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原著論文
1. Nojima T, Oshiro-Ideue T, Nakanoya H, Kawamura H, Morimoto M, Kawaguchi Y, Kataoka N and Hagiwara M (2009) Herpesvirus protein ICP27 switches PML isoform by altering mRNA splicing. Nucleic Acids Res., 2009 Sep 3 [Epub ahead of print]
2. Jiang K, Patel NA, Watson JE, Apostolatos H, Kleiman E, Hanson O, Hagiwara, M., Cooper DR. (2009) Akt2 regulation of Cdc2-like kinases (Clk/Sty), serine/arginine-rich (SR) protein phosphorylation, and insulin-induced alternative splicing of PKCssII mRNA. Endocrinology, 150, 2087-2097.
3. Yomoda, J., Muraki, M., Kataoka, N., Hosoya, T., Suzuki, M., Hagiwara, M. and Kimura, H. (2008) Combination of Clk family kinase and SRp75 modulates alternative splicing of Adenovirus E1A. Genes Cells, 13, 233-244.
4. Ohno, G., Hagiwara, M. and Kuroyanagi, H. (2008) STAR family RNA-binding protein ASD-2 regulates developmental switching of mutually exclusive alternative splicing in vivo. Genes and Dev., 22,360-374.
5. Kuroyanagi, H, Ohno, G., Mitani, S., and Hagiwara, M. (2007) Fox-1 family and SUP-12 coordinately regulate tissue-specific alternative splicing in vivo. Mol. Cell. Biol. 27, 8612-8621.
6. Ideue T, Sasaki Y, Hagiwara M and Hirose T. (2007) Introns play an essential role in splicing-dependent formation of the exon junction complex. Genes & Dev., 21, 1993-1998.
7. Kaida D, Motoyoshi H, Tashiro E, Nojima T, Hagiwara M, Ishigami K, Watanabe H, Kitahara T, Yoshida T, Nakajima H, Tani T, Horinouchi S and Yoshida M (2007) A novel cell cycle inhibitor spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA. Nature Chem. Biol., 3, 576-583.
8. Nojima,T., Hirose,T.,Kimura,H.,& Hagiwara,M. (2007) The interaction between cap-binding complex and REF is required for intronless mRNA export. J. Biol. Chem. 282,15645-15651.
9. Aida, T., Konishi,A., Hagiwara,M., & Hashimoto,K. (2007) Shortened Life-Spans of Biotech Pioneer Patents in Japan: A Lesson from the DNA Chip. Nature Biotech. 25, 533-535.
10. Kimura, H., Takizawa N., Allemand, E., Hori, T., Iborra, F.J., Nozaki, N., Muraki, M., Hagiwara, M.., Krainer, A.R., Fukagawa, T., and Okawa, K. (2006) A novel histone-exchange factor, protein phosphatase 2Cg, mediates the exchange and dephosphorylation of H2A/H2B. J. Cell Biol. 175,389-400
11. Kuroyanagi, H., Kobayashi, T., Mitani, S., and Hagiwara, M. (2006) A transgenic reporter reveals cell-type-specific expression profiles and regulation mechanisms of alternatively-spliced exons in vivo. Nature Methods 3, 909-915
12. Wada, K., Howard, J.T., McConnell, P., Whitney, O., Lints, T., Rivas, M.V. Horita, H., Patterson, M.A., White, S.A., Scharff, C., Haesler, S., Zhao, S., Sakaguchi, H., Hagiwara, M., Shiraki, T., Hirozane-Kishikawa, T., Skene, P., Hayashizaki, Y., Carninci, P., and Jarvis, E.D. (2006) A molecular neuroethological approach for identifying and characterizing a cascade of behaviorally regulated genes. Proc Natl Acad Sci USA. 103(41):15212-15217
13. Hirose T., Ideue, T., Nagai, M., Hagiwara, M., Shu, M., and Steitz, J.A. (2006) A spliceosomal intron-binding protein, IBP160, links position-dependent assembly of intorn-encoded box C/C snoRNP to pre-mRNA splicing. Mol. Cell. 23(5):673-684
14. Fukuhara T, Hosoya T, Shimizu S, Sumi K, Oshiro T, Yoshinaka Y, Suzuki M, Yamamoto N, Herzenberg LA, Herzenberg LA and Hagiwara M (2006) Utilization of host SR protein kinases and RNA-splicing machinery during viral replication. Proc Natl Acad Sci USA. 103(30):11329-11333
15. Ohki, N. and Hagiwara, M. (2005) Bio-Object, a stochastic simulator for post-transcriptional regulation. Bioinformatics 21, 2478-2487.
16. Wada, K.,Sakaguchi, H.,Jarvis, E.,and Hagiwara, M. (2004) Differential expression of glutamate receptors in avian neural pathways for learned vocalization. J. Comp. Neurol. 476,44-64.
17. Muraki, M., Ohkawara, B.,Hosoya, T., Onogi, H.,Koizumi, J.,Koizumi, T., Sumi, K., Yomoda, J., Murray, M. V., Kimura, K., Furuichi, K., Shibuya, H., Krainer, A. R., Suzuki, M. and Hagiwara, M. (2004) Manipulation of alternative splicing by a newly developed inhibitor of Clks. J. Biol. Chem. 279, 24246-24254.
18. Takano, M., Koyama, Y., Ito, H., Hoshino, S.,Onogi, H.,Hagiwara, M., Furukawa, K. and Horigome,T(2004) Regulation of binding of lamin B receptor to chromatin by SR protein kinase and cdc2 kinase in Xenopus egg extracts. J. Biol. Chem. 279,13265-13271.
19. Inoue, K., Zama, T., Kamimoto, T., Aoki, R., Ikeda, Y., Kimura, H. & Hagiwara, M. (2004) TNFa-induced ATF3 Expression Is Bidirectionally Regulated by the JNK and ERK Pathways in Vascular Endothelial Cells. Gene to Cells. 1,59-70
20. Umehara, H., Nishii, Y., Morishima, M., Kakehi, Y., Kioka,N., Amachi,T., Koizumi,J., Hagiwara, M. & Ueda,K (2003) Effect of cisplatin treatment on speckled distribution of a serine/arginine-rich nuclear proteinCROP/Luc7A Biochem. Biophys. Res. Comm. 301,324-329.
21. Suzuki,H.,Wu, JH,,Hossain, K.,Ohhata,T., Du, J., Akhand, AA., Hayakawa, A., Kimura,H., Hagiwara ,M., &Nakashima,I.(2003) Involvement of MKK6 in TCRa beta(int)CD69(lo):a target population for apoptotic cell death in thymocytes. FASEB J.17-1538-40
22. Katsu, R., Onogi, H., Wada, K., Kawaguchi, K. & Hagiwara, M. (2002) Novel SR-related protein Clasp specifically interacts with inactivated Clk4 and induces the exon EB inclusion of Clk. J. Biol. Chem. 277, 44220-44228.
23. Suzuki, T., Yamakuni , T., Hagiwara, M. , & Ichinose, H. (2002) Identification of ATF-2 as a Transcriptional Regulator for the Tyrosine Hydroxylase Gene. J. Biol. Chem. 277, 40768-40774.
24. Kimura, Y., Corcoran, E.E., Eto K., Gengyo-Ando, K., Muramatsu, M., Kobayashi, R., Freedman, J.H., Mitani, S., Hagiwara, M., Means, A.R., & Tokumitsu H. (2002) A CaMK cascade activates CRE-mediated transcription in neurons of Caenorhabditis elegans. EMBO Rep. 3, 962-966.
25. Wada, K.,Inoue,K,& Hagiwara, M. (2002) Identification of methylated protein arginine N-methyltransferase 1,PRMT1 with a new expression cloning strategy. Biochem. Biophys. Acta. 1591,1-10.
26. Zama, Z., Aoki, R., Kamimoto, T., Inoue,K., Ikeda, Y. & Hagiwara M. (2002) A novel dual-specificity phosphatase SKRP1 interacts with the MAPKK MKK7 and inactivates the JNK MAPK pathway: Implication for the precise regulation of the particular MAPK pathway. J. Biol. Chem. 277, 23909-23918.
27. Zama, Z., Aoki, R., Kamimoto, T., Inoue,K., Ikeda, Y. & Hagiwara M. (2002) Scaffold role of a MAP linase phosphatase, SKRP1 for the JNK signaling pathway. J. Biol. Chem. 277, 23919-23926.
28. Kamimoto, T., Zama, T., Aoki, R., Muro, Y. & Hagiwara, M. (2001) Identification of a novel kinesin-related protein, KRMP1, as a target for mitotic peptidyl-prolyl isomerase Pin1. J. Biol. Chem. 276, 37520-37528.
29. Kojima, T., Zama, T., Wada, K., Onogi, H. & Hagiwara, M. (2001) Cloning of Human PRP4 Reveals Interaction with Clk1. J. Biol. Chem. 276, 32247-32256.
30. Osada, M., Inaba, R., Shinohara, H., Hagiwara, M., Nakamura, M. & Ikawa, Y. (2001) Regulatory Domain of Protein Stability of Human P51/TAP63, a P53 Homologue. Biochem. & Biophys. Res. Comm. 283, 1135-1141.
31. Aratani, S., Fujii, R., Oishi, T., Fujita, H., Amano, T., Ohshima, T., Hagiwara, M., Fukamizu, A. & Nakajima, T. (2001) Dual roles of RNA helicase A on CREB-dependent transcription. Mol. Cell. Biol., 21, 4460-4469.
32. Ueda, H.R., Hagiwara, M. & Kitano, H. (2001) Robust oscillations within the interlocked feedback model of Drosophila circadian rhythm. J. Theoret. Biol. 210, 401-406.
33. Kuroyanagi, H., Kimura, T., Wada, K., Hisamoto, N., Matsumoto, K. & Hagiwara, M. (2000) SPK-1, a C. elegans SR proteins kinase homologue, is essential for embryogenesis and required for germ line development. Mech. Dev.. 99, 51-64.
34. Muro,Y., Kamimoto,T., Tomita,Y., and Hagiwara, M., (2000) Spectrum of autoantibodies against a dynamin-related protein,dymple. Arthritis Rheumatism 43, 7, 1516-1519.
35. Inoue, K., Mizuno, T., Wada, K. & Hagiwara, M. (2000) Novel RING finger proteins, Air1p and 2p interact with Hmtlp and inhibit the arginine methylation of Np13p. J. Biol. Chem. 275, 32793-32799.
36. Usukura, J., Nishizawa, Y., Shimomura, A., Kobayashi, K., Nagatsu, T. & Hagiwara, M. (2000) Direct imaging of phosphorylation dependent congormational change and DNA binding of CREB by electron microscopy. Genes to Cells 5, 515-522.
37. Nagai, Y., Miyazaki, M., Aoki, R., Zama, T., Inoue, S., Hirose, K., Iino, M. & Hagiwara, M, (2000) A fluorescent indicator for visualizing cAMP-induced phosphorylation in vivo. Nat. Biotechnol. 18, 313-316.
38. Kawahara, K., Watanabe, S., Ohshima, T., Soejima, Y., Oishi, T., Aratani, S., Nakata, M., Shibata, M., Inoue, K., Amano, T., Fujii, R., Yanai, K., Hagiwara, M., Fukamizu, A., Maruyama, I. & Nakajima, T. (1999) Hypernuclear acetylation in atherosclerotic lesions and activated vascular smooth muscle cells. Biochem. Biophys. Res. Comm. 266, 417-424.
39. Sakaguchi, H., Wada, K., Maekawa, M., Watsuji, T. & Hagiwara, M, (1999) Song-induced phosphorylation of cAMP response element binding protein in the songbird brain. J. Neuroscience 19, 3973-3981.
40. Koizumi, J., Okamoto, Y., Onogi, H., Mayeda, A., and Krainer, A. & Hagiwara, M, (1999) The subcellular localization of SF2/ASF is regulated by the direct interaction with SR protein kinases (SRPKs). J. Biol. Chem. 274, 11125-11131.
41. Okamoto, Y., Onogi, H., Honda, R., Yasuda, H., Wakabayashi, T., Nimura, Y. & Hagiwara, M. (1998) cdc2 kinase-mediated phosphorylation of splicing factor SF2/ASF. Biochem. Biophys. Res. Comm. 249, 872-878
42. Yoshida, K., Imaki, J., Okamoto, Y., Iwakabe, H., Fujisawa, H., Matsuda, A., Nakanishi, S., Matsuda, H. & Hagiwara, M. (1998) CREB-induced transcriptional activation depends on mGluR6 in rod bipolar cells. Mol. Brain Res. 57, 241-247.
43. Shimomura, A., Okamoto, Y., Hirata, Y., Kobayashi, M., Kawakami, K., Kiuchi, K., Wakabayashi, T. & Hagiwara, M. (1998) Dominant negative ATF1 blocks cyclic AMP-induced neurite outgrowth in PC12D Cells. J. Neurochem. 70, 1029-1034.
44. Muro, Y., Ogawa, Y., Kato, Y. & Hagiwara, M. (1998) Autoantibody to thioredoxin reductase in an ovarian cancer patient. Biochem. Biophys. Res. Commun. 242, 267-271.
45. Kuroyanagi, N., Onogi, H., Wakabayashi, T. & Hagiwara, M. (1998) Novel SR-protein-specific kinase, SRPK2, disassembles nuclear speckles. Biochem. Biophys. Res. Commun. 242, 357-364.
46. Kamimoto, T., Nagai, Y., Onogi, H., Muro, Y., Wakabayashi, T. & Hagiwara, M. (1998) Dymple, a novel dynamin-like high molecular weight GTPase lacking a proline-rich carboxyl-terminal domain in mammalian cells. J. Biol. Chem. 273,1044-1051
47. Muro, Y., Kano, T., Sugiura, K. & Hagiwara, M. (1997) Low frequency of autoantibodies against Ki-67 antigen in Japanese patients with systemic autoimmune. J. Autoimmunity 10, 499-503.
48. Nomoto, S., Watanabe, Y., Ninomiya-Tsuji, J., Yang, L.-X., Kiuchi, K., Hagiwara, M., Hidaka, H., Matsumoto, K. & Irie, K. (1997) Functional analyses of mammalian protein kinase kinase C Isozymes in budding yeast and mammalian fibroblasts. Genes to Cells 2, 601-614.
49. Nagai, Y., Kojima, T., Muro, Y., Hachiya, T., Nishizawa, Y., Wakabayashi, T. & Hagiwara, M. (1997) Identification of a novel nuclear speckle-type protein, SPOP. FEBS Lett. 418, 23-26
50. Masunaga, R., Nagasaka, A., Nakai, A., Kotak, M., Sawai, Y., Oda, N., Mokuno, T., Shimazaki, K., Hayakawa, N., Kato, R., Hiran, E., Hagiwara, M., & Hidaka, H. (1997) Alteration of platelet aggregation in patients with thyroid disorders. Metabolism 46, 1128-1131.
51. Watsuji, T., Okamoto, Y., Emi, N., Katsuoka, Y. & Hagiwara. M. (1997) Controlled gene expression with a reverse tetracycline regulated retroviral vector (RTRV) system. Biochem. Biophys. Res. Commun. 234, 769-773
52. Watanabe, Y., Takaetsu, G., Hagiwara, M., Irie, K. & Matsumoto, K. (1997) Characterization of a serum response factor-like protein in Saccharomyces cerevisiae, Rlm1, which has transcriptional activity regulated by the Mpk1 (Slt2) Mitogen-activated protein kinase pathway. Mol. Cell. Biol. 17, 2615-2623.
53. Sugiura, K., Muro, Y., Nagai, Y. & Hagiwara, M. (1997) Expression cloning and intracellular localization of a human ZF5 homologue. Biochem. Biophys. Acta. 1352, 23-26
54. Muro, Y., Kamimoto, T. & Hagiwara, M. (1997) Anti-Mitosin antibodies in a patient with chronic graft-versus-host disease after allogenic bone marrow transplantation. Bone Marrow Transplantation 19, 951-953.
55. Kobayashi, M., Shimomura, A., Hagiwara, M. & Kawakami, K. (1997) Phosphorylation of ATF-1 enhances its DNA binding and transcription of the Na, K-ATPase a1 subunit gene promoter. Nucleic Acids Res. 25, 877-882.
56. Okajima, T., Okuno, S., Fujisawa, H. & Hagiwara, M. (1996) Nuclear localization of Ca2+/Calmodulin-dependent protein kinase IV and calspermin. Bioimage 4, 117-128.
57. Moriguchi, T., Toyoshima, F., Gotoh, Y., Iwamatsu, A., Irie, K., Mori, E., Kuroyanagi, N., Hagiwara, M., Matsumoto, K. & Nishida, E. (1996). Purification and identification of a major activator for p38 from osmotically shocked cells: Activation of MAPKK6 by osmotic shock, tumor necrosis factor-a and H2O2. J. Biol. Chem. 271, 26981-26988.
58. Okada, H., Miyamura, K., Ito, T., Hagiwara, M., Wakabayashi, T., Mizuno, M., Colosi, P., Kurtzman, G. & Yoshida, J. (1996) Gene therapy against an experimental glioma using adeno-associated virus vectors. Gene Therapy 3, 957-964.
59. Shimomura, A., Ogawa, Y., Fujisawa, H. & Hagiwara, M. (1996) Calmodulin-dependent protein kinase II potentiates transcriptional activation through ATF1, but not CREB. J. Biol. Chem. 271, 17957-17960.
60. Moriguchi, T., Kuroyanagi, N., Yamaguchi, K., Gotoh, Y., Irie, K., Kano, T., Shirakabe, K., Muro, Y., Shibuya, H., Matsumoto, K., Nishida, E. & Hagiwara, M. (1996) A novel kinase cascade mediated by MAPKK6 and MKK3. J. Biol. Chem. 271, 13675-13679.
61. Yasunami, M., Suzuki, K., Maruyama, H., Kawakami, H., Nagai, Y., Hagiwara, M. & Ohkubo, H. (1996) Molecular cloning and characterization of a cDNA encoding a novel basic helix-loop-helix protein structurally related to NeuroD/BHF1. Biochem. Biophys. Res. Commun. 220, 754-758.
62. Okada, H., Yoshida, J., Sokabe, M., Wakabayashi, T. & Hagiwara, M. (1996) Suppression of CD44 expression decreases migration and invasion of human glioma cells. Int. J. Cancer. 66, 255-260
63. Yoshida, K., Imaki, J., Fujisawa, H., Harada, T., Ohki, K., Matsuda, H. and Hagiwara, M. (1996) Differential distribution of CaM kinases and induction of c-fos expression by flashing and sustained light in rat retinal cells. Invest. Ophthalmol. Vis. Sci. 37, 174-179.
64. Harada, T., Imaki, J., Hagiwara, M., Ohki, K., Takamura, M., Ohashi, T., Matsuda, H. & Yoshida, K. (1995) Phosphorylation of CREB in rat retinal cells after focal retinal injury. Exp. Eye. Res. 61,769-772
65. Kano, T., Suzuki, Y., Shibuya, M., Kiuchi, K. & Hagiwara, M. (1995) Cocaine-induced CREB phosphorylation and c-fos expression were suppressed in parkinsonism model mice. NeuroReport 6, 2197-2200.
66. Ohki, K., Yoshida, K., Hagiwara, M., Harada, T., Takamura, M., Ohashi, T., Matsuda, H. & Imaki, J. (1995) Nitric oxide induces c-fos gene expression via cyclic AMP response element binding protein (CREB) phosphorylation in rat retinal pigment epithelium. Brain Res. 696, 140-144.
67. Yoshida, K., Imaki, J., Matsuda, H. & Hagiwara, M. (1995) Light-induced CREB phosphorylation and gene expression in rat retinal cells. J. Neurochem. 65,1499-1504.
68. Okada, H., Yoshida, J., Seo, H., Wakabayashi, T., Sugita K. & Hagiwara, M. (1994). Anti-(glioma surface antigen) monoclonal antibody G-22 recognizes overexpressed CD44 in glioma cells. Cancer Immunol. Immunother. 39, 313-317.
69. Alberts, A.S., Arias, J., Hagiwara, M., Montminy, R.M. & Feramisco, J.R. (1994) Recombinant cyclic AMP response element binding protein (CREB) phosphorylated on Ser-133 is transcriptionally active upon its introduction into fibroblast nuclei. J. Biol. Chem. 269,7623-7630.
70. Chrivia, J.C., Kwok, R.P., Lamb, N., Hagiwara, M., Montminy, R.M. & Goodman, R.H. (1993) Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature 365, 855-859.
71. Nakamura, S., Wakusawa, S., Tajima, K., Miyamoto, K.-I., Hagiwara, M. & Hidaka, H. (1993) Effects of isoquinoline sulphonamide compounds on multi-drug-resistant P388 cells. J. Pharmacol. 45, 268-273.
72. Shimohama, S., Narita, M., Matsushima, H., Kimura, J., Kameyama, M., Hagiwara, M., Hidaka, H. & Taniguchi, T. (1993). Assessment of protein kinase C isozymes by two-site enzyme immunoassay in human brains and changes in Alzheimer’s disease. Neurology 43, 1407-1413.
73. Hagiwara, M., Brindle, P., Harootunian, A., Armstrong, R., Rivier, J., Vale, W., Tsien, R., & Montminy, R. M. (1993) Stimulus-transcription coupling through the cAMP responsive factor CREB is rate-limited by the nuclear entry of PK-A. Mol. Cell. Biol. 13, 4852-4859.
74. Kawamoto, F., Fujioka, H., Murakami, R., Syafruddin, Hagiwara, M., Ishikawa, T. & Hidaka, H. (1993) The roles of Ca2+/calmodulin-andcGMP-dependent pathways in gametogenesis of a rodent malaria parasite, Plasmodium berghei. Eur. J. Cell. Biol. 60, 101-107.
75. Matsushima, H., Shimohama, S., Yamaoka, Y., Kimura, J., Taniguchi, T., Hagiwara, M. & Hidaka, H. (1993) Alteration of human platelet protein kinase C with normal aging. Mech. Ageing Dev. 69,129-36.
76. Hagiwara, M., Alberts, A., Brindle, P., Meinkoth, J., Feramisco, J., Deng, T., Karin, M., Shenolikar, S. & Montminy, M. (1992) Transcriptional attenuation following cAMP induction requires PP-1-mediated dephosphorylation of CREB. Cell 70, 105-13.
77. Okazaki, K., Watanabe, M., Ando, Y., Hagiwara, M., Terasawa, M. & Hidaka, H. (1992) Full sequence of neurocalcin, a novel calcium-binding protein abundant in central nervous system. Biochem. Biophys. Res. Commun. 185,147-53.
78. Goto, S., Kobayashi, M., Murate, T., Hotta, T., Hagiwara, M., Hoshino, T., Hidaka, H. & Saito, H. (1992). Thrombin-induced shape change in human megakaryoblastic leukemic cells, MEG-01, is mediated by protein kinase C. Thromb. Res. 68, 87-95.
79. Usuda, N., Hagiwara, M., Kong, Y., Shimizu, T., Hidaka, H. & Nagata, T. (1992) Immunohistochemical locazilation of protein kinase C isozymes. Acta. Histochem. Cytochem. 25, 707-715.
80. Wakusawa, S., Nakamura, S., Tajima, K., Miyamoto, K.-I., Hagiwara, M. & Hidaka, H. (1992) Overcoming of vinblastine resistance by isoquinoline sulfonamide compounds in adriamycin-resistant leukemiacells. Mol. Pharmacol. 41, 1034-1038.
81. Kato, M., Hagiwara, M. & Hidaka, H. (1992) Identification of a 80 kDa calmodulin-binding protein as a new Ca2+/calmodulin-dependent kinase by renaturation blotting assay (RBA). Biochem. J. 281, 339-42.
82. Iwamoto, T., Hagiwara, M., Hidaka, H., Isomura, T., Kioussis, D. & Nakashima, I. (1992) Accelerated proliferation and interleukin-2 production of thymocytes by stimulation of soluble anti-CD3 monoclonal antibody in transgenic mice carrying a rabbit protein kinase C alpha. J. Biol. Chem. 267, 18644-18648.
83. Uchida, C., Hagiwara, M. & Hidaka, H. (1991) Ca(2+)-independent, phospholipid-activated protein kinase in 3Y1 cells. Arch. Biochem. Biophys. 288, 421-426.
84. Terasawa, M., Hagiwara, M., Hachiya, T., Kobayashi, R., Obata, S., Wakabayashi, T. & Hidaka, H. (1991) Identification and characterization of protein kinase C-related enzymes in frog retina. Arch. Biochem. Biophys. 287, 213-7.
85. Hagiwara, M., Wakusawa, S., Miyamoto, K., & Hidaka, H. (1991). Obviation of drug resistance and affinity purification of P-glycoprotein by isoquinoline sulfonamides. Cancer Lett. 60, 103-7.
86. Sumi, M., Kiuchi, K., Ishikawa, T., Ishii, A., Hagiwara, M., Nagatsu, T. & Hidaka, H. (1991). The newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contentsin PC12h cells. Biochem. Biophys. Res. Commun. 181, 968-975.
87. Shimizu, T., Usuda, N., Sugenoya, A., Masuda, H., Hagiwara, M., Hidaka, H., Nagata, T. & Iida, F. (1991) Immunohistochemical evidence for the overexpression of protein kinase C in proliferative diseases of human thyroid. Cell. Mol. Biol. 37, 813-821.
88. Usuda, N., Kong, Y., Hagiwara, M., Uchida, C., Terasawa, M., Nagata, T. & Hidaka, H. (1991) Differential localization of proteikinase C isozymes in retinal neurons. J. Cell Biol. 112, 1241-1247.
89. Kato, M., Hagiwara, M., Nimura, Y., Shionoya, S. & Hidaka, H. (1991). Purification and characterization of calcium-calmodulin kinase II from human parathyroid glands. J Endocrinol. 131, 155-162.
90. Koyama, Y., Fukaya, Y., Ueda, H., Hachiya, T., Hagiwara, M., Hidaka, H. & Marunouchi, T. (1990). Expression of protein kinase C isozyme in human Langerhans' cells. Acta. Derm. Venereol. Stockh. 70, 502-505.
91. Koyama, Y., Hachiya, T., Hagiwara, M., Kobayashi, M., Ohashi, K., Hoshino, T., Hidaka, H. & Marunouchi, T. (1990). Expression of kinaseC isozyme in epidermal Langerhans cells of the mouse. J. Invest. Dermatol. 94, 677-680.
92. Onoda, K., Hagiwara, M., Hachiya, T., Usuda, N., Nagata, T. & Hidaka, H. (1990) Different expression of protein kinase C isozymes inpancreatic islet cells. Endocrinology 126, 1235-40.
93. Chijiwa, T., Mishima, A., Hagiwara, M., Sano, M., Hayashi, K., Inoue,T., Naito, K., Toshioka, T. & Hidaka, H. (1990) Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino) ethyl]-5-isoquinolinesulfonamide, of PC12D pheochromocytoma cells. J. Biol. Chem. 265, 5267-5272.
94. Miyamoto, K., Wakusawa, S., Nakamura, S., Koshiura, R., Otsuka, K., Naito, K., Hagiwara, M. & Hidaka, H. (1990) Circumvention of multi-drug resistance in P388 murine leukemia cells by a novel inhibitor of cyclic AMP-dependent protein kinase, H-87. Cancer Lett. 51, 37-42.
95. Hachiya, T., Hagiwara, M. & Hidaka, H. (1990) Immunoaffinity purification of type I protein kinase C. Arch. Biochem. Biophys. 280, 358-361.
96. Sumi, M., Hagiwara, M. & Hidaka, H. (1990) d-Indobufen inhibits collagen-induced intracellular calcium mobilization and inositol phosphates formation in human platelets. Thromb. Res. 59,319-326.
97. Shimosawa, S., Hachiya, T., Hagiwara, M., Usuda, N., Sugita, K. & Hidaka, H. (1990) Type-specific expression of protein kinase C isozymes in CNS tumor cells. Neurosci. Lett. 108, 11-16.
98. Hagiwara, M., Uchida, C., Usuda, N., Nagata, T., & Hidaka, H. (1990) Zeta-related protein kinase C in nuclei of nerve cells. Biochem. Biophys. Res. Commun. 168, 161-168.
99. Hagiwara, M., Hachiya, T., Watanabe, M., Usuda, N., Iida, F., Tamai, K. & Hidaka, H. (1990) Assessment of protein kinase C isozymes by enzyme immunoassay and overexpression of type II in thyroid adenocarcinoma. Cancer Res. 50, 5515-5519.
100. Hagiwara, M., Sumi, M., Usuda, N., Nagata, T. & Hidaka, H. (1990) Discrepancy of protein kinase C translocation and platelet aggregation-immunocytobiochemical evidence. Arch. Biochem. Biophys. 280, 201-5
101. Tokumitsu, H., Chijiwa, T., Hagiwara, M., Mizutani, A., Terasawa, M. & Hidaka, H. (1990). KN-62, 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine, a specific inhibitor of Ca2+/calmodulin-dependent protein kinase II. J. Biol. Chem. 265, 4315-4320
102. Watanabe, M., Hachiya, T., Hagiwara, M. & Hidaka, H. (1989) Identification of type III protein kinase C in bovine aortic tissue. Arch. Biochem. Biophys. 273, 165-169.
103. Mamiya, S., Hagiwara, M., Ishikawa, T. & Hidaka, H. (1989) Specific inhibition of 40 K protein phosphorylation in platelet by a new antithrombotic agent, d-indobufen. Thromb. Res. 54, 447-456.
104. Mamiya, S., Hagiwara, M., Inoue, S. & Hidaka, H. (1989) Thyroid hormones inhibit platelet function and myosin light chain kinase. J. Biol. Chem. 264, 8575-8279.
105. Kariya, K., Kawahara, Y., Fukuzaki, H., Hagiwara, M., Hidaka, H., Fukumoto, Y. & Takai, Y. (1989). Two types of protein kinase C With different functions in cultured rabbit aortic smooth muscle cells. Biochem. Biophys. Res. Commun. 161, 1020-1027.
106. Tokumitsu, H., Hagiwara, M., Onoda, K. & Hidaka, H. (1989) Anti-gizzard MLCK monoclonal antibody MM13 inhibits superprecipitation and phosphorylation of bovine aortic smooth muscle actomyosin. J. Biochem. 106, 511-514.
107. Chijiwa, T., Hagiwara, M. & Hidaka, H. (1989) A newly synthesized selective casein kinase I inhibitor, N-(2-aminoethy1)-5-chloroisoquinoline-8-sulfonamide,and affinity purification of casein kinase C in neuroblastoma NBC-20 cell: dependence on 1,2-diacylglycerol content and free calcium. J Biol Chem. 264, 5267-5272.
108. Fu, T., Okano, Y., Hagiwara, M., Hidaka, H. & Nozawa, Y. (1989) NCB-20 cell: dependence on 1,2-diacylglycerol content and free calcium. Biochem. Biophys. Res. Commun. 162, 1279-1286.
109. Hagiwara, M., Tokumitsu, H., Onoda, K., Tanaka, T., Ito, M., Kato, N. & Hidaka, H. (1989) Monoclonal antibody assessment of tissue- and species- specific myosin light chain kinase isozymes. J. Biochem. 106, 71-75.
110. Hagiwara, M., Mamiya, S. & Hidaka, H. (1989) Selective binding of L-thyroxine by myosin light chain kinase. J. Biol. Chem. 264, 40-44.
111. Ishikawa, T., Chijiwa, T., Hagiwara, M., Mamiya, S. & Hidaka, H. (1989) Thyroid hormones directly interact with vascular smooth muscle strips. Mol. Pharmacol. 35, 760-765.
112. Tanaka, T., Hagiwara, M., Hidaka, H., Nunoki, K., Ohta, H., Onoda, K., Ito, M., Ohkubo, S., Hiai, H. & Nishizuka, Y. (1989) Selective low level of protein kinase C isozyme in a tumor promoter-dependent mouse leukemia cell line. Biochem. Biophys. Res. Commun. 164,1397-1401.
113. Abougou, J. C., Hagiwara, M., Hachiya, T., Terasawa, M., Hidaka, H. & Hartshorne, D. J. (1989) Phosphorylation of caldesmon. FEBS Lett. 257, 408-410.
114. Hagiwara, M., Mamiya, S., Ochiai, M. & Hidaka, H. (1988) Thyroid hormones inhibit the Ca2+ calmodulin-induced activation of myosin light chain kinase. Biochem. Biophys. Res. Commun. 152, 270-276.
115. Hagiwara, M., Inagaki, M., Takahashi, J., Yoshida, T. & Hidaka, H. (1988) A fluorescent protein kinase C inhibitor: 1-(1-hydroxy-5-isoquinolinylsulfonyl) piperazine. Pharmacology 36, 365-370.
116. Ishikawa, T., Chijiwa, T., Hagiwara, M., Mamiya, S., Saitoh, M. & Hidaka, H. (1988) ML-9 inhibits the vascular contraction via the inhibition of myosin light chain phosphorylation. Mol. Pharmacol. 33, 598-603.
117. Hagiwara, M., Inagaki, M., Kanamura, K., Ohta, H. & Hidaka, H. (1988) Inhibitory effects of aminoglycosides on renal protein phosphorylation by protein kinase C. J. Pharmacol. Exp. Ther. 244, 355-360.
118. Kiuchi, K., Hagiwara, M., Hidaka, H. & Nagatsu, T. (1988) Effect of the 1-methyl-4-phenylpyridinium ion on phosphorylation of tyrosine hydroxylase in rat pheochromocytoma PC12h cells. Neurosci. Lett. 89, 209-215.
119. Ito, T., Tanaka, T., Yoshida, T., Onoda, K., Ohta, H., Hagiwara, M., Itoh, Y., Ogura, M., Saito, H. & Hidaka, H. (1988) Immunocytochemical evidence for translocation of protein kinase C in human megakaryoblastic leukemic cells: synergistic effects of Ca2+ and activators of protein kinase C on the plasma membrane association. J. Cell Biol. 107, 929-937.
120. Hagiwara, M., Ochiai, M., Owada, K., Tanaka, T. & Hidaka, H. (1988) Modulation of tyrosine phosphorylation of p36 and other substrates by the S-100 protein. J. Biol. Chem. 263, 6438-6441.
121. Hagiwara, M., Inoue, S., Tanaka, T., Nunoki, K., Ito, M. & Hidaka, H. (1988) Differential effects of flavonoids as inhibitors of tyrosine protein kinases and serine/threonine protein kinases. Biochem. Pharmacol. 37, 2987-2992.
122. Tanaka, T., Ishikawa, T., Hagiwara, M., Onoda, K., Itoh, H. & Hidaka, H. (1988) Effects of cilostazol, a selective cAMP phosphodiesterase inhibitor on the contraction of vascular smooth muscle. Pharmacology 36, 313-320.
123. Hidaka, H., Tanaka, T., Onoda, K., Hagiwara, M., Watanabe, M., Ohta, H., Ito, Y., Tsurudome, M. & Yoshida, T. (1988). Cell type-specific expression of protein kinase C isozymes in the rabbit cerebellum. J. Biol. Chem. 263, 4523-4526.
124. Watanabe, M., Hagiwara, M., Onoda, K. & Hidaka, H. (1988). Monoclonal antibody recognition of two subtype forms of protein kinase C in human platelets. Biochem. Biophys. Res. Commun. 152, 642-648.
125. Hagiwara, M., Inagaki, M., Watanabe, M., Ito, M., Onoda, K., Tanaka, T. & Hidaka, H. (1987) Selective modulation of calcium-dependent myosin phosphorylation by novel protein kinase inhibitors, isoquinoline sulfonamide derivatives. Mol. Pharmacol. 32, 7-12.
126. Hagiwara, M., Inagaki, M. & Hidaka, H. (1987) Specific binding of a novel compound, N-[2-(methylamino)ethyl]-5-isoquinolinesulfonamide to the active site of cAMP-dependent protein kinase. Mol. Pharmacol. 31, 523-528.
127. Inagaki, M., Hagiwara, M., Saitoh, M. & Hidaka, H. (1986) Protein kinase C negatively modulated by phorbol ester. FEBS. Lett. 202, 277-281.
128. Inagaki, M., Kawamoto, S., Itoh, H., Saitoh, M., Hagiwara, M., Takahashi, J. & Hidaka, H. (1986) Naphthalenesulfonamides as calmodulin antagonists and protein kinase inhibitors. Mol. Pharmacol. 29, 577-81.
129. Hagiwara, M., Endo, T., Kanayama, T. & Hidaka, H. (1984) Effect of (3-chloroanilino)-4-phenylphthalazine (MY-5445), a specific inhibitor of cyclic GMP phosphodiesterase, on human platelet aggregation. J. Pharmacol. Exp. Ther. 228, 467-471.
130. Hagiwara, M., Endo, T. & Hidaka, H. (1984) Effects of vinpocetine on cyclic nucleotide metabolism in vascular smooth muscle. Biochem. Pharmacol. 33, 453-457.

英文総説:
1. Hagiwara.M,Nojima.T(2007)Cross-talks between Transcription and Post-transcriptional Events within a ‘mRNA Factory’ J.Biochem.142,11-15
2. Osada.H,Hagiwara.M,Toshima.K and Imoto.M.(2006) The Education System for Chemical Biology in Japanese Universities ACS Chem. Biol. 1, 492-494.
3. Hagiwara.M. (2005) Alternative splicing: A new drug target of the post-genome era. Biochimica et Biophysica Acta 1754, 324-331.
4. Hidaka,H.and Hagiwara,M.(1991). Development of molecular probes for the research of calmodulin-dependent enzymes. in Advances in Second Messengers and Phosphoprotein Reserch,edited by S.J.Strada and H.Hidaka,Raven Press,New York. 25,241-248
5. Hidaka,H.and Hagiwara,M.(1991). Development of molecular probes for the research of calmodulin-dependent enzymes. in Advances in Second Messengers and Phosphoprotein Reserch,edited by S.J.Strada and H.Hidaka,Raven Press,New York. 25,241-248
6. Hidaka,H., Hagiwara,H. and Tokumitsu,H.(1990). Novel and selective inhibitors of CaM-kinase II and other calmodulin-dependent enzymes. in Calcium Binding Proteins In Normal and Transformed Cells ed. by Roland Pochet,D.Eric,M.Lawson and Claus W. Heizmann,Plenum,press,New York.(Proceedings of the First Europian Symposium on Calcium Binding Proteins in Normal and Transformed Cells, held April 20-22, 1989, in Brussels,Belgium).159-162
7. Hidaka,H.,Hagiwara,H.,Naka,M.and Mamiya,S.(1989). Ca2+-dependent protein kinase cascade of platelets. Acta Haematol.Jpn.52(8),1516-1521.
8. Hidaka,H.and Hagiwara,M.(1989).Molecular Pharmacology of protein kinase C. in Calcium Protein Signaling, ed by Hidaka,H. Plenum Press,New York.255,1-7.
9. Hidaka,H.,Chijiwa,T.and Hagiwara,M.(1989).Molecular pharmacology of protein kinases which control neural development. in Bioinformatics,O.Hatase,and J.H.Wang,eds.,Elsevier Science Publishers B.V.Amsterdam.35-40..
10. Hagiwara,M.and Hidaka,H.(1989).Modulation of Ca2+ calmodiulin-dependent myosin phosphorylation by three types of inhibitors. in Biosignalling in Cardiac and Vascular Systems (Proceedings of the International Symposium on Biosignalling in Cardiac and Vascular Systems,5-7 September 1988, Kyoto, Japan) M.Fujiwara,S.Narumiya,and S.Miwa,eds.,Pergamon Press, Englamd.267-270,
11. Hidaka,H.and Hagiwara,M(1987).Biopharmacological regulation of protein phosphorylation. in Progress in Clinical Biochemistry and Medicine,Springer-Verlag,Berlin,Heidelberg.5,25-42.
12. Hidaka,H.and Hagiwara,M.(1987).Parmacology of the isoquinolinesulfonamide protein kinase C inhibitors.T.I.P.S.8(5),162-164.
13. Hagiwara,M.and Hidaka,H.(1987).Selective inhibitors of phosphorylation in smooth muscle. in Regulation and Contraction of Smooth Muscle,eds. by M.siegman,A.P.Somlyo,N.L.Stephens,Alan R.Liss,Inc.,New York.251-262

和文総説 :
1. 萩原正敏 mRNAスプライシング制御から難治疾患の治療へ 実験医学 (印刷中)
2. 萩原正敏 タンパク質リン酸化酵素を標的とした創薬(2009) 現代化学 No.464, 21-25
3. 萩原正敏 リン酸化依存的スプライシング制御機構 蛋白質 核酸 酵素 増刊『mRNAプログラム』(印刷中)
4. 野島孝之、萩原正敏 ウイルスによるスプライシング暗号の利用と撹乱 (2009)実験医学 Vol.27, No.10, 1482-1487.
5. 萩原正敏 リン酸化酵素阻害剤のケミカルバイオロジー(2008) 「新規素材探索−医薬品リード化合物・食品素材を求めて−」 p129-135 (CMC出版)
6. 萩原正敏 ケミカルバイオロジー概論 (2008) 日薬理誌 132, 4−6.
7. 萩原正敏 リン酸化酵素阻害薬によるケミカルバイオロジー研究の展開 (2008) 日薬理誌 132, 22−25.
8. 萩原正敏、臼木博一(2007) キナーゼ阻害剤 蛋白質核酸酵素 vol.52 no.13 1708-1712
9. 黒柳秀人、萩原正敏(2007)選択的スプライシングを生体内で可視化する 細胞工学 Vol.26 No.1 64−65
10. 萩原正敏(2006)mRNAの選択的スプライシングを標的とした新しい創薬:研究動向と今後の展望 分子細胞治療 vol.5 no.5 10(400)-15(405)
11. 萩原正敏(2006)世界初のケミカルバイオロジー研究会年会 細胞工学 vol.25 no.9 1050-1051
12. 萩原正敏(2006)選択的スプライシング−リバースケミカルジェネティクスからの解明− 現代化学 5月 21−25
13. 萩原正敏(2006)異常スプライシングによる疾患の克服−あらたな創薬ターゲット 医学のあゆみ vol.216 no.12 908-909
14. 萩原正敏.(2005)  リバースケミカルバイオロジーによるアプローチ:特異的阻害剤による選択的スプライシングの制御機構解明に向けて 細胞工学 Vol.24 No.11 1161-1165
15. 萩原正敏.(2005) ケミカルバイオロジーとは"?細胞工学 Vol.24 No.11 1158-1160
16. 萩原正敏(2003)タンパク質リン酸化酵素阻害剤研究の新しい潮流 細胞工学 Vol.22 No.2 147-151
17. 萩原正敏 鈴木正昭(2003)新たなパラダイムを拓く分子プローブの創製:生物学と化学の融合 Vol.22 No.2 134-135
18. 萩原正敏(2002)小鳥の歌学習の分子機構 第24巻10号941-944
19. 萩原正敏(2002)CREBリン酸化による遺伝子発現制御とその可視化 医学のあゆみVol.203 No.8 535-537
20. 萩原正敏(2001) GFPを用いた細胞内リン酸化反応のイメージング Aキナーゼ活性を可視化する新しい蛍光蛋白質ART 科学と生物 Vol.39 No.2 76-78
21. 萩原正敏 (2001) RSドメイン 生体の科学 第52巻 第5号400-401
22. 萩原正敏(2000) Aキナーゼ活性を可視化する新しい方法 脳の科学 22 1311-1317
23. 萩原正敏(1999)悪性黒色腫に発現する融合遺伝子EWS/ATF1のがん化機構における役割の解明 がん治療のあゆみ 第18巻 53-58
24. 萩原正敏 小泉 順(1998)mRNA factory のリン酸化制御ポイント 細胞工学 別冊 Vol.17 No.10 1534−1539
25. 萩原正敏 小泉 順(1998)SRタンパク質キナーゼの分子機構 細胞工学Vol.21 No.3 278-281
26. 萩原正敏(1998) mRNA factoryとは何か?   細胞工学 Vol.17 No.10 1498-1502
27. 萩原正敏(1997)シナプスの可塑性と転写制御 実験医学 Vol.15 No.4 173(455)-176(458)
28. 萩原正敏(1996)細胞表面の受容体から核内転写因子へいかにしてシグナルは伝えられるのか?-cAMPとカルシウムによる転写調節- 日薬理誌107 47-52
29. 萩原正敏()転写制御に関するIn vivo 実験系確立と病態解明への応用 (財)小野医学研究財団第6回研究成果報告集(第2回研究推奨助成) 107-114
30. 萩原正敏(1995)細胞表面から核内転写因子に至るシグナルトランスダクション 月刊細胞 Vol.27 No.9通巻346号 29-32
31. 萩原正敏(1995)CREBを通して覗きみる高次神経系の働き-学習プロセスにおける転写調節因子の役割- 実験医学 Vol.13 No.9 77-81
32. 萩原正敏(1995)転写因子のリン酸化による遺伝子発現制御-CREBを中心として 生化学 第67巻 第12号 1388-1391
33. 萩原正敏(1994)シグナル伝達にかかわる転写因子群 臨床科学 第30巻 第3号 327-331
34. 萩原正敏(1994)医学におけるバイオテクノロジー(22)蛋白質燐酸化酵素の細胞内ソーティングと転写調節 現代医学 第41巻 第3号 595-599
35. 萩原正敏 (1993) 核内プロテインホスファターゼによる転写調節モデル 実験医学 Vol.11 NO.6 70-73
36. 萩原正敏 日高弘義(1991) 環状ヌクレオチドホスホジエステラーゼ 日本臨床 第49巻 第9号 37-42
37. 日高弘義 萩原正敏(1991)血小板活性化機構とプロテインキナーゼ 治療 Vol.73 No.5 27-32
38. 日高弘義 萩原正敏(1991)血小板のカルシウムシグナルと蛋白質リン酸化反応 血小板活性化の生化学別冊 79-90 
39. 日高弘義 萩原正敏(1990)Cキナーゼと細胞増殖 BIOTHERAPY 第4巻 第2号 149-154
40. 日高弘義 萩原正敏(1990)血小板Ca2+シグナルの発生と伝達 血液腫瘍科 第21巻 第3号 256-260
41. 日高弘義 萩原正敏(1988)情報伝達におけるタンパクリン酸化の意義-最近の展開- 膜 13(3) 124-132

出願特許 :
1.

発明の名称:蛋白質のリン酸化を測定するためのモニター蛋白質
@発明者:萩原正敏、井上敏、永井康雄
A出願日:1999年9月2日 (PCT/JP99/04769)
B出願人:国立大学法人東京医科歯科大学

C発明の内容の概略:蛋白のリン酸化による構造変化をFRETによって可視化することに成功し、生きた細胞内のリン酸化反応を計時的にモニターし定量化できるモニター蛋白質ARTを開発した。
2.

発明の名称:異常スプライシング関連疾患の治療薬候補物質
@発明者:萩原正敏, 鈴木正昭
A出願日:2005年1月6日(US? 11/029/470)
2005年1月7日(AU? 2005200040)
B出願人:国立大学法人東京医科歯科大学

C発明の内容の概略::Clk阻害により異常スプライシングを是正する化合物に関する特許。
3.

発明の名称:SR蛋白質のリン酸化制御方法、およびSR蛋白質の活性制御剤を有効成分とする抗ウイルス剤
@発明者:萩原正敏、福原武志、鈴木正昭、細谷孝充
A基礎出願日:2003年12月26日(特願2003-435085)
PCT出願日:2004年12月24日(PCT/JP2004/19393)
B出願人:萩原 正敏
C発明の内容の概略:新規SRタンパク質リン酸化酵素阻害剤のウイルス増殖抑制に関する特許。

4.

発明の名称:生体内における選択的スプライシングレポーター系
@発明者:萩原正敏、黒柳秀人
A米国 出願日:2006年9月26日(US? .11/904, 094)
B出願人:国立大学法人東京医科歯科大学
C発明の内容の概略:線虫で選択的スプライシングを可視化し、制御因子や制御化合物を同定する方法に関する特許。

5.

発明の名称:抗DNAウイルス作用を有するアニリン誘導体
@発明者:萩原正敏、小野木博、細谷 孝充、 山本 誠、 野中 洋介、 平松 俊行
A基礎出願日:2007年8月3日? (特願 2007-203356)
PCT出願日:2008年8月1日? (PCT / JP2008 / 064267 )
B出願人:株式会社 キノファーマ
C発明の内容の概略: DNAウイルスに対して抗ウイルス作用を有するアニリン誘導体に関する特許。

6.

発明の名称:発光タンパク質を用いたリン酸化酵素阻害物質のスクリーニング方法
@発明者:萩原正敏、野村奈美子、木村広、野崎直仁
A基礎出願日:2008年3月4日? (特願 2008-053502)
日本 本出願日 :2009年3月3日? (特願 2009-049763)
B出願人:株式会社キノファーマ
C発明の内容の概略:発光タンパク質エクオリンを用いて、non-RIで高感度かつ簡便にリン酸化酵素阻害物質をスクリーニングする技術に関する特許。

7.

発明の名称:抗RNAウイルス作用を有するアニリン誘導体
@発明者:萩原正敏、小野木博、鈴木正昭、古山 浩子、細谷 孝充、 平松 俊行
A基礎出願日:2008年3月25日? (特願 2008-078728)
PCT出願日:2009年2月4日  (JP2009 / 052253)
B出願人:株式会社 キノファーマ
C発明の内容の概略: RNAウイルスに対して抗ウイルス作用を有するアニリン誘導体に関する特許。

8.

発明の名称:DYRKを阻害するベンゾチアゾール誘導体を含有する医薬組成物
@発明者:萩原 正敏、 澁谷 浩司、 大西 英理子、 小川 靖、     
細谷 孝充、 平松 俊行、 吉田 実代
A基礎出願日:2008年7月23日? (特願 2008-190277)
韓国出願日:2008年12月31日 (KR 10-2008-0138074)
B出願人:株式会社 キノファーマ
C発明の内容の概略: DYRK阻害能を有するベンゾチアゾール誘導体に関する特許。

9.

発明の名称:DYRKを阻害するビチアゾール誘導体を含有する医薬組成物
@発明者:萩原 正敏、 野中 洋介、 土橋 圭子、 吉田 実代、 
平松 俊行
A基礎出願日:2009年2月20日? (特願 2009-038327)
B出願人:株式会社 キノファーマ

C発明の内容の概略: DYRK阻害能を有するビチアゾール誘導体に関する特許。