Ryo Akiba, Yoshitaka Moriwaki, Ryuichiro Ishitani, Naruki Yoshikawa, Multi-objective optimization for designing structurally similar proteins with diverse sequences, Science and Technology of Advanced Materials: Methods, DOI:10.1080/27660400.2025.2611575.(2026)
Aiko Watanabe, Shizuka Ogiwara, Mirei Saito, Masaki Mishima, Masahiro Yamashina, Ryuichiro Ishitani, Yutaka Ito, Keiji Tanaka, Fumika Koyano, Koji Yamano, Hidetaka Kosako, Yoshitaka Moriwaki, Noriyuki Matsuda, The reaction mechanism for glycolysis side product degradation by Parkinson’s disease-linked DJ-1, J. Cell. Biol., 224(8), e202411078, DOI:10.1083/jcb.202411078, (2025)
Kawahara T, Tani Y, Nawa N, Morioka S, Kajiho H, Sasaki J, Sasaki T, Fujiwara T. Circulating phospholipid species and internet addiction severity in Japanese adolescents: a pilot lipidomics study. Front Psychiatry. 2026 Feb 16:17:1751247. doi: 10.3389/fpsyt.2026.1751247.
Zhou X, van der Stoel MM, Kaptan S, Li H, Li S, Hölttä M, Vihinen H, Jokitalo E, Thiele C, Pietiläinen O, Morioka S, Sasaki J, Sasaki T, Vattulainen I, Ikonen E: Control of Golgi- V-ATPase through Sac1-dependent co-regulation of PI(4)P and cholesterol. Nature Commun. 16, 7808, 2025
Yanai S, Sasaki J, Lee-Okada HC, Takahashi F, Kikuchi Y, Morioka S, Yamamoto T, Yuguchi K, Oikawa M, Kajiho H, Baba T, Yokoyama C, Morohashi KI, Suzuki A, Yokomizo T, Sasaki T: Adrenal lipoma formation via PI(3,4,5)P3/AKT-dependent transdifferentiation of adrenocortical cells into adipocytes. Proc. Natl. Acad. Sci USA. 122: e2510306122, 2025
Sako K, Morimoto Y, Morioka S, Hasegawa J, Nakajima H, Fukumoto M, Nishida Y, Shintani Y, Sasaki J, Sasaki T, Kikuchi K, Mochizuki N: Cells adapt to extracellular acidic pH through TM9SF3-mediated PI(4,5)P2 flop. Nature Commun. 16, 8852, 2025
Kawahara T, Tani Y, Nawa N, Morioka S, Kajiho H, Sasaki J, Sasaki T, Fujiwara T.: Circulating phospholipid species and internet addiction severity in Japanese adolescents: a pilot lipidomics study. Front Psychiatry 17, 1751247, 2026
Kurata, H., Ngurari, S., Nita, A., Sakamoto, Y., Nduru, D., and Moroishi, T. A kinase inhibitor screen identifies GSK690693 as a Hippo pathway inhibitor targeting ER-positive breast cancer. J. Biochem. in press (2026) https://doi.org/10.1093/jb/mvag005
Saleh, M.F., Nita, A., Ohta, Y., Kobayashi, A., Li, H., Sakamoto, Y., and Moroishi, T. Hippo Pathway Drives Durable Non-Cell-Autonomous Ferroptosis Resistance in Lung Cancer. Cancer Sci. 117, 683-694 (2026)
Ohta, Y., Kanamori, Y., Maeda, A., Saleh, M.F., Nita, A., Matsumoto, T., Nakayama, K.I., and Moroishi, T. Iron and bile acids synergize to exacerbate congenital cholestatic liver injury via ferroptosis. Am. J. Pathol. 196, 700-715 (2026)
Nduru, D., Ohta, Y., Nita, A., Niimura, M., Ngurari, S., and Moroishi, T. A YAP/TAZ–CDC6 Axis Initiates and Maintains Malignant Transformation. Cancer Sci. 117, 353-363 (2026)
Maeda, A., Nita, A., and Moroishi, T. Glutamine metabolism drives B cell proliferation under elevated atmospheric pressure. Biochem. Biophys. Res. Commun. 790, 152892 (2025)
Liu, S., Kanamori, Y., Ohta, Y., Li, S., Liu, Y., Li, H., Saleh, M.F., Nita, A., Nakayama, K.I., and Moroishi, T. Iron overload in CD11c+ myeloid cells exacerbates acetaminophen hepatotoxicity. Commun. Biol. 8, 1488 (2025)
Harada, N., Niimura, M., Sakamoto, Y., Nita, A., Shimoda, M., Wada, S., Murata, K., Wakao, M., Kamba, T., Shinchi, H., and Moroishi, T. Peptide modulation overrides glycan synergy in gold nanoparticle-based vaccines for cancer immunotherapy. Cancer Med. 14, e71286 (2025)
Kanamori, Y., Nita, A., Nakayama, K.I., Kurotaki, D., Harada, K., and Moroishi, T. Hepatocyte iron suppresses liver fibrosis via fibrolytic neutrophil recruitment in cholestasis. JHEP Rep. 7, 101590 (2025)
Niimura, M., Sakamoto, Y., Shimoda, M., Harada, N., Maeda, A., Wada, S., Murata, K., Thinyakul, C., Liu, S., Ohara, H., Iwamoto, A., Kanamori, Y., Nita, A., Wakao, M., Suda, Y., Oshiumi, H., Hayashi, T., Carson, D. A., Shinchi, H., and Moroishi, T. Harnessing an integrated glyco-nanovaccine technology for enhanced cancer immunotherapy. Commun. Med. (Lond) 5, 378 (2025)
Li, H., Kanamori, Y., Nita, A., Maeda, A., Zhang, T., Kikuchi, K., Yamada, H., Toyomoto, T., Saleh, M.F., Niimura, M., Hinokuma, H., Shimoda, M., Ikeda, K., Suzuki, M., Komohara, Y., Kurotaki, D., Sawa, T., and Moroishi, T. Hippo pathway controls biopterin metabolism to shield adjacent cells from ferroptosis in lung cancer. EMBO Rep. 26, 4124-4152 (2025)
Liu, Y., Liu, S., Sakamoto, Y., Chunthaboon, P., Thinyakul, C., Mori, R., Li, S., Watanabe-Nakayama, T., Omata, S., Morita, Y., and Moroishi, T. LATS1/2–integrin axis confers tumor-generated forces that activate neighboring fibroblasts. Cancer Sci. 116, 2486-2498 (2025)
Ochiai K, Tahara-Arai Y, Kato A, Kaizu K, Kariyazaki H, Umeno M, Takahashi K, Kanda GN, Ozaki H. Automating care by self-maintainability for full laboratory automation, Digit. Discov. 4, 2285–2297 (2025)
Miyata Y, Nishimura M, Nagata A, Jing X, Sultan C.S, Kuribayashi R, Takahashi K, Lee Y, Nishizawa T, Segawa K. Membrane structure-responsive lipid scramblase activity of the TMEM63/OSCA family FEBS Letters. 2025.03; 599(5); 656-666
Miyata Y, Takahashi K, Lee Y, Sultan CS, Kuribayashi R, Takahashi M, Hata K, Bamba T, Izumi Y, Liu K, Uemura T, NomuraN,Iwata S, Nagata S, Nishizawa T, Segawa K. Membrane structure-responsive lipid scrambling by TMEM63B to control plasma membrane lipid distribution Nat Struct Mol Biol. 2025.01;32(1); 185-198
Watanabe A, Ogiwara S, Saito M, Mishima M, Yamashina M, Ishitani R, Ito Y, Tanaka K, Koyano F, Yamano K, Kosako H, Moriwaki Y, Matsuda N. The reaction mechanism for glycolysis side product degradation by Parkinson's disease-linked DJ-1. J Cell Biol. 224(8): e202411078, 2025. doi: 10.1083/jcb.202411078.
Mudiyanselage HNTN, Misawa T, Ochiai K, Demizu Y, Hanazono Y, Ito N, Fujii S. Design, synthesis and structural development of nonsecosteroidal VDR ligands based on the C,C’-diphenyl-m-carborane scaffold. Eur J Med Chem. 302(2), 118320, 2026. doi: 10.1016/j.ejmech.2025.118320.
Yoshida M, Hanazono Y, Numoto N, Yabuno S, Ito N, Azuma T, Oda M. Structural basis of affinity maturation of anti-(4-hydroxy-3-nitrophenyl)acetyl antibodies. Arch. Biochem. Biophys., 775, 110665, 2026. doi: 10.1016/j.abb.2025.110665
Yasukochi S, Numoto N, Hori K, Tenno T, Hibino E, Ito N, Hiroaki H. A Unique Trimeric Assembly of Human Dishevelled 1 PDZ Domain in Crystal: Implication of Homo- and Hetero-Oligomerization During Wnt Signaling Process. Molecules, 30, 3538, 2025. doi: 10.3390/molecules30173538
Mudiyanselage HNTN, Misawa T, Ochiai K, Demizu Y, Hanazono Y, Ito N, Fujii S. Structure-activity relationship and crystallographic analyses of non-secosteroidal vitamin D receptor ligands bearing diphenylsilane core as a hydrophobic pharmacophore. Bioorg. Med. Chem., 128, 118261, 2025. doi: 10.1016/j.bmc.2025.118261
Hanazono Y, Yabuno S, Hayashi T, Numoto N, Kamatari YO, Ito N, Oda M. Crystal structures reveal how the multispecific antibody G2 achieves binding to different peptides. FEBS Letters, 599, 1925–1934, 2025. doi:10.1002/1873-3468.70095
Liu Y, Nakayama Y, Sugita J, Oshima T, Kani K, Kobayashi A, et al. MALAT1 regulates human macrophage metabolism by interacting with HADHB. iScience. 2026;29(3):115107
Mizukoshi C, Kojima Y, Hayashi S, Abe K, Kasugai D, Shimamura T. scSurv: a deep generative model for single-cell survival analysis. Bioinformatics. 2026 Jan 2;42(1):btaf671. doi: 10.1093/bioinformatics/btaf671.
Shimamura T. RNA velocity and beyond: Current advances in modeling single-cell transcriptional dynamics. Allergol Int. 2025 Oct;74(4):525-533. doi: 10.1016/j.alit.2025.08.005.
Yanagi, Y., Ichikawa, H., Nguyen, L. B. T., Hayashi, A., Abe, N., Abe, H. & Uchida, S. mRNA vaccination mitigates pathological retinochoroidal neovascularization in animal models. Vaccine 61, 127451 (2025). https://doi.org/https://doi.org/10.1016/j.vaccine.2025.127451
Dirisala, A., Uchida, S., Toh, K., Li, J., Liu, X., Wen, P., Fukushima, S. & Kataoka, K. Structural stability and RNase resistance of mRNA Polyplex micelles for systemic delivery. J. Control. Release 384, 113935 (2025). https://doi.org/https://doi.org/10.1016/j.jconrel.2025.113935
Marx, V., Mochida, Y., Osawa, S., Tockary, T. A., Norimatsu, J., Yokoo, H., Oba, M. & Uchida, S. Poly(sarcosine) and Poly(2-ethyl-2-oxazoline) Tethered To mRNA Provide Stealth Properties To mRNA Polyplexes. ACS Applied Nano Materials 8, 13628-13638 (2025). https://doi.org/10.1021/acsanm.5c00636
Otani K, Koyama R, Tsuyama J, Sakai S, Hase K, Shichita T. Zoledronic acid attenuates ischemic brain injury by promoting ETS2 and MSR1 expression. Int Immunol. 37, 393-402, 2025
Noriyuki Azuma, Keiko Tadokoro, Masao Yamada, Masato Nakafuku and Hiroshi Nishina (2025) Sonic hedgehog determines early retinal development and adjusts eyeball architecture. Int. J. Mol. Sci. 26, 496.
Noriyuki Azuma, Yuki Yamaguchi, Taku Tanaka, Emiko Matsuzaka, Yuki Saida, Tadashi Yokoi, Hiroshi Handa, Jun Hirayama, Hiroshi Nishina (2025) INTS15,A Subunit of the Integrator Complex, Plays a Key Regulatory Role in Cell Cycle and Differentiation.Genes to Cells 30, e70015
Satoshi Kofuji, Qian Yiming, Hiroshi Nishina (2025) Region-specific roles of stress-activated protein kinase MKK7 in the developing and maturing murine brain. Scientific Reports. 15, 20504. doi: 10.1038/s41598-025-05388-0
Poonperm R, Yoneda T, Imada T, Takahashi S, Ichinose T, Miura H, Hayashi T, Kuse M, Yoshimura M, Nagao K, Obuse C, Nikaido*, Hiratani I*, Takebayashi S*. scRepli-RamDA-seq: a multi-omics technology enabling the analysis of gene expression dynamics during S-phase. Nature communications, 16, (1), 10902-10902. 2025. doi: 10.1038/s41467-025-64688-1
Nakagawa H, Shima Y, Sasagawa Y, Nikaido I. MitoDelta: identifying mitochondrial DNA deletions at cell-type resolution from single-cell RNA sequencing data. BMC genomics, 26, (1), 810-810, 2025. doi: 10.1186/s12864-025-11931-0
Kobayashi, Y., Sunadome, K., Maki, K., Fukunaga, H., Matsubara, H., Ohkubo, S., Maki, R., Yoshikawa, M., Tata, A., Tata, P.R., Matsumoto K., Adachi, T., Iwaki, M., Yamamoto, T., Toyoshima, F. Distinct dermal fibroblasts direct mechano-chemical signaling to the epidermis during pregnancy. bioRxiv 2025.09.11.675503; doi: https://doi.org/10.1101/2025.09.11.675503
小藤 智史、仁科 博史：ストレス応答性キナーゼMKK4を標的とした肝疾患治療法の開発（2025）
Kang Y, Ohka S, Nishizawa D, Hasegawa J, Nakayama K, Yoshida K, Koshika K, Ichinohe T, Ikeda K. Differential effects of antiemetic serotonin receptor antagonist ondansetron on nausea associated with CHRM3 rs2165870 and TACR1 rs3755468 single-nucleotide polymorphisms. Mol Brain 18(1):64, 2025. doi: 10.1186/s13041-025-01237-3.
Nishizawa D, Ikeda K. Genetics of pain and analgesics – current insights and future directions. Pain Research 40(1):113-121, 2025. doi: 10.11154/pain.40.113.
Ide S, Izuo N, Ikekubo Y, Uhl GR, Sora I, Nitta A, Ikeda K. Ifenprodil inhibits nicotine-induced addiction-like behaviors in mice. Life Sciences 384:124116, 2026. doi: 10.1016/j.lfs.2025.124116.
Ide S, Nishitani Y, Sumitani M, Minami M, Isa T, Iseki M, Ohkura M, Okamoto H, Kikuchi T, Sekino Y, Takahashi H, Takeuchi K, Nitta A, Honjo T, Matsumoto H, Miyakawa T, Murai T, Matsumoto T, Nakagome K, Ikeda K. Addiction-related problems in Japan: A regional perspective. Addiction, in press.
Shimada M, Honda M, Honda Y, Kodama T, Hitomi Y, Tokunaga K, Miyagawa T. DNA methylation and multi-omics profiling of T cells uncovers chemotactic pathways and proliferation-linked hypomethylation in narcolepsy type 1. Sleep. 48(12), zsaf278, 2025. doi: 10.1093/sleep/zsaf278.
Ogawa S, Hattori K, Hidese S, Sasayama D, Ota M, Miyakawa T, Tatsumi M, Matsumura R, Yoshida S, Noda T, Takebayashi M, Omori W, Itagaki K, Kajitani N, Okada-Tsuchioka M, Hishimoto A, Boku S, Horai T, Monji A, Mizoguchi Y, Tateishi H, Murakawa-Hirachi T, Yoshimura R, Igata R, Kim Y, Hori H, Kunugi H. Ethanolamine as a potential biomarker and therapeutic target for depressive disorder. Mol Psychiatry, in press.
Furuie H, Hatakeyama T, Harigai W, Katayama T, Tsuchiya KJ, Takahashi N. Animal Models for the Study of ADHD: The Need for Next-Generation Models. Frontiers in Psychiatry, in press.
Matsumoto J, Ito S, Sumiyoshi C, Yasuda Y, Hasegawa N, Fujimoto M, Yamamori H, Sumiyoshi T, Hashimoto R. Cognitive profile of psychiatric patients with coexisting enlarged ventricle and cognitive impairment: a rare cross-diagnostic phenotype predominantly observed in schizophrenia. Psychiatry Clin Neurosci, Online ahead of print, DOI:10.1111/pcn.70012(Epub 2025.12)
Hakamata Y, Mizukami S, Izawa S, Matsui M, Moriguchi Y, Hanakawa T, Hori H, Inoue Y, Tagaya H. The effectiveness and neurobiological actions of memory bias modification: a randomized controlled trial. Psychol Med. 2025; 55: e386. doi: 10.1017/S0033291725102535.
Ueda N, Lin M, Itoh M, Hori H, Narita Z, Niwa M, Ino K, Narita M, Nakano W, Imai R, Matsui M, Kamo T, Kim Y. Decreased non-emotional working memory capacity in women with PTSD: association with symptomatology. Eur J Psychotraumatol. 2025; 16(1): 2543079. doi: 10.1080/20008066.2025.2543079.
Ogawa S, Hori H, Niwa M, Itoh M, Lin M, Yoshida F, Ino K, Kawanishi H, Narita M, Nakano W, Imai R, Matsui M, Kamo T, Kunugi H, Hattori K, Kim Y. Serum lipid and plasma fatty acid profiles in PTSD patients and healthy individuals: Associations with symptoms, cognitive function, and inflammatory markers. Prog Neuropsychopharmacol Biol Psychiatry. 2025; 138: 111298. doi: 10.1016/j.pnpbp.2025.111298.
Hayase Y, Owa T, Hashizume K, Suyama K, Bolorbat T, Sone M, Kanno Y, Hasegawa I, Miyashita S, Taya S, Hoshino M. Pharmacological correction of aberrant DSCAML1 localization by 4-phenylbutyrate ameliorates epileptic phenotypes in a mouse model harboring the patient-specific A2105T mutation. Genes Cells, in press.
