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2019

A study abroad of Dr. Saito.

Kiyoka Saito (PhD, Technical Assistant) started her postdoc at Lund University, Sweden.

 

Visit of Toyama High School students.

Students of Toyama High School visited the Department of Stem Cell Regulation on August 21, 2019. They received mini-lectures from the Professor. The students observed fluorescently labeled cancer stem cells attached to synthetic polymers. They also experienced the mouse embryo observation, the microscopic (phase contrast and fluorescent) observation of undifferentiated hematopoietic cells, the harvesting of the cells, the immunofluorescent staining, and the identification and sorting of hematopoietic cells.

Visit of students participating in TMDU’s 8th International Summer Program.

Medical students of TMDU's partner universities in the United States, Thailand, and Taiwan participating in TMDU’s 8th International Summer Program (ISP2019) visited the Department of Stem Cell Regulation on July 9 and 10, 2019. They received mini-lectures from the Professor. The students observed fluorescently labeled cancer stem cells attached to synthetic polymers. They also experienced the mouse embryo observation, the microscopic observation of undifferentiated hematopoietic cells, the harvesting of the cells, the immunofluorescent staining, and the identification and sorting of hematopoietic cells.

Prof. Taga's 60-year old's birthday party.

We had a party celebrating Prof. Taga's Kanreki (60th birthday) in June.

Degree awarding ceremony was held.

Kiyoka Saito obtained a Ph.D. from TMDU on 26/March. Five students obtained a master's degree from TMDU.

 

2018

A farewell party of Dr. Murota.

Yoshitaka Murota (PhD, Technical Assistant) studied abroad at University of Florida, Department of Medicine.

Visit of Osaka Ibaraki High School students.

Students of Osaka Ibaraki High School visited the Department of Stem Cell Regulation on August 7, 2018. They received lectures by the staff members of the department, followed by practices of microscopic observation of cultured cells including stem cells.

Visit of students from Senior High School at Otsuka, University of Tsukuba.

Students of Senior High School at Otsuka, University of Tsukuba, visited the Department of Stem Cell Regulation on July 23, 2018. They received mini-lectures from the Professor and Assocoate Professor as well as a Technical Assistant of the department. The students experienced the microscopic (phase contrast and fluorescent) observation of undiffrentiated hematopoietic cells, the harvesting of the cells, the immunofluorescent staining, and the identification and sorting of hematopoietic cells.

Visit of Prof. Teixeira from Universidade Federal de Minas Gerais (UFMG), Brazil.

Prof. Mauro Teixeira at Department of Biochemistry and Immunology, Universidade Federal de Minas Gerais (UFMG), Brazil visited the Department of Stem Cell Regulation and gave us a seminar entitled “- Inflammation and its resolution - mediators and relevance “ on June 22, 2018.

 

Visit of Prof. Chambers, Dr. Burdon and and their colleagues from the University of Edinburgh.

Dr. Ian Chambers, Dr. Tom Burdon, Dr. Zhang, and Dr. Ozkan from the University of Edinburgh visited the Department of Stem Cell Regulation on April 18, 2018. We discussed recent findings on hematopoietic and cancer stem cells made by the TMDU side and helpful comments were given by the Edinburgh attendees. Later, we enjoyed our short walk to Kanda Myojin and had a good time together with a dinner.

(The bottom photos of Centre for Regenerative Medicine, the University of Edinburgh are from http://www.crm.ed.ac.uk/about-us/crm-building)

Our new article by Saito et al. has been published in Experimental Cell Research.

Kiyoka Saito, Ikuo Nobuhisa, Kaho Harada, Satomi Takahashi, Maha Anani, Heiko Lickert, Masami Kanai-Azuma, Yoshiakira Kanai, Tetsuya Taga.

aintenance of hematopoietic stem and progenitor cells in fetal intra-aortic hematopoietic clusters by the Sox17-Notch1-Hes1 axis. Experimental Cell Research, 365: 145-155, 2018.

 

In the mouse ontogeny, the dorsal aorta, from which definitive hematopoiesis firstly arises in midgestation mouse embryo, has hematopoietic stem cell-containing clusters. This paper show that the Sox17-Notch1-Hes1 pathway contributes to maintaining the undifferentiated state of the clusters.

Degree awarding ceremony was held.

Yoshitaka Murota obtained a Ph.D. from TMDU on 22/March. Two students obtained a master's degree from TMDU.

2017

Visit of students from Senior High School at Komaba, University of Tsukuba.

Students of Senior High School at Komaba, University of Tsukuba, visited the Department of Stem Cell Regulation on December 14, 2017. They received mini-lectures from the Professor and Assistant Professor as well as a PhD student of the department.

After the mini-lectures, the students experienced the microscopic (phase contrast and fluorescent) observation of cancer cell lines, the harvesting and counting of cultured adherent cells, and the identification and sorting of cancer stem cells.

A student from Tokyo Institute of Technology have joined our laboratory under the internship program.

Since November 14, 2017, Mr. Mongkol Pongsuchart, a student of Prof. Shinae Kondo’s Lab. at Tokyo Institute of Technology (Tokyo Tech), joined us for one week-research under the Tokyo Tech Internship Program with the supervision of Dr. Tabu (Assistant Professor).

 

Visit of Dr. Ivan Velasco from Universidad Nacional Autonoma De Mexico.

Dr. Ivan Velasco from Universidad Nacional Autonoma De Mexico visited the Department of Stem Cell Regulation and held a seminar titled "Enhancing survival, maturation and axonal growth of stem cell-derived neurons" on Novbember 9, 2017. The presentation was quite insightful and many participants, including a TMDU student Erick Luz Madrigal, enjoyed discussion afterward. The conversation continued at dinner.

Visit of Prof. Bradley and Ms. Schmidt from the University of Edinburgh.

Our collaborators, Prof. Bradley and Ms. Schmidt, from the University of Edinburgh, Scotland, UK visited the Department of Stem Cell Regulation on August 25, 2017. We discussed recent advances and future prospects of our collaborative research on the elucidation of stem cell niche by using synthetic polymers.

Later, we enjoyed our short walks to Yushima Seido and Kanda Myojin and strolling in Sensoji as well. Amazake, a fermented rice drink, at Kanda Myojin was quite good at this time of year.

 

Visit of Osaka Ibaraki High School students.

Students of Osaka Ibaraki High School visited the Department of Stem Cell Regulation on August 3, 2017. They received lectures by the staff members of the department, followed by practices of microscopic observation of cultured cells including stem cells.

Degree awarding ceremony was held.

Whang WenQuian obtained a Ph.D. from TMDU on 24/March. Two students obtained a master's degree from TMDU. One is working at a public employee and one has entered the PhD course and is studying at another department.

The excellence speaker of a student workshop and the excellent paper prize of 2016 in our medical research institute.

Yoshitaka Murota(PhD student, D3) has been awarded the second place in a student workshop of our medical research institute on 10/March. Kouichi Tabu(Assistant Professor) has been awarded the excellence paper prize of 2016 in our institute. (A synthetic polymer scaffold reveals the self-maintenance strategies of rat glioma stem cells by organization of the advantageous niche. Stem Cells)

 

An exchange student from Imperial College in UK have joined our laboratory

Miss. Wenqing Grace Yan is participating in research by the schedule for about three months from 28/February as an exchange student from Imperial College in the UK.

Our new article by Harada et al. has been published in Cytokine.

Kaho Harada, Ikuo Nobuhisa, Maha Anani, Kiyoka Saito, Tetsuya Taga.

 

Thrombopoietin contributes to the formation and the maintenance of hematopoietic progenitor-containing cell clusters in the aorta-gonad-mesonephros region.

 

In the midgestation mouse embryo, hematopoietic cell clusters containing hematopoietic stem/progenitor cells arise in the aorta-gonad-mesonephros (AGM) region. This paper showed that thrombopoietin (TPO), a cytokine, contributes to the formation and the maintenance of hematopoietic cell clusters in the AGM region.

Our new article by Wang et al. has been published in Scientific Reports.

Weiqian Wang, Kouichi Tabu, Yuichiro Hagiya, Yuta Sugiyama, Yasuyhiro Kokubu, Yoshitaka Murota, Shun-ichiro Ogura and Tetsuya Taga.

 

Enhancement of 5-aminolevulinic acid-based fluorescence detection of side population-defined glioma stem cells by iron chelation.

 

Cancer stem cells (CSCs) are dominantly responsible for tumor progression and chemo/radio-resistance, resulting in tumor recurrence. 5-aminolevulinic acid (ALA) is clinically used as a reagent for photodynamic diagnosis (PDD) and therapy of cancers including gliomas. We show that side population-defined C6 glioma CSCs (GSCs) possess an ability to escape from the PDD by displaying much less 5-ALA-derived fluorescence. We further show that the GSCs can be detected by 5-ALA in combination with deferoxamine, an iron chelator. Our results provide important new insights into 5-ALA-based PDD of gliomas.

【International press release (TMDU)】
【International press release (EurekAlert!)】
 

【Our paper was reported in a newspaper, Nikkan Kogyo Shinbun on February 8.】

A medical student of Niigata Univ. has joined our laboratory.

Mr. Keita Nakamura has been participating in our research since January 10, 2017 for about two months as a Student Researcher from Niigata Univ.

2016

The 20th anniversary party of Taga's Laboratory

It has been 20 years since Dr. Taga was appointed Professor at Tokyo Medical and Dental University (TMDU) on September 1, 1996. The 20th anniversary party of Taga's Laboratory was held in Yokohama on an occasion of the 39th Annual Meeting of Molecular Biology Society of Japan. (December 1, 2016)

Our new article by Murota et al. has been published in BMC cancer.

Yoshitaka Murota, Kouichi Tabu, and Tetsuya Taga.

 

Requirement of ABC transporter inhibition and Hoechst 33342 dye deprivation for the assessment of side population-defined C6 glioma stem cell metabolism using fluorescent probes. (November 4, 2016)

 

Elucidating the precise properties of cancer stem cells (CSCs) is indispensable for the development of effective therapies against tumors, because CSCs are key drivers of tumor development, metastasis and relapse. In this article, we show that inhibiting ABC transporters and depriving Hoechst 33342 dye are required for the accurate assessment of CSC metabolism, particularly side population-defined C6 glioma stem cell metabolism using fluorescent probes.

Visit of Hongo High School students.

Students of Hongo High School (Tokyo) visited the Department of Stem Cell Regulation on August 22, 2016. They received lectures by the staff members of the department, followed by practice of cell culture and microscopic observation of cultured cells including stem cells and analysis of cells by the cell sorter.

Visit of Osaka Ibaraki High School students.

Students of Osaka Ibaraki High School visited the Department of Stem Cell Regulation on August 3, 2016. They received lectures by the staff members of the department, followed by practices of microscopic observation of cultured cells including stem cells.

Degree awarding ceremony was held.

Yasuhiro Kokubu and Genki Sudo obtained a Ph.D. from TMDU and moved to National Institute of Biomedical Innovation and RIKEN BSI, respectively. One student obtained a master's degree from TMDU. He are working at private company.

The 9th Annual Meeting for Japanese Developmental Neuroscientists & Research Meeting of Joint Usage/Research Program, MRI, TMDU, "Molecular bases of early neural Development" were held

As the 9th annual meeting for Japanese Developmental Neuroscientists & research meeting of Joint Usage/Research Program of Medical Research Institute, Tokyo Medical and Dental University (TMDU), entitled Molecular bases of early neural Development was held on March 18-19, 2016. The meeting organizers were Prof. Tetsuya Taga (TMDU) and Tetsushi Kagawa (National Institute for Physiological Sciences).

Our new article by Tabu et al. has been published in an online version of Stem Cells (January 29, 2016).

【Press release】

2015

Our new article by Tabu et al. has been accepted for publication in Stem Cells.

Kouichi Tabu, Nozomi Muramatsu, Christian Mangani, Mei Wu, Rong Zhang, Taichi Kimura, Kazuo Terashima, Norihisa Bizen, Ryosuke Kimura, Wenqian Wang, Yoshitaka Murota, Yasuhiro Kokubu, Ikuo Nobuhisa, Tetsushi Kagawa, Issay Kitabayashi, Mark Bradley and Tetsuya Taga.

A synthetic polymer scaffold reveals the self-maintenance strategies of rat glioma stem cells by organization of the advantageous niche. Stem Cells, in press. (December 2, 2015)

Our new article by Kokubu et al. has been accepted for publication in Genes to Cells.

Yasuhiro Kokubu, Kouichi Tabu, Wenqian Wang, Nozomi Muramatsu, Yoshitaka Murota, Ikuo Nobuhisa, Masahisa Jinushi, and Tetsuya Taga.

Induction of protumoral CD11c[high] macrophages by glioma cancer stem cells through GM-CSF. Genes to Cells, in press. (November 30, 2015)

Our new article by Sudo et al. has been accepted for publication in Genes to Cells.

Genki Sudo, Tetsushi Kagawa, Yasuhiro Kokubu, Johji Inazawa, and Tetsuya Taga.

An increase of GFAP-positive astrocytes in histone demethylase GASC1/KDM4C/JMJD2C hypomorphic mutant mice. Genes to Cells, in press. (November 27, 2015)

A medical student of Niigata Univ. has joined our laboratory.

Ms. Megumi Wada has been participating in our research since September 24, 2015 for about two months as a Student Researcher from Niigata Univ.

Visit of Mito Dai-ichi High School students.

Students of Mito Dai-ichi High School (Ibaraki Prefecture) visited the Department of Stem Cell Regulation on August 6, 2015. They received lectures by the staff members of the department, followed by practice of cell culture and microscopic observation of cultured cells including stem cells and analysis of cells by the cell sorter.

Visit of Osaka Ibaraki High School students.

Students of Osaka Ibaraki High School visited the Department of Stem Cell Regulation on August 3, 2015. They received lectures by the staff members of the department, followed by practices of microscopic observation of cultured cells including stem cells.

Young Investigator Papaer Award 2015 in Development, Growth & Differentiation.

Maha Anani, MD. PhD. has recieved the Young Investigator Paper Award 2015 of Development, Growth & Differentiation at 48th Annual Meeting of the Japanese Society of Developmental Biologists (June 4, 2015). Her award-winning achievements are as follows:

 

It has been reported that Sox17 is expressed in fetal hematopoietic progenitor cells in the aorta-gonad-mesonephros (AGM) region in embryos while Sox17 is involved in maintenance and differentiation of adult hematopoietic progenitors in bone marrow. Based on the information, this manuscript showed functions of Sox17 in fetal hematopoietic progenitor cells in the AGM by forced expression of Sox17 in those cells. The authors indicated that the Sox17 expressing progenitor cells preferentially developed to common myeloid progenitors (CMPs) after transplantation into irradiated recipient mice. In addition, Sox17-expressing progenitors cells gave rise to CMPs as well as granulocyte/macrophage progenitors (GMPs) in cultures, and their self-renewal proliferation was maintained for some passages. Moreover, those cells showed increased expression of key genes for hematopoietic differentiation compared with that in control cells without Sox17 transduction, and they formed the mixed type colonies consisting of multi-lineage hematopoietic cells in culture. In summary, this manuscript clearly demonstrated critical functions of Sox17 for maintenance and differentiation of fetal hematopoietic progenitors cells, in particular myeloid lineage, by detailed transplantation and culture experiments, and therefore, I would recommend this manuscript for the DGD award.

A farewell party of Dr. Kagawa.

Tetsushi Kagawa (Associate Professor) moved to National Institute for Physiological Sciences as Project Professor as of April 1.

Degree awarding ceremony was held.

Four students obtained a master's degree from TMDU. Among the four, Three are working at private companies and one has entered the PhD course and is studying at our department.

2014

Degree awarding ceremony was held.

Maha Anani obtained the Ph.D. from TMDU and returned to Egypt.

A farewell party of Dr. Tabu.

Koichi Tabu (Project Assistant Professor) moved to Oxygen Biology Laboratory, Medical Research Institute as Assistant Professor.

The manuscript entitled “Sox17 as a candidate regulator of myeloid restricted differentiation potential” has been published in Dev. Growth Differ.

Degree awarding ceremony was held.

Norihisa bizen obtained a Ph.D. from TMDU and moved to Niigata Univ. Three students obtained a master's degree from TMDU. Among the three, Two are working at private companies and one has entered the PhD course and is studying at our department.

The manuscript entitled “Sox17-mediated maintenance of fetal intra-aortic hematopoietic cell clusters” has been published in Mol. Cell. Biol.

【Press release】

【Our paper was reported in the Chemical Daily on April 24.】

【Our paper was reported in the Mynavi News on April 25.】

【Our paper was reported in Nikkei Industrial Daily on June 30.】

 

The excellence paper prize of 2013 in our medical research institute.

Norihisa bizen(Project Assistant Professor) has been awarded the excellence paper prize of 2013 year in our Medical Research Institute (A growth-promoting signaling component cyclin D1 in neural stem cells has anti-astrogliogenic function to execute self-renewal. Stem Cells, 2013 [Epub ahead of print].)

The manuscript entitled “A growth-promoting signaling component cyclin D1 in neural stem cells has anti-astrogliogenic function to execute self-renewal” has been published in Stem Cells.

【Press release】

【Our paper was reported in the Chemical Daily on January 6.】

【Our paper was reported in Nikkei Industrial Daily on January 16.】

 

2013

Degree awarding ceremony was held.

A master course student, Ms. Nozomi Muramatsu has acquired a master's degree in TMDU. The student is working at medical-related company.

An exchange student from Imperial College in UK have joined our laboratory

Mr. Ankur Khajuria is participating in research by the schedule for about three months as an exchange student from Imperial College in the UK.

2012

Degree awarding ceremony was held.

Three students acquired a master's degree in TMDU. Two are working at private companies and the one has entered the PhD course and is studying at another department.

A foreign researcher from Kon Kaen University in Thailand and an exchange student from Imperial College in UK have joined our laboratory

Mr. Pra-Yong Pokpong heve joined our laboratory for half a year as a foreign researcher from Kon Kaen University in Thailand. Ms. Georgina Phillips is participating in research by the schedule for about two months as an exchange student from Imperial College in the UK.

The manuscript entitled “CD45lowc-Kithigh cells have hematopoietic property in the mouse aorta-gonad-mesonephros region” has been published in Experimental Cell Research.

 

2011

The cancer stem cell niche project was reported in Nikkei Industrial Daily

We are search for the optimal microenvironment (niche), in which normal neural stem cells and cancer stem cells could maintain their self-renewal and pluripotential phenotype in vivo. We are screening artificial niche structures using chemically synthesized polymers in collaboration with Professor Mark Bradley and his colleagues in The University of Edinburgh. Our niche project concerning cancer stem cells was reported in Nikkei Industrial Daily on November 1, 2011.

Symposium on Understanding of Organogenesis Toward New Therapy was held

As a research meeting supported by Joint Usage/Research Program of Medical Research Institute, Tokyo Medical and Dental University, the symposium entitled Understanding of Organogenesis Toward New Therapy was held on October 21, 2011. The organizers were Prof. Shoen Kume of Institute of Molecular Embryology and Genetics, Kumamoto University, Profs. Hiroshi Nishina and the staff members of the Department of Stem Cell Regulation.

The best poster prize in 2011 workshop in young researchers for cancer

Kouichi Tabu(JSPS Fellow) has been awarded the best poster prize of 2011 workshop in young researchers for cancer (Aug. 31~Sep. 1. 2011, Artlandhotel Tateshina).

Visiting lectures at Chiba High School

The staff members of the Department of Stem Cell Regulation gave five lectures (40 students in each class) on stem cells, each followed by practice of microscopic observation of tissue specimens at Chiba Prefectural Chiba High School on June 17, 2011. This activity was held as a collaboration between Chiba High School and Tokyo Medical and Dental University.

2010

Our laboratory moved to a M&D tower.

We have moved from the 3-goukan to the M&D tower (24th floor).