研究業績

研究業績(2005年〜現在)

2017年

2016年

2015年

2014年

  • Yoichi Asaoka*, Shoji Hata, Misako Namae, Makoto Furutani-Seiki and Hiroshi Nishina* (2014) The Hippo pathway controls a switch between retinal progenitor cell proliferation and photoreceptor cell differentiation in zebrafish. PLoS ONE 9, e97365
  • Tadanori Shimomura, Norio Miyamura, Shoji Hata, Ryota Miura, Jun Hirayama* and Hiroshi Nishina* (2014) The PDZ-binding motif of Yes-associated protein is required for its co-activation of TEAD-mediated CTGF transcription and oncogenic cell transforming activity. Biochem. Biophys. Res. Commun. 443, 917-923.
  • Zeyu Yang, Kentaro Nakagawa, Aradhan Sarkar, Junichi, Maruyama, Hiroaki Iwasa, Yijun Bao, Mari Ishigami-Yuasa, Shigeru Ito, Hiroyuki Kagechika, Shoji Hata, Hiroshi Nishina, Shinya Abe, Masanobu Kitagawa, Yutaka Hata (2014) Screening with a novel cell-based assay for TAZ activators identifies a compound that enhances myogenesis in C2C12 cells and facilitates muscle repair in the muscle injury model. Mol. Cell. Biol. 34, 1607-1621.
  • Keita Nakanaga, kotaro Hama, Kuniyuki Kano, Takanoa Sato, Hiroshi Yukiura, Asuka Inoue, Daisuke Saigusa, Hidetoshi Tokuyama, Yoshihisa Tomioka, Hiroshi Nishina, Atsuo Kawahara and Junken Aoki (2014) Overexpression of autotaxin, a lysophosphatidic acid-producing enzyme, enhances cardia bifida induced by hypo-sphingosine-1- phosphate signaling in zebrafish embryo. J. Biochem. 155, 235-241.
  • Shuji Terai, Taro Takami, Naoki Yamamoto, Koichi Fujisawa, Tsuyoshi Ishikawa, Yohei Urata, Haruko Tanimoto, Takuya Iwamoto, Yuko Mizunaga, Takashi Matsuda, Takashi Oono, Miho Marumoto, Guzel Burganova, Luiz Fernando Quintanilha, Isao Hidaka, Yoshio Marumoto, Issei Saeki, Koichi Uchida, Takahiro Yamasaki, Kenji Tani, Yasuho Taura, Yasuhiko Fujii, Hiroshi Nishina, Kiwamu Okita, and Isao Sakaida (2014) [review] Status and prospects of liver cirrhosis treatment by using bone marrow-derived cells and mesenchymal cells.. Tissue Engineering Part B: Reviews 20, 1-5.
  • 千葉 恭敬、仁科 博史:肝臓形成および肝がんにおけるHippo-YAPシグナル経路の役割;医学のあゆみ 251:405-409 (2014)
  • 畠 星治、堅田 利明、仁科 博史:器官サイズを調節する転写共役因子YAPの活性制御:生化学 86:464-468 (2014)

2013年

  • Yoichi Asaoka, Shuji Terai, Isao Sakaida and Hiroshi Nishina (2013) [review] The expanding role of fish models in understanding non-alcoholic fatty liver disease (NAFLD). Disease Models & Mechanisms 6, 905-914.
  • Norie Arima1, Yoshimi Uchida1, Ruoxing Yu, Koh Nakayama and Hiroshi Nishina (2013) Acetylcholine Receptors Regulate Gene Expression that Is Essential for Primitive Streak Formation in Murine Embryoid Bodies. Biochem. Biophys. Res. Commun. 435, 447-453
  • Menno J. Oudhoff, Spencer A. Freeman, Amber L. Couzens, Frann Antignano, Ekaterina Kuznetsova, Paul H. Min, Jeffrey P. Northrop, Bernhard Lehnertz, Dalia Barsyte-Lovejoy, Masoud Vedadi, Cheryl H. Arrowsmith, Hiroshi Nishina, Michael R. Gold, Fabio M.V. Rossi, Anne-Claude Gingras, and Colby Zaph (2013) Control of the Hippo pathway by Set7-dependent methylation of Yap. Dev. Cell 26, 188-194.
  • 浅岡 洋一:初期発生期におけるJNKシグナル伝達経路の多様な生理的役割:比較生理生化学 30:59-67 (2013)
  • 山崎 世和、仁科 博史:脳におけるSAPK/JNKシグナルの役割:CLINICAL NEUROSCIENCE;中外医学社 31:654-656 (2013)

2012年

  • Shoji Hata, Jun Hirayama, Hiroaki Kajiho, Kentaro Nakagawa, Yutaka Hata, Toshiaki Katada, Makoto Furutani-Seiki and Hiroshi Nishina (2012) A novel acetylation cycle of the transcription co-activator Yes-associated protein that is downstream of the Hippo pathway is triggered in response to SN2 alkylating agents. J. Biol. Chem. 287, 22089-22098.
  • Yoshimi Uchida, Tomomi Osaki, Tokiwa Yamasaki, Tadanori Shimomura, Shoji Hata, Kazumasa Horikawa, Shigenobu Shibata, Takeshi Todo, Jun Hirayama and Hiroshi Nishina (2012) Involvement of the Stress Kinase Mitogen-activated Protein Kinase Kinase 7 in the Regulation of the Mammalian Circadian Clock. J. Biol. Chem. 287, 8318-8326.
  • Yoshimi Uchida, Tadanori Shimomura, Jun Hirayama and Hiroshi Nishina (2012) Light, reactive oxygen species, and magnetic fields activate ERK/MAPK signaling pathway in cultured zebrafish cells. Appl. Magn. Reson. 42, 69-77.
  • Miki Nishio, Koichi Hamada, Kohichi Kawahara, Masato Sasaki, Fumihito Noguchi, Shuhei Chiba, Kensaku Mizuno, Satoshi O. Suzuki, Youyi Dong, Masaaki Tokuda, Takumi Morikawa, Hiroki Hikasa, Jonathan Eggenschwiler, Norikazu Yabuta, Hiroshi Nojima, Kentaro Nakagawa, Yutaka Hata, Hiroshi Nishina, Koshi Mimori, Masaki Mori, Takehiko Sasaki, Tak W. Mak, Toru Nakano, Satoshi Itami, and Akira Suzuki (2012) Cancer Susceptibility and embryonic lethality in Mob1A/1B double mutant mice. J. Clin. Invest. 122(12):4505-4518.
  • Tadashi Yokoi, Yuko Seko, Tae Yokoi, Hatsune Makino, Shin Hatou, Masakazu Yamada, Tohru Kiyono, Akihiro Umezawa, Hiroshi Nishina, Noriyuki Azuma (2012) Establishment of Functioning Human Corneal Endothelial Cell Line with High Growth Potential. PLoS ONE 7(1):e29677
  • Ken Okada, Akihide Kamiya, Keiichi Ito, Ayaka Yanagida, Hidenori Ito, Hiroki Kondou, Hiroshi Nishina and Hiromitsu Nakauchi (2012) Prospective isolation and characterization of bipotent progenitor cells in early mouse liver development. Stem Cells and Development 21, 1124-1133.
  • Yuko Mizunaga, Shuji Terai, Naoki Yamamoto, Koichi Uchida, Takahiro Yamasaki, Hiroshi Nishina, Yusuke Fujita, Koh Shinoda, Yoshihiki Hamamoto and Isao Sakaida (2012) Granulocyte colony-stimulating factor and interleukin-1β are important cytokines in repair of the cirrhotic liver after bone marrow cell infusion: comparison of humans and model mice. Cell Transplantation 21, 2363-2375.
  • Takuya Iwamoto, Shuji Terai, Yuko Mizunaga, Naoki Yamamoto, Kaoru Omori, Koichi Uchida, Takahiro Yamasaki, Yasuhiko Fujii, Hiroshi Nishina, and Isao Sakaida (2012) Splenectomy enhances the anti-fibrotic effect of bone marrow cell infusion and improves liver function in cirrhotic mice and patients J. Gastroenterol. 47, 300-312.
  • Toshiyuki Oishi, Shuji Terai, Shinya Kuwashiro, Koichi Fujisawa, Toshihiko Matsumoto , Hiroshi Nishina and Isao Sakaida (2012) Ezetimibe reduces fatty acid quantity in liver and decreased inflammatory cell infiltration and improved NASH in medaka model. Biochem. Biophys. Res. Commun. 422, 22-27.
  • Shoji Hata and Hiroshi Nishina (2012) [Letters to the Editor] Reply to Sun et al.: Targeting YAP acetylation in cancer. J. Biol. Chem. 287, 35443.
  • Tokiwa Yamasaki, Hiroshi Kawasaki and Hiroshi Nishina (2012) [review] Diverse roles of JNK and MKK pathways in the brain. J. Signal Trans. 2012: 459265.
  • Hiroshi Nishina (2012) [commentary] hDlk-1: A cell surface marker common to normal hepatic stem/progenitor cells and carcinomas. J. Biochem. 152, 121-123.
  • 平山 順、仁科 博史:活性酸素シグナルと概日リズム:実験医学2012年11月増刊号 36-41 (2012)
  • 宮村 憲央、仁科 博史:モデル生物を用いた肝発生および肝サイズ制御機構の解明:肝胆膵 65:21-28 (2012)
  • 宮村 憲央、瀬藤 光利、仁科 博史:質量顕微鏡法を用いたマウス再生肝の解析:生化学 84:680-684 (2012)
  • 畠 星治、仁科 博史:Hippoシグナリング:シグナル伝達キーワード事典;羊土社 58-60 (2012)
  • 仁科 博史:薬学用語辞典、東京化学同人(分担執筆)(2012)

2011年

  • Tokiwa Yamasaki, Hiroshi Kawasaki*, Satoko Arakawa, Kimiko Shimizu, Shigeomi Shimizu, Orly Reiner, Hideyuki Okano, Sachiko Nishina, Noriyuki Azuma, Josef M. Penninger, Toshiaki Katada, and Hiroshi Nishina* (2011) Stress-activated protein kinase MKK7 regulates axon elongation in the developing cerebral cortex. J. Neurosci. 31, 16872-16883. <難治疾患研究所優秀論文賞>
  • Norio Miyamura1, Takashi Nakamura1, Naoko Goto-Inoue, Nobuhiro Zaima, Takahiro Hayasaka, Tokiwa Yamasaki, Shuji Terai, Isao Sakaida, Mitsutoshi Setou, and Hiroshi Nishina (2011) Imaging mass spectrometry reveals characteristic changes in triglyceride and phospholipid species in regenerating mouse liver. Biochem. Biophys. Res. Commun. 408, 120-125.
  • Tomomi Osaki, Yoshimi Uchida, Jun Hirayama, and Hiroshi Nishina (2011) Diphenyleneiodonium chloride, an inhibitor of NADPH oxidase, suppresses light-dependent induction of clock and DNA repair genes in zebrafish. Biol. Pharm. Bull. 34, 1343-1347.
  • Shinya Takahashi, Arisa Ebihara, Hiroaki Kajiho, Kenji Kontani, Hiroshi Nishina, and Toshiaki Katada (2011) RASSF7 negatively regulates pro-apoptotic JNK signaling by inhibiting the activity of phospholylated-MKK7. Cell Death Differ. 18, 645-655.
  • Shinya Takahashi, Kyoko Sakurai, Arisa Ebihara, Hiroaki Kajiho, Kota Saito, Kenji Kontani, Hiroshi Nishina, and Toshiaki Katada (2011) RhoA activation participates in rearrangement of processing bodies and release of nucleated AU-rich mRNAs. Nucleic Acids Res. 39, 3446-3457.
  • Hiroshi Yukiura, Kotaro Hama, Keita Nakanaga, Masayuki Tanaka, Yoichi Asaoka, Shinichi Okudaira, Naoaki Arima, Asuka Inoue, Takafumi Hashimoto, Hiroyuki Arai, Atsuo Kawahara, Hiroshi Nishina, and Junken Aoki (2011) Autotaxin regulates vascular development via multiple lysophosphatidic acid (LPA) receptors in zebrafish. J. Biol. Chem. 286, 43972-43983.
  • Takuro Hisanaga, Shuji Terai, Takuya Iwamoto, Taro Takami, Naoki Yamamoto, Tomoaki Murata, Toshifumi Matsuyama, Hiroshi Nishina, and Isao Sakaida (2011) TNFR1 mediated signaling is important to induce the improvement of liver fibrosis by bone marrow cell infusion. Cell Tissue Res. 346, 79-88.
  • Shinya Kuwashiro, Shuji Terai, Toshiyuki Oishi, Fujisawa Koichi, Toshihiko Matsumoto, Hiroshi Nishina, and Isao Sakaida (2011) Telmisartan improved nonalcoholic steatohepatitis in medaka (Oryzias latipes) by reducing macrophage infiltration and fat accumulation. Cell Tissue Res. 344, 125-134.
  • Yijun Bao, Kentaro Nakagawa, Zeyu Yang, Mitsunobu Ikeda, KanchanamalaWithanage, Mari Ishigami-Yuasa, Yukiko Okuno, Shoji Hata, Hiroshi Nishina, and Yutaka Hata (2011) A cell-based assay to screen stimulators of the Hippo pathway reveals the inhibitory effect of dobutamine on the YAP-dependent gene transcription. J. Biochem. 150, 199-208.
  • 畑 裕/仁科 博史監修 Hippo pathway 癌・細胞死・再生の新たな鍵を握る器官サイズ制御シグナル 細胞工学2011年9月号 Vol. 30 No. 9
    仁科 博史:Hippo名前の秘密;941-942
    畠 星治, 宮村 憲央, 仁科 博史:Hippo pathwayによる肝臓のサイズと発がんの制御;943-947
  • 浅岡 洋一、仁科 博史:メダカとゼブラフィッシュを用いた肝研究;実験医学2011年8月号 Vol.29 (No.13), 2090-2095 (2011)
  • 仁科 博史: モデル生物-マウスと小型魚類:トランスポートソームの世界−膜輸送研究の源流から未来へ−; 京都廣川書店(執筆分担), 434-439(2011)

2010年

  • Takahiro Negishi, Yoko Nagai, Yoichi Asaoka, Mami Ohno, Misako Namae, Hiroshi Mitani, Takashi Sasaki, Nobuyoshi Shimizu, Shuji Terai, Isao Sakaida, Hisato Kondoh, Toshiaki Katada, Makoto Furutani-Seiki*, and Hiroshi Nishina* (2010) Retinoic acid signaling positively regulates liver specification by inducing wnt2bb gene expression in medaka. Hepatology 51, 1037-1045. Press release <難治疾患研究所優秀論文賞><NBRP Medaka>
  • Jinzhan Wu1, Junko Kubota1, Jun Hirayama1, Yoko Nagai, Sachiko Nishina, Tadashi Yokoi, Yoichi Asaoka, Jungwon Seo, Nao Shimizu, Hiroaki Kajiho, Takashi Watanabe, Noriyuki Azuma, Toshiaki Katada, and Hiroshi Nishina (2010) p38 Mitogen-Activated Protein Kinase Controls a Switch between Cardiomyocyte and Neuronal Commitment of Murine Embryonic Stem Cells by Activating Myocyte Enhancer Factor 2C-Dependent Bone Morphogenetic Protein 2 Transcription. Stem Cells and Development 19, 1723-1734.
  • Jungwon Seo1, Yoichi Asaoka1*, Yoko Nagai, Jun Hirayama, Tokiwa Yamasaki, Misako Namae, Shinya Ohata, Nao Shimizu, Takahiro Negishi, Daiju Kitagawa, Hisato Kondoh, Makoto Furutani-Seiki, Josef M. Penninger, Toshiaki Katada, and Hiroshi Nishina* (2010) Negative regulation of wnt11 expression by Jnk signaling during zebrafish gastrulation J. Cell. Biochem. 110, 1022-1037. ZFIN publication
  • Kentaro Nakagawa1, Misato Sugahara1, Tokiwa Yamasaki1, Hiroaki Kajiho, Shinya Takahashi, Jun Hirayama, Yasuhiro Minami, Yasutaka Ohta, Toshio Watanabe, Yutaka Hata, Toshiaki Katada, and Hiroshi Nishina (2010) Filamin Associates with Stress Signaling Kinases MKK7 and MKK4 and Regulates JNK Activation. Biochem. J. 427, 237-245.
  • Yoko Nagai1, Yoichi Asaoka1, Misako Namae, Kota Saito, Haruka Momose, Hiroshi Mitani, Makoto Furutani-Seiki, Toshiaki Katada, and Hiroshi Nishina (2010) The LIM protein Ajuba is required for ciliogenesis and left-right axis determination in medaka. Biochem. Biophys. Res. Commun. 396, 887-893.
  • Yoichi Asaoka and Hiroshi Nishina (2010) [review] Diverse Physiological Functions of MKK4 and MKK7 during Early Embryogenesis. J. Biochem. 148: 393-401.
  • Yoshimi Uchida, Jun Hirayama, Hiroshi Nishina (2010) [review] A common origin: signaling similarities in the regulation of the circadian clock and DNA damage responses. Biol. Pharm. Bull. 33, 535-544. Cover of the issue
  • Shuhei Tanemura, Tokiwa Yamasaki, Toshiaki Katada, and Hiroshi Nishina (2010) [review] Utility and limitations of SP600125, an inhibitor of stress- responsive c-Jun N-terminal kinase. Curr. Enzym. Inhib. 6, 26-33.
  • G. Gregory Neely, Keiji Kuba, Anthony Cammarato, Kazuya Isobe, Sabine Amann, Liyong Zhang, Mitsushige Murata, Lisa Elmén, Vaijayanti Gupta, Suchir Arora, Rinku Sarangi, Debasis Dan, Susumu Fujisawa, Takako Usami, Cui-ping Xia, Alex C. Keene, Nakissa N. Alayari, Hiroyuki Yamakawa, Ulrich Elling, Christian Berger, Maria Novatchkova, Rubina Koglgruber, Keiichi Fukuda, Hiroshi Nishina, Mitsuaki Isobe, J. Andrew Pospisilik, Yumiko Imai, Arne Pfeufer, Andrew A. Hicks, Peter P. Pramstaller, Sai Subramaniam, Akinori Kimura, Karen Ocorr, Rolf Bodmer, and Josef M. Penninger (2010) A Global In VivoDrosophila RNAi Screen Identifies NOT3 as a Conserved Regulator of Heart Function. Cell 141, 142-153. Cover of the issue
  • Toshihiko Matsumoto, Shuji Terai, Toshiyuki Oishi, Shinya Kuwashiro, Koichi Fujisawa, Naoki Yamamoto, Yusuke Fujita, Yoshihiko Hamamoto, Makoto Furutani-Seiki, Hiroshi Nishina, and Isao Sakaida (2010) Medaka as a Novel and Accurate Model for Human Nonalcoholic Steatohepatitis. Disease Models & Mechanisms 3, 431-440. Press release, Cover of the issue, Faculty of 1000 Medicine
  • Ryuichi Mashima, Kazuho Honda, Yi Yang, Yohei Morita, Akane Inoue, Sumimasa Arimura, Hiroshi Nishina, Hideo Ema, Hiromitsu Nakauchi, Brian Seed, Hideaki Oda, and Yuji Yamanashi (2010) Mice lacking Dok-1, Dok-2, and Dok-3 succumb to aggressive histiocytic sarcoma. Laboratory Investigation 90, 1357-1364.
  • Shigeomi Shimizu, Akimitsu Konishi, Yuya Nishida, Takeshi Mizuta, Hiroshi Nishina, Akitsugu Yamamoto, and Yoshihide Tsujimoto (2010) Involvement of JNK in the regulation of autophagic cell death. Oncogene 29, 2070-2082.
  • Masahiko Tanaka, Hideyuki Hara, Hiroshi Nishina, Kentaro Hanada, Kenichi Hagiwara, and Tomohiko Maehama (2010) An improved method for cell-to-cell transmission of infectious prion. Biochem. Biophys. Res. Commun. 397, 505-508.
  • 仁科 博史:分子細胞生物学 第6版 (Lodish et al.) (翻訳分担)東京化学同人 (2010)
  • 仁科 博史:生物学事典、東京化学同人(執筆分担)(2010)
  • 仁科 博史:小型魚類メダカを用いた肝形成および肝疾患研究:肝細胞研究会ホームページ: 研究交流(2010)
  • 平山 順、内田 好海、宮村 憲央、沢登 健治、仁科 博史:概日リズムによる生理機能の制御機構;自律神経 47, 297-300 (2010)
  • 中村 貴、早坂 孝宏、井上 菜穂子、仁科 博史、瀬藤 光利:「メタボロームの分布可視化法について」メタボロミクス:その解析技術と臨床・創薬応用研究の最前線、メディカルドゥ、遺伝子医学MOOK 16, 131-135 (2010)

2009年

  • Jun Hirayama1, Norio Miyamura1, Yoshimi Uchida, Yoichi Asaoka, Reiko Honda, Kenji Sawanobori, Takeshi Todo, Takuro Yamamoto, Paolo Sassone-Corsi, and Hiroshi Nishina (2009) Common light signaling pathways controlling DNA repair and circadian clock entrainment. Cell Cycle 8, 2794-2801.
  • Shuhei Tanemura, Haruka Momose, Nao Shimizu, Daiju Kitagawa, Jungwon Seo, Tokiwa Yamasaki, Kentaro Nakagawa, Hiroaki Kajiho, Josef M. Penninger, Toshiaki Katada, and Hiroshi Nishina (2009) Blockage by SP600125 of Fce Receptor-induced degranulation and cytokine gene expression in mast cells is mediated through inhibition of phosphatidylinositol 3-kinase signaling pathway. J. Biochem. 145, 345-354. Cover of the issue. 平成22年度JB論文賞受賞
  • Ryota Saito, Tokiwa Yamasaki, Yoko Nagai, Jinzhan Wu, Hiroaki Kajiho, Tadashi Yokoi, Eiichiro Noda, Sachiko Nishina, Hitoshi Niwa, Noriyuki Azuma, Toshiaki Katada, and Hiroshi Nishina (2009) CrxOS Maintains Self-Renewal Capacity of Murine Embryonic Stem Cells. Biochem. Biophys. Res. Commun. 390, 1129-1135
  • Shinya Ohata, Makiko Nawa, Takeshi Kasama, Tokiwa Yamasaki, Kenji Sawanobori, Shoji Hata, Takashi Nakamura, Yoichi Asaoka, Toshio Watanabe, Hitoshi Okamoto, Takahiko Hara, Shuji Terai, Isao Sakaida, Toshiaki Katada, and Hiroshi Nishina (2009) Hematopoiesis-dependent expression of CD44 in murine hepatic progenitor cells. Biochem. Biophys. Res. Commun. 379, 817-823.
  • Norio Miyamura1, Jun Hirayama1, Kenji Sawanobori, Teruya Tamaru, Yoichi Asaoka, Reiko Honda, Takuro Yamamoto, Hatsume Uno, Ken Takamatsu, Hiroshi Nishina (2009) CLOCK:BMAL-independent circadian oscillation of zebrafish Cryptochrome1a gene. Biol. Pharm. Bull. 32, 1183-1187.
  • Nao Shimizu, Hajime Watanabe, Junko Kubota, Jinzhan Wu, Ryota Saito, Tadashi Yokoi, Takumi Era, Takeshi Iwatsubo, Takashi Watanabe, Sachiko Nishina, Noriyuki Azuma*, Toshiaki Katada, and Hiroshi Nishina* (2009) Pax6-5a Promotes Neuronal Differentiation of Murine Embryonic Stem Cells. Biol. Pharm. Bull. 32, 999-1003. Cover of the issue.
  • Yoshifumi Matsumoto, Hiroki Oota, Yoichi Asaoka, Hiroshi Nishina, Koji Watanabe, Janusz M Bujnicki, Shoji Oda, Shoji Kawamura and Hiroshi Mitani (2009) Medaka: a promising model animal for comparative population genomics. BMC Research Notes 2, 88.
  • Takashi Nakamura and Hiroshi Nishina (2009) [review] Liver development: lessons from knockout mice and mutant fish. Hepatol. Res. 39, 633-644.

2008年

  • Shinya Takahashi, Yasuhiro Araki, Yuriko Ohya, Takeshi Sakuno, Shin-ichi Hoshino, Kenji Kontani, Hiroshi Nishina, and Toshiaki Katada (2008) Upf1 potentially serves as a RING-related E3 ubiquitin ligase via its association with Upf3 in yeast. RNA 14, 1950-1958.
  • Tomohiko Maehama, Masahiko Tanaka, Hiroshi Nishina, Makoto Murakami, Yasunori Kanaho, and Kentaro Hanada (2008) RalA functions as an indispensable signal mediator for nutrient sensing system. J. Biol. Chem. 283, 35053-35059.
  • Wada T, Stepniak E, Hui L, Leibbrandt A, Katada T, Nishina H, Wagner EF, Penninger JM. (2008) Antagonistic control of cell fates by JNK and p38-MAPK signaling. Cell Death Differ. 15, 89-93.
  • Shizue Ohsawa, Tomomi Watanabe, Toshiaki Katada, Hiroshi Nishina, Masayuki Miura (2008) Novel antibody to human BASP1 labels apoptotic cells post-caspase activation. Biochem. Biophys. Res. Commun. 371, 639-643.
  • Yoshio Marumoto, Shuji Terai, Yohei Urata, Toshihiko Matsumoto, Yuko Mizunaga, Naoki Yamamoto, Haiyan Jin, Koichi Fujisawa, Tomoaki Murata, Koh Shinoda, Hiroshi Nishina, Isao Sakaida (2008). Continuous high expression of XBP1 and GRP78 is important for the survival of bone marrow cells in CCl4-treated cirrhotic liver. Biochem. Biophys. Res. Commun. 367, 546-552.
  • 仁科 博史:シグナル伝達の分子機構:ベーシックマスター生化学;325-345 オーム社(執筆分担)(2008)

2007年

  • Seiji Ura, Hiroshi Nishina*, Yukiko Gotoh, and Toshiaki Katada (2007) Activation of the JNK patyway by MST1 is essential and sufficient for the induction of chromatin condensation during apoptosis. Mol. Cell. Biol. 27, 5514-5522.
  • Nakamura, T., Imai, Y., Matsumoto, T., Sato, S., Takeuchi, K., Igarashi, K., Harada, Y., Azuma, Y., Krust, A., Yamamoto, Y., Nishina, H., Takeda, S., Takayanagi, H., Metzger, D., Kanno, J., Takaoka, K., Martin, TJ., Chambon, P., Kato, S. (2007) Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts. Cell 130, 811-823.
  • Tsuyoshi Ishikawa, Shuji Terai, Yohei Urata, Yoshio Marumoto, Koji Aoyama, Tomoaki Murata, Yuko Mizunaga, Naoki Yamamoto, Hiroshi Nishina, Koh Shinoda, Isao Sakaida (2007) Administration of. Administration of fibroblast growth factor 2 in combination with bone marrow transplantation synergistically improves carbon tetrachloride-induced liver fibrosis in mice. Cell Tissue Res. 327, 463-470.
  • Shoji Hata, Misako Namae and Hiroshi Nishina (2007) [review] Liver development and regeneration: from laboratory study to clinical therapy. Develop. Growth Differ. 49, 163-170. Cover of the issue.

2006年

  • Daiju Kitagawa, Hiroaki Kajiho, Takahiro Negishi, Seiji Ura, Tomomi Watanabe, Teiji Wada, Hidenori Ichijo, Toshiaki Katada, and Hiroshi Nishina (2006) Release of RASSF1C from the nucleus by DAXX degradation links DNA damage and SAPK/JNK activation. EMBO J. 25, 3286-3297. <難治疾患研究所優秀論文賞>
  • Yuichiro Yokoyama, Shuji Terai, Tsuyoshi Ishikawa, Koji Aoyama, Yohei Urata, Yoshio Marumoto, Toshihiko Matsumoto, Hiroshi Nishina, Kazuyuki Nakamura, Kiwamu Okita, Isao Sakaida (2006) Proteomic analysis of serum marker proteins in recipient mice with liver cirrhosis after bone marrow cell transplantation. Proteomics 6, 2564-2570.
  • Tsuyoshi Ishikawa, Shuji Terai, Yohei Urata, Yoshio Marumoto, Koji Aoyama, Isao Sakaida, Tomoaki Murata, Hiroshi Nishina, Koh Shinoda, Shunji Uchimura, Yoshihiko Hamamoto, and Kiwamu Okita (2006) Fibroblast growth factor 2 facilitates the differentiation of transplanted bone marrow cells into hepatocytes. Cell Tissue Res. 323, 221-231.
  • Wada T, Nakashima T, Nishina H, Penninger JM (2006) [review] RANK-RANKL signaling in osteoclastogenesis. Trends Mol Med. 12: 17-25.
  • 寺井 崇二、浦田 洋平、丸本 芳雄、石川 剛、青山 浩司、大森 薫、山本 直樹、坂井田 功、仁科 博史、奥本 和夫、斎藤 貴史、河田 純男、沖田 極:多施設臨床研究:肝硬変症に対するAMBI療法の開発;再生医療 5:79-87 (2006)
  • 北川 大樹、堅田 利明、仁科 博史:新規核内複合体Daxx-RASSF1CはDNA損傷センサーとして機能してシグナルを核から細胞質へと伝達する;細胞工学 25;1178-1179 (2006)
  • 仁科 博史:1枚の写真館 肝臓に生じたブラックホール?;細胞工学 25 (2006)

2005年

  • Masataka Asagiri, Kojiro Sato, Takako Usami, Sae Ochi, Hiroshi Nishina, Hiroki Yoshida, Ikuo Morita, Erwin F. Wagner, Tak W. Mak, Edgar Serfling, and Hiroshi Takayanagi (2005) Autoamplification of NFATc1 determines its essential role in bone homeostasis. J. Exp. Med. 202, 1261-1269.
  • Taro Takami, Shuji Terai, Yuichiro Yokoyama, Haruko Tanimoto, Kunihiko Tajima, Koichi Uchida, Takahiro Yamasaki, Isao Sakaida, Hiroshi Nishina, Snorri S. Thorgeirsson and Kiwamu Okita (2005) Human homologue of Maid (HHM) is a useful marker protein in hepatocarcinogenesis. Gastroenterology 128, 1369-1380.
  • Saito K, Araki Y, Kontani K, Nishina H, Katada T. (2005) Novel role of the small GTPase Rheb: Its implication in endocytic pathway independent of the activation of mammalian target of rapamycin. J. Biochem. 137, 423-430.
  • Shuji Terai, Isao Sakaida, Hiroshi Nishina, and Kiwamu Okita (2005) Lesson from the GFP/CCl4 model−Translational Research Project: the development of cell therapy using autologous bone marrow cells in patients with liver cirrhosis. J. Hepat. Panc. Surg. 12, 203-207.
  • Sakaida I, Terai S, Nishina H, Okita K (2005) Development of cell therapy using autologous bone marrow cells for liver cirrhosis. Med Mol Morphol. 38, 197-202.
  • Hiroshi Nishina* and Toshiaki Katada (2005) [book] The Biological Function of JNKKs (MKK4/MKK7 Knockout Mice) in The JNK Signaling Pathway (Anning Lin, eds) pp41-49, Landes Bioscience, Texas.
  • Saito, K., Kajiho, H., Araki, Y., Kurosu, H., Kontani, K., Nishina, H., and Katada, T. (2005) Purification and analysis of RIN family − novel Rab5 GEFs. Methods Enzymol. 403: 276-283.
  • 仁科 博史、堅田 利明:MAPキナーゼ;生物薬科学実験講座(石橋貞彦、市川厚、堅田利明 編) pp. 424-433 廣川書店 (2005)
  • 仁科 博史:細胞を利用した治療;医薬品の開発と生産、108-112 東京化学同人(2005)
  • 浦 誠司、仁科 博史:MAPキナーゼとストレス応答;シグナル伝達 集中マスター、58-67, 119-121 羊土社 (2005)
  • 和田 悌司、中島 友樹、仁科 博史、Josef M Penninger:アダプター分子Gab2は骨密度を制御する;細胞工学 24,704-705 (2005)

平山(准教授)

原著論文(英文)

  • Negishi J, Omori Y, Shindo M, Takanashi H, Musha S, Nagayama S, Hirayama J, Nishina H, Nakakura T, Mogi C, Sato K, Okajima F, Mochimaru Y, and Tomura H. Manganese and cobalt activate zebrafish ovarian cancer G-protein-coupled receptor 1 but not GPR4. Journal of Receptors and Signal Transduction. 2017; 37, 401-408.
  • Shimomura T, Miyamura N, Hata S, Miura R, Hirayama J*, and Nishina H*. The PDZ-binding motif of Yes-associated protein is required for its co-activation of TEAD-mediated CTGF transcription and oncogenic cell transforming activity. Biochem. Biophys. Res. Commun. 2014; 443, 917-923 (*Corresponding authors).
  • Egg M, Köblitz L, Hirayama J, Schwerte T, Folterbauer C, Kurz A, Fiechtner B, Möst M, Salvenmoser W, Sassone-Corsi P, and Pelster B. Linking oxygen to time: The bidirectional interaction between the hypoxic signaling pathway and the circadian clock. Chronobiol. Int. 2013; 30, 510-529.
  • Hata S, Hirayama J, Kajiho H, Nakagawa K, Hata Y, Katada T, Furutani-Seiki M, and Nishina H. A novel acetylation cycle of the transcription co-activator Yes-associated protein that is downstream of the Hippo pathway is triggered in response to SN2 alkylating agents. J. Biol. Chem. 2012; 287, 22089-22098.
  • Uchida Y, Osaki T, Yamasaki T, Shimomura T, Hata S, Horikawa K, Shibata S, Todo T, Hirayama J*, and Nishina H. Involvement of the stress kinase Mitogen-activated Protein Kinase Kinase 7 in the regulation of mammalian circadian clock. J. Biol. Chem. 2012; 287, 8318-8326.(*Corresponding author)
  • Uchida Y, Shimomura T, Hirayama J*, and Nishina H. Light, reactive oxygen species, and magnetic fields activate ERK/MAPK signaling pathway in cultured zebrafish cells. Appl. Magn. Reson. 2012; 42: 69-77. (*Corresponding author)
  • Osaki T, Uchida Y, Hirayama J*, and Nishina H. Diphenyleneiodonium chloride, an inhibitor of NADPH oxidase, suppresses light-dependent induction of clock and DNA repair genes in zebrafish. Biol. Pharm. Bull. 2011; 34: 1343-1347 (*Corresponding author)
  • Grimaldi B, Bellet MM, Katada S, Astarita G, Hirayama J, Amin RH, Granneman JG, Piomelli D, Leff T, and Sassone-Corsi P. PER2 Controls Lipid Metabolism by Direct Regulation of PPARγ. Cell Metab. 2010; 12: 509-520.
  • Wu J#, Kubota J#, Hirayama J#, Nagai Y, Nishina S, Yokoi T, Asaoka Y, Seo J, Shimizu N, Kajiho H, Watanabe T, Azuma N, Katada T, and Nishina H. p38 Mitogen-Activated Protein Kinase Controls a Switch between Cardiomyocyte and Neuronal Commitment of Murine Embryonic Stem Cells by Activating MEF2C-dependent BMP2 Transcription. Stem Cells and Development 2010; 19, 1723-1734. (#Contributed equally)
  • Seo J, Asaoka Y, Nagai Y, Hirayama J, Yamasaki T, Namae M, Ohata S, Shimizu N, Negishi T, Kitagawa D, Kondoh H, Furutani-Seiki M, Penninger JM, Katada T, and Nishina H. Negative regulation of wnt11 by JNK signaling is required for convergent extension during vertebrate gastrulation. J. Cell. Biochem. 2010; 110, 1022-1037.
  • Nakagawa K, Sugahara M, Yamasaki T, Kajiho H, Takahashi S, Hirayama J, Minami Y, Ohta Y, Watanabe T, Hata Y, Katada T, and Nishina H. Filamin Associates with Stress Signaling Kinases MKK7 and MKK4 and Regulates JNK Activation. Biochem. J. 2010; 427, 237-245
  • Hirayama J#, *, Miyamura N#, Uchida Y, Asaoka Y, Honda R, Sawanobori K, Todo T, Yamamoto T, Sassone-Corsi P*, and Nishina H. Common light signaling pathways controlling DNA repair and circadian clock entrainment. Cell Cycle 2009; 8, 2794-2801. (#Contributed equally; *Corresponding authors)
  • Miyamura N#, Hirayama J#, *, Sawanobori K, Tamaru T, Asaoka Y, Honda R, Yamamoto T, Uno H, Takamatsu K, and Nishina H. CLOCK:BMAL-independent circadian oscillation of zebrafish Cryptochrome1a gene. Biol. Pharm. Bull. 2009; 32, 1183-1187. (#Contributed equally; *Corresponding author)
  • Tamaru T, Hirayama J, Isojima Y, Nagai K, Norioka S, Takamatsu K, and Sassone-Corsi P. CK2α phosphorylates BMAL1 to regulate the mammalian clock. Nat Struct Mol Biol. 2009; 16: 446-448.
  • Acimovic J, Fink M, Pompon D, Bjorkhem I, Hirayama J, Sassone-Corsi P, Golicnik M, and Rozman D. CREM modulates the circadian expression of CYP51, HMGCR and cholesterogenesis in the liver. Biochem Biophys Res Commun. 2008; 376: 206-210.
  • Nakahata Y, Kaluzova M, Grimaldi B, Sahar S, Hirayama J, Chen D, Guarente LP, and Sassone-Corsi, P. The NAD+-Dependent Deacetylase SIRT1 Modulates CLOCK-Mediated Chromatin Remodeling and Circadian Control. Cell, 2008; 134, 329-340.
  • Hirayama J, Sahar S, Grimaldi B, Tamaru T, Takamatsu K, Nakahata Y, and Sassone-Corsi P. CLOCK-mediated acetylation of BMAL1 Controls Circadian Function. Nature. 2007; 405:1086-1090
  • Hirayama J, Cho S, and Sassone-Corsi P. Circadian Control by the Reduction-Oxidation Pathway-Catalase Represses Light-dependent Clock Gene Expression in the Zebrafish. Proc Natl Acad Sci U S A. 2007; 104:15747-15752.
  • Doi M, Cho S, Yujnovsky I, Hirayama J, Cermakian N, Cato A, and Sassone-Corsi P. Light-Inducible and Clock-Controlled Expression of MAP Kinase Phosphatase 1 in Mouse Central Pacemaker Neurons. J Biol Rhythms. 2007; 22:127-139
  • Kimmins S, Crosio C, Kotaja N, Hirayama J, Monaco L, Ho¨o¨g C, van Duin M, Gossen JA, and Sassone-Corsi P. Differential functions of the Aurora-B and Aurora-C kinases in mammalian spermatogenesis. Mol Endocrinol. 2007; 21:726-739
  • Doi M, Yujnovsky I, Hirayama J, Malerba M, Tirotta E, Sassone-Corsi P, and Borrelli E. Impaired light masking in dopamine D2 receptor-null mice. Nat Neurosci. 2006; 9:732-734.
  • Doi M, Hirayama J, and Sassone-Corsi P. Circadian regulator CLOCK is a histone acetyltransferase. Cell. 2006; 125:497-508.
  • Yujnovsky I#, Hirayama J#, Doi M, Borrelli E, and Sassone-Corsi P. Signaling Mediated by the Dopamine D2 Receptor Potentiates Circadian Regulation by CLOCK:BMAL1. Proc Natl Acad Sci U S A. 2006; 103:6386-6391. (#Contributed equally)
  • Cardone L, Hirayama J, Giordano F, Tamaru T, Palvimo J, and Sassone-Corsi P. Circadian Clock Control by SUMOylation of BMAL1. Science. 2005; 309:1390-1394.
  • Hirayama J, Cardone L, Doi M, and Sassone-Corsi P. Common pathways in circadian and cell cycle clocks: Light-dependent activation of Fos/AP-1 in zebrafish controls CRY-1a and WEE-1. Proc Natl Acad Sci U S A. 2005; 102:10194-10199.
  • Hirayama J, Kaneko M, Cardone L, Cahill G, and Sassone-Corsi P. Analysis of Circadian Rhythms in the Zebrafish. Methods Enzymol. 2005; 393:186-204.
  • Hirayama J, Nakamura H, Ishikawa T, Kobayashi Y, and Todo T. Functional and structural analyses of cryptochrome: Vertebrate CRY regions responsible for interaction with the CLOCK: BMAL1 heterodimer and its nuclear localization. J Biol Chem. 2003; 278:35620-35628.
  • Hirayama J, Fukuda I, Ishikawa T, Kobayashi Y, and Todo T. New role of zCRY and zPER2 as regulators of sub-cellular distributions of zCLOCK and zBMAL proteins. Nucleic Acids Res. 2003; 31:935-943.
  • Ikenaga M, Hirayama J, Kato T, Kitao H, Han ZB, Ishizaki K, Nishizawa K, Suzuki F, Cannon TF, Fukui K, Shimazu T, Kamigaichi S, Ishioka N, and Matsumiya H. Effect of space flight on the frequency of micronuclei and expression of stress-responsive proteins in cultured mammalian cells. J Radiat Res (Tokyo). 2002; 43 :141-147.
  • Ishikawa T, Hirayama J, Kobayashi Y, and Todo T. Zebrafish CRY represses transcription mediated by CLOCK-BMAL heterodimer without inhibiting its binding to DNA. Genes Cells. 2002; 7:1073-1086.
  • Ishizaki K, Nishizawa K, Kato T, Kitao H, Han ZB, Hirayama J, Suzuki F, Cannon TF, Kamigaichi S, Tawarayama Y, Masukawa M, Shimazu T, and Ikenaga M. Genetic changes induced in human cells in Space Shuttle experiment (STS-95). Aviat Space Environ Med. 2001; 72:794-798.
  • Kobayashi Y, Ishikawa T, Hirayama J, Daiyasu H, Kanai S, Toh H, Fukuda I, Tsujimura T, Terada N, Kamei Y, Yuba S, Iwai S, and Todo T. Molecular analysis of zebrafish photolyase/ cryptochrome family: two types of cryptochromes present in zebrafish. Genes Cells. 2000; 5:725-738.

著書・総説(英文)

  • Uchida Y, Hirayama J*, and Nishina H. A common origin: signaling similarities in the regulation of the circadian clock and DNA damage responses. Biol. Pharm. Bull. 2010; 33, 535-544. Cover of the issue (*Corresponding author)
  • Hirayama J, and Sassone-Corsi P. Transcription and Circadian rhymths:Transcription Control and the Circadian Clock. The New Encyclopedia of Neuroscience (Edited by Larry Squire et al.) 2009; 1071-1080
  • Grimaldi B, Nakahata Y, Sahar S, Koluzova M, Gauthier D, Pham K, Patel N, Hirayama J, and Sassone-Corsi, P. Mechanisms of chromatin remodeling and the circadian clock: links with metabolism and physiology. Cold Spring Harbor Symp. Quant. Biol. 2007; 72:105-112.
  • Nakahata Y, Grimaldi B, Sahar S, Hirayama J, and Sassone-Corsi P. Signaling to the circadian clock: plasticity by chromatin remodeling. Curr Opin Cell Bio. 2007; 19:230-237.
  • Hirayama J, and Sassone-Corsi P. Structural and Functional Features of Transcription Factors Controlling the Circadian Clock. Curr Opin Genet Dev. 2005; 15:548-556.
  • Ikenaga M, Ishizaki K, Nishizawa K, Han ZB, Kitao H, Hirayama J, and Kato T. Genetic effects of space radiation and microgravity on cultured human tumor cells. Exploring Future Research Strategies in Space Radiation Sciences, 2000

著書・総説(和文)

  • 平山 順、仁科 博史:活性酸素シグナルと概日リズム:実験医学2012年11月増刊号 36-41 (2012)
  • 平山 順:時計タンパク質の翻訳後修飾と分子時計制御:ファルマシア 48: 285-289 (2012)
  • 平山 順*、内田 好海、宮村 憲央、沢登 健治、仁科 博史:概日リズムによる生理機能の制御機構:自律神経 47: 297-300 (2010)