• Medical Research Institute
  • Tokyo Medical and Dental University
  • Access

Research subject

Research subject

Our education has been conducted through the research on elucidation of mechanisms by which multicellular organs, in particular the central nervous and hematopoietic systems, are developed. We have specially focused on molecular regulation of neural stem cells, hematopoietic stem cells, and cancer stem cells in view of cell-external cues such as cytokines as well as cell-intrinsic programs including chromatin modification. These projects have been performed, for instance by elucidation of stem cell characteristics, analysis of transcriptional regulatory signaling pathways, and identification of niche signals.

  1. Molecular basis for the maintenance of neural stem cells
  2. Regulation of the neural stem cell fate
  3. Characterization of hematopoietic stem cells in fetal hematopoietic organs
  4. Characterization of cancer stem cells
  5. Epigenetic regulation of neural development

Self-renewal of neural stem cells

Transition of hematopoietic tissue in mouse ontogeny

Tumor formation and cencer stem cells