Development of chemical tools for the OZ research

Research abstract

Aim of our group is to develop useful chemical tools and methods that contribute to the elucidation of molecular mechanism of biological phenomena and drug discovery. Major research interests include 1) development of chemical modification methods of biomolecules using strained alkynes, 2) synthesis of diazido photoaffinity probes for target protein identification of bioactive compounds, 3) development of multicomponent conjugation methods for synthesis of multifunctional molecules based on azide chemistry, 4) synthesis of bioactive aromatic compounds via highly reactive benzyne species, and 5) development of molecular probes for bioimaging.

Original papers

1. Yoshida, S., Shimomori, K., Kim, Y., and Hosoya, T. (2016) Single C–F Bond Cleavage of Trifluoromethylarenes with an ortho-Silyl Group. Angew. Chem., Int. Ed. 55, 10406-10409
2. Yoshida, S., Yano, T., Misawa, Y., Sugimura, Y., Igawa, K., Shimizu, S., Tomooka, K., and Hosoya, T. (2015) Direct Thioamination of Arynes via Reaction with Sulfilimines and Migratory N-Arylation. J. Am. Chem. Soc. 137, 14071-14074
3. Yoshida, S., Hatakeyama, Y., Johmoto, K., Uekusa, H., and Hosoya, T. (2014) Transient Protection of Strained Alkynes from Click Reaction via Complexation with Copper. J. Am. Chem. Soc. 136, 13590-13593
4. Takahashi, K., Hosoya, T., Onoe, K., Doi, H., Nagata, H., Hiramatsu, T., Li, X.-L., Watanabe, Yu., Wada, Y., Takashima, T., Suzuki, M., Onoe, H., and Watanabe, Y. (2014) [¹¹C]Cetrozole: an Improved C-[¹¹C]Methylated PET Probe for Aromatase Imaging in the Brain. J. Nucl. Med. 55, 852-857
5. Yoshida, S., Shiraishi, A., Kanno, K., Matsushita, T., Johmoto, K., Uekusa, H., and Hosoya, T. (2011) Enhanced clickability of doubly sterically-hindered aryl azides. Sci. Rep. 1, 82

Reviews

1. Yoshida, S., and Hosoya, T. (2015) The Renaissance and Bright Future of Synthetic Aryne Chemistry.Chem. Lett. 44, 1450-1460