メンバー

助教　岡本 好海

講師　岡本 好海

学歴

2009年 （平成21年3月）東京海洋大学海洋科学部食品生産学科卒業
2014年 （平成26年3月）東京医科歯科大学大学院生命情報科学専攻 博士課程修了
理学博士 （仁科 博史 教授）

職歴

2011年 （平成23年4月）日本学術振興会特別研究員（DC1）
2014年 （平成26年4月）東京医科歯科大学難治疾患研究所発生再生生物学分野
特任助教
2014年 （平成26年7月）国立医薬品食品衛生研究所医薬安全科学部 任期付研究員
2018年 （平成30年6月）IQVIAサービシーズジャパン株式会社
2022年 （令和4年4月） 東京医科歯科大学難治疾患研究所 助教

受賞

2009年（平成21年3月）東京海洋大学 楽水会賞受賞
2010年（平成22年1月）難治疾患研究所研究発表会ベストプレゼンテーション賞受賞
2011年（平成23年1月）難治疾患研究所研究発表会ベストプレゼンテーション賞受賞
2013年（平成25年1月）難治疾患研究所若手研究者研究発表会 第1位
2019年（令和元年11月）臨床薬理研究振興財団研究大賞受賞
2021年（令和3年3月）Wemake ビジネスコンテスト優勝

その他

3児の母、子育て奮闘中

英文原著

  • Jing Pu*, Satoshi Kofuji*, Yoshimi Okamoto-Uchida*, Keiko Danzaki, Ruoxing Yu, Akira Suzuki, Satoshi Kitajima and Hiroshi Nishina (2023) Lethal phenotype-based database screening identifies ceramide as a negative regulator of primitive streak formation. Stem Cells accepted. (*Contributed equally)
  • Sakurako Kobayashi, Nobuhiko Ogasawara, Satoshi Watanabe, Yosuke Yoneyama, Sakura Kirino, Yui Hiraguri, Masami Inoue, Sayaka Nagata, Yoshimi Okamoto-Uchida, Satoshi Kofuji, Hiromichi Shimizu, Go Ito, Tomohiro Mizutani, Shinichi Yamauchi, Yusuke Kinugasa, Yoshihito Kano, Yasuhiro Nemoto, Mamoru Watanabe, Kiichiro Tsuchiya, Hiroshi Nishina, Ryuichi Okamoto, Shiro Yui (2022) Collagen Type I mediated mechnotransduction controls epithelial cell fate conversion during intestinal inflammation. Inflammation and Regeneration 42(1):49.
  • Wang YH, Chen CB, Tassaneeyakul W, Saito Y, Aihara M, Choon SE, Lee HY, Chang MM, Roa FD, Wu CW, Zhang J, Nakkam N, Konyoung P, Okamoto-Uchida Y, Man-Tung Cheung C, Huang JW, Ji C, Cheng B, Chung-Yee Hui R, Chu CY, Chen YJ, Wu CY, Hsu CK, Chiu TM, Ho HC, Lin JY, Yang CH, Chang YC, Su SC, Wang CW, Chung WH; Asian Severe Cutaneous Adverse Reaction Consortium. The Medication Risk of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Asians: The Major Drug Causality and Comparison to the USA FDA Label. Clin Pharmacol Ther. 105:112-120 (2019)
  • Okamoto-Uchida Y, Nakamura R, Matsunaga K, Aihara M, Saito Y.: Specific association of the rs6500265 and rs9933632 SNPs in Japanese patients with antipyretic analgesic-related Stevens–Johnson syndrome and toxic epidermal necrolysis with severe ocular involvements. Pharmacogenetics and Genomics. 28(3):95-98 (2018)
  • Okamoto-Uchida Y, Nakamura R, Sai K, Imatoh T, Matsunaga K, Aihara M, Saito Y.: Effect of Infectious Diseases on the Pathogenesis of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis. Biol Pharm Bull. 40(9):1576-1580 (2017)
  • Imatoh T, Sai K, Fukazawa C, Hinomura Y, Nakamura R, Okamoto-Uchida Y, Segawa K, Saito Y.: Association between infection and severe drug adverse reactions: an analysis using data from the Japanese Adverse Drug Event Report database. Eur J Clin Pharmacol. 73:1643-1653 (2017)
  • Yamasaki T, Deki-Arima N, Kaneko A, Miyamura N, Iwatsuki M, Matsuoka M, Fujimori-Tonou N, Okamoto-Uchida Y, Hirayama J, Marth JD, Yamanashi Y, Kawasaki H, Yamanaka K, Penninger JM, Shibata S, Nishina H.: Age-dependent motor dysfunction due to neuron-specific disruption of stress-activated protein kinase MKK7. Scientific Reports. s41598, 2017.
  • Okamoto-Uchida Y, Yu R, Miyamura N, Arima N, Ishigami-Yuasa M, Kagechika H, Suguru Yoshida S, Hosoya T, Nawa M, Kasama T, Asaoka Y, Wimmer Alois R, Elling U, Penninger JM, Nishina S, Azuma N, Nishina H.: The mevalonate pathway regulates primitive streak formation via protein farnesylation. Scientific Reports. srep37697 (2016)
  • Okamoto-Uchida Y, Nakamura R, Matsuzawa Y, Soma M, Kawakami H, Ishii-Watabe A, Nishimaki-Mogami T, Teshima R, Saito Y: Different results of IgE binding- and crosslinking-based allergy tests caused by allergen immobilization. Biol. Pharm. Bull. 39: 1662-66 (2016)
  • Yu R, Miyamura N, Okamoto-Uchida Y, Arima N, Ishigami-Yuasa M, Kagechika H, Nishina H.: A Modified Murine Embryonic Stem Cell Test for Evaluating the Teratogenic Effects of Drugs on Early Embryogenesis. PLoS One. 10:e0145286 (2015)
  • Maekawa K, Nakamura R, Kaniwa N, Mizusawa S, Kitamoto A, Kitamoto T, Ukaji M, Matsuzawa Y, Sugiyama E, Uchida Y, Kurose K, Ueta M, Sotozono C, Ikeda H, Yagami A, Matsukura S, Kinoshita S, Muramatsu M, Ikezawa Z, Sekine A, Furuya H, Takahashi Y, Matsunaga K, Aihara M, Saito Y; Japan Pharmacogenomics Data Science Consortium. “Development of a simple genotyping method for the HLA-A*31:01-tagging SNP in Japanese.”Pharmacogenomics 16:1689-99 (2015)
  • Falcone FH, Alcocer MJ, Okamoto-Uchida Y, Nakamura R. “Use of Humanized Rat Basophilic Leukemia Reporter Cell Lines as a Diagnostic Tool for Detection of Allergen-Specific IgE in Allergic Patients: Time for a Reappraisal?” Current Allergy & Asthma Reports. 15; 11:67 (2015)
  • Kaniwa N, Ueta M, Nakamura R, Okamoto-Uchida Y, Sugiyama E, Maekawa K, Takahashi Y, Furuya H, Yagami A, Matsukura S, Ikezawa Z, Matsunaga K, Sotozono C, Aihara M, Kinoshita S, Saito Y. “Drugs causing severe ocular surface involvements in Japanese patients with Stevens-Johnson syndrome/toxic epidermal necrolysis.”Allergol International 64; 4:379-81 (2015)
  • Arima N*, Uchida Y*, Ruoxing Yu, Koh Nakayama, Hiroshi Nishina “Acetylcholine Receptors Regulate Gene Expression that Is Essential for Primitive Streak Formation in Murine Embryoid Bodies” Biochem Biophys Res Commun. 7; 435: 447-453 (2013). (*Contributed equally)
  • Uchida Y, Tomomi Osaki, Tokiwa Yamasaki, Tadanori Shimomura, Shoji Hata, Kazumasa Horikawa, Shigenobu Shibata, Takeshi Todo, Jun Hirayama, Hiroshi Nishina “Involvement of the stress kinase mitogen-activated protein kinase kinase 7 in the regulation of the mammalian circadian clock” Journal of Biological Chemistry. 9; 287:8318-8326 (2012).
  • Uchida Y, Tadanori Shimomura, Jun Hirayama, Hiroshi Nishina “Light, Reactive Oxygen Species, and Magnetic Fields Activating ERK/MAPK Signaling Pathway in Cultured Zebrafish Cells” Applyed Magnetic Resonance 42:69-77 (2012).
  • Nakamura R, Ishiwatari A, Higuchi M, Uchida Y, Nakamura R, Kawakami H, Urisu A, Teshima R “Evaluation of the Luciferase Assay-Based In Vitro Elicitation Test for Serum IgE” Allergology International 61:431-437 (2012).
  • Osaki T*, Uchida Y*, Hirayama J, Nishina H “Diphenyleneiodonium chloride, an inhibitor of reduced nicotinamide adenine dinucleotide phosphate oxidase, suppresses light-dependent induction of clock and DNA repair genes in zebrafish.” Biological & Pharmaceutical Bulletin 34:1343-1347 (2011). (*Contributed equally)
  • Uchida Y, Hirayama J, Nishina H“A common origin: signaling similarities in the regulation of the circadian clock and DNA damage responses” Biol. Pharm. Bull. 33: 535-544 (2010). (Cover of the issue)
  • Nakamura R, Uchida Y, Higuchi M, Nakamura R, Tsuge I, Urisu A, and Teshima R “A convenient and sensitive allergy test: IgE crosslinkinginduced luciferase expression in cultured mast cells” Allergy 65: 1266–1273 (2010).
  • Hirayama J, Miyamura N, Uchida Y, Asaoka Y, Honda R, Sawanobori K, Todo T, Yamamoto T, Sassone-Corsi P, Nishina H. “Common light signaling pathways controlling DNA　repair and circadian clock entrainment in zebrafish” Cell Cycle 8: 2794-2801 (2009).
  • Nakamura R, Uchida Y, Higuchi M, Teshima R　“Development of a novel allergy test using a cultured mast cell line” Immuno Tox Letter. 28: 12-13 (2009)

英文総説

  • Okamoto-Uchida Y, Nishimura A, Izawa J, Hattori A, Suzuki N, Hirayama J.: The Use of Chemical Compounds to Identify the Regulatory Mechanisms of Vertebrate Circadian Clocks. Curr Drug Targets. 21(5):425-432 (2020)
  • Okamoto-Uchida Y, Izawa J, Hirayama J ; Chapter2, A Molecular Link between the Circadian Click, DNA Damage Responses, and Oncogene Activation: Oncogenes and Carcinogenesis, IntechOpen (2020)
  • Okamoto-Uchida Y, Izawa J, Nishimura A, Hattori A, Suzuki N, Hirayama J; Post-translational modifications are required for circadian clock regulation in vertebrates. Current Genomics 20(5): 332-339 (2019)
  • Izawa J, Okamoto-Uchida Y, Hirayama J ; Chapter3, Light-dependent regulation of circadian clocks in vertebrates. Chronobiology: The Science of Biological Time Structure, IntechOpen (2019)

和文総説

  • 岡本（内田）好海 , 橋井 則貴, 中村 亮介, 斎藤 嘉朗「スティーヴンス・ジョンソン症候群/中毒性表皮壊死症の発症・重症化予測系の構築に向けて」臨床薬理の進歩 40: 140-149 (2019)
  • 岡本（内田）好海、Yu Ruoxing, 仁科博史「ES細胞分化系を用いた簡便・高解像度な初期胚発生に対する医薬品リスク評価」ファルマシア 53 (12): 1182-86 (2017)
  • 岡本（内田）好海, 児玉 進, 中村 亮介, 斎藤 嘉朗「臨床における重症薬疹とゲノムマーカー」谷本学校 毒性質問箱 第17号: 18-23 (2015)
  • 平山順, 内田好海, 宮村憲央, 沢登健治, 仁科博史「概日リズムによる生理機能の制御機構」自律神経学会誌 47: 297-300 (2010)
  • 中村亮介, 内田好海, 樋口雅一, 手島玲子「培養細胞を用いた新しいアレルギー検査方法の開発」日本免疫毒性学会誌 28: 2-5 (2009)