研究業績 Publication （1991年～2009年）
- 2020年～
- 2010年～2019年
- 総説 Review
2009年
(12) Activation of Testicular Orphan Receptor 4 by Fatty Acids.
Tsai, N.-P.; Huq, M.; Gupta, P.; Yamamoto, K.; Kagechika, H.; Wei, L.-N.
Biochim. Biophys. Acta- Gene Regul. Mech. 2009, 1789, 734-740
DOI: 10.1016/j.bbagrm.2009.09.010
(11) Identification of Absolute Helical Structures of Aromatic Multi-layered Oligo(m-phenylurea)s in solution
Kudo, M.; Hanashima, T.; Muranaka, A.; Sato, H.; Uchiyama, M.; Azumaya, I.; Hirano, T.; Kagechika, H.; Tanatani, A.
J. Org. Chem. 2009, 74, 8154-8163.
DOI: 10.1021/jo901934r
(10) Hypoxia-Inducible Factor-3α Functions as an Accelerator of 3T3-L1 Adipose Differentiation.
Hatanaka, M.; Shimba, S.; Sakaue, M.; Kondo, Y.; Kagechika, H.; Kokame, K.; Miyata, T.; Hara, S.
Biol. Pharm. Bull. 2009, 32, 1166-1172.
DOI: 10.1248/bpb.32.1166
(9) Docosahexaenoic acid induces adipose differentiation-related protein through activation of retinoid X receptor in human choriocarcinoma BeWo cells.
Suzuki, K.; Takahashi, K.; Nishinaki-Mogami, T.; Kagechika, H.; Yamamoto, M.; Itabe, H.
Biol. Pharm. Bull. 2009, 32, 1177-1182.
DOI: 10.1248/bpb.32.1177
(8) Encapsulation of the synthetic retinoids Am80 and LE540 into polymeric micelles and the retinoids' rerease control.
Satoh, T.; Higuchi, Y.; Kawakami, S.; Hashida, M.; Kagechika, H.; Shudo, K.; Yokoyama, M.
J. Controlled Release. 2009, 136, 187-195.
DOI: 10.1016/j.jconrel.2009.02.024
(7) Sorafenib induces apoptosis specifically in cells expressing BCR/ABL by inhibiting its kinase activity to activate the intrinsic mitochondrial pathway.
Kurosu, T.; Ohki, M.; Wu, N.; Kagechika, H.; Miura, O.
Cancer Res. 2009, 69, 3927-3936.
DOI: 10.1158/0008-5472.CAN-08-2978
(6) Activation of the PI3 Kinase Pathway By Retinoic Acid Mediates Sodium/Iodide Symporter Induction and Iodide Transport in MCF-7 Breast Cancer Cells.
Ohashi, E.; Kogai, T.; Kagechika, H.; Brent, G. A.
Cancer Res. 2009, 69, 3443-3450.
DOI: 10.1158/0008-5472.can-08-3234
(5) The transcriotion factors Nur77 and retinoid X receptors participate in amphetamine-induced locomotor activities.
Bourhis E1, Maheux J, Paquet B, Kagechika H, Shudo K, Rompré PP,Rouillard C, Lévesque D.
Psychopharmacol, 2009, 202, 6335-648.
DOI: 10.1007/s00213-008-1343-0
(4) ApoC-III gene expression is sharply increased during adipogenesis and is augmented by retinoid X receptor (RXR) agonists.
Takahashi, Y.; Inoue, J.; Kagechika, H.; Sato, R.
FEBS Lett. 2009, 583, 493-497.
DOI: 10.1016/j.febslet.2008.12.050
(3) Contribution of AP-1 interference induced by TAC-101 to tumor growth suppression in a hepatocellular carcinoma model.
Eshima, K.; Fukaya S.; Sugimoto, A.; Mori, T.; Yokoi, H.; Yamamoto, Y.; Sugiura, S.; Honda, S.; Masuko, N.; Murakami, K.; Yamasaki, Y.; Kagechika, H.
Tumor Biol. 2009, 30, 1-7.
DOI: 10.1159/000189712
(2) Fluorescent visualization of the conformational change of aromatic amide or urea induced by N-methylation.
Hirano, T.; Osaki, T.; Fujii, S.; Komatsu, D.; Azumaya, I.; Tanatani, A.; Kagachika, H.
Tetrahedron Lett. 2009, 50, 488-491.
DOI: 10.1016/j.tetlet.2008.11.044
(1) Acidic heterocycles as novel hydrophilic pharmacophore of androgen receptor ligands with a carborane core structure.
Fujii, S.; Ohta, K.; Goto, T.; Kagechika, H.; Endo, Y.
Bioorg. Med. Chem. 2009, 17, 344-350.
DOI: 10.1016/j.bmc.2008.10.060(1) 13-cis-Retinoic acid alters the cellular morphology of slice-cultured serotonergic neurons in the rat.
2008年
(6) The RXR agonists PA024 and HX630 have different abilities to activate LXR/RXR and to induce ABCA1 expression in macrophage cell line.
Nishimaki-Mogami, T.; Tamehiro, N.; Sato, Y.; Okuhira, K.; Sai, K.; Kagechika, H.; Shudo, K.; Abe-Dohmae, S.; Yokoyama, S.; Ohno, Y.; Inoue, K.; Sawada, J.
Biochem. Pharmacol. 2008, 76, 1006-1013.
DOI: 10.1016/j.bcp.2008.08.005
(5) Polymorphism and Pseudopolymorphism of an Aromatic Amide: Spontaneous Resolution and Crystal-to-Crystal Phase Transition.
Kato, T.; Okamoto, I.; Masu, H.; Katagiri, K.; Tominaga, M.; Yamaguchi, K.; Kagechika, H.; Azumaya,
I. Cryst. Growth Des. 2008, 8, 3871-3877.
DOI: 10.1021/cg800658t
(4) Effects of retinoic acids on the dendritic morphology of cultured hippocampal meurons.
Liu, Y.; Kagechika, H.; Ishikawa, J.; Hirano, H.; Matsukuma, S.; Tanaka, K.; Nakamura, S.
J. Neurochem. 2008, 106, 1104-1116.
DOI: 10.1111/j.1471-4159.2008.05445.x
(3) Chiral Spherical Molecules Constructed from Aromatic Amides: Facile Synthesis and Highly Ordered Network Structure in the Crystal.
Masu, H.; Katagiri, K.; Kato, T.; Kagechika, H.; Tominaga, M.; Azumaya, I.
J Org. Chem. 2008, 73, 5143-5146.
DOI: 10.1021/jo800585h
(2) Identification of An Intermediate in the Deboronation of ortho-Carborane: An Adduct of ortho-Carborane with Two Nucleophiles on One Boron Atom.
Taoda, Y.; Sawabe, T.; Endo, Y. Yamaguchi, K.; Fujii, S.; Kagechika, H.
Chem. Commun. 2008, 7, 2049-2051.
DOI: 10.1039/b716079h
Ishikawa, J.; Sutoh, C.; Ishikawa, A.; Kagechika, H.; Hirano, H.; Nakamura, S.
Eur. J. Neurosci. 2008, 27, 2363-2372.
DOI: 10.1111/j.1460-9568.2008.06191.x
2007年
(7) Redox-Induced Conformational Alteration of N,N-Diarylamides.
Okamoto, I.; Yamasaki, R.; Sawamura, M.; Kato, T.; Nagayama, N.; Takeya, T.; Tamura, O.; Masu, H.; Azumaya, I.; Yamaguchi, K.; Kagechika, H.; Tanatani, A.
Org. Lett. 2007, 9, 5545-5547.
DOI: 10.1021/ol702504x
(6) β-Cryptoxanthin, a novel natural RAR ligand, induces ATP-binding cassette transporters in macrophages.
Matsumoto, A.; Mizukami, H.; Mizuno, S.; Umegaki, K.; Nishikawa, J.; Shudo, K.; Kagechika, H.; Inoue, M.
Biochem. Pharmacol. 2007, 74, 256-264.
DOI: 10.1016/j.bcp.2007.04.014
(5) Effects of retinoic acids on the dendritic morphology of cultured hippocampal meurons.
Liu, Y.; Kagechika, H.; Ishikawa, J.; Hirano, H.; Matsukuma, S.; Tanaka, K.; Nakamura, S.
J. Neurochem. 2007, 106, 1104-1116.
DOI: 10.1111/j.1471-4159.2008.05445.x
(4) STAT5α/PPARγ Pathway Regulates Involucrin Expression in Keratinocyte Differentiation.
Dai, X.; Sayama, K.; Shirakata, Y.; Hanakawa, Y.; Yamasaki, K.; Tokumaru, S.; Yang, L.; Wang, X.; Hirakawa, S.; Tohyama, M.; Yamauchi, T.; Kadowaki, T.; Kagechika, H.; Hashimoto, K.
J. Invest. Dermatol. 2007, 127, 1728-1735.
DOI: 10.1038/sj.jid.5700758
(3) Novel Thyroid Hormone Receptor Antagonists With An N-Alkylated Diphenylamine Skeleton.
Komatsu, T.; Hirano, T.; Songkram, C.; Kawachi, E.; Kagechika, H.
Bioorg. Med. Chem. 2007, 15, 3115-3126.
DOI: 10.1016/j.bmc.2007.02.053
(2) Development of a Library of 6-Arylcoumarins as Candidate Fluorescent Sensors.
Hirano, T.; Hiromoto, K.; Kagechika, H.
Org. Lett. 2007, 9, 1315-1318.
DOI: 10.1021/ol070142z
(1) All-trans Retinoic Acid Induces In Vitro Angiogenesis via Retinoic Acid Receptor: Possible Involvement of Paracrine Effects of Endogenous Vascular Endothelial Growth Factor Signaling.
Saito, A.; Sugawara, A.; Uruno, A.; Kudo, M.; Kagechika, H.; Sato, Y.; Owada, Y.; Kondo, H.; Sato, M.; Kurabayashi, M.; Imaizumi, M.; Tsuchiya, S.; Ito, S.
Endocrinology 2007, 148, 1412-1423.
DOI: 10.1210/en.2006-090n
2006年
(9) Construction of anomalously bent biphenyl structure using conformational properties of calix[4]amide.
Tominaga, M.; Hatano, T.; Uchiyama, M.; Masu, H.; Kagechika, H.; Azumaya, I.
Teterahedron Lett. 2006, 47, 9369-9371.
DOI: 10.1016/j.tetlet.2006.10.062
(8) A New RXR Agonist, HX630, suppresses intimal hyperplasia in a mouse blood flow cessation model.
Haraguchi, G.; Suzuki, J.; Kosuge, H.; Ogawa, M.; Koga, N.; Muto, S.; Itai, A.; Kagechika, H.; Shudo, K.; Isobe, M.
J. Mol. Cell. Cardiol. 2006, 41, 885-892.
DOI: 10.1016/j.yjmcc.2006.07.022
(7) Spontaneous Resolution of Aromatic Sulfonamides: Effective Screening Method and Discrimination of Absolute Structure.
Kato, T.; Okamoto, I.; Tanatani, A.; Hatano, T.; Uchiyama, M.; Kagechika, H.; Masu, H.; Katagiri, K.; Tominaga, M.; Yamaguchi, K.; Azumaya, I.
Org. Lett. 2006, 8, 5017-5020.
DOI: 10.1021/ol061731s
(6) Retinoids Induce Growth Inhibition and Apoptosis in Mast Cell Tumor Cell Lines.
Ohashi , E.; Miyajima, N.; Nakagawa, T.; Takahashi, T.; Kagechika, H.; Mochizuki, M.; Nishimura, R.; Sasaki, N.
J. Vet. Med. Sci. 2006, 68, 797-802.
DOI: 10.1292/jvms.68.797
(5) Solvent-Dependent Conformational Switching of N-Phenylhydroxamic Acid and Its Application in Crystal Engineering.
Yamasaki, R.; Tanatani, A.; Azumaya, I.; Masu, H.; Yamaguchi, K.; Kagechika, H.
Crystal Growth Des. 2006, 6, 2007-2010.
DOI: 10.1021/cg060151z
(4) Genetic and pharmacological evidence that a retinoic acid cannot be the RXR-activating ligand in mouse epidermis keratinocytes.
Calleja, C.; Messaddeq, N.; Chapellier, B.; Yang, H.; Krezel, W.; Li, M.; Metzger, D.; Mascrez, B.; Ohta, K.; Kagechika, H.; Endo, Y.; Mark, M.; Ghyselinck, N. B.; Chambon, P.
Genes Develop. 2006, 20, 1525-1538.
DOI: 10.1101%2Fgad.368706
(3) The synthetic retinoid Am80 reduces scavenger receptor expression and atherosclrosis in mice by inhibiting IL-6.
Takeda, N.; Manabe, I.; Shindo, T.; Iwata, H.; Iimuro, S.; Kagechika, H.; Shudo, K.; Nagai, R. Arterioscl. Thromb. Vas. 2006, 26, 1177-1183.
DOI: 10.1161/01.atv.0000214296.94849.1c
(2) Calix[3]amides－bowl-shaped cyclic trimers toward building block for molecular recognition: self-complementary dimeric structure in the crystal.
Calleja, C.; Messaddeq, N.; Chapellier, B.; Yang, H.; Krezel, W.; Li, M.; Metzger, D.; Mascrez, B.; Ohta, K.; Kagechika, H.; Endo, Y.; Mark, M.; Ghyselinck, N. B.; Chambon, P.
Tetrahedron Lett. 2006, 47, 413-416.
DOI: 10.1016/j.tetlet.2005.11.082
(1) PPARγ ligands stimulate myeloid differentiation and lipogenensis in the human leukemia NB4 cells.
Imabeppu, F.; Katagiri, K.; Masu, H.; Kato, T.; Tominaga, M.; Therrien, B.; Takayanagi, H.; Kaji, E.; Yamaguchi, K.; Kagechika, H.; Azumaya, I.
Dev. Growth Differ. 2006, 48, 177-188.
DOI: 10.1111/j.1440-169x.2006.00855.x2005年
(5) Synthetic Retinoid Am80 Suppresses Smooth Muscle Phenotypic Modulation and In-Stent Neointima Formaiton by Inhibiting KLF5 .
Fujiu, K.; Manabe, I.; Ishihara, A.; Oishi, Y.; Iwata, H.; Nishimura, G.; Shindo, T.; Maemura, K.; Kagechika, H.; Shudo, K.; Nagai, R.
Circulation Res. 2005, 97, 1132-1141.
DOI:
(4) Retinoic acid via RAR alpha inhibits the expression of 24-hydroxylase in human prostate stromal cells.
Lou, Y.-R.; Miettinen, S.; Kagechika, H.; Gronemeyer, H.; Tuohima, P.
Biochem. Biophys. Res. Commun. 2005, 338, 1973-1981.
DOI:
(3) Biochem. Biophys. Res. Commun.
Morita, K.; Kawana, K.; Sodeyama, M.; Shimomura, I.; Kagechika, H.; Makishima, M.
Biochem. Pharmacol. 2005, 71, 98-107.
DOI:
(2) Upregulation of Nitric Oxide Production in Vascular Endothelical Cells by All-trans Retinoic Acid Through the Phosphoinositide 3-Kinase/Akt Pathway.
Uruno, A.; Sugawara, A.; Kanatsuka, H.; Kagechika, H.; Sato, K.; Kudo, M.; Takeuchi, K.; Ito, S.
Circulation. 2005, 112, 727-736.
DOI:
(1) RXR Agonist Enhances the Differentiation of Cardiomyocytes Derived from Embryonic Stem Cells in Serum-Free Conditions.
Honda, T.; Hamazaki, T. S.; Komazaki, S.; Kagachika, H.; Shudo, K.; Asashima, M.
Biochmem. Biophys. Res. Commun. 2005, 33, 1334-1340.
DOI:2004年
(8) Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis.
Ishida, S.; Shigemoto-Mogami, Y.; Shinozaki, Y.; Kagechika, H.; Shudo, K.; Ozawa, S.; Sawada, J.; Ohno, Y.; Inoue, K.
Biochem. Pharmacol. 2004, 68, 2177-2186.
DOI:
(7) Asynthetic Retinoid Am80 (Tamibarotene) Rescue the Memory Deficit Caused by Scopolamine in a Passive Avoidance Paradigm.
Shudo, K.; Kagechika, H.; Yamazaki, N.; Igarashi, M.; Takeda, C.
Biol. Pharm. Bull. 2004, 27, 1887-1889.
DOI:
(6) Retinoic Acid Imprintis Gut-Homing Specificity on T cells.
Iwata, M.; Hirakiyama, A.; Eshima, Y.; Kagechika, H.; Kato, C.; Song S.-Y.
Immunity. 2004, 21, 527-538.
DOI:
(5) Docosahexaenoic Acid Reduces Haloperidol-Induced Dyskinesias in Mice: Involvement of Nur77 and Retinoid Receptors.
Ethier, I.; Kagechika, H.; Shudo, K.; Rouillard, C.; Levesque, D.
Biol. Psychiatry. 2004, 56, 522-526.
DOI:
(4) The Endocrine Disrutors Nonylphenol and Octylphenol Exert Direct Effects on T cells to Suppress Th1 Development and Enhance Th2 Development.
Iwata, M.; Eshima, Y.; Kagechika, H.; Miyaura, H.
Immunol. Lett. 2004, 94, 135-139.
DOI:
(3) Novel Retinoid X Receptor (RXR) Antagonists Having a Dicarba-closo-dodecaborane as a Hydrophobic Moiety.
Ohta, K.; Iijima, I.; Kawachi, E.; Kagechika, H.; Endo, Y.
Bioorg. Med. Chem. Lett. 2004, 14, 5913-5918.
DOI:
(2) Design and synthesis cyclic urea compounds: a pharmacological study for retinoidal activity.
Kurihara, M.; Rouf, A. S. S.; Kansui, H.; Kagechika, H.; Okuda, H.; Miyata, N.
Bioorg. Med. Chem. Lett. 2004, 14, 4131-4134.
DOI:
(1) A Novel Melatonin Derivative Modulates Sleep-wake Cycle in Rats.
Akanmu, M. A.; Songkram, C.; Kagechika, H.; Honda, K.
Neurosci. Lett. 2004, 364, 199-202.
DOI:2003年
(9) Utility of Boron Clusters for Drug Design. Relation Between Estrogen Receptor Binding Affinity and Hydrophobicity of Phenols Bearing Various Types of Carboranyl Groups.
Endo, Y.; Yamamoto, K.; Kagechika, H.
Bioorg. Med. Chem. Lett. 2003, 13, 4089-4092.
DOI:
(8) Absolute Helical Arrangement of Sulfonamide in the Crystal.
Azumaya, I.; Kato, T.; Okamoto, I.: Yamasaki, R.; Tanatani, A.; Yamaguchi, K.; Kagechika, H.; Takayanagi, H.
Org. Lett. 2003, 5, 3939-3942.
DOI:
(7) Cyclooxygenase Inhibitors Derived from Thalidomide.
Suidu, M.; Muroya, Y.; Kakuta, H.; Kagechika, H.; Tanatani, A.; Nagasawa, K.; Hashimoto, Y.
Chem. Pharm. Bull. 2003, 51, 1098-1102.
DOI:
(6) Retinoic Acids Exert Direct Effects on T Cells to Suppress Th1 Development and Enhance Th2 Development via Retinoic Acid Receptors.
Iwata, M.; Eshima, Y.; Kagechika, H.
Int. Immunol. 2003, 15, 1017-1025.
DOI:
(5) Amide Conformational Switching induced by Protonation of Aromatic Substituent.
Yamasaki, R.; Tanatani, A.; Azumaya, I.; Saito, S.; Yamaguchi, K.; Kagechika, H.
Org. Lett. 2003, 5, 1265-1267.
DOI:
(4) A retinoic acid receptor-selective agonist causes jaw deformity in the Japanese flounder, Paralichthys olivaceus.
Haga, Y.; Suzuki, T.; Kagechika, H.; Takeuchi, T.
Aquaculture 2003, 221, 381-392.
DOI:
(3) Effects of Retinoid Ligands on RIP140: Molecular Interaction with Retinoid Receptors and Biological Activity.
Farooqui, M.; Franco, P. J.; Thompson, J.; Kagechika, H.; Chandraratna, R. A. S.; Banaszak, L.; Wei, L.-N.
Biochemsitry 2003, 42, 971-979.
DOI:
(2) Clinically Potential Subclasses of Retinoid Synergists Revealed by Gene Expression Profiling.
Ishida, S.; Shigemoto-Mogami, Y.; Kagechika, H.; Shudo, K.; Ozawa, S.; Sawada, J.; Ohno, Y.; Inoue, K.
Molecular Cancer Therapeutics 2003, 2, 49-58.
DOI:
(1) Effect of Synthetic Retinoid, TAC-101, on Experimental Autoimmune Disease.
Miyagawa, N.; Homma, T.; Kagechika, H.; Shudo, K.; Nagaia, H.
Pharmacology. 2003, 67, 21-31.
DOI:2002年
(5) Determination of Endogenous Levels of Retinoic Acid Isomers in Type II Diabetes Mellitus Patients. Possible Correlation with HbA1c Values.
Yamakoshi, Y.; Fukasawa, H.; Yamauchi, T.; Waki, H.; Kadowaki, T.; Shudo, K.; Kagechika, H.
Biol. Pharm. Bull. 2002, 25, 1268-1271.
DOI:
(4) Molecular construction based on icosahedral carboranes and aromatic N,N'-dimethylurea groups. Aromatic layered molecules and a transition metal complex.
Endo, Y.; Songkram, C.; Yamasaki, R.; Tanatani, A.; Kagechika, H.; Takaishi, K.; Yamaguchi, K.
J. Organomet. Chem. 2002, 657, 48-58.
DOI:
(3) Krueppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling.
Shindo, T.; Manabe, I.; Fukushima, Y.; Tobe, K.; Aizawa, K.; Miyamoto, S.; Kawai-Kowase, K.; Moriyama, N.; Imai, Y.; Kawakami, H.; Nishimatsu, H.; Ishikawa, T.; Suzuki, T.; Morita, H.; Maemura, K.; Sata, M.; Hirata, Y.; Komukai, M.; Kagechika, H.; Kadowaki, T.; Kurabayashi, M.; Nagai, R.
Nature Medicine. 2002, 8, 856-863.
DOI:
(2) Novel Retinoid X Receptor Antagonists: Specific Inhibition of Retinoid Synersism in RXR-RAR Heterodimer Actions.
Takahashi, B.; Ohta, K.; Kawachi, E.; Fukasawa, H.; Hashimoto, Y.; Kagechika, H.
J. Med. Chem. 2002, 45, 3327-3330.
DOI:
(1) Effect of natural and synthetic retinoids on the proliferation and differentiation of three canine melanoma cell lines.
Ohashi, E.; Inoue, K.; Kagechika, H.; Hong, S.-H.; Nakagawa, T.; Takahashi, T.; Mochizuki, M.; Nishimura, R.; Sasaki, N.
J. Vet. Med. Sci. 2002, 64, 169-172.
DOI:2001年
(9) Inhibition of RXR and PPAR ameliorates diet-induced obesity and type 2 diabetes.
Yamauchi, T.; Waki, H.; Kamon, J.; Murakami, K.; Motojima, K.; Komeda, K.; Miki, H.; Kubota, N.; Terauchi, Y.; Tsuchida, A.; Tsuboyama-Kasaoka, N.; Yamauchi, N.; Ide, T.; Hori, W.; Kato, S.; Fukayama, M.; Akanuma, Y.; Ezaki, O.; Itai, A.; Nagai, R.; Kimura, S.; Tobe, K.; Kagechika, H.; Shudo, K.; Kadowaki, T.
J. Clin. Invest. 2001, 108, 1001-1013.
DOI:
(8) Structures of bis- and tris(2-phenyl-o-carboran-1-yl)benzenes. construction of three-dimensional structures converted from planar arylacetylenic arrays.
Songkram, C.; Takaishi, K.; Yamaguchi, K.; Kagechika, H.; Endo, Y.
Tetrahedron Lett. 2001, 42, 6365-6368.
DOI:
(7) Replenishment of the fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity.
Yamauchi, T.; Kamon, J.; Waki, H.; Terauchi, Y.; Kubota, N.; Hara, K.; Mori, Y.; Abe, M.; Tanaka, J.; Ohsumi, J.; Ide, T.; Murakami, K.; Tsuboyama-Kasaoka, N.; Ezaki, O.; Akanuma, Y.; Gavrilova, O.; Vinson, C.; Reitman, M.; Kagechika, H.; Shudo, K.; Yoda, M.; Nakano, Y.; Tobe, K.; Nagai, R.; Kimura, S.; Tomita, M.; Froguel P.; Kadowaki, T.
Nature Medicine. 2001, 7, 941-946.
DOI:
(6) Molecular Construction Based on Icosahedral Carboranes and Aromatic Urea Groups. A New Type of Carboracycles.
Songkram, C.; Yamasaki, R.; Tanatani, A.; Takaishi, K.; Yamaguchi, K.; Kagechika, H.; Endo, Y.
Tetrahedron Lett. 2001, 42, 5913-5916.
DOI:
(5) α-Glucosidase Inhibitors with a 4,5,6,7-Tetrachlorophthalimide Skeleton Pendanted with a Cycloalkyl or Dicarba-closo-dodecaborane Group.
Sou, S.; Takahashi, H.; Yamasaki, R.; Kagechika, H.; Endo, Y.; Hashimoto, Y.
Chem. Pharm. Bull. 2001, 49, 791-793.
DOI:
(4) Structure-Activity Study of Retinoid Agonists Bearing Substituted Dicarba-closo-dodecaborane. Relation between Retinoidal Activity and Conformation of Two Aromatic Nuclei.
Endo, Y.; Iijima, T.; Yaguchi, K.; Kawachi, E.; Inoue, N.; Kagechika, H.; Kubo, A.; Itai, A.
Bioorg. Med. Chem. Lett. 2001, 11, 1307-1311.
DOI:
(3) Inhibition by retinoids of antigen-induced IL-4 production in rat mast cell line RBL-2H3. Hirasawa, N.; Kagechika, H.; Shudo, K.; Ohuchi, K.
Life Sci. 2001, 68, 1287-1294.
DOI:
(2) Novel Retinoidal Tropolone Derivatives. Bioisosteric Relationship of Tropolone Ring with Benzoic Acid Moiety in Retinoid Structure.
Ebisawa, M.; Ohta, K.; Kawachi, E.; Fukasawa, H.; Hashimoto, Y.; Kagechika, H.
Chem. Pharm. Bull. 2001, 49, 501-503.
DOI:
(1) Synergistic Potentiation of Thiazolidinedione-Induced ST 13 Preadipocyte Differentiation by RAR Synergists.
Sato, M.; Yajima, Y.; Kawashima, S.; Tanaka, K.; Kagechika, H.
Biochem. Biophys. Res. Commun. 2001, 280, 646-651.
DOI:2000年
(4) RXR Antagonist Provides a Novel Treatment for Obesity and Type 2 Diabetes.
Yamauchi, T.; Waki, H.; Komeda, K.; Miki, H.; Tobe, K.; Akanuma, Y.; Nagai, R.; Kimura, S.; Kagechika, H.; Shudo, K.; Kadowaki, T.
Diabetes. 2000, 49S, A38.
DOI:
(3) Retinoidal Piperidinecarboxylic Acids. Unexpected Diaza-Substituent Effects in Retinobenzoic Acids.
Ohta, K.; Kawachi, E.; Inoue, N.; Fukasawa, H.; Hashimoto, Y.; Itai, A.; Kagechika, H.
Chem. Pharm. Bull. 2000, 48, 1504-1513.
DOI:
(2) Structures of N,N'-Bis(1,2-dicarba-closo-dodecaborane-1-yl)phenylureas: Building Blocks for Carborane-containing Macromolecules.
Songkram, C.; Tanatani, A.; Yamasaki, R.; Yamaguchi, K.; Kagechika, H.; Endo, Y.
Tetrahedron Lett. 2000, 41, 7065-7070.
DOI:
(1) Polymethylcarborane as a novel bioactive moiety: derivatives with potent retinoid antagonistic activity.
Endo, Y.; Yaguchi, K.; Kawachi, E.; Kagechika, H.
Bioorg. Med. Chem. Lett. 2000, 10, 1733-1736.
DOI:1999年
(7) Retinoid X Receptor-Antagonistic Diazepinylbenzoic Acids.
Ebisawa, M.; Umemiya, H.; Ohta, K.; Fukasawa, H.; Kawachi, E.; Christoffel, G.; Gronemeyer, H.; Tsuji, M.; Hashimoto, Y.; Shudo, K.; Kagechika, H.
Chem. Pharm. Bull. 1999, 47, 1778-1786.
DOI:
(6) Thiazolidinediones with Thyroid Hormone Receptor Agonistic Activity.
Ebisawa, M.; Inoue, N.; Fukasawa, H.; Sotome, T.; Kagechika, H.
Chem. Pharm. Bull. 1999, 47, 1348-1350.
DOI:
(5) A Chiral N-Methylbenzamide: Spontaneous Generation of Optical Activity.
Azumaya, I.; Okamoto, I.; Nakayama, S.; Tanatani, A.; Yamaguchi, K.; Shudo, K.; Kagechika, H.
Tetrahedron 1999, 55, 11237-11246.
DOI:
(4) Identification of a Novel Class of RARb-selective Retinoid Antagonists and their Inhibitory Effects on AP-1 activity and Retinoic Acid-induced Apoptosis in Human Breast Cancer Cells.
Li, Y.; Hashimoto, Y.; Agadir, A.; Kagechika, H.; Zhang, X.-K.
J. Biol. Chem. 1999, 274, 15360-15367.
DOI:
(3) A Layered Artificial Dinucleotide Complex.
Kagechika, H.; Azumaya, I.; Tanatani, A.; Yamaguchi K.; Shudo, K.
Tetrahedron Lett. 1999, 40, 3413-3426.
DOI:
(2) Dicarba-closo-dodecaboranes as a Pharmacophore. Novel Potent Retinoidal Agonists.
Endo, Y.; Iijima, T.; Kagechika, H.; Ohta, K.; Kawachi E.; Shudo, K.
Chem. Pharm. Bull. 1999, 47, 585-587.
DOI:
(1) Dicarba-closo-dodecaboranes as a Pharmacophore. Retinoidal Antagonists and Potential Agonists
Iijima, T.; Endo, Y.; Tsuji, M.; Kawachi, E.; Kagechika H.; Shudo, K.
Chem. Pharm. Bull. 1999, 47, 398-404.
DOI:1998年
(5) Novel DNA minor groove binders with an aromatic layered structure.
Tanatani, A.; Fukutomi, R.; Kakuta, H.; Tomioka, N.; Itai, A.; Hashimoto, Y.; Shudo, K.; Kagechika, H.
Nucleic Acids Symp. Ser. 1998, 39, 31-32.
DOI:
(4) Aromatic Layered Guanidines Bind Sequence-Specifically to DNA Minor Groove with Precise Fit.
Fukutomi, R.; Tanatani, A.; Kakuta, H.; Tomioka, N.; Itai, A.; Hashimoto, Y.; Shudo, K.; Kagechika, H.
Tetrahedron Lett. 1998, 39, 6475-6478.
DOI:
(3) N-Methylated Diphenylguanidines: Conformations, Propeller-type Molecular Chirality, and Construction of Water-soluble Oligomers with Multi-layered Aromatic Structures.
Tanatani, A.; Yamaguchi, K.; Azumaya, I.; Fukutomi, R.; Shudo, K.; Kagechika, H.
J. Am. Chem. Soc. 1998, 120, 6433-6442.
DOI:
(2) Novel Thiazolidinedione Derivatives with Retinoid Synergistic Activity.
Ebisawa, M.; Kawachi, E.; Fukasawa, H.; Hashimoto, Y.; Itai, A.; Shudo, K.; Kagechika, H.
Biol. Pharm. Bull. 1998, 21, 547-549.
DOI:
(1) Potent Retinoid Synergists with A Diphenylamine Skeleton.
Ohta, K.; Tsuji, M.; Kawachi, E.; Fukasawa, H.; Hashimoto, Y.; Shudo, K.; Kagechika, H.
Biol. Pharm. Bull. 1998, 21, 544-546.
DOI:
1997年
(8) Regulation of Retinoidal Actions by Diazepinylbenzoic Acids. Retinoid Synergists which Activate the RXR-RAR Heterodimers.
Umemiya, H. Fukasawa, H.; Ebisawa, M.; Eyrolles, L.; Kawachi, E.; Eisenmann, G.; Gronemeyer, H.; Hashimoto, Y.; Shudo, K.; Kagechika, H.
J. Med. Chem. 1997, 40, 4222-4234.
DOI:
(7) Dinucleotide-Analogous Tetrapeptides. Specific Triplex Formation with Complementary Polynucleotides.
Yamazaki, T.; Komatsu, K.; Umemiya, H.; Hashimoto, Y.; Shudo, K.; Kagechika, H.
Tetrahedron Lett. 1997, 38, 8363-8366.
DOI:
(6) Polyenylidene Thiazolidine Derivatives with Retiniodal Activities.
Tashima, T.; Kagechika, H.; Tsuji, M.; Fukasawa, H.; Kawachi, E.; Hashimoto, Y.; Shudo, K.
Chem. Pharm. Bull. 1997, 45, 1805-1813.
DOI:
(5) A mutation mimicking the ligand-induced conformational change yields a constitutive RXR that senses allosteric effects in heterodimers.
Vivat, V.; Zechel, C.; Wurtz, J.-M.; Bourguet, W.; Kagechika, H.; Umemiya, H.; Shudo, K.; Moras, D.; Gronemeyer, H.; Chambon, P.
EMBO J. 1997, 16, 5697-5709.
DOI:
(4) Photoaffinity-labeling of the Ligand-Interacting Helix of Retinoic Acid Receptor Alpha.
Sasaki, T.; Morisaki, N.; Iwasaki, S.; Kagechika, H.; Fukasawa, H.; Shudo, K.; Shida, Y.; Hashimoto, Y.
Biol. Pharm. Bull. 1997, 20, 913-916.
DOI:
(3) Aromatic Helical Urea and Guanidine.
Tanatani, A.; Kagechika, H.; Azumaya, I.; Fukutomi, R.; Ito, Y.; Yamaguchi, K.; Shudo, K.
Tetrahedron Lett. 1997, 38, 4435-4428.
DOI:
(2) Action Mechanism of Retinoid-Synergistic Dibenzodiazepines.
Umemiya, H.; Kagechika, H.; Fukasawa, H.; Kawachi, E.; Ebisawa, M.; Hashimoto, Y.; Eisenmann, G.; Erb, C.; Pornon, A.; Chambon, P.; Gronemeyer, H.; Shudo, K.
Biochem. Biophys. Res. Commun. 1997, 233, 121-125.
DOI:
(1) Inhibition of IL-1-induced IL-6 Production by Synthetic Retinoids.
Kagechika, H.; Kawachi, E.; Fukasawa, H.; Saito, G.; Iwanami, N.; Umemiya, H.; Hashimoto, Y.; Shudo, K.
Biochem. Biophys. Res. Commun. 1997, 231, 243-248.
DOI:1996年
(8) Evaluation of Differentiation-Inducing Activity of Retinoids on Human Leukemia Cell Lines HL-60 and NB4.
Hashimoto, Y.; Kagechika, H.; Kawachi, E.; Fukasawa, H.; Saito, G.; Shudo, K.
Biol. Pharm. Bull. 1996, 19, 1322-1328.
DOI:
(7) Novel Aromatic Urea Derivatives with DNA-Binding Ability.
Fukutomi, R.; Kagechika, H.; Hashimoto, Y.; Shudo, K.
Chem. Pharm. Bull. 1996, 44, 1983-1985.
DOI:
(6) Facile Formation of Aromatic Cyclic N-Methylamides Based on cis Conformational Preference.
Azumaya, I.; Kagechika, H.; Yamaguchi, K.; Shudo, K.
Tetrahedron Lett. 1996, 37, 5003-5006.
DOI:
(5) Deiodo-trifluoromethylation of Ethyl 3,3',5-Triiodothyroacetate. Divergent Derivatization Based on the Combinatorial Concept.
Sagi, K.; Kagechika, H.; Fukasawa, H.; Hashimoto, Y.; Shudo, K.
Chem. Pharm. Bull. 1996, 44, 1273-1275.
DOI:
(4) (Cis)-Preference of N,N'-Dimethyl-n,N'-Diphenylguanidine and the Guanidinium Salt. Construction of Water-Soluble Aromatic Layered Structure.
Tanatani, A.; Kagechika, H.; Azumaya, I.; Yamaguchi, K.; Shudo, K.
Chem. Pharm. Bull. 1996, 44, 1135-1137.
DOI:
(3) Synthesis of Oligopeptides as Polynucleotide Analogs.
Umemiya, H.; Kagechika, H.; Hashimoto, Y.; Shudo, K.
Nucleosides and Nucleotides. 1996, 15, 465-475.
DOI:
(2) Sterical Properties of N,N'-Dimethylurea Moiety Enhance Formation of Triply Hydrogen-bonded Complexes.
Kagechika, H.; Azumaya, I.; Yamaguchi. K.; Shudo, K.
Chem. Pharm. Bull. 1996, 44, 460-462.
DOI:
(1) Synthesis of Vitamin E Analogues: Possible Active Forms of Vitamin E.
Fujishima, T.; Kagechika, H.; Shudo, K.
Arch. Pharm. Pharm. Med. Chem. 1996, 329, 27-34.
DOI:1995年
(8) Synthesisof Oligopeptides as Polynucleotide Analogs.
Umemiya, H.; Komatsu, K.; Yamazaki, T.; Kagechika, H.; Shudo, K.; Hashimoto, Y.
Nucleic Acids Symp. Ser. 1995, 34, 37-38. v
(7) Correlation of Differentiation-Inducing Activity of Retinoids on Human Leukemia Cell Lines HL-60 and NB4.
Hashimoto, Y.; Kagechika, H.; Kawachi, E.; Fukasawa, H.; Saito, G.; Shudo, K.
J. Cancer Res. Clin. Oncol. 1995, 121, 696-698.
DOI:
(6) Synergists for Retinoid in Cellular Differentiation of Human Promyelocytic Leukemia Cells HL-60.
Umemiya, H.; Kawachi, E.; Kagechika, H.; Fukasawa, H.; Hashimoto, Y.; Shudo, K.
Chem. Pharm. Bull. 1995, 43, 1827-1829.
DOI:
(5) Total Asymmetric Transformation of an N-Methylbenzamide.
Azumaya, I.; Yamaguchi, K.; Okamoto, I.; Kagechika, H.; Shudo, K.
J. Am. Chem. Soc. 1995, 117, 9083-9084.
DOI:
(4) Stereochemistries of Aromatic N-Methylamides in Crystal and Solution. Temperature-dependent Conformational Conversion and Attracting Aromatic-Aromatic Interactions.
Azumaya, I.; Kagechika, H.; Yamaguchi, K.; Shudo, K.
Tetrahedron. 1995, 51, 5277-5290.
DOI:
(3) Specific Oxidation of Retinoic Acid to 4-oxo-Retinoic Acid in Diluted Acid Solutions.
Tanaka, H.; Kagechika, H.; Shudo, K.
Chem. Pharm. Bull. 1995, 43, 356-358.
DOI:
(2) Possible Involvement of Retinoid-like Cofactor in Serum in Hemin/Protoporphyrin-IX-Induced Differentiation of Human Leukemia K562 Cells.
Nakajima, O.; Kagechika, H.; Shudo, K.; Hashimoto, Y.; Iwasaki, S.
Biochem. Biophys. Res. Commun. 1995, 206, 1003-1010.
DOI:
(1) Retinoidal Dienamides and Related Aromatic Amides. Replacement of the 9-Ene Structure of Retinoic acid with a trans- or cis-Amide Group.
Shimasaki, H.; Kagechika, H.; Fukasawa, H.; Kawachi , E.; Shudo, K.
Chem. Pharm. Bull. 1995, 43, 100-107.
DOI:1994年
(1) Synthesis and Biological Activity of Carboxyphenylquinolines and Related Compounds as New Potent Retinoids. Retinobenzoic Acids. VII.
Eyrolles, L.; Kawachi, E.; Kagechika, H.; Hashimoto, Y.; Shudo, K.
Chem. Pharm. Bull. 1994, 42, 2575-2581
DOI: 10.1002/chin.1995352821993年
(1) Retinoids Shudo, K.; Kagechika, H. In "Cancer Chemotherapy: Challenges for the Future Vol. 8" (Excerpta Medica, Ltd. Tokyo) pp 172-177,1993.
Expression of the Ligand-Binding Domain-Containing Region of Retinoic Acid Receptors a, b and g in Escherichia coli and Evaluation of Ligand-Binding Selectivity.
Fukasawa, H.; Iijima, T.; Kagechika, H.; Hashimoto, Y.; Shudo, K.
Biol. Pharm. Bull. 1993, 16, 343-348.
DOI: 10.1248/bpb.16.3431992年
(4) Preference of cis-Amide Structure in N-Acyl-N-methylanilines.
Itai, A.; Toriumi, Y.; Saito, S.; Kagechika, H.; Shudo, K.
J. Am. Chem. Soc. 1992, 114, 10649-10650.
DOI: 10.1021/ja00052a078
(3) Differentiation-Inducing Activity of Retinoic Acid Isomers and Their Oxidized Analogs on Human Promyelocytic Leukemia HL-60 Cells.
Matsushima, Y.; Kawachi, E.; Tanaka, H.; Kagechika, H.; Hashimoto, Y.; Shudo, K.
Biochem. Biophys. Res. Commun. 1992, 189, 1136-1142.
DOI: 10.1016/0006-291x(92)92322-o
(2) Retinoid Antagonists: Molecular Design Based On The Ligand Superfamily Concept.
Eyrolles, L.; Kawachi, E.; Matsushima, Y.; Nakajima, O.; Kagechika, H.; Hashimoto, Y.; Shudo, K.
Med. Chem. Res. 1992, 2, 362-367.
DOI:
(1) Base-catalyzed Isomerization of Retinoic Acid. Synthesis and Differentiation-Inducing Activities of 14-Alkylated all-trans-, 13-cis-, and 20,14-retro-Retinoic Acids.
Tanaka, H.; Kagechika, H.; Kawachi, E.; Fukasawa, H.; Hashimoto, Y.; Shudo, K.
J. Med. Chem. 1992, 35, 567-572.
DOI: 10.1021/jm00081a0201991年
(6) Fluorescent Probes for Retinoic Acid Receptors: Molecular Measures for the Ligand Binding Pocket.
Shimazawa, R.; Hibino, S.; Mizoguchi, H.; Hashimoto, Y.; Iwasaki, S.; Kagechika, H.; Shudo, K. Biochem. Biophys. Res. Commun. 1991, 180, 249-254.
DOI: 10.1016/s0006-291x(05)81284-7
(5) Fluorescent and Photoaffinity Labeling Probes for Retinoic Acid Receptors.
Shimazawa, R.; Sanda, R.; Mizoguchi, H.; Hashimoto, Y.; Iwasaki, S.; Tanaka, H.; Kagechika, H.; Shudo, K.
Biochem. Biophys. Res. Commun. 1991, 179, 259-265.
DOI: 10.1016/0006-291x(91)91363-h
(4) Retinoid Antagonists.
Kaneko, S.; Kagechika, H.; Kawachi, E.; Hashimoto, Y.; Shudo, K.
Med. Chem. Res. 1991, 1, 220-225.
DOI:
(3) An Unsymmetrical 1,1,3,3-Tetramethylallyl Cation.
Gassman, P. G.; Singleton, D. A.; Kagechika, H.
J. Am. Chem. Soc.1991, 113, 6271-6272.
DOI: 10.1021/ja00016a054
(2) Aromatic Architecture. Use of the N-Methylamide Structure as a Molecular Splint.
Yamaguchi, K.; Matsumura, G.; Kagechika, H.; Azumaya, I.; Ito, Y.; Itai , A.; Shudo, K.
J. Am. Chem. Soc. 1991, 113, 5474-5475.
DOI: 10.1021/ja00014a060
(1) Twisted Intramolecular Charge-Transfer Fluorescence of Aromatic Amides: Conformation of the Amide Bonds in the Excited States.
Azumaya, I.; Kagechika, H.; Fujiwara, Y.; Itoh, M.; Yamaguchi, K.; Shudo, K.
J. Am. Chem. Soc. 1991, 113, 2833-2838.
DOI: 10.1021/ja00008a005ページの先頭に戻る