-in-Aid for Scientific Research (B) (Co-I)
2023-2025 JPSP, KAKENHI, Grant-in-Aid for Scientific Research (A) (Co-I)
2023-2024 AMED, Project for Cancer Research and Therapeutic Evolution (Co-I)
2023-2025 JPSP, KAKENHI, Grant-in-Aid for Scientific Research (C) (Co-I)
2022-2025 JPSP, KAKENHI, Grant-in-Aid for Scientific Research (B) (PI)
2022-2024 JPSP, KAKENHI, Grant-in-Aid for Challenging Research (Exploratory) (PI)
2021-2024 JSPS, Fund for the Promotion of Joint International Research, Fostering Joint International Research (B) (Co-I)
2021-2022　 The Hattori Hokokai Foundation, Grant-in-Aid for Engineering Research (PI)
2021-2023　 JPSP, KAKENHI, Grant-in-Aid for Scientific Research (A) (Co-I)
2021-2021　 JST, COI collaborative research fund for young researchers (PI)
2019-2021　 JPSP, KAKENHI, Grant-in-Aid for Young Scientists (PI)
2017-2018　 JPSP, KAKENHI, Grant-in-Aid for Young Scientists (B) (PI)
2016-2019　 JPSP, KAKENHI, Grant-in-Aid for Scientific Research (B) (Co-I)
2015-2016　 JPSP, KAKENHI, Grant-in-Aid for Scientific Research, Challenging Exploratory Research (PI)
2011-2012　 JPSP, KAKENHI, Grant-in-Aid for JSPS Fellows (PI)

Memberships

  • The Society of Polymer Science, Japan
  • The Japan Society of Drug Delivery System
  • American Chemical Society
  • The Japanese Society for Biomaterials
  • The Pharmaceutical Society of Japan
  • Japanese Association of Cancer Immunology
  • The Antibody Society of Japan
  • Japanese Cancer Association
  • Nucleic Acids Therapeutics Society of Japan