難治疾患研究所
先端ナノ医工学分野

研究内容

キーワード

ドラッグデリバリーシステム(DDS)、分子輸送システム(MTS)、mRNA医薬、抗体医薬、がん免疫療法、高分子物理、高分子錯体

研究課題

1. mRNAデリバリー技術の開発
2. 合成高分子による抗体／タンパク質医薬の高機能化
3. 高分子DDSのプロドラッグ化による超選択的薬物送達
4. 高分子DDSの構造機能相関の窮理
5. 高分子MTSの開発
6. がんの完治を目指した薬剤の開発

≪募集中≫ 　日本学術振興会特別研究員（PD）・外国人特別研究員、技術支援員、大学院生
　　　　　　※ ナノ医療イノベーションセンター（iCONM）（神奈川県川崎市）での受入も可

略歴

学歴

職歴（本務）

職歴（兼務）

業績

論文

1. Jumpei Norimatsu, Hayato L. Mizuno, Yuki Mochida, Shigeto Fukushima, Satoshi Uchida, Horacio Cabral*, Yasutaka Anraku*, Ionizable Polymeric Micelles Targeting Transferrin Receptor 1 Enhance Systemic mRNA Delivery to the Brain, Molecular Pharmaceutics 2026, 23(5), 3102-3113, doi: 10.1021/acs.molpharmaceut.5c01925
2. Mao Kinoshita, Ken Kawaguchi, Yuki Mochida, Nguyen B. T. Le, Atsushi Kainuma, Naoko Takeda-Miyata, Motohiro Kojima, Teiji Sawa*, Satoshi Uchida*, Fc-free single-chain antibody mRNA therapy for airway infection of multidrug-resistant Pseudomonas aeruginosa, Nature Communications 2026, 17(1), doi: 10.1038/s41467-026-71040-8
3. Yuto Kikuchi, Hiroaki Kajiho, Junya Hasegawa, Yuki Mochida, Satoshi Uchida, Junko Sasaki*, Takehiko Sasaki*, Phosphatidylinositol 3,4-bisphosphate Emerges as a Lipid Mediator Linking Oxidative Stress to DNA Damage, The Journal of Biochemistry 2026, 180(1), 21-31, doi: 10.1093/jb/mvag027
4. Yoshiaki Tanji, Shu Shimada*, Megumi Kato, Yoshimitsu Akiyama, Megumi Hatano, Shu Tsukihara, Yosuke Igarashi, Keita Kodera, Kohei Okazaki, Koya Yasukawa, Kentaro Umemura, Atsushi Kamachi, Atsushi Nara, Masahiro Yamane, Yoshiya Ishikawa, Erika Mochizuki, Yuki Mochida, Toru Ikegami, Daisuke Ban, Satoshi Uchida, Shinji Tanaka*, Cytokine mRNA-based therapy alleviates dendritic cell and T cell paucity to eliminate aggressive pancreatic cancer in preclinical mouse models, EBioMedicine 2026, 125, 106137, doi: 10.1016/j.ebiom.2026.106137
5. Junjie Li*, Kazuko Toh, Panyue Wen, Xueying Liu, Anjaneyulu Dirisala, Haochen Guo, Joachim F. R. Van Guyse, Saed Abbasi, Yasutaka Anraku, Yuki Mochida, Hiroaki Kinoh, Horacio Cabral, Masaru Tanaka, Kazunori Kataoka*, Steric stabilization-independent stealth cloak enables nanoreactors-mediated starvation therapy against refractory cancer, Nature Biomedical Engineering 2025, doi: 10.1038/s41551-025-01534-1
6. Victor Marx^#, Yuki Mochida^#*, Shigehito Osawa, Theofilus A. Tockary, Jumpei Norimatsu, Hidetomo Yokoo, Makoto Oba, Satoshi Uchida*, Poly(sarcosine) and Poly(2-ethyl-2-oxazoline) Tethered To mRNA Provide Stealth Properties To mRNA Polyplexes, ACS Applied Nano Materials 2025, 8(27), 13628-13638, doi: 10.1021/acsanm.5c00636
7. Yuki Mochida*, Development of Antibody-polymer Conjugates for the Treatment of Intractable Cancers, Yakugaku Zasshi 2025, 145(6), 523-532, doi: 10.1248/yakushi.24-00186-2
8. Ryosuke Maeoka*, Ryosuke Matsuda*, Tsutomu Nakazawa, Yuki Mochida, Noriko Ouji-Sageshima, Kengo Yamada, Takayuki Morimoto, Yasuhiro Takeshima, Shuichi Yamada, Fumihiko Nishimura, Young-Soo Park, Toshihiro Ito, Ichiro Nakagawa, Immunotherapy using allogenic NK cells downregulates mitochondrial-related genes and inhibits the OXPHOS system of malignant meningioma, Biomedicine & Pharmacotherapy 2025, 187, 118099, doi: 10.1016/j.biopha.2025.118099
9. Jumpei Norimatsu, Rashida Hashim, Theofilus A. Tockary, Muhammad Shahid Nazir, Yuki Mochida*, Satoshi Uchida*, Polycations Improve Intracellular Stability of mRNA Delivered Using Lipid Nanoparticles for Prolonged Protein Expression, ACS Applied Nano Materials 2025, 8(21), 10898-10906, doi: 10.1021/acsanm.5c00633, Selected as Front Cover
10. Yuki Mochida, Horacio Cabral, Yutaka Miura, Kensuke Osada, Nobuhiro Nishiyama, Kazunori Kataoka*, Secondary Structure-Guided Assembly of Uniform Disk-Like Polymeric Micelles Incorporating Hydrophobic Platinum Drugs for Improved Tumor Targeting, Chemistry of Materials 2025, 37(7), 2457-2473, doi: 10.1021/acs.chemmater.4c02734, Selected as Front Cover
11. Yukine Ishibashi, Mitsuru Naito*, Yusuke Watanuki, Mao Hori, Satomi Ogura, Kaori Taniwaki, Masaru Cho, Ryosuke Komiya, Yuki Mochida, Kanjiro Miyata*, Size-Dependent Glioblastoma Targeting by Polymeric Nanoruler with Prolonged Blood Circulation, Bioconjugate Chemistry 2024, 35(8), 1154-1159, doi: 10.1021/acs.bioconjchem.4c00235
12. Saed Abbasi, Miki Matsui-Masai, Fumihiko Yasui, Akimasa Hayashi, Theofilus A. Tockary, Yuki Mochida, Shiro Akinaga, Michinori Kohara, Kazunori Kataoka*, Satoshi Uchida*, Carrier-free mRNA vaccine induces robust immunity against SARS-CoV-2 in mice and non-human primates without systemic reactogenicity, Molecular Therapy 2024, 32(5), 1266-1283, doi: 10.1016/j.ymthe.2024.03.022
13. Yuki Mochida, Satoshi Uchida*, mRNA vaccine designs for optimal adjuvanticity and delivery, RNA Biology 2024, 21(1), 1-27, doi: 10.1080/15476286.2024.2333123
14. Pengwen Chen, Wenqian Yang, Yuki Mochida, Shangwei Li, Taehun Hong, Hiroaki Kinoh, Kazunori Kataoka*, Horacio Cabral*, Selective Intracellular Delivery of Antibodies in Cancer Cells with Nanocarriers Sensing Endo/Lysosomal Enzymatic Activity, Angewandte Chemie International Edition 2024, 63(14), e202317817, doi: 10.1002/anie.202317817, Selected as Inside Front Cover
15. Miki Suzuki^#, Yuki Mochida^#, Mao Hori, Akimasa Hayashi, Kazuko Toh, Theofilus A. Tockary, Xueying Liu, Victor Marx, Hidetomo Yokoo, Kanjiro Miyata, Makoto Oba, Satoshi Uchida*, Poly(ethylene Glycol) (PEG)–OligoRNA Hybridization to mRNA Enables Fine‐Tuned Polyplex PEGylation for Spleen‐Targeted mRNA Delivery, Small Science 2024, 4(4), 2300258, doi: 10.1002/smsc.202300258, Selected as Inside Front Cover
16. Debabrata Maiti, Hao Yu, Yuki Mochida, Seongyeon Won, Shinichi Yamashita, Mitsuru Naito, Kanjiro Miyata, Hyun Jin Kim*, Terbium-Rose Bengal Coordination Nanocrystals-Induced ROS Production under Low-Dose X-rays in Cultured Cancer Cells for Photodynamic Therapy, ACS Applied Bio Materials 2023, 6(6), 2505-2513, doi: 10.1021/acsabm.3c00304
17. Yuki Mochida*, Current Status of Next-Generation Immune Checkpoint Inhibitors for the Treatment of Malignant Brain Tumors, Japanese Journal of Cancer and Chemotherapy 2023, 50(6), 694-700
18. Aziz Awaad, Hiroyasu Takemoto*, Muneaki Iizuka, Koichi Ogi, Yuki Mochida, Abdul-Hackam Ranneh, Masahiro Toyoda, Makoto Matsui, Takahiro Nomoto, Yuto Honda, Kotaro Hayashi, Keishiro Tomoda, Tomoyuki Ohtake, Yutaka Miura*, Nobuhiro Nishiyama*, Changeable net charge on nanoparticles facilitates intratumor accumulation and penetration, Journal of Controlled Release 2022, 346, 392-404, doi: 10.1016/j.jconrel.2022.04.025
19. Anjaneyulu Dirisala, Satoshi Uchida*, Junjie Li, Joachim F. R. Van Guyse, Kotaro Hayashi, Sai V. C. Vummaleti, Sarandeep Kaur, Yuki Mochida, Shigeto Fukushima, Kazunori Kataoka*, Effective mRNA Protection by Poly(L‐Ornithine) Synergizes with Endosomal Escape Functionality of a Charge‐Conversion Polymer Toward Maximizing mRNA Introduction Efficiency, Macromolecular Rapid Communications 2022, 43(12), 2100754, doi: 10.1002/marc.202100754
20. Tao Yang, Yuki Mochida, Xueying Liu, Hang Zhou, Jinbing Xie, Yasutaka Anraku, Hiroaki Kinoh, Horacio Cabral*, Kazunori Kataoka*, Conjugation of glucosylated polymer chains to checkpoint blockade antibodies augments their efficacy and specificity for glioblastoma, Nature Biomedical Engineering 2021, 5, 1274-1287, doi: 10.1038/s41551-021-00803-z
21. West Kristian D. Paraiso, Jesús Garcia-Chica, Xavier Ariza, Sebastián Zagmutt, Shigeto Fukushima, Jordi Garcia, Yuki Mochida, Dolors Serra, Laura Herrero, Hiroaki Kinoh, Núria Casals, Kazunori Kataoka, Rosalía Rodríguez-Rodríguez*, Sabina Quader*, Poly-ion complex micelles effectively deliver CoA-conjugated CPT1A inhibitors to modulate lipid metabolism in brain cells, Biomaterials Science 2021, 9(21), 7076-7091, doi: 10.1039/d1bm00689d
22. Hitoshi Shibasaki, Hiroaki Kinoh, Horacio Cabral*, Sabina Quader, Yuki Mochida, Xueying Liu, Kazuko Toh, Kazuki Miyano, Yu Matsumoto, Tatsuya Yamasoba, Kazunori Kataoka*, Efficacy of pH-Sensitive Nanomedicines in Tumors with Different c-MYC Expression Depends on the Intratumoral Activation Profile, ACS Nano 2021, 15(3), 5545-5559, doi: 10.1021/acsnano.1c00364
23. Noriko Nakamura^#, Yuki Mochida^#, Kazuko Toh, Shigeto Fukushima, Horacio Cabral*, Yasutaka Anraku*, Effect of Mixing Ratio of Oppositely Charged Block Copolymers on Polyion Complex Micelles for In Vivo Application, Polymers 2021, 13(1), 5, doi: 10.3390/polym13010005
24. Sabina Quader*, Xueying Liu, Kazuko Toh, Yu-Lin Su, Amit Ranjan Maity, Anqi Tao, West Kristian D. Paraiso, Yuki Mochida, Hiroaki Kinoh, Horacio Cabral, Kazunori Kataoka*, Supramolecularly enabled pH- triggered drug action at tumor microenvironment potentiates nanomedicine efficacy against glioblastoma, Biomaterials 2021, 267, 120463, doi: 10.1016/j.biomaterials.2020.120463
25. Kyoko Koji, Naoto Yoshinaga, Yuki Mochida, Taehun Hong, Takuya Miyazaki, Kazunori Kataoka, Kensuke Osada, Horacio Cabral*, Satoshi Uchida*, Bundling of mRNA strands inside polyion complexes improves mRNA delivery efficiency in vitro and in vivo, Biomaterials 2020, 120332, doi: 10.1016/j.biomaterials.2020.120332
26. Anjaneyulu Dirisala, Satoshi Uchida*, Kazuko Toh, Junjie Li, Shigehito Osawa, Theofilus A. Tockary, Xueying Liu, Saed Abbasi, Kotaro Hayashi, Yuki Mochida, Shigeto Fukushima, Hiroaki Kinoh, Kensuke Osada, Kazunori Kataoka*, Transient stealth coating of liver sinusoidal wall by anchoring two-armed PEG for retargeting nanomedicines, Science Advances 2020, 6(26), eabb8133, doi: 10.1126/sciadv.abb8133
27. Theofilus A Tockary, Wanling Foo, Anjaneyulu Dirisala, Qixian Chen, Satoshi Uchida, Shigehito Osawa, Yuki Mochida, Xueying Liu, Hiroaki Kinoh, Horacio Cabral, Kensuke Osada*, Kazunori Kataoka*, Single-Stranded DNA-Packaged Polyplex Micelle as Adeno-Associated-Virus-Inspired Compact Vector to Systemically Target Stroma-Rich Pancreatic Cancer, ACS Nano 2019, 13(11), 12732-12742, doi: 10.1021/acsnano.9b04676
28. Naoto Yoshinaga, Eol Cho, Kyoko Koji, Yuki Mochida, Mitsuru Naito, Kensuke Osada, Kazunori Kataoka, Horacio Cabral*, Uchida Satoshi*, Bundling mRNA Strands to Prepare Nanoassemblies with Enhanced RNase Stability for In Vivo Delivery, Angewandte Chemie International Edition 2019, 58(33), 11360-11363, doi: 10.1002/anie.201905203
29. Kazumi Suzuki, Yutaka Miura, Yuki Mochida, Takuya Miyazaki, Kazuko Toh, Yasutaka Anraku, Vinicio Melo, Xueying Liu, Takehiko Ishii, Osamu Nagano, Hideyuki Saya, Horacio Cabral*, Kazunori Kataoka*, Glucose transporter 1-mediated vascular translocation of nanomedicines enhances accumulation and efficacy in solid tumors, Journal of Controlled Release 2019, 301, 28-41, doi: 10.1016/j.jconrel.2019.02.021
30. Yu Yi, Hyun Jin Kim, Meng Zheng, Peng Mi, Mitsuru Naito, Beob Soo Kim, Hyun Su Min, Kotaro Hayashi, Federico Perche, Kazuko Toh, Xueying Liu, Yuki Mochida, Hiroaki Kinoh, Horacio Cabral, Kanjiro Miyata*, Kazunori Kataoka*, Glucose-linked sub-50-nm unimer polyion complex-assembled gold nanoparticles for targeted siRNA delivery to glucose transporter 1-overexpressing breast cancer stem-like cells, Journal of Controlled Release 2019, 295, 268-277, doi: 10.1016/j.jconrel.2019.01.006
31. Abdul-Hackam Ranneh, Hiroyasu Takemoto*, Shunya Sakuma, Aziz Awaad, Takahiro Nomoto, Yuki Mochida, Makoto Matsui, Keishiro Tomoda, Mitsuru Naito, Nobuhiro Nishiyama*, An Ethylenediamine-based Switch to Render the Polyzwitterion Cationic at Tumorous pH for Effective Tumor Accumulation of Coated Nanomaterials, Angewandte Chemie International Edition 2018, 57(18), 5057-5061, doi: 10.1002/anie.201801641
32. Kazuki Miyano, Horacio Cabral, Yutaka Miura, Yu Matsumoto, Yuki Mochida, Hiroaki Kinoh, Caname Iwata, Osamu Nagano, Hideyuki Saya, Nobuhiro Nishiyama, Kazunori Kataoka*, Tatsuya Yamasoba, cRGD peptide installation on cisplatin-loaded nanomedicines enhances efficacy against locally advanced head and neck squamous cell carcinoma bearing cancer stem-like cells, Journal of Controlled Release 2017, 261, 275-286, doi: 10.1016/j.jconrel.2017.06.021
33. Yuki Mochida, Horacio Cabral*, Kazunori Kataoka, Polymeric micelles for targeted tumor therapy of platinum anticancer drugs, Expert Opinion on Drug Delivery 2017, 14(12), 1423-1438, doi: 10.1080/17425247.2017.1307338
34. Ming Wang, Yutaka Miura, Kenji Tsuchihashi, Kazuki Miyano, Osamu Nagano, Momoko Yoshikawa, Ami Tanabe, Jun Makino, Yuki Mochida, Nobuhiro Nishiyama, Hideyuki Saya, Horacio Cabral*, Kazunori Kataoka*, Eradication of CD44-variant positive population in head and neck tumors through controlled intracellular navigation of cisplatin-loaded nanomedicines, Journal of Controlled Release 2016, 230, 26-33, doi: 10.1016/j.jconrel.2016.03.038
35. Jun Makino, Horacio Cabral*, Yutaka Miura, Yu Matsumoto, Ming Wang, Hiroaki Kinoh, Yuki Mochida, Nobuhiro Nishiyama, Kazunori Kataoka*, cRGD-installed polymeric micelles loading platinum anticancer drugs enable cooperative treatment against lymph node metastasis, Journal of Controlled Release 2015, 220, 783-791, doi: 10.1016/j.jconrel.2015.10.017
36. Omer F. Mutaf, Akihiro Kishimura*, Yuki Mochida, Ahram Kim, Kazunori Kataoka*, Induction of Secondary Structure through Micellization of an Oppositely Charged Pair of Homochiral Block-and Homopolypeptides in an Aqueous Medium, Macromolecular Rapid Communications 2015, 36(22), 1958-1964, doi: 10.1002/marc.201500368
37. Yuki Mochida, Horacio Cabral, Yutaka Miura, Francesco Albertini, Shigeto Fukushima, Kensuke Osada, Nobuhiro Nishiyama*, Kazunori Kataoka*, Bundled Assembly of Helical Nanostructures in Polymeric Micelles Loaded with Platinum Drugs Enhancing Therapeutic Efficiency against Pancreatic Tumor, ACS Nano 2014, 8(7), 6724-6738, doi: 10.1021/nn500498t
38. Sabina Quader, Horacio Cabral, Yuki Mochida, Takehiko Ishii, Xueying Liu, Kazuko Toh, Hiroaki Kinoh, Yutaka Miura, Nobuhiro Nishiyama, Kazunori Kataoka*, Selective intracellular delivery of proteasome inhibitors through pH-sensitive polymeric micelles directed to efficient antitumor therapy, Journal of Controlled Release 2014, 188, 67-77, doi: 10.1016/j.jconrel.2014.05.048
39. Kensuke Osada, Horacio Cabral, Yuki Mochida, Sangeun Lee, Kazuya Nagata, Tetsuya Matsuura, Megumi Yamamoto, Yasutaka Anraku, Akihiro Kishimura, Nobuhiro Nishiyama, Kazunori Kataoka*, Bioactive Polymeric Metallosomes Self-Assembled through Block Copolymer–Metal Complexation, Journal of the American Chemical Society 2012, 134(32), 13172-13175, doi: 10.1021/ja304615y
40. Masahiro Kawahara, Yusuke Shimo, Azusa Hitomi, Yuki Mochida, Takahiro Sogo, Hiroshi Ueda, Teruyuki Nagamune, Fluorescein-responsive migration of mammalian cells equipped with an antibody/receptor chimera, Journal of Bioscience and Bioengineering 2009, 108, S33, doi: 10.1016/j.jbiosc.2009.08.073

著書

1. 持田祐希, 内田智士, “mRNAデリバリー技術”, 医薬品モダリティにおける創薬技術開発と展望, 情報機構, 2024, p. 8-9, ISBN: 978-4-86-502271-1.
2. 持田祐希, “1. 医療 – ナノマシン開発者”, 未来をつくる仕事図鑑 第2巻 安心できる日常をつくる, 学研プラス, 2020, p. 8-9, ISBN: 978-4-05-501338-3.
3. 持田祐希，山崎裕一，片岡一則,“4. 5. 1 高分子ミセル”, 現代界面コロイド化学の基礎：原理・応用・測定ソリューション．日本化学会編. 第4版，東京，丸善出版，2018，p. 204-206，ISBN 978-4-621-30291-0.

受賞

外部資金

代表

分担

所属学会

• 高分子学会
• 日本DDS学会
• Americal Chemical Society
• 日本バイオマテリアル学会
• 日本薬学会
• 日本がん免疫学会
• 日本抗体学会
• 日本癌学会
• 日本核酸医薬学会
• 分子輸送システム研究会　→　入会（無料）