メンバー

プロジェクト助教　金山 敬子

講師　金山 敬子

学歴

2007年（平成19年3月）北海道大学水産学部生物生産科学科　卒業
2009年（平成21年3月）北海道大学大学院医学研究科　医科学　修士課程修了
2013年（平成25年3月）北海道大学大学院医学研究科　医学　博士課程修了　医学博士

職歴

2013年（平成25年4月）Department of Immunology, Duke University Medical Center（米国）
Postdoctoral fellow
2015年（平成27年11月）Department of Pediatrics, Duke University Medical Center（米国）
Postdoctoral fellow
2018年（平成30年10月）学校法人順天堂　順天堂大学医学部耳鼻咽喉科学講座
研究補助員
2021年（令和3年12月）東京医科歯科大学難治疾患研究所　発生再生生物学分野
特任助教
2022年（令和4年4月）プロジェクト助教

受賞

2012年9月第8回音羽博次奨学基金、北海道大学医学部
2015年12月第38回分子生物学会年会、海外若手研究者招聘企画
2017年4月Award for Outstanding Abstract, Department of Pediatrics Research Retreat, Duke University Medical Center

英文原著

  • Pu J*, Kofuji S*, Okamoto-Uchida Y*, Danzaki K, Yu R, Suzuki A, Kitajima S and Nishina H (2023) Lethal phenotype-based database screening identifies ceramide as a negative regulator of primitive streak formation. Stem Cells accepted. (* Authors contributed equally to this work.)
  • Alwarawrah Y, Danzaki K, Nichols AG, Fee BE, Bock C, Kucera G, Hale LP, Taylor GA, MacIver NJ. Irgm1 regulates metabolism and function in T cell subsets Scientific Reports. 2020 Jan17;12(1):850. DOI: 10.1038/s41598-021-04442-x
  • Fukunaga I, Oe Y, Danzaki K, Ohta S, Chen C, Shirai K, Kawano A, Ikeda K, Kamiya K. Modeling gap junction beta 2 gene-related deafness with human iPSC. Human Molecular Genetics. 2021 Jul 9;30(15):1429-1442. DOI: 10.1093/hmg/ddab097
  • Fukunaga I, Oe Y, Danzaki K, Ohta S, Chen C, Iizumi M, Shiga T, Matsuoka R, Anzai T, Hibiya-Motegi R, Tajima S, Ikeda K, Akamatsu W, Kamiya K. Generation of two iPSC lines from siblings of a homozygous patient with hearing loss and a heterozygous carrier with normal hearing carrying p.G45E/Y136X mutation in GJB2. Stem Cell Research. 2021 May; 53:102290. DOI: 10.1016/j.scr.2021.102290
  • Fukunaga I, Oe Y, Chen C, Danzaki K, Ohta S, Koike A, Ikeda K, Kamiya K. Activin/Nodal/TGF-β Pathway Inhibitor Accelerates BMP4-Induced Cochlear Gap Junction Formation During in vitro Differentiation of Embryonic Stem Cells. Frontiers in Cell and Developmental Biology. 2021 Apr 21; 9:602197. DOI: 10.3389/fcell.2021.602197
  • Deerhake ME, Danzaki K, Inoue M, Cardakli ED, Nonaka T, Aggarwal N, Barclay WE, Ji RR, Shinohara ML. Dectin-1 limits autoimmune neuroinflammation and promotes myeloid cell-astrocyte crosstalk via Card9-independent expression of Oncostatin M. Immunity. 2021 Mar 9;54(3):484-498.e8. DOI: 10.1016/j.immuni.2021.01.004.
  • Fukunaga I, Shirai K, Oe Y, Danzaki K, Ohta S, Shiga T, Chen C, Ikeda K, Akamatsu W, Kawano A, Kamiya K. Generation of two induced pluripotent stem cell lines from PBMCs of siblings carrying c.235delC mutation in the GJB2 gene associated with sensorineural hearing loss. Stem Cell Research. 2020 Jul 19; 47:101910. DOI: 10.1016/j.scr.2020.101910
  • Fukunaga I, Shiga T, Chen C, Oe Y, Danzaki K, Ohta S, Matsuoka R, Anzai T, Hibiya-Motegi R, Tajima S, Ikeda K, Akamatsu W, Kamiya K. Generation of the induced pluripotent stem cell (hiPSC) line (JUFMDOi004-A) from a patient with hearing loss carrying GJB2 (p.V37I) mutation. Stem Cell Research. 2020 Mar; 43:101674. DOI: 10.1016/j.scr.2019.101674
  • Tajima S, Danzaki K, Ikeda K, Kamiya K. Degradation and modification of cochlear gap junction proteins in the early development of age-related hearing loss. Experimental & Molecular Medicine. 2020 Jan;52(1):166-175. DOI: 10.1038/s12276-020-0377-1
  • Rebeles J, Green WD, Alwarawrah Y, Nichols AG, Eisner W, Danzaki K, MacIver NJ, Beck MA. Obesity-Induced Changes in T-Cell Metabolism Are Associated With Impaired Memory T-Cell Response to Influenza and Are Not Reversed With Weight Loss. The Journal of Infectious Diseases. 2019 Apr 19;219(10):1652-1661. DOI: 10.1093/infdis/jiy700.
  • Kanayama M, Xu S*, Danzaki K*, Gibson JR, Inoue M, Gregory SG, Shinohara ML. Skewing of the population balance of lymphoid and myeloid cells by secreted and intracellular osteopontin. Nature Immunology. 2017 18(9):973-984.DOI: 10.1038/ni.3791(* Authors contributed equally to this work.)
  • Danzaki K, Kanayama M, Alcazar O, Shinohara ML. Osteopontin has a protective role in prostate tumor development in mice. European Journal of Immunology. 2016 46(11):2669-2678. DOI: 10.1002/eji.201646391
  • Gerriets VA*, Danzaki K*, Kishton RJ, Eisner W, Nichols AG, Saucillo DC, Shinohara ML, MacIver NJ. Leptin directly promotes T-cell glycolytic metabolism to drive effector T-cell differentiation in a mouse model of autoimmunity. European Journal of Immunology. 2016 46(8):1970-1983. DOI:10.1002/eji.201545861 (* Authors contributed equally to this work.)
  • Kanayama M, Danzaki K, He YM, Shinohara ML. Lung inflammation stalls Th17-cell migration en route to the central nervous system during the development of experimental autoimmune encephalomyelitis. International Immunology. 2016 Sep 28(9):463-469. DOI: 10.1093/intimm/dxw013
  • Kanayama M, Inoue M, Danzaki K, Hammer G, He YW, Shinohara ML. Autophagy enhances NFκB activity in specific tissue macrophages by sequestering A20 to boost anti-fungal immunity. Nature Communications. 2015 Jan 22; 6:5779. DOI: 10.1038/ncomms6779
  • Danzaki K, Matsui Y, Ikesue M, Ohta D, Ito K, Kanayama M, Kurotaki D, Morimoto J, Iwakura Y, Yagita H, Tsutsui H, Uede T. Interleukin-17A Deficiency Accelerates Unstable Atherosclerotic Plaque Formation in Apolipoprotein E-Deficient Mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 2012 Feb 32(2):273-280. DOI: 10.1161/ATVBAHA.111.229997
  • Kanayama M, Morimoto J, Matsui Y, Ikesue M, Danzaki K, Kurotaki D, Ito K, Yoshida T, Uede T. Alpha9beta1 Integrin-Mediated Signaling Serves as an Intrinsic Regulator of Pathogenic Th17 Cell Generation. The Journal of Immunology. 2011 Dec 1;187(11):5851-5864. DOI: 10.4049/jimmunol.1101524
  • Ikesue M, Matsui Y, Ohta D, Danzaki K, Ito K, Kanayama M, Kurotaki D, Morimoto J, Kojima T, Tsutsui H, Uede T. Syndecan-4 deficiency limits neointimal formation after vascular injury by regulating vascular smooth muscle cell proliferation and vascular progenitor cell mobilization. Arteriosclerosis, Thrombosis, and Vascular Biology. 2011 May 31(5):1066-1074. DOI: 10.1161/ATVBAHA.110.217703
  • Matsui Y, Ikesue M, Danzaki K, Morimoto J, Sato M, Tanaka S, Kojima T, Tsutsui H, Uede T. Syndecan-4 prevents cardiac rupture and dysfunction after myocardial infarction. Circulation Research. 2011 May27; 108(11):1328-1339. DOI: 10.1161/CIRCRESAHA.110.235689

英文総説

2017年

  • Nutritional effects on T-cell immunometabolism. Cohen S, Danzaki K, MacIver NJ. European Journal of Immunology. 2017 47(2):225-235. DOI: 10.1002/eji.201646423

和文総説

2010年

  • 檀崎敬子、松井裕、岩倉洋一郎、上出利光「動脈硬化の進展におけるInterleukin-17Aの役割の検討」Host Defense、21巻72-72ページ（2010）