研究業績

過去の論文

原著論文:仁科

  • Naoki Yamamoto, Shuji Terai, Shinya Ohata, Tomomi Watanabe, Kaoru Omori, Koh Shinoda, Koji Miyamoto, Toshiaki Katada, Isao Sakaida, Hiroshi Nishina, and Kiwamu Okita (2004) A subpopulation of bone marrow cells depleted by a novel antibody, anti-Liv8, is useful for cell therapy to repair damaged liver. Biochem. Biophys. Res. Commun. 313, 1110-1118.
  • Gen Nishitai, Nao Shimizu, Takahiro Negishi, Hiroyuki Kishimoto, Kentaro Nakagawa, Daiju Kitagawa, Tomomi Watanabe, Haruka Momose, Shinya Ohata, Shuhei Tanemura, Satoshi Asaka, Junko Kubota, Ryota Saito, Hiroki Yoshida, Tak W. Mak, Teiji Wada, Josef M. Penninger, Noriyuki Azuma, Hiroshi Nishina*, and Toshiaki Katada. (2004) Stress induces mitochondria-mediated apoptosis independent of SAPK/JNK activation in ES cells. J. Biol. Chem. 279, 1621-1626. *Corresponding author
  • Teiji Wada, Nicholas Joza, Hai-ying M. Cheng, Takehiko Sasaki, Ivona Kozieradzki, Kurt Bachmaier, Toshiaki Katada, Martin, Schreiber, Erwin F.Wagner, Hiroshi Nishina, and Josef M. Penninger (2004) MKK7 couples stress signaling to G2/M cell cycle progression and cellular senescence. Nat. Cell Biol. 6, 215-226.
  • Furutani-Seiki, M., Sasado, T., Morinaga, C., Suwa, H., Niwa, K., Yoda, H., Deguchi, T., Hirose, Y., Yasuoka, A., Henrich, T., Watanabe, T., Iwanami, N., Kitagawa, D., Saito, K., Asaka, S., Osakada, M., Kunimatsu, S., Elmasri, H., Winkler, C., Ramialison, M., Loosli, F., Quiring, R., Carl, M., Grabher, C., Winkler, S., Del Bene, F., Shinomiya, A., Kota, Y., Yamanaka, T., Okamoto, Y., Takahashi, K., Todo, T., Abe, K., Takahama, Y., Tanaka, M., Mitani, H., Katada, T., Nishina, H., Nakajima, N., Wittbrodt, J. and Kondoh, H. (2004) Asystematic genome-wide screen for mutations affecting organogenesis in Medaka, Oryzias latipes. Mech. Dev. 121, 647-658.
  • Harun Elmasria, Christoph Winkler, Danie Liedtke, Takao Sasado, Chikako Morinaga, Hiroshi Suw, Katsutoshi Niwa, Thorsten Henrich, Yukihiro Hirose, Akihito Yasuoka, Hiroki Yoda, Tomomi Watanabe, Tomonori Deguchi, Norihisa Iwanami, Sanae Kunimatsu, Masakazu Osakada, Felix Loosli, Rebecca Quiring, Matthias Carl, Clemens Grabher, Sylke Winkler, Filippo Del Bene, Joachim Wittbrodt, Keiko Abe, Yousuke Takahama, Katsuhito Takahashi, Toshiaki Katada, Hiroshi Nishina, Hisato Kondoh, and Makoto Furutani-Seiki (2004) Mutations affecting somite formation in the Medaka (Oryzias latipes) . Mech. Dev. 121, 659-671.
  • Daiju Kitagawa, Tomomi Watanabe, Kota Saito, Satoshi Asaka, Takao Sasado, Chikako Morinaga, Hiroshi Suwa, Katsutoshi Niwa, Akihito Yasuoka, Tomonori Deguch, Hiroki Yoda, Yukihiro Hirose, Thorsten Henrich, Norimasa Iwanami, Sanae Kunimatsu, Masakazu Osakada, Chritoph Winkler, Harun Elmasri, Jochen Wittbrodt, Felix, Loosli, Rebecca Quiring, Matthias Carl, Clemens Grabher, Sylke Winkler, Filippo Del Bene, Toshiaki, Katada, Hiroshi Nishina, Hisato Kondoh, and Makoto Furutani-Seiki (2004) Genetic dissection of the formation of the forebrain in Medaka, Oryzias latipes. Mech. Dev. 121, 673-685.
  • Tomomi Watanabe, Satoshi Asaka, Daiju Kitagawa, Kota Saito, Ryumei Kurashige, Takao Sasado, Chikako Morinaga, Hiroshi Suwa, Katsutoshi Niwa, Thorsten Henrrich, Yukihiro Hirose, Akihito Yasuoka, Hiroki Yoda, Tomonori Deguchi, Norihisa Iwanami, Sanae Kunimatsu, Masakazu Osakada, Felix Loosl, Rebecca Quiring, Matthias Carl, Clemens Grabher, Sylke Winkler, Filippo Del Bene, Jochen Wittbrodt, Keiko Abe, Yosuke Takahama, Katsuhito Takahashi, Toshiaki Katada, Hiroshi Nishina*, Hisato Kondoh, and Makoto Furutani-Seiki* (2004) Mutations affecting liver development and function in Medaka, Oryzias latipes, screened by multiple criteria. Mech. Dev. 121, 791-802. *Corresponding authors
  • Masato Matsuoka, Hideki Igisu, Kentaro Nakagawa, Toshiaki Katada, and Hiroshi Nishina (2004) Requirement of MKK4 and MKK7 for CdCl2- or HgCl2-induced Activation of c-Jun NH2-terminal Kinase in Mouse Embryonic Stem Cells. Toxicol. Lett. 152, 175-181.
  • Isao Sakaida, Shuji Terai, Naoki Yamamoto, Koji Aoyama, Tsuyoshi Ishikawa, Hiroshi Nishina, and Kiwamu Okita (2004) Transplantation of bone marrow cells reduces CCl4-induced liver fibrosis in mice. Hepatology 40, 1304-1311.
  • Kaoru Omori, Shuji Terai, Tsuyoshi Ishikawa, Kouji Aoyama, Isao Sakaida, Hiroshi Nishina, Koh Shinoda, Shunji Uchimura, Yoshihiko Hamamoto, and Kiwamu Okita (2004) Molecular signature associated with plasticity of bone marrow cell under persistent liver damage by self-organizing-map-based gene expression. FEBS Lett. 578, 10-20.
  • Hiroyuki Kishimoto, Kentaro Nakagawa, Tomomi Watanabe, Daiju Kitagawa, Haruka Momose, Jungwon Seo, Gen Nishitai, Nao Shimizu, Shinya Ohata, Shuhei Tanemura, Satoshi Asaka, Takayuki Goto, Hiromichi Fukushi, Hiroki Yoshida, Akira Suzuki, Takehiko Sasaki, Teiji Wada, Josef M. Penninger, Hiroshi Nishina*, and Toshiaki Katada (2003) Different Properties of SEK1 and MKK7 in Dual Phosphorylation of Stress-induced Activated Protein Kinase SAPK/JNK in Embryonic Stem Cells. J. Biol. Chem. 278, 16595-16601. *Corresponding author
  • Saibil SD, Ohteki T, White FM, Luscher M, Zakarian A, Elford A, Shabanowitz J, Nishina H, Hugo P, Penninger J, Barber B, Hunt DF, Ohashi PS (2003) Weak agonist self-peptides promote selection and tuning of virus-specific T cells. Eur. J. Immunol. 33, 685-696.
  • Okamura-Oho, Y., Miyashita, T., Nagao, K., Shima, S., Ogata, Y., Katada, T., Nishina, H., and Yamada, M. (2003) Dentatorubral-pallidoluysian atrophy (DRPLA) protein is phosphorylated by c-Jun NH2-Terminal Kinase. Hum. Mol. Genet. 12, 1535-1542.
  • Haruka Momose, Hiroshi Kurosu, Kenji Kontani, Kyoko Tsujita, Noriko Tsujimoto, Hiroshi Nishina, and Toshiaki Katada. (2003) Dual Phosphorylation of Phosphoinositide 3-Kinase Adaptor Grb2-Associated Binder 2 Is Responsible for Superoxide Formation Synergistically Stimulated by Fcg and Formyl-Methionyl-Leucyl-Phenylalanine Receptors in Differentiated THP-1 Cells. J. Immunol. 171, 4227-4234.
  • Shuji Terai, Isao Sakaida, Naoki Yamamoto, Kaoru Omori, Tomomi Watanabe, Shinya Ohata, Toshiaki Katada, Koji Miyamoto, Koh Shinoda, Hiroshi Nishina, and Kiwamu Okita (2003) An invivo model for monitoring trans-differentiation of bone marrow cells into functional hepatocytes. J. Biochem. 134, 551-558.
  • Kitagawa, D., Tanemura, S., Ohata, S., Shimizu, N., Seo, J., Nishitai, G., Watanabe, T., Nakagawa, K., Kishimoto, H., Wada, T., Tezuka, T., Yamamoto, T., Nishina, H.*, and Katada, T. (2002) Activation of Extracellular Signal-regulated Kinase by Ultraviolet Is Mediated Through Src-dependent Epidermal Growth Factor Receptor Phosphorylation. J. Biol. Chem. 277, 366-371. *Corresponding author
  • Yamamoto, A., Miyazaki, T., Kadono, Y., Takayanagi, H., Miura, T., Nishina, H., Katada, T., Wakabayashi, K., Oda, H., Nakamura, K., and Tanaka, S. (2002) Possible Involvement of IkB Kinase 2 and MKK7 in Osteoclastogenesis Induced by Receptor Activator of Nuclear factor kB Ligand. J. Bone Miner. Res. 17, 612-621.
  • Watanabe, T. Nakagawa, K, Ohata, S, Kitagawa, D., Nishitai, G., Seo, J., Tanemura, S., Shimizu, N., Kishimoto, H., Wada, T., Aoki, J., Arai, H., Iwatsubo, T., Mochita, M., Watanabe, T., Satake, M., Ito, Y., Matsuyama, T., Mak, T. W., Penninger, J. M., Nishina, H.*, and Katada, T. (2002) SEK1/MKK4-mediated SAPK/JNK signaling participates in embryonic hepatoblast proliferation via a pathway different from NF-kB-induced anti-apoptosis. Dev. Biol. 250, 332-347. *Corresponding author
  • Takayanagi, H., Kim, S., Koga, T., Nishina, H., Isshiki, M., Yoshida, H., Saiura, A., Isobe, M., Yokochi, T., Inoue, J., Wagner, E. F., Mak, T. W., Kodama, T., and Taniguchi, T. (2002) Induction and Activation of the Transcription Factor NFATc1 (NFAT2) Integrate RANKL Signaling. Dev. Cell 3, 889-901.
  • Wada, T., Nakagawa, K., Watanabe, T., Nishitai, G., Seo, J., Kishimoto, H., Kitagawa, D., Sasaki, T, Penninger, J. M., Nishina, H.*, and Katada, T. (2001) Impaired Synergistic Activation of Stress-activated Protein Kinase SAPK/JNK in Mouse Embryonic Stem Cells Lacking SEK1/MKK4. J. Biol. Chem. 276, 30892-30897. *Corresponding author
  • Sasaki, T., Wada, T., Kishimoto,, H., Irie-Sasaki, J., Matsumoto, G., Goto, T., Yao, Z., Wakeham, A., Mak, T. W., Suzuki, A., Katada, T., Nishina, H., and Penninger, J. M. (2001) The stress kinase MKK7 is a negative regulator of antigen receptor and growth factor receptor induced proliferation in hematopoietic cells. J. Exp. Med. 194, 757-768.
  • Yoshida, H., Hamano, S., Senaldi, G., Covey, T., Faggioni, R., Mu, S., Xia, M., Wakeham, A., Nishina, H., Potter, J., Saris, C. J. M., and Mak, T. W. (2001) WSX-1 is required for the initiation of Th1 responses and resistance to L. major infection. Immunity 15, 569-578.
  • Bachmaier, K., Krawczyk, C., Kozieradzki, I., Kong, Y-Y., Sasaki, T., Oliveira-dos-Santos, A., Mariathasan, S., Bouchard, D., Wakeham, A., Itie, A., Le, J., Ohashi, P., Sarosi, I., Nishina, H., Lipkowitz, S., and Penninger, J. M. (2000) Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b. Nature 403, 211-216.
  • Nishina, H., Vaz, C., Billia, P., Nghiem, M., Sasaki, T., Pompa, J. L., Furlonger, K., Paige, C., Hui, C-C., Fischer, K. D., Kishimoto, H., Iwatsubo, T., Katada, T., Woodgett, J. R., and Penninger, J. M. (1999) Defective liver formation and liver cell apoptosis in mice lacking the stress signaling kinase SEK1/MKK4. Development 126, 505-516.
  • Yoshida, H., Nishina, H., Takimoto, H., Marengere, L. E. M., Wakeham, A. C., Bouchard, D., Kong, Y-Y., Ohteki, T., Shahinian, A., Bachmann, M., Ohashi, P. S., Penninger, J. M., Crabtree, G. R, and Mak, T. W. (1998) The Transcription Factor NF-ATc1 Regulates Lymphocyte Proliferation and Th2 Cytokine Production. Immunity 8, 115-124.
  • H. Kishimoto, H., Hoshino, Ohori, M., Kontani, K., Nishina, H., Suzawa, M., Kato, S., and T. Katada (1998) Molecular mechanism of human CD38 gene expression by retinoic acid: Identification of retinoic acid response element in the first intron. J. Biol. Chem. 273, 15429-15434.
  • Fischer, K. D., Kong, Y-Y, Nishina, H., Tedford, K., Marengere, L., Kozieradzki, I., Sasaki, T., Starr, M., Chan, G., Gardener, S., Nghiem, M. P., Bouchard, D., Barbacid, M., Bernstein, A., and Penninger, J. M. (1998) Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor. Current Biology 8, 554-562.
  • Sasaki, T, Maehama, T, Yamamoto, T., Takasuga, S., Hoshino, S., Nishina, H., Hazeki, O., and Katada, T. (1998) Activation of c-Jun N-terminal kinase (JNK) by lysophosphatidic acid in Swiss 3T3 ibroblasts. J. Biochem. 124, 934-939.
  • Nishina, H., Radvanyl, L., Raju, K., Sasaki, T., Kozieradzki, I., and Penninger, J. M. (1998) Impaired TCR-mediated apoptosis and Bcl-XL expression in T cells lacking the stress kinase activator SEK1/MKK4. J. Immunol. 161, 3416-3420.
  • Nishina, H., Fischer, K. D., Radvanyi, L., Shahinian, A., Hakem, R., Rubie, E. A. , Bernstein, A., Mak, T. W., Woodgett, J. R., and Penninger, J. M. (1997) Stress-signaling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3. Nature 385, 350-353.
  • Suzuki, A., Pompa, J. L., Hakem, R., Elia, A., Yoshida, R., Mo, R., Nishina, H., Chuang, T., Wakeham, A., Itie, A., Koo, W., Fukumoto, M., Hui, C. C., and Mak, T. W. (1997) Brca2 is required for embryonic cellular proliferation in the mouse. Genes Dev. 10, 1242-1252.
  • Masuda, W., Takenaka, S., Inageda, K., Nishina, H., Takahashi, K., Katada, T., Tsuyama, S., Inui, H., Miyatake, K., and Nakano, Y. (1997) Oscillation of ADP-ribosyl cyclase activity during the cell cycle and function of cyclic ADP-ribose in a unicellular organism, Euglena gracilis. FEBS. Lett. 405, 104-106.
  • Nishina, H., Bachmann, M., Oliveira-dos-Santos, A. J., Kozieradzki, I., Fischer, K. D., Odermatt, B., Wakeham, A., Shahinian, A., Takimoto, H., Bernstein, A., Mak, T. W., Woodgett, J. R., Ohashi, P. S., and Penninger, J. M. (1997) Impaired CD28-mediated Interleukin 2 Production and Proliferation in Stress Kinase SAPK/ERK1 Kinase (SEK1)/Mitogen-activated Protein Kinase Kinase4 (MKK4)-deficient T Lymphocytes. J. Exp. Med. 186, 941-953.
  • Yao, Z., Diener, K., Wang, X. S., Zukowski, M., Matsumoto, G., Zhou, G., Mo, R., Sasaki, T., Nishina, H., Hui, C. C., Tan, T-H., Woodgett, J. R., and Penninger, J. M. (1997) Activation of Stress-activated Protein Kinases/c-Jun N-terminal Protein Kinases (SAPKs/JNKs) by a Novel Mitogen-activated Protein Kinase Kinase (MKK7). J. Biol. Chem. 272, 32378-32383.
  • Hara-Yokoyama, M., Kukimoto, I., Nishina, H., Kontani, K., Hirabayashi, Y., Irie, F., Sugiya, H., Furuyama, S., and Katada, T. (1996) Inhibition of NAD+ glycohydrolase and ADP-ribosyl cyclase activities of leukocyte cell surface antigen CD38 by gangliosides. J. Biol. Chem. 271, 12951-12955.
  • Kontani, K., Kukimoto, I., Nishina, H., Hoshino, S., Hazeki, O., Kanaho, Y., and Katada, T. (1996) Tyrosine phosphorylation of the c-cbl proto-oncogene product mediated by cell surface antigen CD38 in HL-60 cells. J. Biol. Chem. 271, 1534-1537.
  • Kukimoto, I., Hoshino, S., Kontani, K., Inageda, K., Nishina, H., Takahashi, K., and Katada, T. (1996) Stimulation of ADP-ribosyl cyclase activity of the cell surface antigen CD38 by zinc ions resulting from inhibition of its NAD+ glycohydrolase activity. Eur. J. Biochem. 239, 177-182.
  • Inageda, K., Takahashi, K., Tokita, K., Nishina, H., Kanaho, Y., Kukimoto, I., Kontani, K., Hoshino, S., and Katada, T. (1995) Enzyme properties of Aplysia ADP-ribosyl cyclase: Comparison with NAD glycohydrolase of CD38 antigen. J. Biochem. 117, 125-131.
  • Ohoka, Y., Kontani, K., Iiri, T., Nishina, H., and Katada, T. (1995) Involvement of pertussis toxin-sensitive mechanism in retinoic acid-induced differentiation of human leukemic HL-60 cells. J. Biochem. 117, 190-196.
  • Inanobe, A., Morishige, K.I., Takahashi, N., Ito, H., Yamada, M., Takumi, T., Nishina, H., Takahashi, K., Kanaho, Y., Katada, T., and Kurachi, Y. (1995) Gbg directly binds to the carboxyl terminus of the G protein-gated muscarinic K+ channel, GIRK1. Biochem. Biophys. Res. Commun. 212, 1022-1028.
  • Maehama, T., Nishina, H., Hoshino, S., Kanaho, Y., and Katada, T. (1995) NAD+-dependent ADP-ribosylation of T lymphocyte alloantigen RT6.1 reversibly proceeding in intact rat lymphocytes. J. Biol. Chem. 270, 22747-22751.
  • Mizuguchi, M., Otsuka, N., Sato, M., Ishii, Y., Kon, S., Yamada, M., Nishina, H., Katada, T., and Ikeda, K. (1995) Neuronal localization of CD38 antigen in the human brain. Brain Res. 697, 235-240.
  • Nishina, H., Nimota, K., Kukimoto, I., Maehama, T., Takahashi, K., Hoshino, S., Kanaho, Y., and Katada, T. (1995) Significance of Thr182 in the nucleotide-exchange and GTP-hydrolysis reactions of the alpha subunit of GTP-binding protein Gi2. J. Biochem. 118, 1083-1089.
  • Takahashi, K., Kukimoto, I., Tokita, K.I., Inageda, K., Inoue, S.I., Kontani, K., Hoshino, S, Nishina, H., Kanaho, Y., and Katada, T. (1995) Accumulation of cyclic ADP-ribose measured by a specific radioimmunoassay in differentiated human leukemic HL-60 cells with all-trans-retinoic acid. FEBS Lett. 371, 204-208.
  • Wada, T., Inageda, K., Aritomo, K., Tokita, K., Nishina, H., Takahashi, K., Katada, T., and Sekine, M. (1995) Structural characterization of cyclic ADP-ribose by NMR spectroscopy. Nucleos Nucleot 14, 1301-1314.
  • Penninger, J. M., Timms, E., Shahinian, A., Jero-Bremond, A., Nishina, H., Ionescu, J., Hedrick, S. M., and Mak, T. W. (1995) Alloreactive gd Thymocytes Utilize Distinct Costimulatory Signals from Peripheral T Cells. J. Immunol 155, 3847-3855.
  • Maehama, T., Sekine, N., Nishina, H., Takahashi, K., and Katada, T. (1994) Characterization of botulinum C3-catalyzed ADP-ribosylation of rho proteins and identification of mammalian C3-like ADP-ribosyltransferase. Mol. Cell. Biochem. 138, 135-140.
  • Maehama, T., Nishina, H., and Katada, T. (1994) ADP-ribosylarginine glycohydrolase catalyzing the release of ADP-ribose from the cholera toxin-modified a-subunits of GTP-binding proteins. J. Biochem. 116, 1134-1138.
  • Nishina, H., Inageda, K., Takahashi, K., Hoshino, S., Ikeda, K., and Katada, T. (1994) Cell surface antigen CD38 identified as ecto-enzyme of NAD glycohydrolase has hyaluronate-binding activity. Biochem. Biophys. Res. Commun. 203, 1318-1323.
  • Yoshida, T., Suzuki, T., Sato, H., Nishina, H., and Iba, H. (1993) Analysis of fra-2 gene expression. Nucleic Acids Res., 21, 2715-2721.
  • Kontani, K., Nishina, H., Ohoka, Y., Takahashi, K., and Katada, T. (1993) NAD glycohydrolase specifically induced by retinoic acid in human leukemic HL-60 cells. Identification of the NAD glycohydrolase as leukocyte cell surface antigen CD38. J. Biol. Chem. 268, 16895-16898.
  • Suzuki, T., Hashimoto, Y., Okuno, H., Sato, H., Nishina, H., and Iba, H. (1991) High- level Expression of Human c-jun Gene Causes Cellular Transformation of Chicken Embryo Fibroblasts. Jpn. J. Cancer Res. 82, 58-64.
  • Suzuki, T., Okuno, H., Yoshida, T., Endo, T., Nishina, H., and Iba, H. (1991) Difference in transcriptional regulatory function between c-Fos and Fra-2. Nucleic Acids Res. 19, 5537-5542.
  • Inageda, K., Nishina, H., and Tanuma, S. (1991) Mono-ADP-ribosylation of Gs by an Eukaryotic Arginine-specific ADP-ribosyltransferase Stimulates the Adenylate Cyclase System. Biochem. Biophys. Res. Commun. 176, 1014-1019.
  • Maruta, H., Inageda, K., Aoki, T., Nishina, H., and Tanuma, S. (1991) Characterization of Two Forms of Poly(ADP-ribose)Glycohydrolase in Guinea Pig Liver. Biochemistry 30, 5907-5912.
  • Tsai, Y., Abe, H., Maruta, H., Hatano, T., Nishina, H., Sakagami, H., Okuda, T., and Tanuma, S. (1991) Effect of Chemically Defined Tannins on Poly (ADP-ribose) Glycohydrolase Activity. Biochem. Int. 14, 889-897.
  • Nishina, H., Sato, H., Suzuki, T., Sato, M.,and Iba, H. (1990) Isolation and characterization of fra-2, an additional member of the fos gene family. Proc. Natl. Acad. Sci. USA 87, 3619-3623.
  • Iba, H., Shindo, Y., Nishina, H., and Yoshida, T. (1988) Transforming Potential and Growth Stimulating Activity of the v-fos and c-fos Genes Carried by Avian Retrovirus Vectors. Oncogene Res. 2, 121-133.
  • Fujiwara, K. T., Ashida, K., Nishina, H., Iba, H., Miyajima, N., Nishizawa, M., and Kawai, S. (1987) The Chicken c-fos Gene : Cloning and Nucleotide Sequence Analysis. J. Virol. 61, 4012-4018.

著書・総説(英文):仁科

  • Nishina, H.*, Watanabe, T. Nakagawa, K, Ohata, S, Asaka, S., and Katada, T. (2004) [book] SAPK/JNK signaling participates in embryonic hepatoblast proliferation via a pathway different from NF-kB-induced anti-apoptosis. in Stem Cell and Liver Regeneration (Okita, K., eds) pp. 1-14, Springer-Verlag Tokyo, Inc., Tokyo.
  • Hiroshi Nishina*, Teiji Wada, and Toshiaki Katada (2004) [review] Physiological roles of SAPK/JNK signaling pathway. J. Biochem. 136: 123-126.
  • Hiroshi Nishina*, Kentaro Nakagawa, Noriyuki Azuma, and Toshiaki Katada. (2003) [review] Activation Mechanism and Physiological Roles of Stress-Activated Protein Kinase/c-Jun NH2-Terminal Kinase in Mammalian Cells. J. Biol. Regul. Homeost. Agents. 17, 295-302. *Corresponding author
  • Katada, T. , Kontani, K., Wada, T., Hosoda, N., Hoshino, S., and Nishina, H. (2000) [review] Enzymatic and Signal Transduction Properties of CD38/NADase and PC-1/Phosphodiesterase. Chem. Immunol. 75: 60-78.
  • Nishina, H. and Penninger, J. M. (1998) [book] SEK1. in The gene knockout facts book (Mak, T. W., eds) pp. 933-934, Academic Press, San Diego
  • Kontani, K., Kukimoto, I., Kanda, Y., Inoue, S., Kishimoto, H., Hoshino, S., Nishina, H., Takahashi, K., Hazeki, O., and Katada, T. (1997) [review] Signal transduction via the CD38/NAD+ glycohydrolase. Adv. Exp. Med. Biol. 419: 421-430.
  • Katada, T., Iiri, T., Takahashi, K., Nishina, H., and Kanaho, Y. (1995) [book] in Bacterial Toxins and Virulence Factors in Disease (Moss, J., Iglewski, B., Vaughan, M., and Tu, T.A., eds) pp. 459-489, Marcel Dekker, Inc., New York.
  • Katada, T., Kontani, K., Inanobe, A., Kobayashi, I., Ohoka, Y., Nishina, H., and Takahashi, K. (1994) [book] in Methods in Enzymology (Vol. 237; Heterotrimeric G Proteins) (Iyengar, R., eds) pp. 131-139, Academic Press, San Diego.
  • Katada, T., Ohoka, Y., Tomita, U., Iiri, T., Nishina, H., and Takahashi, K. (1992) [book] in Neurotransmitter Receptors and Intracellular Signaling (Yoshida, H., and Ui, M., eds) pp. 30-43, Excerpta Medica, Amsterdam.
  • Tanuma, S., Uchida, K., Suzuki, H., Nishina, H., Maruta, H., Sugimura, T., and Miwa, M. (1992) [book] in ADP-Ribosylation Reaction (Poirier, G., and Moreau, P., eds) pp. 282-285, Springer-Verlag, New York.

著書・総説(和文):仁科

  • 和田悌司、仁科博史、堅田利明、Josef M Penninger:MKK7のストレス応答によるG2/M期進行、細胞老化抑止の制御;実験医学 22:1398-1400 (2004)
  • 仁科博史、中川健太郎、堅田利明:SAPK/JNK系の活性化機構と生理的役割;実験医学 22:1551-1556 (2004)
  • 渡辺智美、仁科博史:メダカを用いた肝形成および肝機能の解明;生化学 76:1454-1458 (2004)
  • 仁科博史、渡辺智美、大畑慎也、浅香聡、堅田利明:初期肝形成時のシグナル伝達機構;胆肝膵 46巻3号: 295-302 (2003)
  • 仁科博史、堅田利明:SAPK/JNK系の生理的役割;実験医学 17:113-118 (1999)
  • 仁科博史、堅田利明:T細胞機能とSEK1, SEK2;臨床免疫 32:518-524 (1999)
  • 仁科博史、堅田利明:sek1(SAPK/ERK kinase-1);Molecular Medicine 34:ノックアウトマウス・データブック:452-453 (1997)
  • 仁科博史、堅田利明:百日咳毒素;治療学 31:1475-1478 (1997)
  • 仁科博史、堅田利明:シグナル伝達分子三量体GTP結合蛋白質の構造と機能;生体の科学 48: 229-235 (1997)
  • 堅田利明、仁科博史、高橋勝宣、星野真一、紺谷圏二、前濱朝彦、柊元 巌:シグナル伝達系に登場した新しいNAD+代謝酵素;蛋白質 核酸 酵素 40: 1900-1911 (1995)
  • 堅田利明、紺谷圏二、柊元 巌、井上晋一、星野真一、櫨木 修、高橋勝宣、仁科博史:シグナル伝達系におけるNAD+代謝酵素とサイクリックADPリボース;日薬理誌 106 (suppl. 1): 45P-49P (1995)
  • 仁科博史、堅田利明:Gタンパク質;Annual Review 細胞生物学1993(矢原一郎、御子柴克彦、月田承一郎 編) pp. 271-280 中外医学社 (1993)
  • 伊庭英夫、仁科博史、佐藤宏宣:fos遺伝子ファミリー;実験医学 8:796-801 (1990)