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研究業績　Publication （2010年～2019年

  • 2020年～
  • 1991年～2009年
  • 総説 Review

    2019年

    (11) Development of Boron-Cluster-Based Progesterone Receptor Antagonists Bearing a Pentafluorosulfanyl (SF5) Group.
    Mori, S.; Tsuemoto, N.; Kasagawa, T.; Nakano, E.; Fujii, S.; Kagechika, H.
    Chem. Pharm. Bull. 2019, 67, 1278-1283.
    DOI: 10.1248/cpb.c19-00522.



    (10) A Polarity-Sensitive Fluorescent Amino Acid and its Incorporation into Peptides for the Ratiometric Detection of Biomolecular Interactions.
    Yokoo, H.; Kagechika, H.; Ohsaki, A; Hirano T.
    ChemPlusChem 2019, 84, 1716-1719.
    DOI: 10.1002/cplu.201900489



    (9) A New LC-MS Assay for the Quantitative Analysis of Vitamin K Metabolites in Human Urine.
    McDonald, M. G.; Yeung, C. K.; Teitelbaum, A. M.; Johnson, A. L.; Fujii, S.; Kagechika, H.; Rettie, A. E.
    J. Lipid Res. 2019, 60, 892-899.
    DOI: 10.1194/jlr.D087916

    (8) Two new alkaloids from Crinum asiaticum var. japonicum. Endo, Y.; Sugiura, Y.; Funasaki, M.; Kagechika, H.; Ishibashi, M.; Ohsaki, A.
    J. Nat. Med. 2019, 73, 648-652.
    DOI: 10.1007/s11418-019-01304-9

    (7) Design, synthesis and biological evaluation of novel nonsteroidal progesterone receptor antagonists based on phenylamino-1,3,5-tirazine scaffold.
    Kaitoh, K.; Nakatsu, A.; Mori, S.; Kagechika, H.; Hashimoto, Y.; Fujii, S.
    Chem. Pharm. Bull. 2019, 67, 566-575.
    DOI: 10.1248/cpb.c19-00094



    (6) A new regulatory mechanism for Raf kinase activation, retinoic acid-bound Crabp1.
    Park, S. W.; Nhieu, J.; Persaud, S. D.; Miller, M. C.; Xia, Y.; Lin, Y.-W.; Lin, Y.-L.; Kagechika, H.; Mayo, K. H.; Wei, L/-N.
    Sci. Rep. 2019, 9, 10929.
    DOI: 10.1038/s41598-019-47354-7

    (5) Development of Novel Lithocholic Acid Derivatives as Vitamin D Receptor Agonists.
    Masuno, H.; Kazui, Y.; Tanatani, A.; Fujii, S.; Kawachi, E.; Ikura, T.; Ito, N.; Yamamoto, K.; Kagechika, H.
    Bioorg. Med. Chem. 2019, 27, 3674-3681.
    DOI: 10.1016/j.bmc.2019.07.003



    (4) Structural development of a type-1 ryanodine receptor (RyR1) Ca2+-release channel inhibitor guided by endoplasmic reticulum Ca2+ assay.
    Mori, S.; Iinuma, H.; Manaka, N.; Ishigami-Yuasa, M.; Murayama, T.; Nishijima, Y.; Sakurai, A.; Arai, R.; Kurebayashi, N.; Sakurai, T.; Kagechika, H.
    Eur. J. Med. Chem. 2019, 179, 837-848.
    DOI: 10.1016/j.ejmech.2019.06.076



    (3) Design and synthesis of cyclohexyl-p-carborane derivatives as a new class of progesterone receptor antagonists.
    Fujii, S.; Yanagida, N.; Mori, S.; Kawachi, E.; Kagechika, H.
    Heterocycles 2019, 99, 425-445.
    DOI: 10.3987/COM-18-S(F)38



    (2) Spontaneous Chiral Resolution of N,N’-Diarylsquaramides : Formation of Various Types of One-handed Helical Networks During Crystallization.
    Kanda, M.; Urushibara, Ko.; Park, S.; Fujii, S.; Masu, H.; Katagiri, K.; Azumaya, I.; Kagechika, H.; Tanatani, A.
    Tetrahedron 2019, 75, 2771-2777.
    DOI: 10.1016/j.tet.2019.03.049



    (1) Class IIb HDAC inhibition enhances the inhibitory effect of Am80, a synthetic retinoid, in prostate cancer.
    Ishigami-Yuasa, M.; Ekimoto, H.; Kagechika, H.
    Biol. Pharm. Bull. 2019, 42, 448-452.
    DOI: 10.1248/bpb.b18-00782



    2018年

    (14) Highlighted Paper selected by Editor-in-Chie Structure-Activity Relationship of Novel Androgen Receptor Antagonists Bearing a (Benzoylaminophenoxy)phenol Pharmacophore.
    Kazui, Y.; Fujii, S.*; Yamada, A.; Ishigami-Yuasa, M.; Kagechika, H.; Tanatani, A.
    Bioorg. Med. Chem. 2018, 26, 5118-5127.
    DOI: 10.1016/j.bmc.2018.09.008



    (13) Prevention of acute liver injury by suppressing plasma kallikrein-dependent activation of latent TGF-b.
    Li, M.; Qin, X.-Y.; Furutani, Y.; Inoue, I.; Sekihara, S.; Kagechika, H.; Kojima S.
    Biochem. Biophys. Res. Chem. 2018, 504, 857-864.
    DOI: 10.1016/j.bbrc.2018.09.026

    (12) HX600, a synthetic agonist for RXR-Nurr1 heterodimer complex, preventsischemia-induced neuronal damage.
    Loppi, S.; Kolosowska, N.; Kärkkäinen, O.; Korhonen, P.; Huuskonen, M.; Grubman, A.; Dhungana, H.; Wojciechowski, S.; Pomeshchik, Y.; Giordano, M.; Kagechika, H.; White, A.; Auriola, S.; Koistinaho, J.; Landreth, G.; Hanhineva, K.; Kanninen, K.; Malm, T.
    Brain Behav. Immunol. 2018, 73, 670-681.
    DOI: 10.1016/j.bbi.2018.07.021

    (11) Development of novel inhibitors for histone methyltransferase SET7/9 based on cyproheptadine．
    Hirano, T.; Fujiwara, T.; Niwa, H.; Hirano, M.; Ohira, K.; Okazaki, Y.; Sato, S.; Umehara, T.; Maemoto, Y.; Ito, A.; Yoshida, M.; Kagechika, H.
    ChemMedChem 2018, 13, 1530-1540.
    DOI: 10.1002/cmdc.201800233



    (10) Novel non-steroidal progesterone receptor (PR) antagonists with a phenanthridinone skeleton.
    Nishiyama, Y.; Mori, S.; Makishima, M.; Fujii, S.; Kagechika, H.; Hashimoto, Y.; Ishikawa, M.
    ACS Med. Chem. Lett. 2018, 9, 641-645.
    DOI: 10.1021/acsmedchemlett.8b00058

    (9) Development of biotin-retinoid conjugates as chemical probes for analysis of retinoid function.
    Fujii, S.; Mori, S.; Kagechika, H.; Parra, M. A. M.*; Gronemeyer, H.
    Bioorg. Med. Chem. Lett. 2018, 28, 2442-2445.
    DOI: 10.1016/j.bmcl.2018.06.011



    (8) Efficient High-Throughput Screening by Endoplasmic Reticulum Ca2+ Measurement to Identify Inhibitors of Ryanodine Receptor Ca2+-Release Channels.
    Murayama, T.; Kurebayashi, Ishigami-Yuasa, M.; Mori, A.; Suzuki, Y.; Akima, R.; Ogawa, H.; Suzuki, J.; Kanemaru, K.; Oyamada, H.; Kiuchi, Y.; Iino, K.; Kagechika, H.; Sakurai, T.
    Mol. Pharmacol. 2018, 94, 722-730.
    DOI: 10.1124/mol.117.111468

    (7) Characterization and comparison of transcriptional activities of the retinoid X receptors by various organotin compounds in three prosobranch gastropods; Thais clavigera, Nucella lapillus and Babylonia japonica.
    Urushitani, H.; Katsu, Y.; Kagechika, H.; Sousa, A. C. A.; Barroso, C. M.; Ohta, Y.; Shiraishi, H.; Iguchi, T.; Horiguchi, T.
    Aquatic Toxicol. 2018, 199, 103-155.
    DOI: 10.1016/j.aquatox.2018.03.029

    (6) Prevention of hepatocellular carcinoma by targeting MYCN-positive liver cancer stem cells with acyclic retinoid.
    Qin, X.-Y.; Suzuki, H.; Honda, M.; Okada, H.; Kaneko, S.; Inoue, I.; Ebisui, E.; Hashimoto, K.; Carninci, P.; Kanki, K.; Tatsukawa, H.; Ishibashi, N.; Masaki, T.; Matsuura, T.; Kagechika, H.; Toriguchi, K.; Hatano, E.; Shirakami, Y.; Shiota, G.; Shimizu, M.; Moriwaki, H.; Kojima, S.
    Proc. Nat. Acad. Sci. USA 2018, 115, 4969-4974.
    DOI: 10.1073/pnas.1802279115

    (5) AKAPs-PKA disruptors increase AQP2 activity independently of vasopressin in a model of nephrogenic diabetes insipidus.
    Ando, F.; Mori, S.; Yui, N.; Morimoto, T.; Nomura, N.; Sohara, E.; Rai, T.; Sasaki, S.; Kondo, Y.; Kagechika, H.; Uchida, S.
    Nat. Commun. 2018, 9, 1411.
    DOI: 10.1038/s41467-018-03771-2

    (4) Identification of selective inhibitors for diffuse-type gastric cancer cells by screening of annotated compounds in preclinical models.
    Shimada, S.; Akiyama, Y.; Mogushi, K.; Ishigami-Yuasa, M.; Kagechika, H.; Nagasaki, H.; Fukamachi, H.; Yuasa, Y.; Tanaka, S.
    Br. J. Cancer 2018, 118, 972-984.
    DOI: 10.1038/s41416-018-0008-y

    (3) Conformational Properties of Aromatic Oligoamides Bearing Pyrrole Rings.
    Tojo, Y.; Urushibara, K.; Yamamoto, S.; Mori, H.; Masu, H.; Kudo, M.; Hirano, T.; Azumaya, I.; Kagechika, H.; Tanatani, A.
    J. Org. Chem. 2018, 83, 4606-4617.
    DOI: 10.1021/acs.joc.8b00349



    (2) Unique properties of 1,5-naphthyridin-2(1H)-one derivatives as environmental-polarity-sensitive fluorescent dyes.
    Yokoo, H.; Ohsaki, A.; Kagechika, H.; Hirano, T.
    Eur. J. Org. Chem. 2018, 16, 679-687.
    DOI: 10.1002/ejoc.201701609



    (1) Novel YAP1 Activator, Identified by Transcription-Based Functional Screen, Limits Multiple Myeloma Growth.
    Maruyama, J.; Inami, K.; Michishita, F.; Jiang, X. L.; Iwasa, H.; Nakagawa, K.; Ishigami-Yuasa, M.; Kagechika, H.; Miyamura, N.; Hirayama, J.; Nishina, H.; Nogawa, D.; Yamamoto, K.; Hata, Y.
    Mol. Cancer Res. 2018, 16, 197-211.
    DOI: 10.1158/1541-7786.

    2017年

    (14) Sucupiranins A−L, Furanocassane Diterpenoids from the Seeds of Bowdichia virgilioides.
    Endo,Y.; Kasahara,T.; Harada,K.; Kubo, M.; Etoh, T.; Ishibashi, M.; Ishiyama, A.; Iwatsuki, M.; Otoguro, K.; Ohmura, S.; Akisue, G.; Hirano, T.; Kagechika, H.; Fukuyama, Y.; Ohsaki, A.
    J. Nat. Prod    . 2017, 80, 3120-3127.
    DOI: 10.1021/acs.jnatprod.7b00249

    (13) Modulating Biocatalytic Activity toward Sterically Bulky Substrates in CO2-Expanded Biobased Liquids by Tuning the Physicochemical Properties.
    Hoang, H. N.; Granero-Fernandez, E.; Yamada, S.; Mori, S.; Kagechika, H.; Medina-Gonzalez, Y.; Matsuda, T.
    ACS Sus. Chem. Eng. 2017, 5, 11051-11059.
    DOI: 10.1021/acssuschemeng.7b03018

    (12) Crystal Engineering of N,N’-Diphenylurea Compounds Featuring Phenyl-Perfluorophenyl Interaction.
    Yamasaki, R.; Iida, M.; Ito, A.; Fukuda, K.; Tanatani, A.; Kagechika, H., Masu, H. Okamoto, I.
    Cryst. Growth Des. 2017, 17, 5858-5866.
    DOI: 10.1021/acs.cgd.7b00951

    (11) Novel non-steroidal progesterone receptor ligands based on m-carborane containing a secondary alcohol: effect of chirality on ligand activity.
    Mori, S.; Takagaki, R.; Fujii, S.; Urushibara, K.; Tanatani, A.; Kagechika, H.
    Chem. Pharm. Bull. 2017, 65, 1051-1057.
    DOI: 10.1248/cpb.c17-00544



    (10) Suppressive effects of RXR agonist PA024 on adrenal CYP11B2 expression, aldosterone secretion and blood pressure.
    Suzuki, D.; Saito-Hakoda, A.; Ito, R.; Shimizu, K.; Parvin, R.; Shimada, H.; Noro, E.; Suzuki, S.; Fujiwara, I.; Kagechika, H.; Rainey, W. E.; Kure, S.; Ito, S.; Yokoyama, A.; Sugawara, A.
    Plos ONE 2017, 12, e0181055.
    DOI: 10.1371/journal.pone.0181055

    (9) Selective Reagent for Detection of N-ε-Monomethylation of a Peptide Lysine Residue through SNAr Reaction.
    Mori, S.; Hirano T.; Takaguchi, A.; Fujiwara, T.; Okazaki, Y.; Kagechika, H.
    Eur. J. Org. Chem. 2017, 25, 3606-3611.
    DOI: 10.1002/ejoc.201700488



    (8) Development of WNK signaling inhibitors as a new class of antihypertensive drugs.
    Ishigami-Yuasa, M.; Watanabe, Y.; Mori, T.; Masuno, H.; Fujii, S.; Kikuchi, E.; Uchida, S.; Kagechika, H.
    Bioorg. Med. Chem. 2017, 25, 3845-3852.
    DOI: 10.1016/j.bmc.2017.05.034



    (7) Drug-Repositioning Screening for Keap1-Nrf2 Binding Inhibitors using Fluorescence Correlation Spectroscopy.
    Yoshizaki, Y.; Mori, T.; Ishigami-Yuasa, M.; Kikuchi, E.; Takahashi, D.; Zeniya, M.; Nomura, N.; Mori, Y.; Araki, Y.; Ando, F.; Mandai, S.; Kasagi, Y.; Arai, Y.; Sasaki, E.; Yoshida, S.; Kagechika, H.; Rai, T.; Uchida, S.; Sohara, E.
    Sci. Rep. 2017, 7, 3945.
    DOI: 10.1038/s41598-017-04233-3

    (6) Development of nonsteroidal glucocorticoid receptor modulators based on N-benzyl-N-(4-phenoxyphenyl)benzenesulfonamide scaffold.
    Yoshioka, H.; Yamada, A.; Nishiyama, Y.; Kagechika, H.; Hashimoto, Y.; Fujii, S.
    Bioorg. Med. Chem. 2017, 25, 3461-3470.
    DOI: 10.1016/j.bmc.2017.04.032



    (5) Retinoid derivative Tp80 exhibits anti-hepatitis C virus activity through restoration of GI-GPx expression.
    Nguyen, B. N.; Okuno, Y.; Ajiro, M.; Iida, K.; Denawa, M.; Yamamoto, M.; Sakamoto, N.; Kagechika, H.; Hagiwara, M.
    J. Med. Virol. 2017, 89, 1224-1234.
    DOI: 10.1002/jmv.24739

    (4) CO2-expanded bio-based liquids as novel solvents for enantioselective biocatalysis.
    Hoang, H. N.; Nagashima, Y.; Mori, S.; Kagechika, H.; Matsuda, T.
    Tetrahedron 2017, 73, 2984-2989.
    DOI: 10.1016/j.tet.2017.04.024

    (3) 9-cis Retinoic acid modulates myotrophin expression and its miR in physiological and pathophysiological cell models.
    Perri, M.; Caroleo, Nannan M. C.; Gallelli, L. L.; De Sarro, G.; Kagechika, H.; Cione, E.
    Exp. Cell Res. 2017, 354, 25-30.
    DOI: 10.1016/j.yexcr.2017.03.022

    (2) Identifying the receptor subtype selectivity of retinoid X and retinoic acid receptors via quantum mechanics.
    Tsuji, M.; Shudo, K.; Kagechika, H.
    FEBS Open Bio. 2017, 7, 391-396.
    DOI: 10.1002/2211-5463.12188

    (1) Down-regulation of histone deacetylase 4, －5 and －6 as a mechanism of synergistic enhancement of apoptosis in human lung cancer cells treated with the combination of a synthetic retinoid, Am80 and green tea catechin.
    Oya, Y.; Mondal, A.; Rawangkan, A.; Umsumarng, S.; Iida, K.; Watanabe, T.; Kanno, M.; Suzuki, K.; Li, Z.; Kagechika, H.; Shudo, K.; Fujiki, H.; Suganuma, M.
    J. Nutr. Biochem. 2017, 42, 7-16.
    DOI: 10.1016/j.jnutbio.2016.12.015

    2016年

    (6) Identification of Cyproheptadine as an Inhibitor of SET Domain Containing Lysine Methyltransferase 7/9 (Set7/9) That Regulates Estrogen-Dependent Transcription.
    Handa, N.; Umehara, T.; Sonoda, T.; Ogawa, K.; Tariq, M.; Nishino, N.; Dan, S.; Kagechika, H.; Yamori, T.; Yokoyama, S.; Yoshida, M.
    J. Med. Chem. 2016, 59, 3650-3660.
    DOI: 10.1021/acs.jmedchem.5b01732

    (5) Development of an “OFF-ON-OFF” fluorescent pH sensor suitable for the study of intracellular pH.
    Hirano, T.; Noji, Y.; Shiraishi, T.; Ishigami-Yuasa, M.; Kagechika, H.
    Tetrahedron 2016, 72, 4925-4930.
    DOI: 10.1016/j.tet.2016.06.065



    (4) Validation of chemical compound library screening for transcriptional co-activator with PDZ-binding motif inhibitors using GFP-fused transcriptional co-activator with PDZ-binding motif
    Nagashima, S.; Maruyama, J.; Kawano, S.; Iwasa, H.; Nakagawa, K.; Ishigami-Yuasa, M.; Kagechika, H.; Nishina, H.; Hata, Y.
    Cancer Sci. 2016, 107, 791-802.
    DOI: 10.1111/cas.12936

    (3) Steric structure–activity relationship of cyproheptadine derivatives as inhibitors of histone methyltransferase Set7/9.
    Fujiwara, T.; Ohira, K.; Urushibara, K.; Ito, A.; Yoshida, M.; Kanai, M.; Tanatani, A.; Kagechika, H.; Hirano, T.
    Bioorg. Med. Chem. 2016, 24, 4318-4323.
    DOI: 10.1016/j.bmc.2016.07.024



    (2) All trans-retinoic acid analogs promote cancer cell apoptosis through non-genomic Crabp1 mediating ERK1/2 phosphorylation.
    Persaud, S. D.; Park, S. W.; Ishigami-Yuasa, M.; Koyano-Nakagawa, N.;, Kagechika, H.; Wei, L.-N.
    Sci. Rep. 2016, 6, 22396.
    DOI: 10.1038/srep22396

    (1) Two new diterpenoids from Salvia przewarskii.
    Tsukada, H.; Kawabeb, H.; Ohtakac, A.; Saitod, Y.: Okamotoe, Y.: Torie, M.; Kagechika, H.; Hirotab, H.; Gongf, X.; Kurodac, C.; Ohsaki, A.
    Nat. Prod. Commun. 2016, 11, 159-161.
    DOI: 10.1177/1934578X1601100206

    2015年

    (14) Molecular mechanism by which acyclic retinoid induces nuclear localization of transglutaminase 2 in human hepatocellular carcinoma cells.
    Shrestha, R.; Tatsukawa, H.; Shrestha, R.; Ishibashi, N.; Matsuura, T.; Kagechika, H.; Kose, S.; Hitomi, K.; Imamoto, N.; Kojima, S.
    Cell Death Dis. 2015, 6, e2002.
    DOI: 10.1038/cddis.2015.339

    (13) Effects of RXR Agonists on Cell Proliferation/Apoptosis and ACTH Secretion/Pomc Expression.
    Saito-Hakoda, A.; Uruno, A.; Yokoyama, A.; Shimizu, K.; Parvin, R.; Kudo, M.; Saito-Ito, T.; Sato, I.; Kogure, N.; S uzuki, D.; Shimada, H.; Yoshikawa, T .; Fujiwara, I.; Kagechika, H.; Iwasaki, Y.; Kure, S.; Ito, S.; Sugawara, A.
    Plos ONE 2015, 10, e0141960.
    DOI: 10.1371/journal.pone.0145286

    (12) A Modified Murine Embryonic Stem Cell Test for Evaluating the Teratogenic Effects of Drugs on Early Embryogenesis.
    Yu. R.: Miyamura, N.; Okamoto-Uchida, Y.; Arima, N.; Ishigami-Yuasa, M.; Kagechika, H.; Nishina, H.
    Plos ONE 2015, 10, e0145286.
    DOI: 10.1248/bpb.b18-00782

    (11) A cell-based screening for TAZ activators identifies ethacridine, a widely used antiseptic and ab ortifacient, as a compound that promotes dephosphorylation of TAZ and inhibits adipogenesis in C3H10T1/2 cells.
    Kawano, S.; Maruyama, J.; Nagashima, S.; Inami, K.; Qiu, W.; Iwasa, H.; Nakagawa, K.; Ishigami-Yuasa, M.; Kagechika, H.; Nishina, H.; Hata, Y.
    J. Biochem. 2015, 158, 413-423.
    DOI: 10.1093/jb/mvv051

    (10) 6-Arylcoumarins: versatile scaffolds for fluorescent sensors.
    Shiraishi, T.; Kagechika, H.; Hirano, T.*
    New J. Chem. 2015, 39, 8389-8396.
    DOI: 10.1039/c5nj01609f



    (9) Docking simulations suggest that all-trans retinoic acid could bind to retinoid X receptors.
    Tsuji, M.; Shudo, K.; Kagechika, H.
    J. Comput. Aided Mol. Des. 2015, 29, 975-988.
    DOI: 10.1007/s10822-015-9869-9

    (8) A new cell-based assay to evaluate myogenesis in mouse myoblast C2C12 cells.
    Kodaka, M.; Yang, Z.; Nakagawa, K.; Maruyama, J.; Xu, X.; Sarkar, A.; Ichimura, A.; Nasu, Y.; Ozawa, T.; Iwasa, H.; Ishigami-Yuasa, M.; Ito, S.; Kagechika, H.; Hata, Y.
    Exp. Cell. Res. 2015, 336, 171-181.
    DOI: 10.1016/j.yexcr.2015.06.015

    (7) Carboxylic derivatives of vitamin K2 inhibit hepatocel lular carcinoma cell growth through caspase/transglutaminase-related signaling pathways.
    Qin, X.-Y.; Fujii, S.; Shimizu, A.; Kagechika, H.; KOJIMA, S.
    J. Nutr. Sci.Vitaminol. 2015, 61, 285-290.
    DOI: 10.3177/jnsv.61.285.

    (6) Design and synthesis of 4-benzyl-1-(2H)-phthalazinone derivatives as novel an drogen receptor antagonists.
    Inoue, K.; Urushibara, K.; Kanai, M.; Yura, K.; Fujii, S.; Ishigami-Yuasa, M.; Hashimoto, Y.; Mori, S.; Kawachi, E.; Matsumura, M.; Hirano, T.; Kagechik, H.; Tanatani, A.
    Eur. J. Med. Chem. 2015, 102, 310-319.
    DOI: 110.1016/j.ejmech.2015.08.002



    (5) Discovery of Novel SPAK Inhibitors That Block WNK Kinase Signaling to Cation Chloride Transporters.
    Nishiyama, S.; Urushibara, K.; Masu, H.; Azumaya, I.; Kagechika, H. Tanatani, A.
    J. Am. Soc. Nephrol. 2015, 26, 1525-1536.
    DOI: 10.1681/ASN.2014060560.

    (4) Conformational and chiral properties of cyclic-tri(N-methyl-meta-benzamide) bearing amidino groups.
    Inoue, K.; Urushibara, K.; Kanai, M.; Yura, K.; Fujii, S.; Ishigami-Yuasa, M.; Hashimoto, Y.; Mori, S.; Kawachi, E.; Matsumura, M.; Hirano, T.; Kagechik, H.; Tanatani, A.
    Chirality 2015, 27, 487-491.
    DOI: 10.1002/chir.22476

    (3) Systematic synthesis and anti-inflammatory activity of ω-carboxylated menaquinone derivatives - Investigations on identified and putative vitamin K2 metabolites.
    Fujii, S.; Shimizu, A.; Takeda, N.; Oguchi, K.; Katsurai, T.; Shirakawa, H.; Komai, M.; Kagechika, H.
    Bioorg. Med. Chem. 2015, 23, 2344-2352.
    DOI: 10.1016/j.bmc.2015.03.070



    (2) Retinoic acid receptor signaling is required to maintain glucose-stimulated insulin secretion and b-cell mass.
    Brun, P.-J.; Grijalva, A.; Rausch, R.; Watson, E.; Yuen, J. J.; Das, B. C.; Shudo, K.; Kagechika, H.; Leibel, R. L.; Blaner, W. S.
    FASEB J. 2015, 29, 671-683.
    DOI: 10.1096/fj.14-256743

    (1) Development of 1,3-diphenyladamantane derivatives as nonstero idal progesterone receptor antagonists.
    Mori, S.; Takeuchi, Y.; Tanatani, A.; Kagechika, H.; Fujii, S.
    Bioorg. Med. Chem. 2015, 23, 803-809.
    DOI: 10.1016/j.bmc.2014.12.047



    2014年

    (6) Retinoid X receptor a attenuates host antiviral response by suppressing type I interferon.
    Ma, F.; Liu, S.-Y.; Razani, B.; Arora, N.; Li, B.; Kagechika, H.; Tontonoz, P.; Nunez, V.; Ricote, M.; Cheng, G.
    Nat. Commun. 2014, 5, 5494.
    DOI: 10.1038/ncomms6494

    (5) Retinoic acid receptor-α up-regulates proopiomelanocortin gene expres sion in AtT20 corticotroph cells.
    Uruno, A.; Saito-Hakoda, A.; Yokoyama, A.; Kogure, N.; Matsuda, K.; Parvin, R.; Shimizu, K.; Sato, I.; Kudo, M.; Yoshikawa, T.; Kagechika, H.; Iwasaki, Y.; Ito, S.; Sugawara, A.
    Endocr. J. 2014, 61, 1105-1114.
    DOI: 10.1507/endocrj.EJ14-0115

    (4) Lipase-catalyzed asymmetric acylation of boron cluster-containing secondary alcohols.
    Mori, S.; Takagaki, R.; Fujii, S.; Matsumura, M.; Tanatani, A.; Kagechika, H.
    Tetrahedron Asy. 2014, 25, 1505-1512.
    DOI: 10.1016/j.tetasy.2014.10.009



    (3) Activation of liver X receptor suppresses the production of the IL-12 family of cytokines by blocking nuclear translocation of NF-kappa Bp50.
    Canavan, M.; McCarthy, C.; Ben Larbi, N.; Dowling, J. K.; Collins, L.; O'Sullivan, F.; Hurley, G.; Murphy, C.; Quinlan, A.; Moloney, G.; Darby, T.; MacSharry, J.; Kagechika, H.; Moynagh, P.; Melgar, S.; Loscher, C. E.
    Innate Immun.     2014, 20, 675-687.
    DOI: 10.1177/1753425913501915

    (2) Development of a novel fluorescent sensor to detect a specific range of pH.
    Shiraishi, T.; Saito, T.; Kagechika, H.; Hirano, T.
    Tetrahedron Lett. 2014, 55, 6784-6786.
    DOI: 10.1016/j.tetlet.2014.10.037



    (1) Structural development of p-carborane-based potent non-secosteroidal vitamin D analogs.
    Fujii, S.; Sekine, R.; Kano, A.; Masuno, H.; Songkram, C.; Kawachi, E.; Hirano, T.; Tanatani, A.; Kagechika, H.
    Bioorg. Med. Chem. 2014, 22, 589-5901.
    DOI: 10.1016/j.bmc.2014.09.020



    2013年

    (13) The Retinoic Acid Receptor Agonist Am80 Increases Mu cosal Inflammation in an IL-6 Dependent Manner During Trichuris muris Infection.
    Hurst, R. J. M.; De Caul, A.; Little, M. C.; Kagechika, H.; Else, K. J.
    J. Clin. Immunol. 2013, 33, 1386-1394.
    DOI:

    (12) Design and synthesis of 4-(4-benzoylaminophenoxy)phenol derivatives as androgen receptor antagonists.
    Yamada, A.; Fujii, S.; Mori, S.; Kagechika, H.
    ACS Med. Chem. Lett. 2013, 4, 937-941.
    DOI: 10.1021/ml4001744



    (11) Crystal structures of complexes of vitamin D receptor ligand-binding domain with lithocholic acid derivatives.
    Masuno, H.; Ikura, T.; Morizono, D.; Orita, I.; Yamada, S.; Shimizu, M.; Ito, N.
    J. Lipid Res.     2013, 54, 2206-2213.
    DOi: 10.1194/jlr.M038307

    (10) Synthesis of porphyrinylamide and observation of N-methylation-induced trans-cis amide conformational alteration.
    Matsumura, M.; Tanatani, A.; Kaneko, T.; Azumaya, I.; Masu, H.; Hashizume, D.; Kagechika, H.; Muranaka, A.; Uchiyama, M.
    Tetrahedron 2013, 69, 10927-10932.
    DOI: 10.1016/j.tet.2013.10.069

    (9) Chemical library screening for WNK signalling inhibitors using fluorescence correlation spectroscopy.
    Mori, T.; Kikuchi, E.; Watanabe, Y.; Fujii, S.; Ishigami?Yuasa, M.; Kagechika, H.; Sohara, E.; Rai, T.; Sasaki, S.; Uchida, S.
    Biochem. J. 2013, 455, 339-345.
    DOI: 10.1042/BJ20130597

    (8) Retinoid X Receptor Agonists Modulate Foxp3 + Regulatory T Cell and Th17 Cell Differentiation with Differential Dependence on Retinoic Acid Receptor Activation.
    Takeuchi, H.; Yokota-Nakatsuma, A.; Ohoka, Y.; Kagechika, H.; Kato, C.; Si-Young Song, S.-Y.; Iwata, M.
    J. Immunol. 2013, 191, 3725-3733.
    DOI: 10.4049/jimmunol.1300032

    (7) Copper-mediated C-C cross-coupling reaction of monocarba-closo-dodecaborate anion for construction of functional molecules.
    Kanazawa, J.; Takita, R.; Jankowiak, A.; Fujii, S.; Kagechika, H.; Hashizume, D.; Shudo, K.; Kaszy?ski, P.; Uchiyama, M.
    Angew. Chem. Int. Ed. 2013, 52, 8017-8021.
    DOI: 10.1002/anie.201302448

    (6) Molecular mechanism of 9-cis-retinoic acid inhibition of adipogenesis in 3T3-L1 cells.
    Sagara, C.; Takahashi, K.; Kagechika, H.; Takahashi, N.
    Biochem. Biophys. Res. Commun. 2013, 433, 102-107.
    DOI: 10.1016/j.bbrc.2013.02.057

    (5) Cellular retinoic acid binding protein I mediates rapid non-canonical activation of ERK1/2 by all-trans retinoic acid.
    Persaud, S. D.; Lin, Y.-W.; Wu, C.-Y.; Kagechika, H.; Wei, L.-N.
    Cell. Signal. 2013, 25, 19-25.
    DOI: 10.1016/j.cellsig.2012.09.002

    (4) Unusual conformational preference of an aromatic secondary urea: solvent-dependent open- closed conformational switching of N,N’-bis(porphyrinyl)urea.
    Matsumura, M.; Tanatani, A.; Azumaya, I.; Masu, H.; Hashizume, D.; Kagechika, H.; Muranaka, A.; Uchiyama, M.
    Chem. Commun. 2013, 49, 2290-2292.
    DOI: 10.1039/C2CC37583D

    (3) Structures of histone methyltransferase SET7/9 in complexes with adenosylmethionine derivatives.
    Niwa, H.; Handa, N.; Tomabechi, Y.; Honda, K.; Toyama, M.; Ohsawa, N.; Shirouzu, M.; Kagechika, H.; Hirano, T.; Umehara, T.; Yokoyama, S.
    Acta Cryst. 2013, D69, 595-602.
    DOI: 10.1107/S0907444912052092

    (2) Increased Hydrophobicity and Estrogenic Activity of Simple Phenols with Silicon and Germanium-Containing Substituents.
    Fujii, S.; Miyajima, Y.; Masuno, H.; Kagechika, H.
    J. Med. Chem. 2013, 56, 160-166.
    DOI: 10.1021/jm3013757



    (1) Structure-activity relationship study on benzoic acid part of diphenylamine-based retinoids.
    Ohta, K.; Kawachi, E.; Shudo, K.; Kagechika, H.
    Bioorg. Med. Chem. Lett. 2013, 23, 81-84.
    DOI: 10.1016/j.bmcl.2012.11.008



    2012年

    (12) The retinoic acid receptor agonist Am80 increases mucosal inflammation during an intestinal helminth infection of mice.
    Hurst, R. J. M.; Bell, L. V.; de Caul, A.; Kagechika, H.; Else, K.
    J. Immunology 2012, 137, 125-126.
    DOI: 10.1007/s10875-013-9936-8

    (11) Fluorescent properties of coumarins with dual functions constructed by two sequential reactions.
    Hirano, T.; Kubo, H.; Shiraishi, T.; Hiromoto, K.; Fujiwara, T.; Kagechika, H.
    Tetrahedron Lett. 2012, 53, 5916-5919.
    DOI: 10.1016/j.tetlet.2012.08.085



    (10) A Fluorescent Alkaloid from Quassia amara and Its Properties in Living Cells.
    Taniguchi, K.; Takizawa, S.; Hirano, T.; Murata, S.; Kagechika, H.; Kishida, A.; Ohsaki. A.
    ChemPlusChem 2012, 77, 427-431.
    DOI: 10.1002/cplu.201200016

    (9) Redox-responsive conformational alteration of aromatic amides bearing N-quinonyl system.
    Okamoto, I.; Takahashi, Y.; Sawamura, M.; Matsumura, M.; Masu, H.; Katagiri, K.; Azumaya, I.; Nishino, M.; Kohama, Y.; Morita, N.; Tamura, O.; Kagechika, H.; Tanatani, A.
    Tetrahedron 2012, 68, 5346-5355.
    DOI: 10.1016/j.tet.2012.04.114



    (8) Development of androgen receptor ligands by application of ten-vertex para-carborane as a novel hydrophobic core structure.
    Fujii,S.; Ohta, K.; Goto, T.; Oda, A.; Masuno, H.; Endo, Y.; Kagechika, H.
    Med. Chem. Commun. 2012, 3, 680-684.
    DOI: 10.1039/C2MD00294A



    (7) Retinoic acid receptor agonists regulate expression of ATP-binding cassette transporter G1 in macrophages.
    Ayaori, M.; Yakushiji, E.; Ogura, M.; Nakaya, K.; Hisada, T.; Uto- Kondo, H.; Takiguchi, S.; Terao, Y.; Sasaki, M.; Komatsu, T.; Iizuka, M.; Yogo, M.; Uehara, Y.; Kagechika, H.; Nakanishi, T.; Ikewaki, K.
    Biochim. Biophys. Acta- Mol Cell Biol. Lipids 2012, 1821, 561-572.
    DOI: 10.1016/j.bbalip.2012.02.004

    (6) Synthesis and helical properties of aromatic multilayered oligoureas.
    Kudo, M.; Katagiri, K.; Azumaya, I.; Kagechika, H.; Tanatani, A.
    Tetrahedron 2012, 68, 4455-4463.
    DOI: 10.1016/j.tet.2011.12.038



    (5) Molecular Chirality and Chiral Capsule-type Dimer Formation of Cyclic Triamides via Hydrogen-Bonding Interactions.
    Fujimoto, N.;Matsumura, M.;Azumaya, I.; Nishiyama, S.; Masu, H.;Kagechika, H.; Tanatani, A.
    Chem. Commun. 2012, 48, 4809-4811.
    DOi: 10.1039/C2CC18177K



    (4) Solvent-dependent conformational and fluorescence change of an N-phenylbenzohydroxamic acid derivative bearing two pyrene moieties.
    Kanai, M.; Hirano, T.; Azumaya I.; Okamoto I.; Kagechika H.; Tanatani, A.
    Tetrahedron 2012, 68, 2778-2783.
    DOI: 10.1016/j.tet.2012.02.012



    (3) RXR antagonism induces G0/G1 cell cycle arrest and ameliorates obesity by up-regulating the p53.p21Cip1 pathway in adipocytes.
    Nakatsuka, A.; Wada, J.; Hida, K.; Hida, A.; Eguchi, J.; Teshigawara, S.; Murakami, K.; Kanzaki, M.; Inoue, K.; Terami, T.; Katayama, A.; Ogawa, D.; Kagechika, H.; Makino, H.
    J. pathology 2012, 226, 784-795.
    DOI: 10.1002/path.3001

    (2) NR4A nuclear receptors mediate carnitine palmitoyltransferase 1A gene expression by the rexinoid HX600.
    Ishizawa, M. Kagechika, H.; Makishima, M.
    Biochem. Biophys. Res. Commun. 2012, 418, 780-785.
    DOI: 10.1016/j.bbrc.2012.01.102

    (1) Novel vitamin D receptor ligands bearing a spherical hydrophobic core structure-Comparison of bicyclic hydrocarbon derivatives with boron cluster derivatives.
    Wongmayura, A.; Fujii, S.; Ito, S.; Kano, A.; Taoda, Y.; Kawachi, E.; Kagechika, H.; Tanatani, A.
    Bioorg. Med Chem. Lett. 2012, 22, 1756-1760.
    DOI: 10.1016/j.bmcl.2011.12.137



    2011年

    (15) Boron Cluster-based Development of Potent Non-Secosteroidal Vitamin D Receptor Ligands: Direct Observation of Hydrophobic Interaction between Protein Surface and Carborane.
    Fujii, S.; Masuno, H.; Taoda, H.; Kano, A.; Wongmayura, A.; Nakabayashi, M.; Ito, N.; Shimizu, M.; Kawachi, E.; Hirano, T.; Endo, Y.; Tanatani, A.; Kagechika, H.
    J. Am. Chem. Soc. 2011, 133, 20933-20941.
    DOI: 10.1021/ja208797n



    (14) Synthesis of soluble aromatic multilayered tetra(m-phenylurea) and analysis of its helical conformation in various solvents.
    Kudo, M.; Azumaya, I.; Kagechika, H.; Tanatani, A.
    Chirality 2011, 1E, E84-E90.
    DOI: 10.1002/chir.21010

    (13) 6-Arylcoumarins as novel nonsteroidal type progesterone antagonists: An example with receptor-binding- dependent fluorescence.
    Sakai,H.; Hirano, T.; Mori,S.; Fujii, S.; Masuno, H.; Kinoshita, M.; Kagechika, H.; Tanatani, A.
    J. Med. Chem.     2011, 54, 7055-7065.
    DOI: 10.1021/jm2005404



    (12) Crystal structure, docking study and structure-activity relationship of carborane-containing androgen receptor antagonist 3-(12-hydroxymethyl-1,12-dicarba-closo- dodecarboran-1-yl)benzonitrile.
    Ohta, K., Goto, T., Fujii, S., Kawahata, M., Oda, A., Ohta, S., Yamaguchi, K., Hirono, S., Endo, Y.
    Bioorg. Med. Chem. 2011, 19, 3540-3548.
    DOI: 10.1016/j.bmc.2011.04.017

    (11) p-Carborane-based androgen antagonists active in LNCaP cells with a mutated androgen receptor.
    Fujii, S.; Yamada, A.; Tomita, K.; Nagano, M.; Goto, T.; Ohta, K.; Harayama, T.; Endo, Y.; Kagechika, H.
    Med. Chem. Commun. 2011, 2, 877.
    DOI: 10.1039/C1MD00001B



    (10) Efficient and diversity-oriented total synthesis of Riccardin C and application to develop novel macrolactam derivatives.
    Iwashita, M.; Fujii, S.; Ito, S.; Hirano, T.; Kagechika, H.
    Tetrahedron 2011, 67, 6073-6082.
    DOI: 10.1016/j.tet.2011.06.018



    (9) All-trans retinoic acid and a novel synthetic retinoid tamibarotene (Am80) differentially regulate CD38 expression in human leukemia HL-60 cells: possible involvement of protein kinase C-delta.
    Uruno, A.; Noguchi, N.; Matsuda, K.; Nata, K.; Yoshikawa, T.; Chikamatsu, Y.; Kagechika, H.; Harigae, H.; Ito, S.; Okamoto, H.; Sugawara, A.
    J. Leukocyte Biol. 2011, 90, 235-247.
    DOI: 10.1189/jlb.0109025

    (8) MyD88 and Retinoic Acid Signaling Pathways Interact to Modulate Gastrointestinal Activities of Dendritic Cells.
    Villablanca, E. J.; Wang, S.; de Calisto, J.; Gomes, D. C. O.; Kane, M. A.; Napoli, J. L.; Blaner, W. S.; Kagechika, H.; Blomhoff, R.; Rosemblatt, M.; Bono, M. R.; von Andrian, U. H.; Mora, J. R.
    Gastroenterology 2011, 141, 176-185.
    DOI: 10.1053/j.gastro.2011.04.010

    (7) c-Jun N-terminal kinase activation by oxidative stress suppresses retinoid signaling through proteasomal degradation of retinoic acid receptor alpha protein in hepatic cells.
    Hoshikawa, Y.; Kanki, K.; Ashla, A.A.; Arakaki, Y.; Azumi, J.; Yasui, T.; Tezuka, Y.; Matsumi, Y.; Tsuchiya, H.; Kurimasa, A.; Hisatome, I.; Hirano, T.; Fujimoto, J.; Kagechika, H.; Shomori, K.; Ito, H.; Shiota, G.
    Cancer Sci. 2011, 102, 934-941.
    DOI: 10.1111/j.1349-7006.2011.01889.x

    (6) Crystal structure of spherical aromatic amide: pseudopolymorphs and formation of infinite water cluster in the channel structure.
    Masu, H.; Sagara, Y.; Imabeppu, F.; Takayanagi, H.; Katagiri, K.; Kawahata, M.; Tominaga, M.; Kagechika, H.; Yamaguchi, K.; Azumaya, I.
    CrystEngComm 2011, 13, 406-409.
    DOI: 10.1039/C0CE00301H

    (5) Hmx4 regulates Sonic hedgehog signaling through control of retinoic acid synthesis during forebrain patterning.
    Gongal, P. A.; March L. D.; Holly V. L.; Pillay L. M.; Berry-Wynne K. M.; Kagechika, H.; Waskiewicz, A.
    J. Div. Biol. 2011, 355, 55-64.
    DOI: 10.1016/j.ydbio.2011.04.018

    (4) Diphenylamine-based Retinoid Antagonists: Regulation of RAR and RXR Function Depending on the N-Substituent.
    Ohta, K.; Kawachi, E,; Fukasawa H,; Shudo, K.; Kagechika, H.
    Bioorg. Med. Chem. 2011, 19, 2501-2507.
    DOI: 10.1016/j.bmc.2011.03.026



    (3) Retinoid X receptor gamma signaling accelerates CNS remyelination.
    Huang, J. K.; Jarjour, A. A.; Nait-Oumesmar, B.; Kerninon, C.; Williams, A. Krezel, W.; Kagechika, H.; Bauer, J.; Zhao, C.; Baron-Van Evercooren, A.; Chambon, P.; ffrench-Constant, C.; Franklin, R. J. M.
    Nature Neurosci. 2011, 14, 45-53.
    DOI: 10.1038/nn.2702

    (2) Tributyltin chloride induces ABCA1 expression and apolipoprotein A-I -mediated cellular cholesterol efflux by activating LXRalpha/RXR.
    Cui, H.; Okuhira, K.; Ohoka, N.; Naito, M.; Kagechika, H.; Hirose, A,; Nishimaki-Mogami, T.
    Biochem. Pharmacol. 2011, 81, 819-824.
    DOI: 10.1016/j.bcp.2010.12.023

    (1) Calix[3]amide-based anion receptors: High affinity for fluoride ion and a twisted binding model.
    Katagiri, K.; Furuyama, T.; Masu, H.; Kato, T.; Matsumura, M.; Uchiyama, M.; Tanatani, A.; Tominaga, M.; Kagechika, H.; Yamaguchi, K.; Azumaya, I.
    Supramol. Chem. 2011, 23, 125-130.
    DOI: 10.1080/10610278.2010.514909

    2010年

    (13) Modulation of intramolecular heterodimer-induced fluorescence quenching of tricarbocyanine dye for the development of fluorescent sensors.
    Hirano, T.; Akiyama, J.; Mori, S.; Kagechika, H.
    Org. Biomol. Chem.     2010, 8, 5568-5575.
    DOI: 10.1039/C0OB00207K



    (12) Design and Synthesis of Novel Retinoid Synergists having a Dibenzodiazepine Skeleton.
    Ohta, K.; Kawachi, E.; Shudo, K.; Kagechika, H.
    Heterocycles 2010, 81, 2465-2470.
    DOI: 10.1002/chin.201112175

    (11) Design and synthesis of androgen receptor full antagonists bearing a p-carborane cage: Promising ligands for anti-androgen withdrawal syndrome.
    Goto, T.; Ohta, K.; Fujii, S.; Ohta, S.; Endo, Y.
    J. Med. Chem.     2010, 53, 4917-4926.
    DOI: 10.1021/jm100316f



    (10) Synthesis and Biological Activity of Fluorinated Vitamin D.
    Fujishima, T.; Fujii, S.; Harayama, T.
    Curr. Org. Chem. 2010, 14, 962-976.
    DOI: 10.2174/138527210791111786

    (9) Development of novel bisubstrate-type inhibitors of histone methyltransferase SET7/9.
    Mori, S.; Iwase, K.; Iwanami, N.; Tanaka, Y.; Kagechika, H.; Hirano, T.
    Bioorg. Med. Chem. 2010, 18, 8158-8168.
    DOI: 10.1016/j.bmc.2010.10.022



    (8) Efficient Induction of CCR9 on T Cells Requires Coactivation of Retinoic Acid Receptors and Retinoid X Receptors (RXRs): Exaggerated T Cell Homing to the Intestine by RXR Activation with Organotins.
    Takeuchi, H.; Yokota, A.; Ohoka, Y.; Kagechika, H.; kato, C.; Song, S.-Y.; Iwata, M.
    J. Immunol. 2010, 185, 5289-5299.
    DOI: 10.4049/jimmunol.1000101

    (7) Cyclic-tri(N-methyl-meta-benzamide)s: substituent effects on the bowl- shaped conformation in the crystal and solution states.
    Kakuta, H.; Azumaya, I.; Masu, H.; Matsumura, M.; Yamaguchi, K.; Kagechika, H.; Tanatani, A.
    Tetrahedron 2010, 66, 8254-8260.
    DOI: 10.1016/j.tet.2010.08.049



    (6) Retinoic Acid Induces Expression of the Thyroid Hormone Transporter, Monocarboxylate Transporter 8 (Mct8).
    Kogai, T.; Liu, Y.-Y.; Richter, L. L.; Mody, K.; Kagechika, H.; Bent, G. A.
    J. Biol. Chem. 2010, 285, 27279-27288.
    DOI: 10.1074/jbc.M110.123158

    (5) Effect of oxygen substituent in the aniline part of benzanilide on the regioselectivity in direct arylation using palladium-phosphine reagents.
    Harayama, T.; Asai, M.; Miyagoe, T.; Abe, H.; Takeuchi, Y.; Yamaguchi, A.; Fujii, S.
    Heterocycles 2010, 81, 1881-1889.
    DOI: 10.3987/COM-10-11982



    (4) In Vitro Murine Spermatogenesis in an Organ Culture System.
    Gohbara, A.; Katagiri, K.; Sato, T.; Kubota, Y.; Kagechika, H.; Araki, Y.; Araki, Y.; Ogawa, T.
    Biol. Reprod. 2010, 83, 262-267.
    DOI: 10.1095/biolreprod.110.083899

    (3) Latent Enamine Functionality of 5-Methyl-2,3-dihydropyradines.
    Ito, S.; Hirano, T.; Sugimoto, A.; Kagechika, H.; Takeuchi, S.; Yamaguchi, T.
    Chem. Pharm. Bull. 2010, 58, 885-1002.
    DOI: 10.1248/cpb.58.922

    (2) Inhibition of Mammary Carcinoma Cell Growth by RXR is Mediated by the Receptor's Oligomeric Switch.
    Yasmin, R.; Kannan-Thulasiraman, P.; Kagechika, H.; Dawson, M. I.; Noy, N.
    J. Mol. Biol. 2010, 397, 1121-1131.
    DOI: 10.1016/j.jmb.2010.02.030

    (1) Enhancement of imatinib-induced apoptosis of BCR/ABL-expressing cells by nutlin-3 through synergistic activation of the mitochondrial apoptoic pathway.
    Kurosu, T.; Wu, N.; Oshikawa, G.; Kagechika, H.; Miura, O.
    Apoptosis     2010, 15, 608-620.
    DOI: 10.1007/s10495-010-0457-0

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