Institute of Integrated Research, Institute of Science Tokyo

Department of Advanced Nanomedical Engineering,
Medical Research Laboratory
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Yuki MOCHIDA

Research Keywords Biography Achievements Memberships
持田 祐希

Yuki Mochida, Ph.D.

Associate Professor

researchmap, ORCiD

Research Keywords

Drug delivery system (DDS), Molecular Transport System (MTS), mRNA therapeutics，Antibody therapeutics, Cancer immunotherapy，Polymer physics, Polymer-metal complex

[Recruiting] JSPS Postdoctoral Fellows working at Innovation Center of NanoMedicine (iCONM) in Kawasaki

Biography

Education

2009.3　 B. Eng. Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo
2011.3　 M. Eng. Department of Bioengineering, Graduate School of Engineering, The University of Tokyo
2014.3　 Ph.D. (Eng.) Department of Bioengineering, Graduate School of Engineering, The University of Tokyo
　 "A Study on the Characterization and Biological Activity of Polymeric Micelles Incorporating Platinum Antitumor Agents"

Research History

2011.4-
2013.3　		 JSPS Research Fellow (DC1), The University of Tokyo
2014.4-
2015.3　		 Project Researcher, The University of Tokyo
2015.4-
2015.5　		 Research Scientist, Innovation Center of NanoMedicine (iCONM)
2015.6-
2023.3　		 Senior Research Scientist, Innovation Center of NanoMedicine (iCONM)
2023.4-　 Dupty Principal Research Scientist, Innovation Center of NanoMedicine (iCONM)
2023.4-　 Associate Professor,Department of Advanced Nanomedical Engineering, Medical Research Laboratory, Institute of Integrated Research, Institute of Science Tokyo (former name Tokyo Medical and Dental University)

Achievements

Publications

  1. Victor Marx#, Yuki Mochida#*, Shigehito Osawa, Theofilus A Tockary, Jumpei Norimatsu, Hidetomo Yokoo, Makoto Oba, Satoshi Uchida*, Poly(sarcosine) and Poly(2-ethyl-2-oxazoline) Tethered To mRNA Provide Stealth Properties To mRNA Polyplexes, ACS Appl. Nano Mater. 2025, 8(27), 13628-13638
  2. Yuki Mochida*, Development of Antibody-polymer Conjugates for the Treatment of Intractable Cancers, Yakugaku Zasshi 2025, 145(6), 423-532
  3. R. Maeoka*, R. Matsuda*, T. Nakazawa, Y. Mochida, N. Ouji-Sageshima, K. Yamada, T. Morimoto, Y. Takeshima, S. Yamada, F. Nishimura, Y.-S. Park, T. Ito, I. Nakagawa, Immunotherapy using allogenic NK cells downregulates mitochondrial-related genes and inhibits the OXPHOS system of malignant meningioma, Biomed. & Pharmacother. 2025, 187, 118099
  4. J. Norimatsu, R. Hashim, T. A. Tockary, M. S. Nazir, Y. Mochida*, S. Uchida*, Polycations Improve Intracellular Stability of mRNA Delivered Using Lipid Nanoparticles for Prolonged Protein Expression, ACS Appl. Nano Mater. 2025, 8(21), 10898-10906 Selected as Front Cover
  5. Y. Mochida, H. Cabral, Y. Miura, K. Osada, N. Nishiyama, K. Kataoka, Secondary Structure-Guided Assembly of Uniform Disk-Like Polymeric Micelles Incorporating Hydrophobic Platinum Drugs for Improved Tumor Targeting, Chem. Mater. 2025, 37, 2457-2473 Selected as Front Cover
  6. Y. Ishibashi, M. Naito, Y. Watanuki, M. Hori, S. Ogura, K. Taniwaki, M. Cho, R. Komiya, Y. Mochida, K. Miyata, Size-Dependent Glioblastoma Targeting by Polymeric Nanoruler with Prolonged Blood Circulation, Bioconjug. Chem. 2024, 35, 1154-1159
  7. S. Abbasi, M. Matsui-Masai, F. Yasui, A. Hayashi, T. A. Tockary, Y. Mochida, S. Akinaga, M. Kohara, K. Kataoka, S. Uchida, Carrier-free mRNA vaccine induces robust immunity against SARS-CoV-2 in mice and non-human primates without systemic reactogenicity. Mol. Ther. 2024, 32, 1266-1283
  8. Y. Mochida, S. Uchida, mRNA vaccine designs for optimal adjuvanticity and delivery. RNA Biol. 2024, 21, 1-27
  9. P. Chen, W. Yang, Y. Mochida, S. Li, T. Hong, H. Kinoh, K. Kataoka, H. Cabral, Selective Intracellular Delivery of Antibodies in Cancer Cells with Nanocarriers Sensing Endo/Lysosomal Enzymatic Activity. Angew. Chem. Int. Ed. 2024, 63, e202317817 Selected as Inside Front Cover
  10. M. Suzuki#, Y. Mochida#, M. Hori, A. Hayashi, K. Toh, T. A. Tockary, X. Liu, V. Marx, H. Yokoo, K. Miyata, M. Oba, S. Uchida, Poly(ethylene glycol)(PEG)–oligoRNA hybridization to mRNA enables fine‐tuned polyplex PEGylation for spleen‐targeted mRNA delivery. Small Sci. 2024, 4, 2300258 Selected as Inside Front Cover
  11. D. Maiti, H. Yu, Y. Mochida, S. Won, S. Yamashita, M. Naito, K. Miyata, H. J. Kim, Terbium-Rose Bengal Coordination Nanocrystals-Induced ROS Production under Low-Dose X-rays in Cultured Cancer Cells for Photodynamic Therapy. ACS Appl. Bio Mater. 2023, 6, 2505-2513
  12. Y. Mochida, Current Status of Next-Generation Immune Checkpoint Inhibitors for the Treatment of Malignant Brain Tumors. Jpn. J. Cancer Chemother. 2023, 50, 694-700
  13. A. Awaad, H. Takemoto, M. Iizuka, K. Ogi, Y. Mochida, A. H. Ranneh, M. Toyoda, M. Matsui, T. Nomoto, Y. Honda, K. Hayashi, K. Tomoda, T. Ohtake, Y. Miura, N. Nishiyama, Changeable net charge on nanoparticles facilitates intratumor accumulation and penetration. J. Control. Release 2022, 346, 392-404
  14. A. Dirisala, S. Uchida, J. Li, J. F. R. V. Guyse, K. Hayashi, S. V. C. Vummaleti, S. Kaur, Y. Mochida, S. Fukushima, K. Kataoka, Effective mRNA Protection by Poly(L-ornithine) Synergizes with Endosomal Escape Functionality of a Charge-Conversion Polymer toward Maximizing mRNA Introduction Efficiency. Macromol. Rapid Commun. 2022, 43, 2100754
  15. T. Yang, Y. Mochida, X. Liu, H. Zhou, J. Xie, Y. Anraku, H. Kinoh, H. Cabral, K. Kataoka, Conjugation of glucosylated polymer chains to checkpoint blockade antibodies augments their efficacy and specificity for glioblastoma. Nat. Biomed. Eng. 2021, 5, 1274-1287
  16. W. K. D. Paraiso, J. Garcia-Chica, X. Ariza, S. Zagmutt, S. Fukushima, J. Garcia, Y. Mochida, D. Serra, L. Herrero, H. Kinoh, N. Casals, K. Kataoka, R. Rodríguez-Rodríguez, S. Quader, Poly-ion complex micelles effectively deliver CoA-conjugated CPT1A inhibitors to modulate lipid metabolism in brain cells. Biomater. Sci. 2021, 9, 7076-7091.
  17. H. Shibasaki, H. Kinoh, H. Cabral, S. Quader, Y. Mochida, X. Liu, K. Toh, K. Miyano, Y. Matsumoto, T. Yamasoba, K. Kataoka, Efficacy of pH-Sensitive Nanomedicines in Tumors with Different c-MYC Expression Depends on the Intratumoral Activation Profile. ACS Nano 2021, 15, 5545-5559
  18. N. Nakamura#, Y. Mochida#, K. Toh, S. Fukushima, H. Cabral, Y. Anraku, Effect of Mixing Ratio of Oppositely Charged Block Copolymers on Polyion Complex Micelles for In Vivo Application. Polymers 2021, 13, 5
  19. S. Quader, X. Liu, K. Toh, Y.-L. Su, A. R. Maity, A. Tao, W. K. D. Paraiso, Y. Mochida, H. Kinoh, H. Cabral, K. Kataoka, Supramolecularly enabled pH-triggered drug action at tumor microenvironment potentiates nanomedicine efficacy against glioblastoma. Biomaterials 2021, 267, 120463
  20. K. Koji, N. Yoshinaga, Y. Mochida, T. Hong, T. Miyazaki, K. Kataoka, K. Osada, H. Cabral, S. Uchida, Bundling of mRNA strands inside polyion complexes improves mRNA delivery efficiency in vitro and in vivo. Biomaterials 2020, 261, 120332
  21. A. Dirisala, S. Uchida, K. Toh, J. Li, S. Osawa, T. A. Tockary, X. Liu, S. Abbasi, K. Hayashi, Y. Mochida, S. Fukushima, H. Kinoh, K. Osada, K. Kataoka, Transient stealth coating of liver sinusoidal wall by anchoring two-armed PEG for retargeting nanomedicines. Sci. Adv. 2020, 6, eabb8133
  22. T. A. Tockary, W. Foo, A. Dirisala, Q. Chen, S. Uchida, S. Osawa, Y. Mochida, X. Liu, H. Kinoh, H. Cabral, K. Osada, K. Kataoka, Single-Stranded DNA-Packaged Polyplex Micelle as Adeno-Associated-Virus-Inspired Compact Vector to Systemically Target Stroma-Rich Pancreatic Cancer. ACS Nano 2019, 13, 12732-12742
  23. N. Yoshinaga, E. Cho, K. Koji, Y. Mochida, M. Naito, K. Osada, K. Kataoka, H. Cabral, S. Uchida, Bundling mRNA Strands to Prepare Nano‐Assemblies with Enhanced Stability Towards RNase for In Vivo Delivery. Angew. Chem. Int. Ed. 2019, 58, 11360-11363
  24. K. Suzuki, Y. Miura, Y. Mochida, T. Miyazaki, K. Toh, Y. Anraku, V. Melo, X. Liu, T. Ishii, O. Nagano, H. Saya, H. Cabral, K. Kataoka, Glucose transporter 1-mediated vascular translocation of nanomedicines enhances accumulation and efficacy in solid tumors. J. Control. Release 2019, 301, 28-41
  25. Y. Yi, H. -J. Kim, M. Zheng, P. Mi, M. Naito, B. S. Kim, H. S. Min, K. Hayashi, F. Perche, K. Toh, X. Liu, Y. Mochida, H. Kinoh, H. Cabral, K. Miyata, K. Kataoka, Glucose-linked sub-50-nm unimer polyion complex-assembled gold nanoparticles for targeted siRNA delivery to glucose transporter 1-overexpressing breast cancer stem-like cells. J. Control. Release 2019, 295, 268-277
  26. A. H. Ranneh, H. Takemoto, S. Sakuma, A. Awaad, T. Nomoto, Y. Mochida, M. Matsui, K. Tomoda, M. Naito, N. Nishiyama, Ethylenediamine-based betaine structure switches the neutral net harge of polyzwitterion into cationic at tumorous pH for effective tumor accumulation of the coated Nanomaterials. Angew. Chem. Int. Ed. 2018, 57, 5057-5061
  27. K. Miyano, H. Cabral, Y. Miura, Y. Matsumoto, Y. Mochida, H. Kinoh, K. Iwata, O. Nagato, H. Saya, N. Nishiyama, K. Kataoka, T. Yamasoba, cRGD peptide installation on cisplatin-loaded nanomedicines enhances efficacy against locally advanced head and neck squamous cell carcinoma bearing cancer stem-like cells. J. Control. Release 2017, 261, 275-286
  28. Y. Mochida, H. Cabral, K. Kataoka, Polymeric micelles for targeted tumor therapy of platinum anticancer drugs. Expert Opin. Drug Deliv. 2017, 14, 1423-1438
  29. M. Wang, Y. Miura, K. Tsuchihashi, K. Miyano, O. Nagano, M. Yoshikawa, A. Tanabe, J. Makino, Y. Mochida, N. Nishiyama, H. Saya, H. Cabral, K. Kataoka, Eradication of CD44-variant positive population in head and neck tumors through controlled intracellular navigation of cisplatin-loaded nanomedicines. J. Control. Release 2016, 230, 26-33
  30. J. Makino, H. Cabral, Y. Miura, Y. Matsumoto, P. Mi, H. Kinoh, Y. Mochida, N. Nishiyama, K. Kataoka, cRGD-installed polymeric micelles loading platinum anticancer drugs enable cooperative treatment against lymph node metastasis. J. Control. Release 2015, 220 PartB, 783-791
  31. O. F. Mutaf, A. Kishimura, Y. Mochida, A. Kim, K. Kataoka, Induction of secondary structure through micellization of an oppositely charged pair of homochiral block- and homopolypeptides in an aqueous medium. Macromol. Rapid. Commun. 2015, 36, 1958-1964
  32. Y. Mochida, H. Cabral, Y. Miura, F. Albertini, S. Fukushima, K. Osada, N. Nishiyama, K. Kataoka, “Bundled Assembly of Helical Nanostructures in Polymeric Micelles Loaded with Platinum Drugs Enhancing Therapeutic Efficiency against Pancreatic Tumor”, ACS Nano, 2014, 8, 6724-6738
  33. S. Quader, H. Cabral, Y. Mochida, T. Ishii, X. Liu, K. Toh, Y. Miura, N. Nishiyama, K. Kataoka., Selevtive intracellular delivery of proteasome inhibitors through pH-sensitive polymeric micelles directed to efficient antitumor therapy, J. Control. Release 2014, 188, 67-77
  34. K. Osada, H. Cabral, Y. Mochida, S. Lee, K. Nagata, T. Matsuura, M. Yamamoto, Y. Anraku, A. Kishimura, N. Nishiyama, K. Kataoka, Bioactive Polymeric Metallosomes Self-Assembled through Block Copolymer-Metal Complexation, J. Am. Chem. Soc. 2012, 134, 13172-13174
  35. M. Kawahara, Y. Shimo, A. Hitomi, Y. Mochida, T. Sogo, H. Ueda, T. Nagamune, Fluorescein-responsive migration of mammalian cells equipped with an antibody/receptor chimera, J. Biosci. Bioeng. 2009, 108, S33

Books

  1. Y. Mochida, “1. Medicine – Nanomachine developer”. Picture book of works that create future vol. 2 – Create a safe daily life, Tokyo, Gakken Plus, 2021, p. 8-9, ISBN 978-4-05-501338-3.
  2. Y. Mochida, Y. Yamasaki, K. Kataoka, “4. 5. 1 Polymeric micelle”. Colloid and Surface Chemistry, The Chemical Society of Japan ed. 4th ed., Tokyo, Maruzen Publishing., 2018, p. 204-206, ISBN 978-4-621-30291-0.

Awards

2023.7 13th IPC (International Polymer Conference)　 Young Scientist Poster Award
2022.11 17th Nano Biomedical Society Award
2022.3 Best Presentation Award, COI Meetup for Young Scientists
2021.6 Best Presentation Award, 37th Japan DDS conference
2021.1 Best Presentation Award, 15th COINS General meeting
2019.2 Seiichi Tejima Research Awards (Paper Award)
2014.11 Best Presentation Award, The 23th Polymer Materials Forum
2014.7 Best Presentation Award, The 43th Biomedical Polymer Symposium
2014.3 The Dean Award for Academic Excellence from Graduate School of Engineering, The University of Tokyo

Research Fundings

2025-2027 JPSP, KAKENHI, Grant-in-Aid for Challenging Research (Exploratory) (PI)
2024-2028 AMED, Research and Development Program for Innovative Biologics (Co-I)
2024-2025 AMED, Project for Cancer Research and Therapeutic Evolution (PI)
2024-2027 JPSP, KAKENHI, Grant-in-Aid for Scientific Research (B) (Co-I)
2023-2025 JPSP, KAKENHI, Grant-in-Aid for Scientific Research (A) (Co-I)
2023-2024 AMED, Project for Cancer Research and Therapeutic Evolution (Co-I)
2023-2025 JPSP, KAKENHI, Grant-in-Aid for Scientific Research (C) (Co-I)
2022-2025 JPSP, KAKENHI, Grant-in-Aid for Scientific Research (B) (PI)
2022-2024 JPSP, KAKENHI, Grant-in-Aid for Challenging Research (Exploratory) (PI)
2021-2024 JSPS, Fund for the Promotion of Joint International Research, Fostering Joint International Research (B) (Co-I)
2021-2022　 The Hattori Hokokai Foundation, Grant-in-Aid for Engineering Research (PI)
2021-2023　 JPSP, KAKENHI, Grant-in-Aid for Scientific Research (A) (Co-I)
2021-2021　 JST, COI collaborative research fund for young researchers (PI)
2019-2021　 JPSP, KAKENHI, Grant-in-Aid for Young Scientists (PI)
2017-2018　 JPSP, KAKENHI, Grant-in-Aid for Young Scientists (B) (PI)
2016-2019　 JPSP, KAKENHI, Grant-in-Aid for Scientific Research (B) (Co-I)
2015-2016　 JPSP, KAKENHI, Grant-in-Aid for Scientific Research, Challenging Exploratory Research (PI)
2011-2012　 JPSP, KAKENHI, Grant-in-Aid for JSPS Fellows (PI)

Memberships

  • The Society of Polymer Science, Japan
  • The Japan Society of Drug Delivery System
  • American Chemical Society
  • The Japanese Society for Biomaterials
  • The Pharmaceutical Society of Japan
  • Japanese Association of Cancer Immunology
  • The Antibody Society of Japan
  • Japanese Cancer Association
  • Nucleic Acids Therapeutics Society of Japan
  • Research Group on Molecular Transport Systems