業績リスト

2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001

2000 | 1999 | 1998 | 1997 | 1996 | 1995 | 1994 | 1993 | 1992 | 1991 | 1990 | 1989 | 1988 | 1987

1986 | 1985 | 1984 | 1983 | 1982 | 1981 | 1980 | 1979 | 1978 | 1977 | 1976 | 1975

2014

  1. Uno M, Saitoh Y, Mochida K, Tsuruyama E, Kiyono T, Imoto I, Inazawa J, Yuasa Y, Kubota T, Yamaoka S. NF-κB inducing kinase, a central signaling component of the non-canonical pathway of NF-κB, contributes to ovarian cancer progression. PLoS One, 9, e88347, 2014.
  2. Tsuchida R, Osawa T, Wang F, Nishii R, Das B, Tsuchida S, Muramatsu M, Takahashi T, Inoue T, Wada Y, Minami T, Yuasa Y, Shibuya M. BMP4/Thrombospondin-1 loop paracrinically inhibits tumor angiogenesis and suppresses the growth of solid tumors. Oncogene 2014: , in press.

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2013

  1. Fukamachi H, Kato S, Asashima M, Ichinose M, Yuasa Y. Activin A regulates growth of gastro-intestinal epithelial cells by mediating epithelial-mesenchymal interaction. Development Growth and Differentiation 2013:55:786-791.
  2. Fukamachi H, Seol HS, Shimada S, Funasaka C, Baba K, Kim JH, Park YS, Kawachi H, Yook JH, Eishi Y, Kojima K, Kim WH, Jang SJ, Yuasa Y. CD49fhigh cells retain sphere-forming and tumor-initiating activities in human gastric tumors. PLoS One 2013:8:e72438.
  3. Hashimoto Y, Akiyama Y, Yuasa Y. Multiple-to-multiple relationships between microRNAs and target genes in gastric cancer. PLoS One 2013:8:e62589.
  4. Osawa T, Tsuchida R, Muramatsu M, Shimamura T, Wang F, Suehiro J, Kanki Y, Wada Y, Yuasa Y, Aburatani H, Miyano S, Minami T, Kodama T, Shibuya M. Inhibition of histone demethylase JMJD1A improves anti-angiogenic therapy and reduces tumor associated macrophages. Cancer Res 2013:73:3019-3028.
  5. Rotkrua P, Shimada S, Mogushi, K, Akiyama Y, Tanaka H, Yuasa Y. Circulating microRNAs as biomarkers for early detection of diffuse-type gastric cancer using a mouse model. Brit. J. Cancer 2013: 108:932-940.

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2012

  1. Shimada S, Mimata A, Sekine M, Mogushi K, Akiyama Y, Fukamachi H, Jonkers J, Tanaka H, Eishi Y, Yuasa Y. Synergistic tumour suppressor activity of E-cadherin and p53 in a conditional mouse model for metastatic diffuse-type gastric cancer. Gut 2012:61:344-353.
  2. Yuasa Y, Nagasaki H, Oze I, Akiyama Y, Yoshida S, Shitara K, Ito S, Hosono S, Watanabe M, Ito H, Tanaka H, Kang DH, Pan K-F, You W-C, Matsuo K. IGF2 hypomethylation of blood leukocyte DNA is associated with gastric cancer risk. Int. J. Cancer 2012:131:2596-2603.
  3. Song M-Y, Pan K-F, Su H-J, Zhang L, Ma J-L, Li J-Y, Yuasa Y, KangDH, Kim YS, You W-C. Identification of serum microRNAs as novel non-invasive biomarkers for early detection of gastric cancer. PLoS One 2012:7:e33608.
  4. Li L, Choi JY, Lee KM, Sung H, Park SK, Oze I, Pan KF, You WC, Chen YX, Fang JY, Matsuo K, Kim WH, Yuasa Y, Kang D. DNA methylation in peripheral blood: a potential biomarker for cancer molecular epidemiology. J. Epidemiol. 2012:22:384-394.
  5. Voon D. C., Wang, H., Koo, J. K., Nguyen, T. A., Hor, Y. T., Chu, Y. S., Ito, K., Fukamachi, H., Chan, S. L., Thiery, J. P., Ito, Y. (2012) Runx3 protects gastric epithelial cells against epithelial-mesenchymal transition-induced cellular plasticity and tumorigenicity. Stem Cells 2012:30:2088-2099.
  6. Tsuchiya, Y., Saito, Y., Taniuchi, S., Sakuma, A., Maekawa, T., Fukamachi, H., Takeuchi, S., Takahashi, S. (2012) Runx3 expression and its roles in mouse endometrial cells. J. Reprod. Develop. 2012:58:592-598.

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2011

  1. Otsubo T, Akiyama Y, Hashimoto Y, Shimada S, Goto K, Yuasa Y: MicroRNA-126 inhibits SOX2 expression and contributes to gastric carcinogenesis. PLoS One 2011:6:e16617.
  2. Mimata A, Fukamachi H, Eishi Y, Yuasa Y: Loss of E-cadherin in mouse gastric epithelial cells induces signet ring-like cells, a possible precursor lesion of diffuse gastric cancer. Cancer Sci. 2011:102:942-950.
  3. Fukamachi H, Shimada S, Ito K, Ito Y, Yuasa Y. CD133 is a marker of gland-forming cells in gastric tumors and Sox17 is involved in its regulation. Cancer Sci. 2011:102:1313-1321.
  4. Rotkrua P, Akiyama Y, Hashimoto Y, Otsubo T, Yuasa Y: MiR-9 down-regulates CDX2 expression in gastric cancer cells. Int.J.Cancer 2011:129:2611-2620.
  5. Wang F, Osawa T, Tsuchida R, Yuasa Y, Shibuya M. Downregulation of receptor for activated C-kinase 1 (RACK1) suppresses tumor growth by inhibiting tumor cell proliferation and tumor-associated angiogenesis. Cancer Sci. 2011:102:2007-2013
  6. Ito K, Chuang L. S. H, Ito T, Chang TL, Fukamachi H, Salto–Tellez M, Ito Y. Loss of Runx3 is a key event in inducing precancerous state of the stomach. Gastroenterology 2011:140:1536-1546.
  7. Dhondt J, Peeraer E, Verheyen A, Nuydens R, Buysschaert I, Poesen K, Van Geyte K, Beerens M, Shibuya M, Haigh JJ, Meert T, Carmeliet P, Lambrechts D. Neuronal FLT1 receptor and its selective ligand VEGF-B protect against retrograde degeneration of sensory neurons. FASEB J 2011：25:1461-1473.
  8. Kato T, Ito Y, Hosono K, Suzsuki T, Tamaki H, Minamino T, Kato S, Sakagami H, Shibuya M, Majima M. Vascular endothelial growth factor receptor-1 signaling promotes liver repair through restoration of liver microvasculature after acetaminophen hepatotoxicity. Toxicol Sci. 2011:120:218-229.
  9. Wang F, Yamauchi M, Muramatsu M, Osawa T, Tsuchida R, Shibuya M. RACK1 regulates VEGF/Flt1-mediated cell migration via activation of a PI3K/Akt pathway. J Biol Chem. 2011:286:9097-9106.
  10. Osawa T, Tsuchida R, Muramatsu M, Yuasa Y, Shibuya M. Human glioblastoma cells exposed to long-term hypoxia and nutrient starvation stimulated induction of secondary T cell leukemia in mice. Blood Cancer J, 2011:1, e6.
  11. Lu Y, Xiong Y, Huo Y, Han J, Yang X, Zhang R, Zhu DS, Klein-Heßling S, Li J, Zhang X, Han X, Li Y, Shen B, He Y, Shibuya M, Feng GS, Luo J. Grb-2-associated binder 1 (Gab1) regulates postnatal ischemic and VEGF-induced angiogenesis through the protein kinase A-endothelial NOS pathway. Proc Natl Acad Sci U S A. 2011:108:2957-2962.
  12. Kubota Y, Takubo K, Hirashima M, Nagoshi N, Kishi K, Okuno Y, Nakamura-Ishizu A, Sano K, Murakami M, Ema M, Omatsu Y, Takahashi S, Nagasawa T, Shibuya M, Okano H, Suda T. Isolation and function of tissue resident vascular precursors marked by myelin protein zero. J Exp Med. 2011:208:949-960.
  13. Brave SR, Ratcliffe K, Wilson Z, James N, Ashton SE, Wainwright A, Kendrew J, Dudley P, Broadbent N, Sproat G, Taylor S, Barnes C, Silva JC, Farnsworth CL, Hennequin L, Ogilvie DJ, Jürgensmeier JM, Shibuya M, Wedge SR, Barry ST. Assessing the Activity of Cediranib, a VEGFR-2/-3 tyrosine kinase inhibitor, against VEGFR-1 and members of the structurally related PDGFR-family. Mol Cancer Ther. 2011:10:861-873.
  14. Laurent J, Faes-Van't Hull E, Touvrey C, Kuonen F, Lan Q, Lorusso G, Doucey MA, Ciarloni L, Imaizumi N, Alghisi GC, Fagiani E, Zaman K, Stupp R, Shibuya M, Delaloye JF, Christofori G, Ruegg C. Proangiogenic programming of CD11b+ myelomonocytes in breast cancer by PlGF during hematopoietic progenitors differentiation. Cancer Res. 2011:71:3781-3791.
  15. Yao J, Wu X, Zhuang G, Kasman IM, Vogt T, Phan V, Shibuya M, Ferrara N, Bais C. Expression of a functional VEGFR-1 in tumor cells is a major determinant of anti-PlGF antibodies efficacy. Proc Natl Acad Sci U S A. 2011:108:11590-11595.
  16. Wang F, Osawa T, Tsuchida R, Yuasa Y, Shibuya M. Down-regulation of RACK1 suppresses tumor growth by inhibiting tumor cell proliferation and tumor-associated angiogenesis. Cancer Sci. 2011:102:2007-2013.
  17. Bhardwaj S, Roy H, Babu M, Shibuya M, Yla-Herttuala S. Adventitial gene transfer of VEGFR-2 specific VEGF-E chimera induces MCP-1 expression in vascular smooth muscle cells and enhances neointimal formation. Atherosclerosis. 2011:219: 84-91.
  18. Han J, Lee JE, Jin J, Lim JS, Oh N, Kim K, Chang SI, Shibuya M, Kim H, Koh GY. The spatiotemporal development of adipose tissue. Development. 2011:138:5027-5037.
  19. Osawa T, Muramatsu M, Wang F, Tsuchida R, Kodama T, Minami T, Shibuya M. Increased expression of histone demethylase JHDM1D under nutrient starvation suppresses tumor growth via downregulating angiogenesis. Proc Natl Acad Sci U S A. 2011:108:20725-20729.

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2010年

  1. Wada R, Akiyama Y, Hashimoto Y, Fukamachi H, Yuasa Y: miR-212 is down-regulated and suppresses methyl-CpG-binding protein MeCP2 in human gastric cancer. Int.J.Cancer.127:1106-1114.
  2. Hashimoto Y, Akiyama Y, Otsubo T, Shimada S, Yuasa Y: Involvement of epigenetically silenced microRNA-181c in gastric carcinogenesis. Carcinogenesis.31:774-784.
  3. Wen XZ, Akiyama Y, Pan KF, Liu ZJ, Lu ZM, Zhou J, Gu LK, Dong CX, Zhu BD, Ji JF, You WC, Deng DJ: Methylation of GATA-4 and GATA-5 and development of sporadic gastric carcinomas. World J. Gastroenterology, 2010:16:1201-1208.
  4. Chang TL, Ito K, Ko TK, Liu Q, Salto-Tellez M, Yeoh KG, Fukamachi H, Ito Y: Claudin-1 has tumor suppressive activity and is a direct target of RUNX3 in gastric epithelial cells. Gastroenterology, 2010:138:255-265.
  5. Yuasa Y: Epigenetics in molecular epidemiology of cancer: a new scope. Adv Genet. 2010:71:211-235.

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2009年

  1. Yuasa Y, Nagasaki H, Akiyama Y, Hashimoto Y, Takizawa T, Kojima K, Kawano T, Sugihara K, Imai K, and Nakachi K: DNA methylation status is inversely correlated with green tea intake and physical activity in gastric cancer patients. Int. J. Cancer 2009:124:2677-2682.
  2. Hellebrekers DMEI, Lentjes, MHFM, van den Bosch SM, Wouters AD, Daenen K, Melotte V, Smits KM, Partouns-Hendriks IEJM, Akiyama Y, Yuasa Y, Sanduleanu S, Khalid-de Bakker C, Jonkers D, Weijenberg MP, Louwagie J, van Criekinge W, Carvalho B, Meijer GA, Baylin SB, Herman JG, de Bru?ne AP & van Engeland M: GATA4 and GATA5 are potential tumor suppressors and biomarkers in colorectal cancer. Clinical Cancer Res., 2009:15:3990-3997.
  3. Komi Y, Suzuki Y, Shimamura M, Kajimoto S, Nakajo S, Masuda M, Shibuya M, Itabe H, Shimokado K, Oettgen P, Nakaya K, Kojima S. Mechanism of Inhibition of Tumor Angiogenesis by beta-Hydroxyisovalerylshikonin. Cancer Sci. 100:269-277, 2009.
  4. Osawa T, Muramatsu M, Watanabe M, Shibuya M. Hypoxia and Low Nutrition Double Stress Induces Aggressiveness in a Murine Model of Melanoma. Cancer Sci. 100:844-851, 2009.
  5. Kubota Y, Takubo K, Shimizu T, Ohno H, Kishi K, Shibuya M, Saya H, Suda T. M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis. J Exp Med. 206:1089-102, 2009
  6. Wittko IM, Sch?nzer A, Kuzmichev A, Schneider FT, Shibuya M, Raab S, Plate KH. VEGFR-1 regulates adult olfactory bulb neurogenesis and migration of neural progenitors in the rostral migratory stream in vivo. J Neurosci. 29: 8704-8714, 2009.
  7. Imai N, Miwa H, Shikami M, Suganuma K, Gotoh M, Hiramatsu A, Wakabayashi M, Watarai M, Hanamura I, Imamura A, Mihara H, Shitara K, Shibuya M, Nitta M. Growth inhibition of AML cells with specific chromosome abnormalities by monoclonal antibodies to receptors for vascular endothelial growth factor. Leukemia Res. 33: 1650-1657, 2009.
  8. Xiong Y, Huo Y, Chen C, Zeng H, Lu X, Wei C, Ruan C, Zhang X, Hu Z, Shibuya M, Luo J. VEGF Receptor-2 Y1175 signaling controls VEGF-induced vWF release from endothelial cells via PLCgamma1- and PKA-dependent pathways. J Biol Chem. 284: 23217-2324, 2009.
  9. Suzuki H, Ohkuchi A, Matsubara S, Takei Y, Murakami M, Shibuya M, Suzuki M, Sato Y. Effect of recombinant placental growth factor 2 on hypertension induced by full-length mouse soluble fms-like tyrosine kinase 1 adenoviral vector in pregnant mice. Hypertension. 54:1129-1135, 2009.

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2008年

  1. Jin S-H, Akiyama Y, Fukamachi H, Yanagihara K, Akashi T, Yuasa Y: IQGAP2 inactivation through aberrant promoter methylation and promotion of invasion in gastric cancer cells. Int. J. Cancer, 2008:122:1040-1046.
  2. Otsubo T, Akiyama Y, Yanagihara K, Yuasa Y: SOX2 is frequently down-regulated in gastric cancers and inhibits 　cell growth through cell cycle arrest and apoptosis. Brit. J. Cancer 2008:98:824-831.
  3. Wanajo A , Sasaki A , Nagasaki H, Shimada S, Otsubo T, Owaki S, Shimizu Y, Eishi Y, Kojima K, Nakajima Y, Kawano T, Yuasa Y, Akiyama Y: Methylation of the calcium channel-related gene, CACNA2D3, is frequent and a poor prognostic factor in gastric cancer. Gastroenterology, 2008:135:80-590.
  4. Fukamachi H, Mimata A, Tanaka I, Ito K, Ito Y, Yuasa, Y: Differentiation in vitro of Runx3-/-p53-/- gastric epithelial cells into intestinal type cells. Cancer Sci. 2008:99:671-676.
  5. Kurakata H, Oka M, Matsubara Y, Niwa T, Utsunomiya H, Fujishiro M, Miki K, Fukamachi H, Kubota S, Ichinose M: Developmentally regulated expression of matrix metalloproteinases during fetal rat colon morphogenesis. Develop Growth Differ., 2008:50: 41-48.
  6. Sakuma A, Fukamachi H, Ito K, Ito Y, Takeuchi S, Takahashi S: Loss of Runx3 affects ovulation and estrogen-induced endometrial cell proliferation in female mice. Mol Reprod Develop., 2008:75:1653-1661.
  7. Ito K, Lim A. C.-B, Salto-Tellez M, Motoda L, Osato M, Chuang L. S. H, Lee C. W. L, Voon D. C.-C, Koo J. K. W, Wang H, Fukamachi H, Ito Y: RUNX3 attenuates β-catenin/T cell factors in intestinal tumorigenesis. Cancer Cell, 2008:14: 226-237.
  8. Hiratsuka S, Watanabe A, Sakurai Y, Akashi-Takamura S, Ishibashi S, Miyake K, Shibuya M, Akira S, Aburatani H, Maru Y. The S100A8-serum amyloid A3-TLR4 paracrine cascade establishes a pre-metastatic phase. Nat Cell Biol. 10:1349-1355, 2008.
  9. Poesen K, Lambrechts D, Van Damme P, Dhondt J, Bender F, Frank N, Bogaert E, Claes B, Heylen L, Verheyen A, Raes K, Tjwa M, Eriksson U, Shibuya M, Nuydens R, Van Den Bosch L, Meert T, D'Hooge R, Sendtner M, Robberecht W, Carmeliet P. Novel Role for VEGF-Receptor-1 and its Ligand VEGF-B in Motor Neuron Degeneration. J Neurosci 28: 10451-10459, 2008.
  10. Nishi JI, Minamino T, Miyauchi H, Nojima A, Tateno K, Okada S, Orimo M, Moriya J, Fong GH, Sunagawa K, Shibuya M, Komuro I. Vascular Endothelial Growth Factor Receptor-1 Regulates Postnatal Angiogenesis Through Inhibition of the Excessive Activation of Akt. Circulation Res 103: 261-268, 2008.
  11. Kami J, Muranaka K, Yanagi Y, Obata R, Tamaki Y, Shibuya M. Inhibition of choroidal neovascularization by blocking vascular endothelial growth factor receptor tyrosine kinase. Jpn J Ophthalmol 52: 91-98, 2008.
  12. Kerber M, Reiss Y, Wickersheim A, Jugold M, Kiessling F, Heil M, Tchaikovski V, Waltenberger J, Shibuya M, Plate KH, Machein MR. Flt-1 signaling in macrophages promotes glioma growth in vivo. Cancer Res 68: 7342-7351, 2008.
  13. Tammela T, Zarkada G, Wallgard E, Murtomaki A, Suchting S, Wirzenius M, Waltari M, Hellstrom M, Schomber T, Peltonen R, Freitas C, Duarte A, Isoniemi H, Laakkonen P, Christofori G, Yla-Herttuala S, Shibuya M, Pytowski B, Eichmann A, Betsholtz C, Alitalo K. Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation. Nature 54: 656-660, 2008.
  14. Fukuhara S, Sako K, Minami T, Noda K, Kim HZ, Kodama T, Shibuya M, Takakura N, Koh GY, Mochizuki N. Differential function of Tie2 at cell-cell contacts and cell-substratum contacts regulated by angiopoietin-1. Nat Cell Biol 10: 513-526, 2008.
  15. Endo Y, Sugiyama A, Li SA, Ohmori K, Ohata H, Yoshida Y, Shibuya M, Takei K, Enari M, Taya Y. Regulation of clathrin-mediated endocytosis by p53. Genes Cells 13: 375-386, 2008.
  16. Tsuchida R, Das B, Yeger H, Koren G, Shibuya M, Thorner PS, Baruchel S, Malkin D. Cisplatin treatment increases survival and expansion of a highly tumorigenic side-population fraction by upregulating VEGF/Flt1 autocrine signaling. Oncogene 27: 3923-3934, 2008.
  17. Murakami, M. Zheng Y, Hirashima M, Suda T, Morita Y, Ooehara J, Ema H, Fong GH, Shibuya M. VEGFR1 Tyrosine Kinase Signaling Promotes Lymphangiogenesis as Well as Angiogenesis Indirectly via Macrophage Recruitment. Arterioscler Thromb Vasc Biol 28: 658-664, 2008.
  18. Taguchi, E., Nakamura K, Miura T, Shibuya M, Isoe T. Anti-tumor activity and tumor vessel normalization by the vascular endothelial growth factor receptor tyrosine kinase inhibitor KRN951 in a rat peritoneal disseminated tumor model. Cancer Sci 99: 623-630, 2008.
  19. Yuasa Y: Frontiers in epigenetics medicine: foreword: Miniseries collected from a symposium organized by the Study Group on Epigenetics Medicine held at the 77th Annual Meeting of the Japanese Society for Hygiene. Environ. Health Prev. Med., 2008:13:2.
  20. Murakami M, Shibuya M. Involvement of vascular endothelial growth factor receptor-1 in rheumatoid arthritis. Inflammation and Regeneration, 28: 78-85, 2008.
  21. Shibuya M. Vascular endothelial growth factor-dependent and -independent regulation of angiogenesis. BMB Rep 41: 278-286, 2008.

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2007年

Original

  1. Tani Y, Akiyama Y, Fukamachi H, Yanagihara K, Yuasa Y: Transcription factor SOX2 up-regulates stomach-specific pepsinogen A gene expression. J. Cancer Res. Clin. Oncol. 133: 263-269, 2007.
  2. Jinawath A, Akiyama Y, Sripa B, Yuasa Y: Dual blockade of the Hedgehog and ERK1/2 pathways coordinately decreases proliferation and survival of cholangiocarcinoma cells. J. Cancer Res. Clin. Oncol. 133: 271-278, 2007.
  3. Satoh Y, Ohkawa R, Nakamura K, Higashi K, Kaneko M, Yokota H, Aoki J, Arai H, Yuasa Y, Yatomi Y: Lysophosphatidic acid protection against apoptosis in the human pre-B-cell line Nalm-6. Eur. J. Haemat. 78:510-517, 2007.
  4. Makita N, Sato J, Rondard P, Fukamachi H, Yuasa Y, Aldred MA, Hashimoto M, Fujita T, Iiri T: Human Gs mutant causes pseudohypoparathyroidism type Ia/neonatal diarrhea, a potential cell-specific role of the palmitoylation cycle. Proc. Natl. Acad. Sci. U.S.A. 2007:104:17424-17429.
  5. Taniwaki K, Fukamachi H, Komori K, Ohtake Y, Nonaka T, Sakamoto T, Shiomi T, Okada Y, Itoh T, Itohara S, Seiki M, Yana I: Stroma-derived matrix metalloproteinase (MMP)-2 promotes membrane type 1-MMP-dependent tumor growth in mice. Cancer Res., 67:4311-4319, 2007.
  6. Inoue N, Kondo T, Kobayashi K, Aoki M, Numaguchi Y, Shibuya M, Murohara T: Therapeutic Angiogenesis Using Novel Vascular Endothelial Growth Factor-E/Human Placental Growth Factor Chimera Genes. Arterioscler Thromb Vasc Biol., 27:99-105, 2007.
  7. Shinoda G, Umeda K, Heike T, Arai M, Niwa A, Ma F, Suemori H, Luo HY, Chui DH, Torii R, Shibuya M, Nakatsuji N, Nakahata T: {alpha}4-integrin+ endothelium derived from primate embryonic stem cells generates both primitive and definitive hematopoietic cells. Blood. 109:2406-2415, 2007.
  8. Zheng Y, Watanabe M, Kuraishi T, Hattori S, Kai C, Shibuya M: Chimeric VEGF-ENZ7/PlGF Specifically Binding to VEGFR-2 Accelerates Skin Wound Healing via Enhancement of Neovascularization. Arterioscler, Thromb, Vasc. Biol., 27:503-511, 2007.
  9. Wirzenius M, Tammela T, Uutelaff M, He Y, Odorisio T, Sambruno G, Nagy JA, Dvorak HF, Yla-Herttuala S, Shibuya M, Alitalo K: Distinct vascular endothelial growth factor signals for lymphatic vessel enlargement and sprouting. J. Exp. Med. 204:1431-1340, 2007.
  10. Nagano M, Yamashita T, Hamada H, Ohneda K, Kimura K, Nakagawa T, Shibuya M, Yoshikawa H, Ohneda O: Identification of functional endothelial progenitor cells suitable for the treatment of ischemic tissue using human umbilical cord blood. Blood. 110:151-160, 2007.
  11. Yamauchi M, Imajoh-Ohmi S, Shibuya M: A novel anti-angiogenic pathway of thrombospondin-1 mediated by suppression of the cell cycle. Cancer Science 98:1491-1497, 2007.
  12. Kunizaki M, Hamamoto R, Silva FP, Yamaguchi K, Nagayasu T, Shibuya M, Nakamura Y, Furukawa Y.The lysine 831 of vascular endothelial growth factor receptor 1 is a novel target of methylation by SMYD3. Cancer Res., 67:10759-1065, 2007.
  13. Usui R, Shibuya M, Ishibashi S, Maru Y: Ligand-independent activation of vascular endothelial growth factor receptor 1 by low-density lipoprotein. EMBO Rep. 8:1155-1161, 2007.

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2006年

Original

  1. Wen X-Z, Akiyama Y, Baylin SB, Yuasa Y: Frequent epigenetic silencing of the bone morphogenetic protein 2 gene through methylation in gastric carcinomas. Oncogene 2006:25:2666-2673.
  2. Wakana K, Akiyama Y, Aso T, Yuasa Y: Involvement of GATA-4/-5 transcription factors in ovarian carcinogenesis. Cancer Letters 2006:241:281-288.
  3. Sekine A, Akiyama Y, Yanagihara K, Yuasa Y: Hath1 up-regulates gastric mucin genes in gastric cells. Biochem. Biophys. Res. Commun. 2006:344:1166-1171.
  4. Jinawath A, Akiyama Y, Yuasa Y, Pairojkul C: Expression of phosphorylated ERK1/2 and homeodomain protein CDX2 in cholangiocarcinoma. J. Cancer Res. Clin. Oncol. 2006:132:805-810.
  5. Tsuruzoe S, Ishihara K, Uchimura Y, Watanabe S, Sekita Y, Aoto T, Saitoh H, Yuasa Y, Niwa H, Kawasuji M, Baba H, Nakao M: Inhibition of DNA binding of Sox2 by the SUMO conjugation. Biochem. Biophys. Res. Commun. 2006:351:920-926.
  6. Guo M, House MG, Akiyama Y, Qi Y, Capagna DC, Harmon J, Baylin SB, Brock MV, Herman JG: Hypermethylation of the GATA gene family in esophageal cancer. Int. J. Cancer 2006:119:2078-2083.
  7. Takano-Maruyama M, Hase K, Fukamachi H, Kato Y, Koseki H, Ohno H: Foxl1-deficient mice exhibit aberrant epithelial cell positioning due to dysregulated EphB/EphrinB expression in the small intestine. Amer J Physiol Gastrointest Liver Physiol 2006:291:G163-G170.
  8. Yano T, Ito K, Fukamachi H, Chi X-Z, Wee H-J, Inoue K, Ida H, Bouillet P, Strasser A, Bae S-C, Ito Y: The RUNX3 tumor suppressor upregulates Bim in gastric epithelial cells undergoing transforming growth factor ?-induced apoptosis. Mol Cell Biol 2006:26:4474-4488.

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2005年

Original

  1. Yuasa Y, Nagasaki H, Akiyama Y, Sakai H, Nakajima T, Ohkura Y, Takizawa T, Koike M, Tani M, Iwai T, Sugihara K, Imai K, Nakachi K: Relationship between CDX2 gene methylation and dietary factors in gastric cancer patients.
    Carcinogenesis 2005:26:193-200.
  2. Jinawath A, Miyake S, Yanagisawa Y, Akiyama Y, Yuasa Y: Transcriptional regulation of the human DNA methyltransferase 3A and 3B genes by Sp3 and Sp1 zinc finger proteins. Biochemical J. 2005:385:557-564.
  3. Wu XS, Akiyama Y, Igari T, Kawamura T, Hiranuma S, Shibata T, Tsuruta K, Koike M, Arii S, Yuasa Y: Expression of homeodomain protein CDX2 in gallbladder carcinomas. J. Cancer Res. Clin. Oncol., 2005:131:271-278.
  4. Maekawa M, Yamamoto T, Tanoue T, Yuasa Y, Chisaka O, Nishida E: Requirement of the MAP kinase signaling pathways for mouse preimplantation development. Development 2005:132:1773-1783.
  5. Sasajima Y, Tanaka H, Miyake S, Yuasa Y: A novel EID family member, EID-3, forms a homodimer or heterodimer with EID-2. Biochem. Biophys. Res. Commun. 2005:333:969-975.
  6. Sakai H, Jinawath A, Yamaoka S, Yuasa Y: Upregulation of MUC6 mucin gene expression by NF- kB and Sp factors. Biochem. Biophys. Res. Commun. 2005:333:1254-1260.
  7. Galm O, Suzuki H, Akiyama Y, Esteller M, Malcolm MV, Osieka R, Baylin SB, Herman JG: Inactivation of the tissue inhibitor of metallortoteinases-2 gene by promoter hypermethylation in lymphoid malignancies. Oncogene 2005:24:4799-4805.
  8. Fukamachi H, Narita T, Yahagi N, Takeda H, Ichinose M. Endothelin-3 controls growth of colonic epithelial cells by mediating epithelial-mesenchymal interaction. Develop. Growth Differ. 2005:47:572-580.
  9. Ohsugi M, Kuroki K, Fukamachi H, O'Reilly LA, Kuida K, Strasser A, Yonehara, S. Transforming growth factor-β-dependent sequential activation of Smads, Bim and caspase-9 mediates physiological apoptosis in gastric epithelial cells. Mol. Cell. Biol. 2005:25:10017-10028.

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2004年

Original

  1. Li X-L, Eishi Y, Bai Y-Q, Sakai H, Akiyama Y, Tani M, Takizawa T, Koike M, Yuasa Y: Expression of the SRY-related HMG box protein SOX2 in human gastric carcinoma. Int. J. Oncology 2004:24:257-263
  2. Sakai H, Eishi Y, Li X-L, Akiyama Y, Miyake S, Takizawa T, Konishi N, Tatematsu M, Koike M, Yuasa Y: PDX1 homeobox protein expression in pseudopyloric glands and gastric carcinomas. Gut 2004:53:323-330.
  3. Ren C-Y, Akiyama Y, Miyake S, Yuasa Y: Transcription factor GATA-5 selectively up-regulates mucin gene expression. J. Cancer Res. Clin. Oncol., 2004:130:245-252.
  4. Wen X-Z, Miyake S, Akiyama Y, Yuasa Y: BMP-2 modulates the proliferation and differentiation of normal and cancerous gastric cells. Biochem. Biophys. Res. Commun., 2004:316:100-106.
  5. Douglas DB, Akiyama Y, Esteller M, Gabrielson E, Weitzman S, Williams T, Herman JG, Baylin SB: Hypermethylation of a small CpGuanine-rich region correlates with loss of activator protein-2alpha during progression of breast cancer. Cancer Res., 2004:64:1611-1620.
  6. Suzuki H, Watkins DN, Jair K-M, Schuebel KE, Markowitz SD, Chen W-D, Pretlow TP, Yang B, Akiyama Y, van Engeland M, Toyota M, Tokino T, Hinoda Y, Imai K, Herman JG, Baylin SB: Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer. Nat. Genet., 2004:36:582-584.
  7. Guo M, Akiyama Y, House MG, Hooker CM, Heath E, Gabrielson E, Yang SC, Han Y, Baylin SB, Herman JG , Brock MV: Hypermethylation of the GATA Genes in Lung Cancer. Clini. Cancer Res., 2004:10:7917-7924.
  8. Ryu GH, Tanaka H, Kim DH, Kim JH, Bae SH, Kwon YN, Rhee JS, MacNeill SA, Seo YS: Genetic and biochemical analyses of Pfh1 DNA helicase function in fission yeast. Nucleic Acids Res., 2004:32:42054216.
  9. Tanaka H, Ryu GH, Seo YS, MacNeill SA: Genetics of lagging strand DNA synthesis and maturation in fission yeast: suppression analysis links the Dna2-Cdc24 complex to DNA polymerase delta. Nucleic Acids Res., 2004:32:6367-6377.

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2003年

  1. Miyake S, Yanagisawa Y, Yuasa Y: A novel EID-1 family member, EID-2, associates with histone deacetylases and inhibits muscle differentiation. J. Biol. Chem. 2003:278:17060-17065.
  2. Bai Y-Q, Miyake S, Iwai T, Yuasa Y: CDX2, a homeobox transcription factor, up-regulates transcription of the p21/WAF1/CIP1 gene. Oncogene 2003:22:7942-7949.
  3. Yamamoto H, Bai Y-Q, Yuasa Y: Homeodomain protein CDX2 regulates goblet-specific MUC2 gene expression. Biochem. Biophys. Res. Commun. 2003:300:813-818.
  4. Ishikawa T, Fujita T, Suzuki Y, Okabe S, Yuasa Y, Iwai T, Kawakami Y: Tumor-specific immunological recognition of frameshift-mutated peptides in colon cancer with microsatellite instability. Cancer Res. 2003:63:5564-5572.
  5. Brock MV, Gou M, Akiyama Y, Muller A, Wu T-T, Montgomery E, Deasel M, Germonpre P, Rubinson L, Heitmiller RF, Yang SC, Forastiere AA, Baylin SB & Herman JG. Prognostic importance of promoter hypermethylation of multiple genes in esophageal adenocarcinoma. Clinical Cancer Res. 2003:9:2912-2919.
  6. Akiyama Y, Watkins N, Suzuki H, Jair K-W, van Engeland M, Esteller M, Sakai H, Ren C-Y, Yuasa Y, Herman JG and Baylin SB: GATA-4 and GATA-5 transcription factor genes and potential downstream anti-tumor target genes are epigenetically silenced in colorectal and gastric cancer. Mol. Cell. Biol. 2003:23:8429-8439.
  7. Xie GX, Han X, Ito E, Yanagisawa Y, Maruyama K, Sugano S, Suzuki Y, Wang Y, Gabriel A, Stevens SK, Mitchell J, Sharma M, Palmer PP. Gene structure, dual-promoters and mRNA alternative splicing of the human and mouse regulator of G protein signaling GAIP/RGS19. J. Mol. Biol. 2003:325:721-732.
  8. Yuasa Y: Control of gut differentiation and intestinal type gastric carcinogenesis. Nature Rev. Cancer 2003:3:592-600.

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2002年

  1. Bai Y-Q, Yamamoto H, Akiyama Y, Tanaka H, Takizawa T, Koike M, Yagi OK, Saitoh K, Takeshita K, Iwai T, Yuasa Y: Ectopic expression of homeodomain protein CDX2 in intestinal metaplasia and carcinomas of the stomach.　Cancer Letters 2002:176:47-55.
  2. Hiwasa T, Shimada H, Ochiai T, Liu T-L, Yuasa Y, Takiguchi M, Ohkoshi M: Decrease in growth factor receptors after treatment with serine protease inhibitor ONO-3403. Int. J. Oncol.2002:20:797-802.
  3. Homma MK, Li D, Krebs EG, Yuasa Y, Homma Y: Association and regulation of casein kinase 2 activity by adenomatous polyposis coli protein. Proc. Natl. Acad. Sci. U.S.A. 2002:99:5959-5964.
  4. Yanagisawa Y, Ito E, Yuasa Y, Maruyama K: DNA methyltransferases DNMT3A and DNMT3B have two types of promoters with different CpG contents. Biochimica Biophysica Acta 2002:1577:457-465.
  5. Tanaka H, Ryu G-H, Seo Y-S, Tanaka K, Okayama H, MacNeill SA, Yuasa Y: The fission yeast pfh1+ gene encodes an essential 5' to 3' DNA helicase require for the completion of S-phase. Nucleic Acids Research 2002:30:4728-4739.
  6. Nakajima Y, Nagai K, Miyake S, Ohashi K, Kawano T, Iwai T, Evaluation of an indicator for lymph node metastasis of esophageal squamous cell carcinoma invading the submucosal layer. Jpn J Cancer Res, 2002:93:305-312.
  7. Yuasa Y: DNA methylation in cancer and ageing. Mechanisms of Ageing and Development 2002:123:1649-1654.

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2001年

  1. Nakajima T, Akiyama Y, Shiraishi J, Arai T, Yanagisawa Y, Ara M, Fukuda Y, Sawabe M, Saitoh K, Kamiyama R, Hirokawa K, Yuasa Y: Age-related hypermethylation of the hMLH1 promoter in gastric cancers. Int. J. Cancer 2001:94:208-211.
  2. Esteller M, Fraga MF, Guo M, Garcia-Foncillas J , Hedenfalk I, Godwin AK, Trojan J, Vaurs-Barriere C, Bignon Y-J, Ramus S, Benitez J, Caldes T, Akiyama Y, Yuasa Y, Launonen V, Canal MJ, Rodriguez R, Capella G, Peinado MA, Borg A, Aaltonen LA, Ponder BA, Baylin SB, Herman JG: DNA methylation patterns in hereditary human cancers mimic sporadic tumorigenesis. Human Molecular Genetics 2001:10:3001-3007.
  3. Sato Y, Akiyama Y, Tanizawa T, Shibata T, Saito K, Mori S, Kamiyama R, Yuasa Y: Molecular characterization of the genomic breakpoint junction in the t(11;18)(q21;q21) translocation of a gastric MALT lymphoma. Biochem. Biophys. Res. Commun. 2001:280:301-306.
  4. Akiyama Y, Nagasaki H, Nakajima T, Sakai H, Nomizu T, Yuasa Y: Infrequent frameshift mutations in the simple repeat sequences of hMLH3 in hereditary nonpolyposis colorectal cancers. Jpn. J. Clinical Oncology 2001:31:61-64.
  5. Kai M, Tanaka H, Wang TS: Fission yeast rad17 associates with chromatin in response to aberrant genomic structures. Molecular and Cellular Biology 2001:21:3289-3301.
  6. Nakajima Y, Miyake S, Nagai K, Kawano T,　Iwai T: CPT-11 may provide therapeutic efficacy for esophageal squamous cell cancer and the effects correlate with the level of DNA Topoisomerase I protein. Jpn. J. Cancer Res. 2001:92:1335-1341.

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2000年

  1. Bai Y-Q, Akiyama Y, Nagasaki H, Yagi OK, Kikuchi Y, Saito N, Takeshita K, 　Iwai T, Yuasa Y: Distinct expression of CDX2 and GATA4/5, development-related genes, in human gastric cancer cell lines. Molecular Carcinogenesis 2000:28:184-188.
  2. Yanagisawa Y, Akiyama Y, Iida S, Ito E, Nomizu T, Sugihara K, Yuasa Y, Maruyama K: Methylation of the hMLH1 promoter in familial gastric cancer with microsatellite instability. Int. J. Cancer 2000:85:50-53.
  3. Iida S, Akiyama Y, Nakajima T, Ichikawa W, Nihei Z, Sugihara K, Yuasa Y: Alterations and hypermethylation of the p14ARF gene in gastric cancers.
    Int. J. Cancer 2000:87:654-658
  4. Akiyama Y, Nagasaki H, Yagi OK, Nomizu T, Yuasa Y: -catenin and adenomatous
    polyposis coli (APC) mutations in adenomas from hereditary nonpolyposis colorectal cancer patients. Cancer Letters 2000:157:185-191.
  5. Furihata M, Shuin T, Takeuchi T, Sonobe H, Ohtsuki Y, Akiyama Y, Yuasa Y: Missense mutation of the hMSH6 and p53 genes in sporadic urothelial transitional cell carcinoma. Int. J. Oncology 2000:16:491-496.
  6. Suzuki L, Woessner JP, Uchida H, Kuroiwa H, Yuasa Y, Waffenschmidt S, Goodenough UW, Kuroiwa T: A zygote-specific protein with hydroxyproline-rich glycoprotein domains and lectin-like domains involved in the assembly of the cell wall of Chlamydomonas reinhardt. (chlorophyta). J. Phycol. 2000:36:571-583.
  7. Yuasa Y: Molecular genetics of colorectal and gastric cancers. J. Clinical Biochemistry and Nutrition, 2000:28:167-175.

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1999年

  1. Yagi OK, Akiyama Y, Yuasa Y: Genomic structure and alterations of homeobox gene CDX2 in colorectal carcinomas.
    British Journal of Cancer 1999:79:440-444.
  2. Ito E, Iwahashi Y, Yanagisawa Y, Suzuki Y, Sugano S, Yuasa Y, Maruyama K: Two short sequences have positive effects on the human p27kip1 gene transcription.
    Gene 1999:228:93-100.
  3. Ito E, Yanagisawa Y, Iwahashi Y, Suzuki Y, Nagasaki H, Akiyama Y, Sugano S, Yuasa Y, Maruyama K: A core promoter and a frequent single-nucleotide polymorphism of the mismatch repair gene hMLH1.
    Biochem. Biophys. Res. Commun. 1999:256:488-494.
  4. Bai Y-Q, Akiyama Y, Nagasaki H, Lu S-L, Arai T, Morisaki T, Kitamura M, Muto A, Nagashima M, Nomizu T, Iwama T, Itoh H, Baba S, Iwai T, Yuasa Y: Predominant germline mutation of the hMSH2 gene in Japanese hereditary nonpolyposis colorectal cancer kindreds.
    International J. Cancer, 1999:82:512-515.
  5. Iida S, Akiyama Y, Ichikawa W, Yamashita T, Nomizu T, Nihei Z, Sugihara K, Yuasa Y: Infrequent germline mutation of the E-cadherin gene in Japanese familial gastric cancer kindreds.
    Clinical Cancer Research, 1999:5:1445-1447.
  6. Lu S-L, Kawabata M, Imamura T, Miyazono K, Yuasa Y: Two divergent signaling pathways for TGF- separated by a mutation of its type II receptor gene.
    Biochem. Biophys. Res. Commun. 1999:259:385-390.
  7. Bruder CEG, Ichimura K, Tingby O, Hirakawa K, Komatsuzaki A, Tamura A, Yuasa Y, Collins VP, Dumanski JP: A group of schwannomas with interstitial deletions on 22q located outside the NF2 locus shows no detectable mutations in the NF2 gene.
    Human Genetics 1999:104:418-424.
  8. Bruder CEG, Ichimura K, Blennow E, Ikeuchi T, Yamaguchi T, Yuasa Y, Collins VP, Dumanski JP: Severe phenotype of neurofibromatosis type 2 in a patient with a 7.4-MB constitutional deletion on chromosome 22: Possible localization of a neurofibromatosis type 2 modifier gene?
    Genes, Chromosomes & Cancer 1999:25:184-190.
  9. Arai T, Akiyama Y, Nagasaki H, Murase N, Okabe S, Ikeuchi T, Saito K, Iwai T, Yuasa Y: EXTL3/EXTR1 alterations in colorectal cancer cell lines.
    International J. Oncology 1999:15:915-919.
  10. Akiyama Y, Arai T, Nagasaki H, Yagi OK, Nakahata A, Nakajima T, Ohkura Y, Iwai T, Saitoh K, Yuasa Y: Frequent allelic imbalance on chromosome 18q21 in early superficial colorectal cancers.
    Jpn. J. Cancer Res. 1999:90:1329-1337.
  11. Maruyama M, Nagahama T, Yuasa Y: Intraperitoneal versus intravenous CPT-11 for peritoneal seeding and liver metastasis.
    Anticancer Res. 1999:19:4187-4192.

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1998年

  1. Arai T, Akiyama Y, Okabe S, Ando M, Endo M, Yuasa Y: Genomic structure of the human Smad3 gene and its infrequent alterations in colorectal cancers.
    Cancer Letters 1998:122:157-163.
  2. Yagi OK, Akiyama Y, Nomizu T, Iwama T, Endo M, Yuasa Y: Proapoptotic gene BAX is frequently mutated in hereditary nonpolyposis colorectal cancers but not in adenomas.
    Gastroenterology 1998:114:268-274.
  3. Akiyama Y, Yagi OK, Ishikawa T, Nagasaki H, Saitoh K, Yuasa Y: Genetic alterations are frequent in APC but rare in the TGF- type II receptor gene in cancer in adenoma of the colon. Cancer Letters 1998:125:89-96.
  4. Yanagisawa Y, Ito E, Iwahashi Y, Akiyama Y, Yuasa Y, Maruyama K: Isolation and characterization of the 5' region of the human mismatch repair gene hPMS1.
    Biochem. Biophys. Res. Commun. 1998:243:738-743.
  5. Tahara S, Tanaka K, Yuasa Y, Okayama H: Functional domains of Rep2, a transcriptional activator subunit for Res2-Cdc10, controlling the cell cycle "start".
    Molecular Biology of the Cell 1998:9:1577-1588.
  6. Lu S-L, Kawabata M, Imamura T, Akiyama Y, Nomizu T, Miyazono K, Yuasa Y: HNPCC associated with germline mutation in the TGF- type II receptor gene.
    Nature Genetics 1998:19:17-18.
  7. Arai T, Akiyama Y, Yamamura A, Hosoi T, Shibata T, Saitoh K, Okabe S, Yuasa Y: Allelotype analysis of early colorectal cancers with lymph node metastasis.
    International J. Cancer 1998:79:418-423.
  8. Iwahashi Y, Ito E, Yanagisawa Y, Akiyama Y, Yuasa Y, Onodera T, Maruyama K: Promoter analysis of the human mismatch repair gene hMSH2.
    Gene 1998:213:141-147.
  9. Arai T, Akiyama Y, Okabe S, Saito K, Iwai T, Yuasa Y: Genomic organization and mutation analysis of the DR5/TRAIL receptor 2 gene in colorectal carcinoma.
    Cancer Letters 1998:133:197-204.
  10. Ikezoe T, Takeuchi S, Arai T, Yuasa Y, Taguchi H: Analysis of the Smad3 gene in hematological malignancies.
    International J. Hematology 1998:68:457-458.

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1997年

  1. Akiyama Y, Iwanaga R, Saitoh K, Shiba K, Ushio K, Ikeda E, Iwama T, Nomizu T, Yuasa Y: Transforming growth factor- type II receptor gene mutations in adenomas from hereditary nonpolyposis colorectal cancer patients. Gastroenterology 1997:112:33-39.
  2. Oto M, Koguchi A, Yuasa Y: Analysis of a polyadenine tract of the TGF- type II receptor gene in colorectal cancers by non-gel sieving capillary electrophoresis. Clinical Chemistry 1997:43:759-763.
  3. Yagi OK, Akiyama Y, Ohkura Y, Ban S, Endo M, Saitoh K, Yuasa Y: Analyses of the APC and TGF- type II receptor genes, and microsatellite instability in mucosal colorectal carcinomas. Jpn. J. Cancer Res. 1997:88:718-724.
  4. Akiyama Y, Tsubouchi N, Yuasa Y: Frequent somatic mutations of hMSH3 with reference to microsatellite instability in hereditary nonpolyposis colorectal cancers. Biochem. Biophys. Res. Commun. 1997:236:248-252.
  5. Hori H, Kawano T, Endo M, Yuasa Y: Genetic polymorphisms of tobacco- and alcohol-related metabolizing enzymes and human esophageal squamous cell carcinoma susceptibility.
    6. Journal of Clinical Gastroenterology 1997:25:568-575.
  6. Akiyama Y, Sato H, Yamada T, Nagasaki H, Tsuchiya A, Abe R, Yuasa Y: Germline mutation of the hMSH6/GTBP gene in an atypical hereditary nonpolyposis colorectal cancer kindred. Cancer Research 1997:57:3920-3923.
  7. Suzuki L, Yuasa Y, Kuroiwa T: Transcription and translation involved in pellicle formation in the Chlamydomonas reinhardtii zygote. Cytologia 1997:62:421-425.
  8. Suzuki L, Yuasa Y, Kuroiwa T: Transcription and translation involved in uniparental inheritance and cell nuclei fusion in the Chlamydomonas reinhardtii zygote.
    Cytologia 1997:62:427-433.

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1996年

  1. Sasaki A, Nagashima M, Shiseki M, Katai H, Maruyama K, Iwanaga R, Akiyama Y, Yuasa Y, Yokota J: Microsatellite instability in gastric cancer prone families. Cancer Letters 1996:99:169-175.
  2. Homma MK, Homma Y, Yamasaki M, Ohmi-Imajoh S, Yuasa Y: Growth inhibition by phospholipase C inhibitor peptides of colorectal carcinoma cells derived from familial adenomatous polyposis.
    Cell Growth & Differentiation 1996:7:281-288.
  3. Lu S-L, Akiyama Y, Nagasaki H, Nomizu T, Ikeda E, Baba S, Ushio K, Iwama T, Maruyama K, Yuasa Y: Loss or somatic mutations of hMSH2 occur in hereditary nonpolyposis colorectal cancers with hMSH2 germline mutations.
    Jpn. J. Cancer Res. 1996:87:279-287.
  4. Akiyama Y, Nagasaki H, Nihei Z, Iwama T, Nomizu T, Yuasa Y: Frequent microsatellite instabilities and analyses of the related genes in familial gastric cancers. Jpn. J. Cancer Res. 1996:87:595-601.
  5. Yuasa Y, Akiyama Y, Lu S-L, Wu C, Nagasaki H, Nomizu T, Baba S, Ushio K, Iwama T, Nakabeppu Y, Sekiguchi M: Analysis of the hMSH2 and hMTH1 genes in hereditary nonpolyposis colorectal cancer. "New Strategies for Treatment of Hereditary Colorectal Cancer" ed. Shozo Baba.
    Churchill Livingstone Japan, 1996:99-114.
  6. Hori H, Miyake S, Akiyama Y, Endo M, Yuasa Y: Clonal heterogeneity in human esophageal squamous cell carcinomas on DNA analysis.
    Jpn. J. Cancer Res. 1996:87:923-929.
  7. Lu S-L, Zhang W-C, Akiyama Y, Nomizu T, Yuasa Y: Genomic structure of the
    transforming growth factor type II receptor gene and its mutations in hereditary nonpolyposis colorectal cancers.
    Cancer Research 1996:56:4595-4598.
  8. Akiyama Y, Iwanaga R, Ishikawa T, Sakamoto K, Nishi N, Nihei Z, Iwama T, Saitoh K, Yuasa Y: Mutations of the transforming growth factor- type II receptor gene are strongly related to sporadic proximal colon cancers with microsatellite instability. Cancer 1996:78:2478-2484.

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1995年

  1. Oto M, Suehiro T, Akiyama Y, Yuasa Y: Microsatellite instability in cancer identified by non-gel sieving capillary electrophoresis. Clinical Chemistry. 1995:41:482-483.
  2. Oto M, Suehiro T, Yuasa Y: DNA hybridization analysis of PCR products by non-gel sieving capillary electrophoresis.
    PCR Methods & Applications. 1995:4:303-304.
  3. Oto M, Suehiro T, Yuasa Y: Identification of mutated p53 in cancer by non-gel sieving capillary electrophoretic SSCP analysis. Clinical Chemistry. 1995:41:1787-1788.
  4. Wu C, Nagasaki H, Maruyama K, Nakabeppu Y, Sekiguchi M, Yuasa Y: Polymorphisms and probable lack of mutation in a human mutT homolog, hMTH1, in hereditary nonpolyposis colorectal cancer. Biochem. Biophys. Res. Commun. 1995:214:1239-1245.
  5. Lu S-L, Akiyama Y, Nagasaki H, Saitoh K, Yuasa Y: Mutations of the transforming growth factor- type II receptor gene and genomic instability in hereditary nonpolyposis colorectal cancer. Biochem. Biophys. Res. Commun. 1995:216:452-457.
  6. Yamada T, Terada Y, Homma MK, Nonoguchi H, Sasaki S, Yuasa Y, Tomita K, Marumo F: AVP inhibits EGF-stimulated MAP kinase cascade in Madin-Darby canine kidney cells.
    Kidney International. 1995:48:745-752.
  7. Terada Y, Tomita K, Homma MK, Nonoguchi H, Yang T, Yamada T, Yuasa Y, Krebs EG, Marumo F: Sequential activation of MAP kinase cascade by angiotensin II in opossum kidney cells. Kidney International. 1995:48:1801-1809.

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1994年

  1. Terada Y, Tomita K, Homma MK, Nonoguchi H, Yang T, Yamada T, Yuasa Y, Krebs EG, Sasaki S, Marumo F: Sequential activation of Raf-1 kinase, mitogen activated protein (MAP) kinase kinase, MAP kinase, and S6 kinase by hyperosmolarity in renal cells. J. Biol. Chem. 1994 : 269 : 31296-31301.
  2. Arai T, Ichimura K, Hirakwa K, Yuasa Y: DNA amplifications and elevated expression of proto-oncogene in addition to altered DNA ploidy in metastatic brain tumors. Clinical and Experimental Metastasis. 1994:12:267-275.
  3. Miyake S, Nagai K, Yoshino K, Oto M, Endo M, Yuasa Y: Point mutations and allelic deletion of tumor suppressor gene DCC in human esophageal squamous cell carcinomas and their relation to metastasis. Cancer Reserch. 1994:54:3007-3010.
  4. Homma MK, Homma Y, Namba M, Yuasa Y: Enhanced phosphoinositide metabolism in colorectal carcinoma cells derived from familial adenomatous polyposis patients. Journal of Cellular Biochemistry. 1994:55:477-485.
  5. Wu C, Akiyama Y, Imai K, Miyake S, Nagasaki H, Oto M, Okabe S, Iwama T, Mitamura K, Masumitsu H, Nomizu T, Baba S, Maruyama K, Yuasa Y: DNA alterations in cells from hereditary nonpolyposis colorectal cancer patients. Oncogene. 1994:9:991-994.

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1993年

  1. Oto, M., Miyake, S., Yuasa, Y. Optimization of non-radioisotopic single strand conformation polymorphism (Non RI-SSCP) analysis with a conventional minislab gel electrophoresis apparatus. Analytical Biochemistry, 213, 19-22 (1993).
  2. Kamiyama, T., Aoki, N., Yuasa, Y. B-raf oncogene : Activation by rearrangements and assignment to human chromosome 7. Jpn. J. Cancer Res. 84, 250-256 (1993).

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1992年

  1. Ando, M., Takemura, K., Maruyama, M., Endo, M., Iwama, T., Yuasa, Y. Mutations in c-K-ras 2 gene codon 12 during colorectal tumorigenesis in familial adenomatous polyposis patients. Gastroenterology, 103, 1725-1731 (1992).
  2. Arai, E., Ikeuchi, T., Karasawa, S., Tamura, A., Yamamoto,K., Kida, M., Ichimura, K., Yuasa, Y., Tonomura, A. A constitutional translocation, t(4;22)(q12;q12.2), associated with neurofibromatosis type 2. American Journal of Medical Genetics, 44, 163-167 (1992).

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1991年

  1. Kazumoto, K., Matumoto, M., Tamada, J., Handa, I., Tamura, M., and Yuasa, Y. Enhanced expression of the c-myc oncogenes in human brain tumors. p.343-348. K. Tabuchi ed. "Biological aspects of brain tumors", Springer-Verlag, Tokyo (1991).
  2. Ichimura, K., Hirakawa, K., Komatsuzaki, A., and Yuasa., Y. Oncogene expression in acoustic neurinomas. p.337-342 K. Tabuchi ed. "Biological aspects of brain tumors" Springer-Verlag, Tokyo (1991).
  3. Sakamoto, K., Resau, J, H., Shamsuddin, A, M., Yuasa, Y., Hoshino, H., Nakano, G., and Nagamachi, Y., Long-term explant culture of human colon and a 3-step transformation model for rat colonic epothelium. Pathobiology 59, 404-411 (1991).
  4. Ando, M., Maruyama, M., Oto, M., Takemura, K., Endo, M., and Yuasa, Y. Higher frequency of point mutations in the c-K-ras2 gene in human colorectal adenomas with severe atypia than in carcino¬mas. Jpn. J. Cancer Res. 82, 245-249 (1991).
  5. Hoshino, Y., Horikawa, I., Oshimura, M., and Yuasa, Y. Normal human chromosome 5, on which a familial adenomatous polyposis gene is located, has tumor suppressive activity. Biochem. Biophys. Res. Commun. 174, 298-304 (1991).

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1990年

  1. Yuasa, Y., Yamazaki, H., Maruo, K., Ueyama, Y., Shibuya, M., and Tamaoki, N. Alterations of mouse proto-oncogenes in sarcomas induced after transplantation of human tumors in athymic nude mice. Jpn. J. Cancer Res. 81, 333-339 (1990).
  2. Yuasa, Y., Kamiyama, T., Kato, M., Iwama, T., Ikeuchi, T., and Tonomura, A. Transforming genes from familial adenomatous polyposis pa¬tient cells detected by a tumorigenicity assay. Oncogene 5, 589-596 (1990).
  3. Kazumoto, K., Tamura, M., Hoshino, H., and Yuasa, Y. Enhanced expression of the sis and c-myc oncogenes in human meningiomas. J. Neurosurg. 72, 786-791 (1990).

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1989年

  1. Yamamoto, A., Horai, S., and Yuasa, Y. Increased level of mitochondrial gene expression in polyps of familial polyposis coli patients. Biochem. Biophys. Res. Commun. 159, 1100-1106 (1989).

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1988年

  1. Namba, M., Nishitani, K., Fukushima, F., Kimoto, T., and Yuasa,Y. Multistep neoplastic transformation of normal human fibroblasts by Co-60 gamma rays and Ha-ras oncogenes. Mutation Res. 199, 415-423 (1988).

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1987年

  1. Hara, K., Taguchi, F., Yuasa, Y., and Yogo, Y. Malignant transformation by a human activated ras oncogene of a revertant cell line derived from BK virus-induced hamster tumor. Kitasato Medicine 17, 582-586 (1987).
  2. Yuasa, Y., and Sudo, K. Transforming genes in human hepatomas detected by a tumorigenicity assay. Jpn. J. Cancer Res. (Gann) 78, 1036-1040 (1987).
  3. Yuasa, Y. Human cellular oncogenes detected by DNA transfection. Asian Med. J. 30, 295-303 (1987).

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1986年

  1. Yuasa, Y., Oto, M., Sato, C., Miyaki, M., Iwama, T., Tonomura, A., and Namba, M. Colon carcinoma K-ras 2 oncogene of a familial polyposis coli patient. Jpn. J. Cancer Res. (Gann) 77, 901-907 (1986).
  2. Yuasa, Y., Reddy, E.P., Rhim, J.S., Tronick, S.R., and Aaronson, S.A. Activated N-ras in a human rectal carcinoma cell line associated with clonal homozygosity in myb locus-restriction fragment polymorphism. Jpn. J. Cancer Res. (Gann) 77, 639-647 (1986).

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1985年

  1. Tronick, S.R., Eva, A., Srivastava, S.K., Kraus, M.H., Yuasa, Y., and Aaronson, S.A. The role of human ras proto-oncogenes in cancer. "Epidemiology and quantitation of environmental risk in humans from radiation and other agents". Plenum Publishing Corporation, (1985).
  2. Aaronson, S.A., Yuasa, Y., Robbins, K.C., Eva, A., Gol, R., and Tronick, S.R. Oncogenes and the neoplastic process. "Genetic and phenotypic markers of tumors" Plenum Publishing Corporation 261-277 (1985).
  3. Srivastava, S.K., Yuasa, Y., Reynolds, S.H., and Aaronson, S.A. Effects of two major activating lesion on the structure and conformation of human ras oncogene products. Proc. Natl. Acad. Sci. U.S.A. 82, 38-42 (1985).

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1984年

  1. Tronick, S.R., Yuasa, Y., Robbins, K.C., Eva, A., Gol, R., and Aaronson, S.A. Oncogene research : Closing in on a better understanding of cancer causation. in 'Acquired Immune Deficiency Syndrome'. Annals of New York Acad. Sci. 437, 150-160 (1984).
  2. Yuasa. Y., Eva, A., Kraus, M.H., Srivastava, S.K., Needleman, S.W., Pierce, J.H., Rhim, J.S., Gol, R., Reddy, E.P., Tronick, S.R., and Aaronson, S.A. ras -related oncogenes of human tumors. "Cancer Cells 2, Oncogenes and Viral Genes" Cold Spring Harbor Laboratory, New York 433-439 (1984)
  3. Kraus, M., Yuasa, Y., and Aaronson, S.A. A position 12-activated H-ras oncogene in all HS578T mammary carcinosarcoma cells but not normal cells of the same patient. Proc. Natl. Acad. Sci. U.S.A. 81, 5384-5388 (1984).
  4. Fujita, J., Yoshida, O., Yuasa, Y., Rhim, J.S., Hatanaka, M., and Aaronson, S.A. Ha-ras oncogene are activated by somatic alterations in human urinary tract tumors. Nature 309, 464-466 (1984).
  5. Yuasa, Y., Gol, R.A., Chang, A., Chiu, I.-M., Reddy, E.P., Tronick, S.R., and Aaronson, S.A. Mechanism of activation of an N-ras oncogene of SW-1271 human lung carcinoma cells. Proc. Natl. Acad. Sci. U.S.A. 81, 3670-3674 (1984).

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1983年

  1. Needleman, S.W., Yuasa, Y., Srivastava, S., and Aaronson, S.A. Normal cells of patients with high cancer risk syndromes lack transforming activity in the NIH/3T3 transfection assay. Science 222, 173-175 (1983).
  2. Yuasa, Y., Srivastava, S.K., Dunn, C.Y., Rhim, J.S., Reddy, E.P., and Aaronson, S.A. Acquisition of transforming properties by alternative point mutations within c-bas/has human proto-oncogene. Nature 303, 775-779 (1983).

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1982年

  1. Srinivasan, A., Dunn, C.Y., Yuasa, Y., Devare, S.G., Reddy, E.P., and Aaronson, S.A. Abelson murine leukemia virus : Structural requirements for transforming gene function. Proc. Natl. Acad. Sci. U.S.A. 79, 5508-5512 (1982).

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1981年

  1. Watanabe, S., Yoshiike, K., Yuasa, Y., and Uchida, S. Natural occurrence of deletion mutant of human papovavirus BK capable of inducing T antigen. J. Gen. Virol. 54, 431-435 (1981).

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1980年

  1. Yuasa, Y., Hirai, R., Huh, N., and Segawa, K. Double transformation of Indian Muntjac cells by avian and murine sarcoma viruses. Jpn. J. Exp. Med. 50, 23-33 (1980).

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1979年

  1. Watanabe, S., Yoshiike, K., Nozawa, A., Yuasa, Y. and Uchida, S. Viable deletion mutant of human papovavirus BK that induces insulinomas in hamsters. J. Virol. 32, 934-942 (1979).
  2. Kanazawa,K., Yamamoto, T. and Yuasa, Y. Enhancement by asbestos of oncogenesis by Moloney murine sarcoma virus in CBA mice. Int. J. Cancer 23, 866-874 (1979).
  3. Hirai, R., Yuasa, Y. and Yamamoto, T. Heat-labile character of murine sarcoma-xenotropic leukemia virus complex in duck cells. Virology 96, 615-621 (1979).

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1978年

  1. Segawa, K., Oda, K., Yuasa, Y., Shiroki, K., and Shimojo, H. Phosphorylation of chromatin- and ribosome-associated proteins in cells transformed by adenovirus, murine sarcome virus, and methyl cholanthrene. J. Virol. 27, 800-808 (1978).
  2. Yuasa, Y., Hirai, R., Huh, N., Shimojo, H., and Yamamoto, T. Transformation of Indian muntjac cells by murine and avian sarcoma viruses. Gann 69, 441-445 (1978).

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1977年

  1. Yuasa, Y. and Shimojo, H. Isolation and preliminary characterization of temperature-sensitive mutants of the murine sarcoma leukeamia virus complex. J. gen. Virol. 36, 257-266 (1977).

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1976年

  1. Kai, K., Ikeda, H., Yuasa, Y., Suzuki, S., and Okada, T. Mouse strain resistant to N-, B-, and NB-tropic murine leukemia viruses. J. Virol. 20, 436-440 (1976).

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1975年

  1. Kuroki, T., Miyashita, S., and Yuasa, Y. Development of a 3T3-like line from an embryo culture of an inbred strain of Syrian golden hamster. Cancer Res. 35, 1819-1825 (1975).
  2. Yuasa, Y., Shimojo, H., Aoyagi, T., and Umezawa, H. Effect of protease inhibitor on focus formation by murine sarcoma virus. J. Natl. Cancer Inst. 54, 1255-1256 (1975).

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