Research

Research Subjects

Pathophysiology of malocclusion
             and the biological significance of normal occlusion

 


 
  • Periodontal tissue in the hypofunction teeth
  • Studies on interrelation between masticatory muscle and temporomandibular joint
  • Studies on occlusion and age-related changes in cranio-maxillofacial morphology and function
  • Studies on interrelation between cranio-maxillofacial complex and whole body
  • Studies on interrelation between malocclusion and temporomandibular joint
  • Biomechanical analysis in occlusion

 
 

Studies on the transplantation of teeth

 


 
  • Influence of mechanical stimulation to the trasplantation teeth (fundamental and clinical research)

 
 

Biological response to orthodontic force

 


 
  • Influense of the various proteins and hormones in the experimental tooth movement
  • Reaction of periodontal ligament cells and bone system cells to mechanical stimuli

 
 
 

Orthodontic Materials

 


 
  • Improvements and clinical application of the super-elastic nickel titanium wire
  • Development and clinical application of super engineering plastic wire
  • Studies on the metal archfact in MRI

 
 
 

Occlussion and Sense of Taste

 


 
 
 
 

Sleep and Breathing Disorders 

 


 
 
 
 
 

Publications

2017

Original Articles

  • Fukushima-Nakayama Y, Ono T, Hayashi M, Inoue M, Wake H, Ono T, Nakashima T. Reduced mastication impairs memory function. J Dent Res. 2017;96:1058-1066. 
  • Manabe A, Ishida T, Yoon HS, Yang SS, Kanda E, Ono T. Differential changes in the adenoids and tonsils in Japanese children and teenagers: A cross-sectional study. Sci Rep. 2017;7:9734. 
  • Uchima Koecklin KH, Hiranuma M, Kato C, Funaki Y, Kataguchi T, Yabushita T, Kokai S, Ono T. Unilateral nasal obstruction during later growth periods affects craniofacial muscles in rats. Front Physiol. 2017;7:669.
  • Yamaguchi H, Ishida Y, Hosomichi J, Suzuki J, Usumi-Fujita R, Shimizu Y, Kaneko S, Ono T. New approach to transfect NF-kappaB decoy oligodeoxynucleotides into the periodontal tissue using ultrasound-microbubble method. Int J Oral Sci. 2017;9:80-86. 
  • Abe Y, Kato C, Uchima Koecklin KH, Okihara H, Ishida T, Fujita K, Yabushita T, Kokai S, Ono T. Unilateral nasal obstruction affects motor representation development within the face primary motor cortex in growing rats. J Appl Physiol. 2017;122:1494-1503. 
  • Imai H, Tanaka Y, Nomura N, Doi H, Tsusumi Y, Ono T, Hanawa T. Magnetic susceptibility, artifact volume in MRI, and tensile properties of swaged Zr-Ag composites for biomedical applications. J Mech Behav Biomed Mater. 2017;66:152-8.
  • Yamaguchi H, Ishida Y, Hosomichi J, Suzuki J, Hatano K, Usumi-Fujita R, Shimizu Y, Kaneko S, Ono T. NF-κB decoy transfection by ultrasound-microbubble inhibits periodontitis. PLoS One. 2017;12:e0186264.
  • Hsu JC, Watari I, Funaki Y, Kokai S, Ono T. Unilateral nasal obstruction induces degeneration of fungiform and circumvallate papillae in rats. J Form Med Assoc. 2017. pii: S0929-6646(16)30518-6.
  • Matsumoto Y, Sringkarnboriboon S, Ono T. Proinflammatory mediators related to orthodontically induced periapical root resorption in rat mandibular molars. Eur J Orthod. 2017;39:686-691.
  • Uesugi S, Kokai S, Kanno Z, Ono T. Prognosis of primary and secondary insertions of the orthodontic miniscrews: what we have learnt from 500 implants. Am J Orthod Dentofacial Orthop. 2017;152:224-231.
  • Hosomichi J, Kuma Y, Oishi S, Nagai H, Maeda H, Usumi-Fujita R, Shimizu Y, Kaneko S, Shitano C, Suzuki J, Yoshida K, Ono T. Intermittent hypoxia causes mandibular growth retardation and macroglossia in growing rats. Am J Orthod Dentofacial Orthop. 2017;151:363-371.
  • Ishida Y, Ono T. Nonsurgical treatment of skeletal Class II gummy smile adult case using zygomatic temporary anchorage devices and improved superelastic nickel-titanium alloy wires. Am J Orthod Dentofacial Orthop. 2017;152:693-705.
  • Kasahara Y, Usumi-Fujita R, Hosomichi J, Kaneko S, Ishida Y, Shibutani N, Shimizu Y, Okito A, Oishi S, Kuma Y, Yamaguchi H, Ono T. Low-intensity pulsed ultrasound reduces periodontal atrophies in the occlusal hypofunctional teeth. Angle Orthod. 2017;87:709-716.
  • An J, Matsumoto Y, Ono T. The relationships between the arrangement of teeth, root resorption, and dental maturity in bovine mandibular incisors. Korean J Orthod. 2017;47:365–374. 
  • Suzuki K, Kokai S, Uesugi S, Nishiyama A, Ono T. Evaluation of the laterality of the tissue oxygen saturation of masticatory muscles in subjects with facial asymmetry. Orthodontic Waves. 2017;76:232-237.
  • Matsumura T, Ishida Y, Kawabe A, Ono T. Quantitative analysis of the relationship between maxillary incisors and the incisive canal by cone-beam computed tomography in an adult Japanese population. Progr Orthod. 2017;18:24.   

Awards & Honors

  • Ogawa T. The 76th Annual Meeting of the Japanese Orthodontic Society, Excellent Exhibition Award,Japanese Orthodontic Society,2016.11
  • Ozawa E. The 76th Annual Meeting of the Japanese Orthodontic Society, Excellent Exhibition Award,Japanese Orthodontic Society,2016.11
  • Ishida T. The 76th Annual Meeting of the Japanese Orthodontic Society, Excellent Exhibition Award,Japanese Orthodontic Society,2016.11

2016

Original Articles

  • Lai WJ, Midorikawa Y, Kanno Z, Takemura H, Suga K, Soga K, Ono T, Uo M. Development and modification of a device for three-dimensional measurement of orthodontic force system: The V-bend system re-visited. Dent Mater J. 2016.12; 35 (6): 908-917. 
  • Hosomichi J, Kuma Y, Oishi S, Nagai H, Maeda H, Usumi-Fujita R, Shimizu Y, Kaneko S, Shitano C, Suzuki J, Yoshida K, Ono T. Intermittent hypoxia causes mandibular growth retardation and macroglossia in growing rats. Am J Orthod Dentofacial Orthop. 2017.02; 151 (2): 363-371.
  • Imai H, Tanaka Y, Nomura N, Doi H, Tsutsumi Y, Ono T, Hanawa T. Magnetic susceptibility, artifact volume in MRI, and tensile properties of swaged Zr-Ag composites for biomedical applications J Mech Behav Biomed Mater. 2017.02; 66 152-158.
  • Uchima Koecklin KH, Hiranuma M, Kato C, Funaki Y, Kataguchi T, Yabushita T, Kokai S, Ono T. Unilateral nasal obstruction during later growth periods affects craniofacial muscles in rats. Front Physiol. 2017.01; 7 (669): 1-10.
  • Ishida Y, Ono T. Nonsurgical treatment of skeletal class II gummy smile adult case using zygomatic temporary anchorage devices and improved superelastic nickel-titanium alloy wires. Am J Orthod Dentofacial Orthop. 2017;
  • 本田康二, 大村進, 藤田紘一, 渋谷直樹, 米満郁男, 島﨑一夫, 村田彰吾, 高須曜, 山下陽介, 岩井俊憲, 小野卓史, 藤内祝. 上下顎同時骨延長術を施行した著しい垂直的上顎劣成長を伴う下顎前突症の1例. 日本顎変形症学会誌. 2016.12; 26 (4): 275-283.
  • Makiguchi M, Funaki Y, Kato C, Okihara H, Ishida T, Yabushita T, Kokai S, Ono T. Effects of increased occlusal vertical dimension on the jaw-opening reflex in adult rats. Arch Oral Biol. 2016.12; 72 39-46.
  • Kita S, Oshima M, Shimazaki K, Iwai T, Omura S, Ono T. Computational fluid dynamic study of nasal respiratory function before and after bimaxillary orthognathic surgery with bone trimming at the inferior edge of the pyriform aperture. J Oral Maxillofac Surg. 2016.11; 74 (11): 2241-2251.
  • Dei A, Miyamoto JJ, Takada JI, Ono T, Moriyama K. Evaluation of blood flow and electromyographic activity in the perioral muscles. Eur J Orthod. 2016.10; 38: 525-531.
  • Oishi S, Shimizu Y, Hosomichi J, Kuma Y, Nagai H, Maeda H, Usumi-Fujita R, Kaneko S, Shibutani N , Suzuki J, Yoshida K, Ono T. Intermittent hypoxia Influences alveolar bone proper microstructure via hypoxia-inducible factor and VEGF expression in periodontal ligaments of growing rats. Front phsyiol. 2016.09; 7 Article 416.
  • 本田康二, 大村進, 藤田紘一, 渋谷直樹, 米満郁男, 島﨑一夫, 村田 彰吾, 高須曜, 山下陽介, 岩井俊憲, 小野卓史, 藤内祝. 横浜市立大学附属市民総合医療センター歯科・口腔外科・矯正歯科における過去16年間の顎変形症治療に関する実態調査 日本顎変形症学会誌. 2016.08; 26 (3): 195-201.
  • 前川南, 簡野瑞誠, 小野卓史, 宇尾基弘. オールプラスチック製歯科矯正用ワイヤーの開発. 日本歯科理工学会誌. 2016.05; 35 (3): 189-192.
  • Arai Y, Aoki K, Shimizu Y, Tabata Y, Ono T, Murali R, Mise-Omata S, Wakabayashi N. Peptide-induced de novo bone formation after tooth extraction prevents alveolar bone loss in a murine tooth extraction model. Eur J Pharmacol. 2016.04;
  • 小海暁, 小野卓史. 根完成歯自家移植と矯正歯科治療のコンビネーション. 口腔病学会雑誌. 2016.03; 83 (1): 42-43. ( 医中誌 )
  • 山田恭平, 大森浩子, 桐本博章, 島﨑一夫, 小野卓史. 下顎側方偏位を伴う顎変形症患者における顎関節症状と下顎頭形態との関連. Orthod Waves-Jpn Ed. 2016.03; 75 (1): 1-7.
  • Abbassy MA, Watari I, Bakry AS, Ono T, Hassan A. Calcitonin and vitamin D3 have high therapeutic potential for improving diabetic mandibular growth. Int J Oral Sci. 2016.03; 8 (1): 39-44.
  • Miyazaki M, Yonemitsu I, Takei M, Kure-Hattori I, Ono T. The imbalance of masticatory muscle activity affects the asymmetric growth of condylar cartilage and subchondral bone in rats. Arch Oral Biol. 2016.03; 63 22-31.
  • Oishi S, Shimizu Y, Hosomichi J, Kuma Y, Nagai H, Maeda H, Usumi-Fujita R, Kaneko S, Shitano C, Suzuki J, Yoshida K, Ono T. Intermittent hypoxia induces disturbances in craniofacial growth and defects in craniofacial morphology. Arch Oral Biol. 2016.01; 61 115-124. ( PubMed )
  • Uesugi S, Yonemitsu I, Kokai S, Takei M, Omura S, Ono T. Features in subjects with the frontal occlusal plane inclined toward the contralateral side of the mandibular deviation. Am J Orthod Dentofacial Orthop. 2016.01; 149 (1): 46-54.
  • Sakaguchi-Kuma T, Hayashi N, Fujishiro H, Yamaguchi K, Shimazaki K, Ono T, Akita K. An anatomic study of the attachments  on the condylar process of the mandible: muscle bundles from the temporalis. Surg Radiol Anat. 2016;38:461-467.

Awards & Honors

  • Yamaguchi H. The 75th Annual Meeting of the Japanese Orthodontic Society, Excellent Exhibition Award,Japanese Orthodontic Society,2016.11
  • Kato C. The 75th Annual Meeting of the Japanese Orthodontic Society, Excellent Exhibition Award,Japanese Orthodontic Society,2016.11
  • Usumi-Fujita R. The 75th Annual Meeting of the Japanese Orthodontic Society, Excellent Exhibition Award,Japanese Orthodontic Society,2016.11
  • Fukushima Y. The 75th Annual Meeting of the Japanese Orthodontic Society, Excellent Exhibition Award,Japanese Orthodontic Society,2016.11

2015

Original Articles

  • Kokai S, Kanno Z, Koike S, Uesugi S, Takahashi Y, Ono T, Soma K. Retrospective study of 100 autotransplanted teeth with complete root formation and subsequent orthodontic treatment. Am J Orthod Dentofacial Orthop. 2015.12; 148 (6): 982-989.
  • Ishida T, Ikemoto S, Ono T. Nasomaxillary hypoplasia with a congenitally missing tooth treated with Le Fort II osteotomy, autotransplantation and nickel-titanium alloy wire. Am J Orthod Dentofacial Orthop. 2015.09; 148 (3): 479-492.
  • Kato G, Shimizu Y, Sugamori Y, Maeda M, Takahashi M, Tamura Y, Murali R, Ono T, Ohya K, Aoki K. The inhibitory effects of a RANKL-binding peptide on articular and periarticular bone loss in a murine model of collagen-induced arthritis: A bone histomorphometric study. Arthritis Res Ther. 2015.09; 17 251.
  • Abbassy MA, Watari I, Bakry AS, Hamba H, Hasan AH, Tagami J, Ono T. Diabetes detrimental effects on enamel and dentin formation. J Dent. 2015.05; 43 (5): 589-596.
  • Kokai S, Fukuyama E, Sato Y, Hsu JC, Takahashi Y, Harada K, Ono T. Comprehensive treatment approach for bilateral cleft lip and palate in an adult with premaxillary osteotomy, tooth autotransplantation, and 2-jaw surgery. Am J Orthod Dentofacial Orthop. 2015.01; 147 (1): 114-126. ( PubMed )
  • 喜田壮馬, 島﨑一夫, 矢島康治, 大村進, 小野卓史, 大島まり . 上下顎移動術前後における鼻呼吸機能の流体解析. 生産研究. 2015.01; 67 (1): 55-58.
  • Ono R, Watari I, Kubono-Mizumachi M, Ono T. GLP-1R expression in the major salivary glands of rats. J Oral Biosci. 2015; 57 (4): 200-204.
  • Nunthayanon K, Honda E, Shimazaki K, Ohmori H, Inoue-Arai MS, Kurabayashi T, Ono T. A pilot study on characterization of articulatory movements during fricative /s/ sound in an anterior open bite subject: a tooth-visualized 3-T MRI movie evaluation. J World Feder Orthod . 2015; 4 71-77.
  • Okito A, Nakahama K, Akiyama M, Ono T, Morita I. Involvement of the G-protein-coupled receptor 4 in RANKL expression by osteoblasts in an acidic environment. Biochem Biophys Res Commun. 2015; 458 (2): 435-440.

Awards & Honors

  • Abe Y. The 74th Annual Meeting of the Japanese Orthodontic Society, Excellent Exhibition Award,Japanese Orthodontic Society,2016.11
  • Oishi S. The 74th Annual Meeting of the Japanese Orthodontic Society, Excellent Exhibition Award,Japanese Orthodontic Society,2016.11
  • Ishida T. The 74th Annual Meeting of the Japanese Orthodontic Society, Excellent Exhibition Award,Japanese Orthodontic Society,2016.11
  • Usumi R. The 74th Annual Meeting of the Japanese Orthodontic Society, Excellent Exhibition Award,Japanese Orthodontic Society,2016.11

2014

Original Articles

  • Shimizu Y, Yonemitsu I, Ono T. Facilitating mandibular horizontal growth in a Class II high-angle case with modified functional appliance. J World Fed Orthod. 2014; 3; e27-39
  • Funaki Y, Hiranuma M, Shibata M, Kokai S, Ono T. Effects of nasal obstruction on maturation of the jaw-opening reflex in growing rats. Arch Oral Biol. 2014; 59(5); 530-538
  • Kawakubo N, Miyamoto JJ, Katsuyama N, Ono T, Honda E, Kurabayashi T, Taira M, Moroyama K. Effects of cortical activations on enhancement of handgrip force during teeth clenching: An fMRI study. Neurosci Res. 2014; 79; 67-75
  • Shimazaki K, Otsubo K, Yonemitsu I, Kimizuka S, Omura S, Ono T. Severe unilateral scissor bite and bimaxillary protrusion treated by horse-shoe Le Fort I osteotomy combined with mid-alveolar osteotomy. Angle Orthod. 2014; 84(2); 374-379
  • Kawabe A, Nakagawa I, Kanno Z, Tsutsumi Y, Hanawa T, Ono T. Evaluation of biofilm formation in the presence of saliva on poly (ethylene glycol) deposited titanium. Dent Mater J. 2014; 33(5); 638-647
  • Yoon HS, Ishida T, Ono T. Influences of lymphoid tissues on facial pattern. J World Fed Orthod. 2014; 3(4); 163-168
  • Privatananupunt J, Watari I, Podyma-Inoue KA, Kubono M, Ono T. Expression of glucose-dependent insulinotropic polypeptide and its receptor in the rat major salivary glands. Acta Histochemica. 2014; 116(4); 545-550
  • Okihara H, Ito J, Kokai S, Ishida T, Hiranuma M, Kato C, Yabushita T, Ishida K, Ono T, Michikawa M. Liquid diet induces memory impairment accompanied by a decreased number of hippocampal neurons in mice. J Neurosci Res. 2014; 92(8); 1010-1017
  • Aoyama E, Watari I, Podyma-Inoue KA, Yanagishita M, Ono T. Expression of glucagon-like peptide-1 receptor and glucose dependent insulinotropic polypeptide receptor is regulated by the glucose concentration in mouse osteoblastic MC3T3-E1 cells. Int J Mol Med. 2014.08; 34(2); 475-482
  • Shimizu Y, Hosomichi J, Nakamura S, Ono T. Micro-computed tomography analysis of changes in the periodontal ligament and alveolar bone proper induced by occlusal hypofunction of rat molars. Korean J Orthod. 2014; 44(5); 263-267
  • Ishida T, Ono T. Asymmetric severe skeletal Class II division 1 patient with temporo- mandibular joint disorder treated with zygomatic anchorage devices and Ni-Ti alloy wires. Angle Orthod. 2014; 84(5); 919-930
  • Kuma Y, Usumi-Fujita R, Hosomichi J, Oishi S, Maeda H, Nagai H, Shimizu Y, Kaneko S, Shitano C, Suzuki J, Yoshida K, Ono T. Impairment of nasal airway under intermittent hypoxia during growth period in rats. Arch Oral Biol. 2014; 59(11); 1139-1145
  • Hsu JC, Watari I, Ono R, Privatananupunt J, Mizumachi-Kubono M, Honda K, Ishida Y, Ono T. Degeneration of fungiform and circumvallate papillae following molar extraction in rats. Acta Odontol Scand. 2014; 72(8); 880-886
  • Ikeda Y, Yonemitsu I, Takei M, Shibata S, Ono T. Mechanical loading leads to osteoarthritis-like changes in the hypofunctional temporomandibular joint in rats. Arch Oral Biol. 2014; 59(12); 1368-1376

2013

Original Articles

  • Usumi-Fujita R, Hosomichi J, Ono N, Shibutani N, Kaneko S, Shimizu Y, Ono T: Occlusal hypofunction causes periodontal atrophy and VEGF/VEGFR inhibition in tooth movement. Angle Orthod 83:48-56, 2013.
  • Shindoi JM, Matsumoto Y, Sato Y, Ono T, Harada K: Soft tissue cephalometric norms for orthognathic and cosmetic surgery. J Oral Maxillofac Surg 71:e24-30, 2013.
  • Hikita R, Miyamoto JJ, Ono T, Honda E, Kurabayashi T, Moriyama K: Activation patterns in the auditory association area involved in glottal stop perception. J Oral Biosci 55:34-39, 2013.
  • Kapila S, Park Y, Ahmad N, Hosomichi J, Hayami T, Tacon C: Mechanisms for Relaxin’s Modulation of MMPs and Matrix Loss in Fibrocartilages. Ital J Anat Embryol 118:62-65, 2013.
  • Ohmori H, Ono T: Unilateral scissors bite treated with a removable plate that incorporates a Ti-Ni wire. Orthodontics 14:e222-e226, 2013.
  • Koike S, Sujino T, Ohmori H, Shimazaki K, Fukuyama E, Kanai T, Hibi T, Ono T: Gastric emptying rate in subjects with malocclusion examined by [13C] breath test. J Oral Rehabil 40:574-81, 2013.
  • Shimizu Y, Ishida T, Hosomichi J, Kaneko S, Hatano K, Ono T: Soft diet causes greater alveolar osteopenia in the mandible than in the maxilla. Arch Oral Biol 58:907-11, 2013.
  • Imai H, Tanaka Y, Nomura N, Tsutsumi Y, Doi H, Kanno Z, Ohno K, Ono T, Hanawa T: Three-dimensional quantification of susceptibility artifacts from various metals in magnetic resonance images.ActaBiomater 9:8433-9, 2013.
  • Ishida T, Yabushita T, Ono T: Functional reversibility of temporomandibular joint mechanoreceptors.Arch Oral Biol 58:1078-83, 2013.
  • Hiranuma M, Kokai S, Fujita K, Ishida T, Shibata M, Naito S, Yabushita T, Ono T: Effects of a liquid diet on the response properties of temporomandibular joint nociceptive neurons in the trigeminal subnucleus caudalis of growing rats. Orthod Craniofac Res 16:214-22, 2013.
  • Ishida T, Yoon HS, Ono T: Asymmetrical distalization of maxillary molars with zygomatic anchorage, improved superelastic nickel-titanium alloy wires, and open-coil springs. Am J Orthod Dentofacial Orthop 144:583-93, 2013.
  • Shitano C, Baba O, Kaneko S, Hosomichi J, Shimizu Y, Shibutani N, Usumi R, Takano Y, Ono T: Alveolar bone loss induced by the orthodontic tooth movement under hypofunctional conditions in rats. Orthod Waves 72:148-55, 2013.
  •  Review Articles
  • Abbassy MA, Watari I, Bakry AS, Ono T: Chapter 16, The effect of type 1 Diabetes Mellitus on the dento-craniofacial complex. Type 1 Diabetes, ISBN 978-953-51-1017-0, Ed. Escher AP, Li A, pp401-30, In Tech, 2013.

2012

Original Articles

  • Kato C, Fujita K, Naito S, Shibata M, Ishida T, Kokai S, Yabushita T, Ono T: Increased occlusal vertical dimension induces cortical plasticity in the rat face primary motor cortex. Behav Brain Res 228: 254-260, 2012.
  • Ng IW, Ono T, Inoue-Arai MS, Honda E, Kurabayashi T, Moriyama K: Differential articulatory movements during Japanese /s/ and /t/ as revealed by MR image sequences with tooth visualization. Arch Oral Biol 57: 749-59, 2012.
  • Abbassy MA, Horiuchi M, Harouny NME, Kanno Z, Ono T: Comparative cephalometric study of Class I malocclusion in Egyptian and Japanese adult females. Orthod Waves 71: 59-65, 2012.
  • Mizumachi-Kubono M, Watari I, Ishida Y, Ono T: Reduced mechanical stress on the periodontium influences AQP5 expression and distribution in the rat submandibular salivary gland. Arch Oral Biol 57: 877-883, 2012.
  • Kure-Hattori I, Watari I, Takei M, Ishida Y, Yonemitsu I, Ono T: Effect of functional shift of the mandible on lubrication of the temporomandibular joint. Arch Oral Biol 57: 987-994, 2012.
  • Sakamoto-Ozaki K, Matsumoto Y, Kanno Z, Iida J, Soma K: Development of a surgical procedure for biointegration of a newly designed orthodontic onplant. Orthodontics 13: 216-225, 2012.
  • Ohmori H, Kirimoto H, Ono T: Comparison of the physiological properties of human periodontal-masseteric reflex evoked by incisor and canine stimulation. Front Physiol 3: 233, 2012.
  • Ono T: Orale Dysfunktionen in der kieferorthopädischen Praxis: der Anteil des peripheren und des zentralen Nervensystems auf die Lage der Zunge bei Mundatmung. Inf Orthod Kieferorthop 44: 293-301, 2012.
  • Sakai K, Shimazaki K, Kokai S, Fukuyama E, ONO T: Effects of different surgical procedures on the upper-airway dimension in subjects with mandibular prognathism. Jpn J Jaw Deform 22: 239-243, 2012.
  • Review Articles
  • Ono T. Tongue and upper airway function in subjects with and without obstructive sleep apnea. Jpn Dent Sci Rev 48: 71-80, 2012.